新興・再興感染症及び予防接種政策推進研究事業

(○:委員長)
脇田 隆字 ご所属・役職 国立感染症研究所・所長
 
ウイルス学、肝炎ウイルス学
Wakita T, T Pietschmann, T Kato, T Date, M Miyamoto, Z Zhao, K Murthy, A Habermann, H-G Krausslich, M Mizokami, R Bartenschlager, T J Liang. Production of Infectious Hepatitis C Virus in Tissue Culture from a Cloned Viral Genome. Nat Med. 2005 11:791-6.  
Wakita T and Wands JR. Specific inhibition of hepatitis C virus expression by antisense oligodeoxy-nucleotides: In vitro model for selection of target sequence. J Biol Chem. 1994 269:14205-10  
Wakita T, Kakumu S, Shibayama M, Yoshioka K, Ito Y, Shinagawa T, Ishikawa T, Takayanagi M, Morishima T. Detection of pre-C and core region mutants of hepatitis B virus in chronic hepatitis B virus carriers. J Clin Invest. 1991 88: 1793-801  
 
  喜田 宏 北海道大学 人獣共通感染症国際共同研究所    特別招聘教授 統括
  ウイルス学、人獣共通感染症学、ワクチン学
  「人獣共通感染症 初・改訂2と3版」喜田 宏 他共著,木村 哲/喜田 宏編, 医薬ジャーナル社 (2004,2011と2016)
  Chua BY, Sekiya T, Koutsakos M, Nomura N, Rowntree LC, Nguyen THO, McQuilten HA, Ohno M, Ohara Y, Nishimura T, Endo M, Itoh Y, Habel JR, Selva KJ, Wheatley AK, Wines BD, Hogarth PM, Kent SJ, Chung AW, Jackson DC, Brown LE, Shingai M, Kedzierska K, Kida H: Immunization with inactivated whole virus particle influenza virus vaccines improves the humoral response landscape in cynomolgus macaques. PLoS Pathog 18(10):e1010891, 2022.
  Ohno M, Sagata M, Sekiya T, Nomura N, Shingai M, Endo M, Kimachi K, Suzuki S, Nguyen CT, Nakayama M, Ishigaki H, Ogasawara K, Itoh Y, Kino Y, Kida H: Assessing the pyrogenicity of whole influenza virus particle vaccine in cynomolgus macaques. Vaccine 41: 787-794, 2023.
       
 
  遠藤弘良 聖路加国際大学名誉教授
  公衆衛生学、国際保健
  (研究論文)
S.Miyano,G.Syakantu, K.Komada, H.Endo, T.Sugishita, Cost-effectiveness analysis of the national decentralization policy of antiretroviral treatment programme in Zambia, Cost Effectiveness and Resource Allocation, 2017, 15:4,
  (報告書)
F.Harvey,H.Endo et al., A report by the Independent Oversight and Advisory Committee for the WHO Health Emergency Programme, 2019
  (報告書)
F.Harvey,H.Endo et al., A report by the Independent Oversight and Advisory Committee for the WHO Health Emergency Programme, 2020
       
 
 
  山崎晋一朗 千葉県病院局病院局長
  専門分野:医療行政
  特になし
 
  (業績・実績その2)
  (業績・実績その3)
 
       
 
 
  小池和彦 関東中央病院・病院長
  専門分野 内科学、感染症、消化器
  Hirano J, Yoshio S, Sakai Y, Songling L, Suzuki T, Itoh Y, Zhang H, Chen DV, Haga S, Oomori H, Kodama T, Maeda Y, Ono Y, Takahashi Y, Standley DM, Yamamoto M, Moriishi K, Moriya K, Kanto T, Takehara T, Koike K, Matsuura Y, Okamoto T. Hepatitis C virus modulates signal peptide peptidase to alter host protein processing. Proc Natl Acad Sci U S A 2021 Jun 1;118(22):e2026184118.
  Shinohara T, Otani A, Yamashita M, Wakimoto Y, Jubishi D, Okamoto K, Kanno Y, Ikeda M, Ishigaki K, Nakai Y, Harada S, Okugawa S, Koike K, Moriya K. Acute Pancreatitis During COVID-19 Pneumonia. Pancreas 2020 Nov/Dec;49(10):e106-e108.
  Hatakeyama S, Sugaya N, Ito M, Yamazaki M, Ichikawa M, Kimura K, Kiso M, Shimizu H, Kawakami C, Koike K, Mitamura K, Kawaoka Y. Emergence of Influenza B Viruses With Reduced Sensitivity to Neuraminidase Inhibitors. JAMA 2007;297:1435-1442.
       
 
 
  笹川千尋 千葉大学真菌医学研究センター・センター長
(東京大学名誉教授)
  微生物学、感染症学、免疫学
  Isolation and characterization of Helicobacter suis from huma stomach. Rimbara E, Suzuki M, Matsui H, Nakamura M, Morimoto M, Sasakawa C, Matsuda H, Nomura S, Osaki T, Nagata N, Shibayama K, Tokunaga K. Proc Natl Acad Sci USA. 2021. 118(13):e2026337118.doi: 10.1073.
  Experimental inoculation of a tissue homogenate containing porcine
circovirus type 3 obtained two in vivo passages in NIBS miniature pigs.
Hyashi S, Sato T, Ono H, Ito S, Takai R, Shibuya K, Sasakawa C.
Vet Microbiol. 2023 281:109740. Doi: 10.1016.
  TECPR1 conjugates LC3 to damaged endomembranes upon detection
Of sphingomyelin exposure. Boyle KB, Ellison CJ, Elliott PR, Schuschnig M, Grimes K, Dionne MS, Sasakawa C, Munro S, Martens S, Randow F. EMBO J. 2023 6:e113012.doi: 10.15252/embj.
       
 
 
髙子 徹 AMED 科学技術顧問
専門分野:薬理、創薬科学
  (業績・実績その1)
Baba M, Okamoto M, Kawamura M, Makino M , Higashida T, Takashi T, Kimura Y, Ikeuchi T, Tetsuka T, Okamato T. Inhibition of human immunodeficiency virus type 1 replication and cytokine production by fluoroquinoline derivatives. Mol. Pharmacol. 1998, 53(6), 1097-1103 
  (業績・実績その2)
  (業績・実績その3)
     
 
 
堀田 博 神戸大学 名誉教授
公益財団法人甲南会 理事
専門分野:ウイルス学、微生物感染症学
 

Suppression of viral RNA polymerase activity is necessary for persistent infection during the transformation of measles virus into SSPE virus. Sakamoto K, Konami M, Kameda S, Satoh Y, Wakimoto H, Kitagawa Y, Gotoh B, Jiang DP, Hotta H, Itoh M. PLoS Pathog. 19(7): e1011528, 2023.

 

Amentoflavone inhibits hepatitis B virus infection via the suppression of preS1 binding to host cells. Aoki-Utsubo C, Indrasetiawan P, Fukano K, Muramatsu M, Artanti N, Hanafi M, Hotta H, Kameoka M. Microbiol Immunol. 67(6):281-292, 2023.

  医学教科書「コンパクト微生物学 改訂第5版」小熊惠二,堀田博 (監修), 林俊治, 石戸聡 (編集), 南江堂,2021.
     
 
 
  森   亨 (公財)結核予防会結核研究所名誉所長
  結核 公衆衛生 疫学
  Mori T: TB Epidemiology under Rapidly Declining Phase. Shimo’s Fight against TB in Japan–. Shimao-Takeda Lectureship. International Conference on Emerging Infectious Diseases in the Pacific Rim. US-Japan Cooperative Medical Science Program, 28 March, 2023, Manila, Philippines
 
  森  亨:我が国における結核対策の進展と課題.第98回日本結核・非結核性抗酸菌症学会総会特別講演.東京.2023年6月
 
  森  亨・岡輝明:剖検記録からみた最近の結核臨床診断の精度.結核 96(1): 1-5, 2021