難治性疾患政策研究事業

（○：委員長）

	浅香正博		北海道医療大学学長
	消化器内科学、がん予防学
		An increasing trend of gastric cancer deaths and inadequate preventive measures in elderly adults. Matsushima R, Matsushima S, Kobayashi M, Fujimori K, Sakamoto N, Asaka M.2023 Aug;28(4):e12988. doi: 10.1111/hel.
		Gastric cancer deaths by age group in Japan: Outlook on preventive measures for elderly adults. Asaka M, Kobayashi M, Kudo T, Akino K, Asaka Y, Fujimori K, Kikuchi S, Kawai S , Kato M. Cancer Sci 2020; 111:3845-3853
		Kyoto global consensuss report on Helicobacter pylori gastritis.  Sugano K, Tack J, Kuipers EJ, Graham DY, El-Omar EM, Miura S, Haruma K, Asaka M, Uemura N, Malfertheiner P. Gut 2015: 64:1353-1367.

 

○	五十嵐　隆		国立成育医療研究センター　理事長
	小児科学
		Igarashi T, Gu:nter W, Sekine T, Inatomi J, Shiraga H, Takahashi S, Suzuki J, Tsuru N, Yanagihara T, Shimazu M, Jentsch TJ, Thakker RV: Functional characterization of renal chloride channel, CLCN5, mutations associated with Dent’s Japan disease. Kidney Int 54: 1850-1856, 1998
		Igarashi T, Inatomi J, Sekine T, Cha SH, Kanai Y, Kunimi M, Tsukamoto K, Satoh H, Shimadzu M, Tozawa F, Mori T, Shiobara M, Seki G, Endou H: Mutations in SLC4A4 cause permanent isolated proximal renal tubular acidosis with ocular abnormalities. Nature Genet 23:264-266, 1999
		Enomoto A, Kimura H, Chairoungdua A, Shigeta Y, Jutabha P, Cha SH, Hosoyamada M, Takeda M, Sekine T, Igarashi T, Matsuo H, Kikuchi Y, Oda T, Ichida K, Hosoya T, Shimokata K, Niwa T, Kanai Y, Endou H: Molecular identification of a renal/urate/anion exchanger that regulates blood urate levels. Nature 417: 447-452, 2002

 

	長村　義之		日本鋼管病院　病理診断科部長、 慶應義塾大学 客員教授
	病理学　ゲノム病理学
		Tahara S, Osamura RY, Hattori Y, Ishisaka E, Inomoto C, Sugihara H, Teramoto A, Morita A: Concurrent IgG4-related hypophysitis and clinically nonfunctioning gonadotroph pituitary neuroendocrine tumor. BMC Endocr Disord 2023, 23:96.
		Schmitt FC, Bubendorf L, Canberk S, Chandra A, Cree IA, Engels M, Hiroshima K, Jain D, Kholova I, Layfield L, Osamura RY, et al: The World Health Organization Reporting System for Lung Cytopathology. Acta Cytol 2023, 67:80-91.
		Osamura RY, Inomoto C, Tahara S, Oyama KI, Matsuno A, Teramoto A: Pathology of Crooke Cells in the Human Pituitaries: A Timely Review. Appl Immunohistochem Mol Morphol. 2023 Aug 1;31(7):485-9.

 

	片山一朗		大阪公立大学大学院医学研究科　特任教授
	皮膚科学
		The two faces of mast cells in vitiligo pathogenesis. Katayama I, Yang L, Takahashi　A, Yang F, Wataya-Kaneda M. Explor Immunol.1(4)269-284.2021
		Morphological Alterations and Increased S100B Expression in Epidermal Langerhans Cells Detected in Skin from Patients with Progressive Vitiligo.Yang F, Yang L, Teng L, Zhang H, Katayama I.Life(Basel).11(6)579.2021
		A Lower Irradiation Dose of 308 nm Monochromatic Excimer Light Might Be Sufficient for Vitiligo Treatment: A Novel Insight Gained from In Vitro and In Vivo Analyses.Kuroda Y, Yang L, Lai S, Guo J, Sayo T, Takahashi Y, Tsuruta D, Katayama I. Int J Mol Sci,22(19)10409.2021

 
 

	加藤　義治		東京女子医科大学整形外科 前教授・講座主任
	整形外科学　運動器学
		研究論文 Katoh Y. Effects of Ethane-1-hydroxy-1,1-diphospho-nate on cell differentiation, and proteoglycan and calcium metabolism in the proximal tibia of young rats.　Bone.12: 59-65、1991
		著作 「CKD・透析に併発する運動器疾患」　加藤　義治、稲葉　雅章　編, 加藤　義治, 透析と骨関節障害の病態と治療、108-120, 透析患者の椎体骨折, 195-209, 医薬ジャーナル社, 2018
		Itoh Tatsuo，Kato Yoshiharu：Posterior decompression for cervical ossfication of the posterior longitudinal ligament．「Ossification of the Posterior Longitudinal Ligament」（Yonenobu K, Sako T, Ono K eds）Springer，Tokyo：pp218①143-152，1997

 
 

	小池隆夫		北海道内科リウマチ科病院　最高顧問 北海道大学　名誉教授
	リウマチ学・臨床免疫学・内分泌学・糖尿病学
		Krilis M, Qi M, Ioannou Y, Zhang JY, Ahmadi Z, Wong JWH, Vlachoyiannopoulos PG, Moutsopoulos HM, Koike T, Sturgess AD, Chong BH,Krilis SA, Giannakopoulos B. Clinical relevance of nitrated Beta 2-Glycoprotein I in antiphospholipid syndrome: implications for thrombosis risk. J Autoimmunity.122(8) ,2021.
		Fukae J, Isobe M, Hattori T, Fujieda Y, Kono M, Abe N, Kitano A, Narita A, Henmi M, Sakamoto F, Aoki Y, Ito T, Mitsuzaki A, Matsuhashi M, Shimizu M, Tanimura K, Sutherland K, Kamishima T, Atsumi T, Koike T. Convolutional neural network for classification of two-dimensional array images generated from clinical information may support diagnosis of rheumatoid arthritis. Sci Rep. 2020 10(1):5648.
		Bohgaki M, Koike T: Chapter 60:Clinical manifestations. George C. Tsokos. SYSTEMIC LUPUS ERYTHEMATOSUS. Basic, Applied and Clinical Aspects. second edition. Academic Press.575-579. 2020.

 
 

	甲村　英二		公立学校共済組合近畿中央病院病院長
	脳神経外科学
		MicroRNA‐10b is overexpressed in malignant glioma and associated with tumor invasive factors, uPAR and RhoC. Sasayama T, Nishihara M, Kondoh T, Hosoda K, Kohmura E. International Journal of Cancer, 2009; 125(6): 1407-1413.
		Compensatory glutamine metabolism promotes glioblastoma resistance to mTOR inhibitor treatment. Tanaka K, Sasayama T, Irino Y, Takata  K, Nagashima H, Satoh N, Kyotani  K, Mizowaki T, Imahori T, Ejima  Y, Masui k,Gini B, Yang H, HosodaK, SasakiR, Mischel PS,Kohmura E. Journal of clinical investigation, 2015; 125(4): 1591-1602.
		Machine learning to predict in-hospital morbidity and mortality after traumatic brain injury. Matsuo K, Aihara H, Nakai T,  Morishita A, Tohma Y, Kohmura E. Journal of Neurotrauma, 2020; 37(1): 202-210.

 
 

	澤　倫太郎		日本医師会総合政策研究機構　主席研究員
	胎児生理学、産科学、医療経済学
		Sawa R, Asakura H, Power GG.　　　　　　　　　　　 Changes in plasma adenosine during simulated birth of fetal sheep. J Appl Physiol 70(4): 1524-1528, 1991
		Sawa R, Yoneyama Y, Otsubo Y, Suzuki S, Kubonoya K, Power GG, Araki T. Fetal plasma hypoxanthine level in growth-retarded fetuses before labor. J Clin Endocrinol Metab 82: 4028-4033, 1997
		Ishihara O, Seung Chik Jwa, Kuwabara A, Ishikawa T,  Kugu K, Sawa R, Banno K,Saito H Assisted reproductive technology inJapan: a summary report for 2016 by the Ethics committee of the Japan society of obstetrics and gynecology. Reprod Med Biol.1-10,2018

 
 

	高橋　孝雄		慶應義塾大学　教授（医学部小児科）
	小児神経学、発達神経生物学
		In utero exposure to valproic acid throughout pregnancy causes phenotypes of autism in offspring mice. Mitsuhashi T, Hattori S, Fujimura K, Shibata S, Miyakawa T, Takahashi T. Dev Neurosci 2023; DOI: 10.1159/000530452
		In utero exposure to valproic acid induces neocortical dysgenesis via dysregulation of neural progenitor cell proliferation/differentiation. Fujimura K, Mitsuhashi T, Shibata S, Shimozato S, Takahashi T. J Neurosci 2016;36:10908-10919.
		Sequence of neuron origin and neocortical laminar fate: relation to cell cycle of origin in the developing murine cerebral wall. Takahashi T, Goto T, Miyama S, Nowakowski RS, Caviness VS Jr. J Neurosci 1999;19:10357-10371

 
 

	竹中　洋		京都府立医科大学　学長
	耳鼻咽喉科学
		Enhanced human IgE production results from exposure to the aromaticHydrocarbons from diesel exhaust;direct effects on B-cell IgE production, Takenaka H,et al J Allery CLin Immunol;1998.95:103-115.
		コア・ローテイション　耳鼻咽喉科・頭頸部外科 編集　竹中洋、高橋姿、久育男 金芳堂、2004年1月5日
		気道アレルギーの成立とその制御：竹中　洋 第110回日本耳鼻咽喉科学術総会宿題報告 東京、2009.05.14.

 
 

	坪内　博仁		鹿児島市立病院　病院長
	消化器病学、肝臓病学
		Analysis of factors affecting progression-free survival of first-line chemotherapy in older patients with advanced gastrointestinal cancer. Nakazawa J, Kawahira M, Kawahira M, Kodama T, Arima S,Iwashita Y, Mawatari S, Hashimoto S, Kanmura S, Hori T, Tsubouchi H, Ido A. J Geriatr Oncol. 2021 Nov;12(8):1200-1207.
		Phase 1 study on the safety and efficacy of E6011, antifractalkine antibody, in patients with Crohn's disease. Matsuoka K, Naganuma M, Hibi T, Tsubouchi H, Oketani K, Katsurabara T, Hojo S, Takenaka O, Kawano T, Imai T, Kanai T. J Gastroenterol Hepatol. 2021 Aug;36(8):2180-2186.
		Analysis of the safety of pretransplant corticosteroid therapy in patients with acute liver failure and late-onset hepatic failure in Japan. Hisanaga T, Hidaka I, Sakaida I, Nakayama N, Ido A, Kato N, Takikawa Y, Inoue K, Shimizu M, Genda T, Terai S, Tsubouchi H, Takikawa H, Mochida S. JGH Open. 2021 Mar 5;5(4):428-433.

 
 

	富野康日己		医療法人社団松和会　理事長 順天堂大学　名誉教授
	腎臓内科学
		The Influence of an Unexpected Switch of Hemodialysis Facilities on the Quality of Life (QOL) in Hemodialysis Patients.  Yoshio Shimizu, Keiichi Wakabayashi, Junichiro Nakata, Hiroaki Io, Chieko Hamada, Yasuhiko Tomino, Yusuke Suzuki. International Journal of Nephrology and  Renovascular Disease. 2022 April 13; 15:151-160. DOI: 10.2147/UNRD.S358915. eCollection 2022
		Post-Operative Kidney Function Using Deep Hypothermic Circulatory Arrest (DHCA) in Aortic Arch Operation. Masahide Higo, Yoshio Shimizu, Keiichi Wakabayashi, Takehiko Nakano, Yasuhiko Tomino, Yusuke Suzuki. International Journal of Nephrology and Renovascular Disease 2022: 15 239-252, Sep 26. DOI: 10.2147/IJNRD.S373828
		「ドクター富野のもっともわかりやすいCKD集中講義」富野康日己(著)、総合医学社　2022年1月15日

 
 

	永井　正規		埼玉医科大学　名誉教授
	疫学
		Prevalence and Incidence of Polymyositis and Dermatomyositis in Japan. Ohta A, Nagai M, Nishina M, Tomimitsu H, Kohsaka H.Mod Rheumatol 24:477-480, 2013.
		A case control study of female systemic lupus erythematosus in Japan. MASAKI NAGAI,TOMIO HIROHATA,YOSHIFUJI MATSUMOTO,HIROSHI HASHIMOTO,MASAKAZU KONDO,KOTARO OZASA,MITSURU MORI,TSUTOMU HASHIMOTO,HIDEAKI NAKAGAWA,TOSHITAKA OMURA,MASAKI MORI,TAKESHI TOJO,HIROSHI YANAGAWA,European Journal of Public Health, Volume 3, Issue 3:172-176, 1992
		「新しい疫学」永井正規他共著，日本公衆衛生協会，（1995）．

 
 

	西澤　正豊		新潟医療福祉大学　学長
	脳神経内科学
		Effect of rovatirelin in patients with cerebellar ataxia: two randomised double-blind placebo-controlled phase 3 trials. Nishizawa M, Onodera O, Hirakawa A, Shimizu Y, Yamada M, Rovatirelin Study Group, J Neurol Neurosurg Psychiatry 91(3): 254-262, 2020.
		Assessment of Ataxia Rating Scales and Cerebellar Functional Tests. Critique and recommendations. Perez-Lloret S, van de Warrenburg B, Rossi M, Rodríguez-Blázquez C, Zesiewicz T, Saute JAM, Durr A, Nishizawa M, Martinez-Martin P, Stebbins GT, Schrag A, Skorvanek M, members of the MDS Rating Scales Review Committee: Mov Disord 36 (2): 283-297. 2021.
		Clinicopathological features in anterior visual pathway in neuromyelitis optica. Hokari M, Yokoseki A, Arakawa M, Saji E, Yanagawa K, Yanagimura F, Toyoshima Y, Okamoto K, Ueki S, Hatase T, Ohashi R, Fukuchi T, Akazawa K, Yamada M, Kakita A, Takahashi H, Nishizawa M, Kawachi I: Ann Neurol. 79(4): 605-24, 2016

 
 

	貫和　敏博		東北大学　名誉教授
	呼吸器内科
		Gefitinib Alone Versus Gefitinib Plus Chemotherapy for Non-Small-Cell Lung Cancer With Mutated Epidermal Growth Factor Receptor: NEJ009 Study. Hosomi Y, Morita S, Sugawara S, Kato T, Fukuhara T, Gemma A, Takahashi K, Fujita Y, Harada T, Minato K, Takamura K, Hagiwara K, Kobayashi K, Nukiwa T, Inoue A; North-East Japan Study Group. J Clin Oncol. 2020 Jan 10;38(2):115-123.
		貫和敏博、肺がん.　がん生物学イラストレイテッド、第2版、渋谷正史・湯浅保仁編集、羊土社、2019.
		Safety and pharmacokinetics of Alpha-1 MP (Prolastin®-C) in Japanese patients with alpha1-antitrypsin (AAT) deficiency. Seyama K, Nukiwa T, Sato T, Suzuki M, Konno S, Takahashi K, Nishimura M, Steinmann K, Sorrells S, Chen J, Hayashi KI. Respir Investig. 2019 Jan;57(1):89-96.

 
 

	平田結喜緒		兵庫県予防医学協会副会長・理事，東京医科歯科大学名誉教授
	内分泌・代謝学、高血圧、糖尿病、心血管病
		Salusin-β as a powerful endogenous antidispogenic neuropeptide. Suzuki-Kemuriyamsa N,Nakano-Tateno T,Tani Y,Hirata Y,Schichi M. Sci.Rep.2016; 6,20988;doi:10.1038/srep20988
		PDL-1 expression according to EGFR mutation status in pretreated non-small cell lung cancer. Hata A,Katakami N,Nanjo S,Okuda C,Masago K,Fujita S,Yoshida H, Zama H K,Imai Y, Hirata Y. Oncotarget 2017; 8:113807-113816
		PDL-１ expression and T７９０M status in EGFR-mutant non-small cell lung cancer.Hata A,Katakami N, Nanjo S,okuda C, Kaji R,Masago K,Fujita S,Yoshida H,Zama H,Imai K, Hirata　Y. Lung Cancer 2017; 111:182-189

 
 

	福島　雅典		京都大学名誉教授 一般財団法人LHS(ラーニングヘルスソサエティー)研究所代表理事
	トランスレーションナルリサーチ、臨床試験管理学、腫瘍内科学
		Titanium bridge modification for type 2 thyroplasty to improve device mechanical & safety performance. Sanuki T, Nishimura T, Aburada T, Fukushima M. AurisNasusLarynx.2021Nov3:S0385-8146(21)00252-2. doi: 10.1016/j.anl.2021.10.011. Epub ahead of print. PMID: 34742621.
		Multicenter phase III trial of regenerative treatment for chronic tympanic membrane perforation. Kanemaru SI, Kanai R, Omori K, Yamamoto N, Okano T, Kishimoto I, Ogawa K, Kanzaki S, Fujioka M, Oishi N, Naito Y, Kakehata S, Nakamura H, Yamada S, Omae K, Kawamoto A, Fukushima M. Auris Nasus Larynx. 2021 Dec;48(6):1054-1060. doi: 10.1016/j.anl.2021.02.007. Epub 2021 Mar 26. PMID
		Long-term outcome of cultivated oral mucosal epithelial transplantation for fornix reconstruction in chronic cicatrising diseases. Komai S, Inatomi T, Nakamura T, Ueta M, Horiguchi G, Teramukai S, Kimura Y, Kagimura T, Fukushima M, Kinoshita S, Sotozono C.  Br J Ophthalmol. 2022 Oct;106(10):1355-1362. doi: 10.1136/bjophthalmol-2020-318547. Epub 2021 May 18.

 
 

	宮﨑　久義		特定非営利活動法人日本医療マネジメント学会 理事長
	麻酔、病院管理、地域医療、生活習慣病
		医療安全管理者が抱える業務遂行上の困難―フォーカス・グループ・インタビューの分析から―.堀込由紀,佐々木美奈子,中山純果,末永由理,本谷園子,駒崎俊剛,菅野雄介,山元友子,坂本すが,宮﨑久義,日本医療マネジメント学会雑誌22（3）：124-129.2021
		中小規模施設における医療安全管理者による医療事故調査制度関連業務の遂行状況と担当すべき職種－施設規模別、加算別での比較.末永由理,佐々木美奈子,李廷秀,髙橋静子,是村利幸,駒崎俊剛,本谷園子,菅野雄介,中山純果,堀込由紀,坂本すが,宮﨑久義,日本医療マネジメント学会雑誌23（1）：2-7.2022
		Critical Pathway: Practical applications and its development in Japan. Hisayoshi Miyazaki,Teruhiko Matsushima. JMAJ48(11):568-571.2005

 
 

	宮下　俊之		北里大学　名誉教授
	小児科学、分子遺伝学、分子生物学
		Miyashita, T. and Reed, J.C. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 1995, 80, 293-299.
		Nagao, K., Iwai, Y. and Miyashita, T. RCAN1 is an important mediator of glucocorticoid-induced apoptosis in human leukemic cells. PLOS ONE 2012, 7, e49926
		Ikemoto, Y., Takayama, Y., Fujii, K., Masuda, M., Kato, C., Hatsuse, H., Fujitani, K., Nagao, K., Kameyama, K., Ikehara, H., Toyoda, M., Umezawa, A. and Miyashita, T. Somatic mosaicism containing double mutations in PTCH1 revealed by generation of induced pluripotent stem cells from nevoid basal cell carcinoma syndrome. J. Med. Genet. 2017, 54, 579-584

 
 

	山下　英俊		山形市保健所・保健医療監
	眼科学、公衆衛生
		Tanaka Y, Katoh S, Hori S, Miura M, and Yamashita H: Vascular endothelial growth factor in diabetic retinopathy. Lancet 349: 1520, 1997
		ten Dijke P, Yamashita H, Ichijo H, Franzen P, Laiho M, Miyazono K, and Heldin C-H: Characterization of type I receptors for transforming growth factor-β and activin.  Science 264: 101-104, 1994
		Nishi K, Nishitsuka K, Yamamoto T, Yamashita H: Factors correlated with visual outcomes at two and four years after vitreous surgery for proliferative diabetic retinopathy. PLOS ONE 2021 Jan 14;16(1):e0244281. doi: 10.1371/journal.pone.0244281. eCollection 2021.

 
 

	吉栖　正生		安田女子大学　教授　広島大学　名誉教授
	循環器病学
		Role of osteoprotegerin in arterial calcification: development of new animal model. Orita Y, Yamamoto H, Kohno N, Sugihara M, Honda H, Kawamata S, Mito S, Soe NN, Yoshizumi M. Arterioscler Thromb Vasc Biol. 27:2058-2064, 2007
		Disruption of osteoprotegerin has complex effects on medial destruction and adventitial fibrosis during mouse abdominal aortic aneurysm formation. Bumdelger B, Otani M, Karasaki K, Sakai C, Ishida M, Kokubo H, Yoshizumi M. PLoS One. 15:e0235553, 2020
		Extraction of apex beat waveform from acoustic pulse wave by sound sensing system using stochastic resonance. Fujita E, Horikawa M, Nobuhiro Y, Maeda S, Kojima S, Ogura Y, Murata K, Kisaka T, Taoda K, Kaneko S, Yoshizumi M. Sci Rep. 11:13711 2021