化学物質リスク研究事業

(○:委員長)
 
  青木康展 国立環境研究所・名誉研究員
  専門分野 毒性学
  青木康展、環境基準・指針値の設定の現状と今後、ファルマシア 2023;59(6):510-515.  
 
  Aoki Y et al. Characteristic mutations induced in the small intestine of Msh2-knockout gpt delta mice. Genes Environ. 2021 Jul 5;43(1):27. doi: 10.1186/s41021-021-00196-0.
  Aoki Y et al. Oxidative-stress-driven mutagenesis in the small intestine of the gpt delta mouse induced by oral administration of potassium bromate. Mutat Res. Feb-Mar 2020;850-851:503136. doi: 10.1016/j.mrgentox.2020.503136.
       
 
 
  池田耕一 公財日本建築衛生管理教育センター評議委員
  建築衛生学
  “Study of the different Cutoff Point of the QEESI Questionnaire as a Screening Tool for Sick Building Syndrome Diagnosis in Taiwan” Koichi Ikeda, Lin-lin Huang, Sachiko Hojo, Naoki Kagi and Han-Cheng Juang, Journal of Asian Architecture and Building Engineering, vol.13 no.2, pp.1-7 2014
  「室内環境にかかわる疾病―アレルギー、化学物質過敏症、シックハウス症候群―」池田耕一:東京電機大学出版局刊、2010 「室内空気質・温熱環境の実態と今後の課題」池田耕一:ビル用マルチパッケージ型空調システム―計画・設計から性能の評価まで―公益社団法人空気調和・衛生工学会編、2014
  「A Study on Environmental Pollution Caused by Radioactive Substances and its Countermeasure Techniques (Part2), Radiation Dose in Park」Koichi IKEDA, Atsuo NOZAKI, Yasunori NARITA, Hoshio GOTO, Yoshihiko KANAYAMA, Kazuki IWAOKA, Hidenori YONEHARA and Hiroshi YOSHINO: Proceedings for The International Conference on Healthy Buildings 2012, pp. 1-4, 2012
       
 
 
  岡 淳一郎 東京理科大学薬学部 名誉教授
  神経薬理学
  Cognitive and hippocampal synaptic profiles in monosodium glutamate-induced obese mice.  S. Sasaki-Hamada, Y. Hojyo, R. Mizumoto, H. Koyama, S. Yanagisawa, J-I. Oka.  Neurosci. Res. 170, 201-207 (2021).
  Fluorescein permeability of the blood-brain barrier is enhanced in juvenile- but not young adult-onset type 1 diabetes in rats.  Y. Tsuneoka, T. Nishimura,
J-I. Oka.  Biol. Pharm. Bull. 44(8), 1088-1092 (2021).
  Long-term exposure to high glucose induces changes in the expression of AMPA receptor subunits and glutamate transmission in primary cultured cortical neurons. S. Sasaki-Hamada, E. Sanai, M. Kanemaru, G. Kamanaka,
J-I. Oka.  Biochem. Biophys. Res. Commun. 589, 48-54 (2022).
       
 
 
  川本俊弘 中央労働災害防止協会労働衛生調査分析センター 所長
  環境保健学 産業中毒学
  Rationale and study design of the Japan environment and children's study (JECS). Kawamoto T, Nitta H, Murata K, Toda E, Tsukamoto N, Hasegawa H, Yamagata Z, Kayama F, Kishi R, Ohya Y, Saito H, Sago H, Okuyama M, Ogata Y, Yokoya S, Koresawa Y, Shibata Y, Nakayama S, Michikawa T, Takeuchi A, Satoh H, Working Group of the Epidemiological Research for Children’s Environmental Health. BMC Public Health. 2014 Jan 10;14:25. doi: 10.1186/1471-2458-14-25.
  Comparison of IgG against plastic resin in workers with and without chemical dermatitis. Kawamoto T, Tsuji M, Isse T. BMC Public Health. 2015 Sep; 15: 930. doi: 10.1186/s12889-015-2302-4.
  Associations Between Metal Levels in Whole Blood and IgE Concentrations in Pregnant Women Based on Data From the Japan Environment and Children's Study. Tsuji M, Koriyama C, Ishihara Y, Yamamoto M, Yamamoto-Hanada K, Kanatani K, Bamai YA, Onishi K, Senju A, Araki S, Shibata E, Morokuma S, Sanefuji M, Kitazawa H, Saito M, Umezawa M, Onoda A, Kusuhara K, Tanaka R, Kawamoto T; Japan Environment & Children’s Study Group. J Epidemiol. 2019 Dec;29(12):478-486. doi: 10.2188/jea.JE20180098. 
       
 
 
  代田 眞理子 国立大学法人東京農工大学 農学部附属感染症未来疫学研究センター 客員教授
  生殖発生毒性学
  Dose-dependent acceleration in the delayed effects of neonatal oral exposure to low-dose 17α-ethynylestradiol on reproductive functions in female Sprague–Dawley rats. Shirota M, Kawashima J, Nakamura T, Kamiie J, Shirota K, Yoshida M.  Journal of Toxicological Sciences 40: 727-738 (2015)
  Delayed effects of single neonatal subcutaneous exposure of low-dose 17α-ethynylestradiol on teproductive function in female rats. Shirota M, Kawashima J, Ogawa Y, Kamiie J, Yasuno K, Shirota K, Yoshida M. Journal of Toxicological Sciences 37: 681-689 (2012)
 
  Internal dose-effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in gonadotropin-primed weanling rat model. Shirota M, Kaneko T, Okuyama M, Sakurada Y, Shirota K, Matsuki Y. Archives of Toxicology 81: 261-269 (2007)
 
       
 
 
  豊島 聰 公益財団法人日本薬剤師研修センター 理事長
  レギュラトリーサイエンス、衛生化学、免疫化学
  環境汚染物質と免疫毒性. 豊島 聰.水質汚濁研究.1987;10:528-531
  サブタイプ特異的サイトカイン分泌への没食子酸誘導体の影響.  加藤 慶、山下 正三、北中 進、豊島 聰. 薬学雑誌. 2001;121:451-457
  「医薬品のレギュラトリーサイエンス 改訂2版」豊島聰、黒川達夫 編著、南山堂、(2016)
           
 
 
若林敬二 静岡県立大学 特任教授
  環境発がん
  Wakabayashi, K., Nagao, M., Esumi, H. and Sugimura, T. Food-derived mutagens and carcinogens. Cancer Res. (Suppl.), 52: 2092s-98s (1992).
  Ohe, T., Watanabe, T. and Wakabayashi, K. Mutagens in surface waters: a review. Mutat. Res., 567(2-3):109-49 (2004).
  Mutoh, M., Teraoka, N., Takasu, S., Takahashi, M., Onuma, K., Yamamoto, M., Kubota, N., Iseki, T., Kadowaki, T., Sugimura, T. and Wakabayashi, K. Loss of adiponectin promotes intestinal carcinogenesis in Min and wild-type mice. Gastroenterology, 140(7):2000-8 (2011).