難治性疾患政策研究事業

（○：委員長）

○	新井　一		順天堂大学・学長
	脳神経外科
		Mori E, Ishikawa M, Kato T, Kazui H, Miyake H, Miyajima M, Nakajima M, Hashimoto M, Kuriyama N, Tokuda T, Ishii K, Kaijima N, Hirata Y, Saito M, Arai H: Guidelines for management of idiopathic normal pressure hydrocephalus: Second edition. Neurol Med Chir (Tokyo) 52:775-809, 2012
		Sugano H, Nakanishi H, Nakajima M, Higo T, Iimura Y, Tanaka K, Hosozawa M, Niijima S, Arai H. Posterior quadrant disconnection surgery for Sturge-Weber syndrome. Epilepsia 55(5):683-9, 2014
		Iihara K, Tominaga T, Saito N, Suzuki M, Date I, Fujii Y, Hongo K, Houkin K, Kato A, Kato Y, Kawamata T, Kim P, Kinouchi H, Kohmura E, Kurisu K, Maruyama K, Mikuni N, Miyamoto S, Morita A, Nakase H, Narita Y, Nishikawa R, Nozaki K, Ogasawara K, Ohata K, Sakai N, Sakamoto H, Shiokawa Y, Sonoda Y, Takahashi JC, Ueki K, Wakabayashi T, Yamamoto T, Yoshida K, Kayama T, Arai H; Japan Neurosurgical Society. The Japan Neurosurgical Database: Overview and Results of the First-year Survey. Neurol Med Chir (Tokyo) 60(4):165-190, 2020

 
 

	有賀　正		社会医療法人母恋　理事長 北海道大学　名誉教授
	専門分野　小児科学、感染免疫学、遺伝子治療
		Cho K, Yamada M, Agematsu K, Kanegane H, Miyake N, Ueki M, Akimoto T, Kobayashi M, Ikemoto S, Tanino M, Fujita A, Hayasaka I, Miyamoto S, Tanaka-Kubota M, Nakata K, Shiina M, Ogata K, Minakami H, Matsumoto N, Ariga T. Heterozygous Mutations in OAS1 Cause Infantile-onset Pulmonary Alveolar Proteinosis with Hypogammaglobulinemia. Am J Hum Genet 102, 480-486, 2018.
		Hamada H, Suzuki H, Onouchi Y, Ebata R, Terai M, Fuse S, Okajima Y, Kurotobi S, Hirai K, Soga T, Ishiguchi Y, Okuma Y, Takada N, Yanai M, Sato J, Nakayashiro M, Ayusawa M, Yamamoto E, Nomura Y, Hashimura Y, Ouchi K, Masuda H, Takatsuki S, Hirono K, Ariga T, Higaki T, Otsuki A, Terauchi M, Aoyagi R, Sato T, Fujii Y, Fujiwara T, Hanaoka H, Hata A, for the KAICA trial Investigators.  Efficacy of primary treatment with immunoglobulin plus cyclosporine for prevention of coronary artery abnormalities in Kawasaki disease (KAICA study): a phase 3, randomized, open-label, blinded-endpoints trial. Lancet. 2019 Mar 16;393(10176):1128-1137. doi: 10.1016/S0140-6736(18)32003-8.
		Uchiyama T, Takahashi S, Nakabayashi K, Okamura K, Edasawa K, YamadaM, Watanabe N, Mochizuki E, Yasuda T, Miura A, Kato M, Tomizawa D, Otsu M, Ariga T, Onodera M, Nonconditioned ADA-SCID gene therapy using retroviral vector reveals ADA requirement inhematopoietic system and clonal dominance of vector-marked clones, Molecular Therapy: Methods &Clinical Development (2021)

 
 

	池田　康夫		学校法人根津育英会武蔵学園 学園長 早稲田大学 総長室参与、 慶應義塾大学名誉教授
	血液学
		（業績・実績その１） Kuwana M, Okazaki Y, Ikeda Y.  Detection of circulating B cells producing anti-GPIb autoantibodies in patients with immune thrombocytopenia.  PLoS One. 2014 Jan 22;9(1):e86943. doi: 10.1371/journal.pone.0086943. eCollection 2014.
		（業績・実績その２） Ikeda Y, Shimada K, Teramoto T, Uchiyama S, Yamazaki T, Oikawa S, Sugawara M, Ando K, Murata M, Yokoyama K, Ishizuka N.  Low-dose aspirin for primary prevention of cardiovascular events in Japanese patients 60 years or older with atherosclerotic risk factors: a randomized clinical trial.  JAMA. 2014 Dec 17;312(23):2510-20. doi: 10.1001/jama.2014.15690.
		（業績・実績その３） Platelet production using adipose-derived mesenchymal stem cells: Mechanistic studies and clinical application.  Y Uruga-Ono, Y Ikeda, Y Matsubara, Journal of Thrombosis & Haemostasis, 2021 Feb, Vol19(2), 342-350.  Cf. First Pub @20 Nov 2020

 
 

	磯部光章		榊原記念病院　院長・東京医科歯科大学　名誉教授
	循環器内科
		Isobe M, Yagita H, Okumura K, Ihara A: Specific acceptance of cardiac allograft after treatment with anti-ICAM-1 and anti-LFA-1.  Science, 255: 1125-1127, 1992
		Isobe M, Maejima Y, Saji M, Tateishi U: Evaluation of tocilizumab for intractable Takayasu arteritis and 18 F-fluorodeoxyglucose-positron emission tomography for detecting inflammation under tocilizumab treatment. J Cardiol 2021 May;77(5):539-544.
		Isobe M, Tezuka D: Isolated Cardiac Sarcoidosis: Clinical Characteristics, Diagnosis and Treatment. Int J Cardiol 182: 132-140, 2015.

 
 

	江口　勝美		社会医療法人財団白十字会佐世保中央病院　顧問 長崎大学名誉教授
	リウマチ・膠原病・免疫学
	1	The association of increase of Human T-cell leukemia virus type-1 （HTLV-1）proviral load(PVL) with infection in HTLV-1-positive patients with rheumatoid arthritis: A longitudinal analysis of changes in HTLV-1 PVLs in a single center cohort study. Iwamoto N, Araki T, eguchi K, et al. Frontiers in Immunology. May 06, 2022.doi:10.3389/fimmu.2022.887783.
	2	Clinical features and human T-cell leukemia virus type-1(HTLV-1) proviral load in HTLV-1-positive patients with rheumatoid arthritis: Baseline date in a single cohort study. Eguchi K, Iwanaga M, Terada K, et al. Mod Rheumatol.30(3):471-480, 2020.
	3	Hypocomplementemic urticarial vasculitis case with hemophagocytic lymphohistiocytosis following SARS-CoV-2mRNA vaccination. Iwamura N, Eguchi K, Koga T, et la. Immunological Medicine. Doi.org/10.1080/25785826.2023.2193286

 
 

	大澤真木子		東京女子医科大学元教授、立教女学院理事長
	小児神経学
		Sato T, Murakami T, Ishiguro K, Shichiji M, Saito K, Osawa M, Nagata S, Ishigaki K. Respiratory management of patients with Fukuyama congenital muscular dystrophy. Brain Dev. 2016, 38(3):324-30.
		Nationwide survey (incidence, clinical course, prognosis) of Rasmussen's encephalitis．Muto, A., Oguni, H., Takahashi, Y., Shirasaka, Y., Sawaishi, Y., Yano, T., Hoshida, T., Osaka, H., Nakasu, S., Akasaka, N., Sugai, K., Miyamoto, A., Takahashi, S., Suzuki, M., Ohmori, I., Nabatame, S., Osawa, M.：Brain & Dev．2010　32（6）；445–53
		Hino N, Kobayashi M, Shibata N ，Yamamoto T,Saito K ,Osawa M   Clinicopathological study on eyes from cases of Fukuyama type congenital muscular dystrophy. Brain Dev. 2001　23:97-107.

 
 

	片山一朗		大阪公立大学大学院医学研究科　特任教授
	皮膚科学
		The two faces of mast cells in vitiligo pathogenesis. Katayama I, Yang L, Takahashi　A, Yang F, Wataya-Kaneda M. Explor Immunol.1(4)269-284.2021
		Morphological Alterations and Increased S100B Expression in Epidermal Langerhans Cells Detected in Skin from Patients with Progressive Vitiligo.Yang F, Yang L, Teng L, Zhang H, Katayama I.Life(Basel).11(6)579.2021
		A Lower Irradiation Dose of 308 nm Monochromatic Excimer Light Might Be Sufficient for Vitiligo Treatment: A Novel Insight Gained from In Vitro and In Vivo Analyses.Kuroda Y, Yang L, Lai S, Guo J, Sayo T, Takahashi Y, Tsuruta D, Katayama I. Int J Mol Sci,22(19)10409.2021

 
 

	加藤　義治		東京女子医科大学整形外科 前教授・講座主任
	整形外科学　運動器学
		研究論文 Katoh Y. Effects of Ethane-1-hydroxy-1,1-diphospho-nate on cell differentiation, and proteoglycan and calcium metabolism in the proximal tibia of young rats.　Bone.12: 59-65、1991
		著作 「CKD・透析に併発する運動器疾患」　加藤　義治、稲葉　雅章　編, 加藤　義治, 透析と骨関節障害の病態と治療、108-120, 透析患者の椎体骨折, 195-209, 医薬ジャーナル社, 2018
		Itoh Tatsuo，Kato Yoshiharu：Posterior decompression for cervical ossfication of the posterior longitudinal ligament．「Ossification of the Posterior Longitudinal Ligament」（Yonenobu K, Sako T, Ono K eds）Springer，Tokyo：pp218①143-152，1997

 
 

	楠　進		独立行政法人地域医療機能推進機構・理事
	脳神経内科
		Kusunoki S, Willison HJ, Jacobs BC. Antiglycolipid antibodies in Guillain-Barré and Fisher syndromes: discovery, current status and future perspective. J Neurol Neurosurg Psychiatry. 2021; 92(3):311-318
		Yoshikawa K, Kuwahara M, Morikawa M, Kusunoki S. Bickerstaff brainstem encephalitis with or without anti-GQ1b antibody. Neurol Neuroimmunol Neuroinflamm 2020 Sep 15;7(6): e889.
		Kuwahara M, Suzuki H, Samukawa M, Hamada Y, Takada K, Kusunoki S. Clinical features of CIDP with LM1-associated antibodies. J Neurol Neurosurg Psychiatry 2013; 84: 573-575.

 
 

	黒岩　義之		財務省診療所長、横浜市立大学　名誉教授
	脳神経内科学
		Toh T, Urata R, Nakawatase A, Yamazaki T, Kuroiwa Y, Baba Y, Fujino K, Kurokawa T: Sensor-level- and ECDL-based brain functional connectivity networks using scalp-recorded EEGs: A comparison of AD and FTD patients and healthy subjects. Computational Neuroscience 9(2):38-44, 2016.
		Kimura K, Inoue KI, Kuroiwa Y, Tanaka F, Takada M: Propagated but topologically distributed forebrain neurons expressing alpha-synuclein in aged macaques. Plos one 11(11):e0166861. Nov.2016. doi:10.1371/journal.pone. 0166861
		Omoto S, Kuroiwa Y, Fujino S, Fujino K, Kurokawa T, Baba Y: Greater N1 potential during centrifugal saccades as compared to centripetal saccades in humans: A scalp-recorded electroencephalographic study. The Autonomic Nervous System (Journal of the Japan Society of Neurovegetative Research)，54(4):306-315, Dec. 2017.

 
 

	澤　倫太郎		日本医師会総合政策研究機構　主席研究員
	胎児生理学、産科学、医療経済学
		Sawa R, Asakura H, Power GG.　　　　　　　　　　　 Changes in plasma adenosine during simulated birth of fetal sheep. J Appl Physiol 70(4): 1524-1528, 1991
		Sawa R, Yoneyama Y, Otsubo Y, Suzuki S, Kubonoya K, Power GG, Araki T. Fetal plasma hypoxanthine level in growth-retarded fetuses before labor. J Clin Endocrinol Metab 82: 4028-4033, 1997
		Ishihara O, Seung Chik Jwa, Kuwabara A, Ishikawa T,  Kugu K, Sawa R, Banno K,Saito H Assisted reproductive technology inJapan: a summary report for 2016 by the Ethics committee of the Japan society of obstetrics and gynecology. Reprod Med Biol.1-10,2018

 
 

	清野　裕		関西電力病院・総長
	糖尿病学、内分泌代謝学
		Effect of Roxadustat on Thyroid Function in Patients with Renal Anemia. Haraguchi T, Seino Y, et al., J Clin Endocrinol Metab,2023 Aug 19;dgad483.
		Glucose-dependent insulinotropic polypeptide counteracts diet-induced obesity along with reduced feeding,elevated plasma leptin and activation of leptn-responsive and proopiomelanocortin neurons in the arcuate nucleus. Han W, Wang L, Ohbayashi K, Takeuchi M, O’Farrell L, Coskun T, Rakhat Y, Yabe D, Iwasaki Y, Seino Y, Yada T. Diabetes Obes Metab.2023 Jun;25(6):1534-1546
		Efficacy and Safety of 6-Month High Dietary Protein Intake in Hospitalized Adults Aged 75 or Older at Nutritional Risk: An Exploratory Randomized, Controlled Study. Moyama S, Yamada Y, Makabe N, Fujita H, Araki A, Suzuki A, Seino Y, Shide K, Kimura K, Murotani K, Honda H, Kobayashi M, Fujita S, Yasuda K, Kurose A, Tsukiyama K, Seino Y, Yabe D.  Nutrients.2023 Apr 22;15(9):2024.

 
 

	竹中　洋		京都府立医科大学　学長
	耳鼻咽喉科学
		Enhanced human IgE production results from exposure to the aromaticHydrocarbons from diesel exhaust;direct effects on B-cell IgE production, Takenaka H,et al J Allery CLin Immunol;1998.95:103-115.
		コア・ローテイション　耳鼻咽喉科・頭頸部外科 編集　竹中洋、高橋姿、久育男 金芳堂、2004年1月5日
		気道アレルギーの成立とその制御：竹中　洋 第110回日本耳鼻咽喉科学術総会宿題報告 東京、2009.05.14.

 
 

	富野康日己		医療法人社団松和会　理事長 順天堂大学　名誉教授
	腎臓内科学
		The Influence of an Unexpected Switch of Hemodialysis Facilities on the Quality of Life (QOL) in Hemodialysis Patients.  Yoshio Shimizu, Keiichi Wakabayashi, Junichiro Nakata, Hiroaki Io, Chieko Hamada, Yasuhiko Tomino, Yusuke Suzuki. International Journal of Nephrology and  Renovascular Disease. 2022 April 13; 15:151-160. DOI: 10.2147/UNRD.S358915. eCollection 2022
		Post-Operative Kidney Function Using Deep Hypothermic Circulatory Arrest (DHCA) in Aortic Arch Operation. Masahide Higo, Yoshio Shimizu, Keiichi Wakabayashi, Takehiko Nakano, Yasuhiko Tomino, Yusuke Suzuki. International Journal of Nephrology and Renovascular Disease 2022: 15 239-252, Sep 26. DOI: 10.2147/IJNRD.S373828
		「ドクター富野のもっともわかりやすいCKD集中講義」富野康日己(著)、総合医学社　2022年1月15日

 
 

	永井　正規		埼玉医科大学　名誉教授
	疫学
		Prevalence and Incidence of Polymyositis and Dermatomyositis in Japan. Ohta A, Nagai M, Nishina M, Tomimitsu H, Kohsaka H.Mod Rheumatol 24:477-480, 2013.
		A case control study of female systemic lupus erythematosus in Japan. MASAKI NAGAI,TOMIO HIROHATA,YOSHIFUJI MATSUMOTO,HIROSHI HASHIMOTO,MASAKAZU KONDO,KOTARO OZASA,MITSURU MORI,TSUTOMU HASHIMOTO,HIDEAKI NAKAGAWA,TOSHITAKA OMURA,MASAKI MORI,TAKESHI TOJO,HIROSHI YANAGAWA,European Journal of Public Health, Volume 3, Issue 3:172-176, 1992
		「新しい疫学」永井正規他共著，日本公衆衛生協会，（1995）．

 
 

	貫和　敏博		東北大学　名誉教授
	呼吸器内科
		Gefitinib Alone Versus Gefitinib Plus Chemotherapy for Non-Small-Cell Lung Cancer With Mutated Epidermal Growth Factor Receptor: NEJ009 Study. Hosomi Y, Morita S, Sugawara S, Kato T, Fukuhara T, Gemma A, Takahashi K, Fujita Y, Harada T, Minato K, Takamura K, Hagiwara K, Kobayashi K, Nukiwa T, Inoue A; North-East Japan Study Group. J Clin Oncol. 2020 Jan 10;38(2):115-123.
		貫和敏博、肺がん.　がん生物学イラストレイテッド、第2版、渋谷正史・湯浅保仁編集、羊土社、2019.
		Safety and pharmacokinetics of Alpha-1 MP (Prolastin®-C) in Japanese patients with alpha1-antitrypsin (AAT) deficiency. Seyama K, Nukiwa T, Sato T, Suzuki M, Konno S, Takahashi K, Nishimura M, Steinmann K, Sorrells S, Chen J, Hayashi KI. Respir Investig. 2019 Jan;57(1):89-96.

 
 

	日比紀文		北里大学北里研究所病院　炎症性腸疾患先進治療センター　特別顧問、慶応義塾大学　名誉教授
	専門分野；消化器内科学、消化器免疫学、臨床腫瘍学
		AJM300 (carotegrast methyl), an oral antagonist of α4-integrin, as induction therapy for patients with moderately active ulcerative colitis: a multicentre, randomised, double-blind, placebo-controlled, phase 3 study. Matsuoka K, Watanabe M, Ohmori T, Nakajima K, Ishida T, Ishiguro Y, Kanke K, Kobayashi K, Hirai F, Watanabe K, Mizusawa H, Kishida S, Miura Y, Ohta A, Kajioka T, Hibi T; AJM300 Study Group.Lancet Gastroenterol Hepatol. 2022 Jul;7(7):648-657. doi: 10.1016/S2468-1253(22)00022-X. Epub 2022 Mar 30.PMID: 35366419 Clinical Trial
		Efficacy of Biologic Drugs in Short-Duration Versus Long-Duration Inflammatory Bowel Disease: A Systematic Review and an Individual-Patient Data Meta-Analysis of Randomized Controlled Trials. Ben-Horin S, Novack L, Mao R, Guo J, Zhao Y, Sergienko R, Zhang J, Kobayashi T, Hibi T, Chowers Y, Peyrin-Biroulet L, Colombel JF, Kaplan GG, Chen MH.Gastroenterology. 2022 Feb;162(2):482-494. doi: 10.1053/j.gastro.2021.10.037. Epub 2021 Oct 29.PMID: 34757139 Free article.
		Improving IBD outcomes in the era of many treatment options. Kobayashi T, Hibi T. Nat Rev Gastroenterol Hepatol. 2023 Feb;20(2):79-80.

 
 

	福島　雅典		京都大学名誉教授 一般財団法人LHS(ラーニングヘルスソサエティー)研究所代表理事
	トランスレーションナルリサーチ、臨床試験管理学、腫瘍内科学
		Titanium bridge modification for type 2 thyroplasty to improve device mechanical & safety performance. Sanuki T, Nishimura T, Aburada T, Fukushima M. AurisNasusLarynx.2021Nov3:S0385-8146(21)00252-2. doi: 10.1016/j.anl.2021.10.011. Epub ahead of print. PMID: 34742621.
		Multicenter phase III trial of regenerative treatment for chronic tympanic membrane perforation. Kanemaru SI, Kanai R, Omori K, Yamamoto N, Okano T, Kishimoto I, Ogawa K, Kanzaki S, Fujioka M, Oishi N, Naito Y, Kakehata S, Nakamura H, Yamada S, Omae K, Kawamoto A, Fukushima M. Auris Nasus Larynx. 2021 Dec;48(6):1054-1060. doi: 10.1016/j.anl.2021.02.007. Epub 2021 Mar 26. PMID
		Long-term outcome of cultivated oral mucosal epithelial transplantation for fornix reconstruction in chronic cicatrising diseases. Komai S, Inatomi T, Nakamura T, Ueta M, Horiguchi G, Teramukai S, Kimura Y, Kagimura T, Fukushima M, Kinoshita S, Sotozono C.  Br J Ophthalmol. 2022 Oct;106(10):1355-1362. doi: 10.1136/bjophthalmol-2020-318547. Epub 2021 May 18.

 
 

	宮﨑　久義		特定非営利活動法人日本医療マネジメント学会 理事長
	麻酔、病院管理、地域医療、生活習慣病
		医療安全管理者が抱える業務遂行上の困難―フォーカス・グループ・インタビューの分析から―.堀込由紀,佐々木美奈子,中山純果,末永由理,本谷園子,駒崎俊剛,菅野雄介,山元友子,坂本すが,宮﨑久義,日本医療マネジメント学会雑誌22（3）：124-129.2021
		中小規模施設における医療安全管理者による医療事故調査制度関連業務の遂行状況と担当すべき職種－施設規模別、加算別での比較.末永由理,佐々木美奈子,李廷秀,髙橋静子,是村利幸,駒崎俊剛,本谷園子,菅野雄介,中山純果,堀込由紀,坂本すが,宮﨑久義,日本医療マネジメント学会雑誌23（1）：2-7.2022
		Critical Pathway: Practical applications and its development in Japan. Hisayoshi Miyazaki,Teruhiko Matsushima. JMAJ48(11):568-571.2005

 
 

	山下英俊		山形市保健所・保健医療監
	眼科学、公衆衛生
		Tanaka Y, Katoh S, Hori S, Miura M, and Yamashita H: Vascular endothelial growth factor in diabetic retinopathy. Lancet 349: 1520, 1997
		ten Dijke P, Yamashita H, Ichijo H, Franzen P, Laiho M, Miyazono K, and Heldin C-H: Characterization of type I receptors for transforming growth factor-β and activin.  Science 264: 101-104, 1994
		Nishi K, Nishitsuka K, Yamamoto T, Yamashita H: Factors correlated with visual outcomes at two and four years after vitreous surgery for proliferative diabetic retinopathy. PLOS ONE 2021 Jan 14;16(1):e0244281. doi: 10.1371/journal.pone.0244281. eCollection 2021.