難治性疾患政策研究事業
（○：委員長）
| ○ | 新井 一 | 順天堂大学・学長 | |
| 脳神経外科 | |||
| Mori E, Ishikawa M, Kato T, Kazui H, Miyake H, Miyajima M, Nakajima M, Hashimoto M, Kuriyama N, Tokuda T, Ishii K, Kaijima N, Hirata Y, Saito M, Arai H: Guidelines for management of idiopathic normal pressure hydrocephalus: Second edition. Neurol Med Chir (Tokyo) 52:775-809, 2012 | |||
| Sugano H, Nakanishi H, Nakajima M, Higo T, Iimura Y, Tanaka K, Hosozawa M, Niijima S, Arai H. Posterior quadrant disconnection surgery for Sturge-Weber syndrome. Epilepsia 55(5):683-9, 2014 | |||
| Iihara K, Tominaga T, Saito N, Suzuki M, Date I, Fujii Y, Hongo K, Houkin K, Kato A, Kato Y, Kawamata T, Kim P, Kinouchi H, Kohmura E, Kurisu K, Maruyama K, Mikuni N, Miyamoto S, Morita A, Nakase H, Narita Y, Nishikawa R, Nozaki K, Ogasawara K, Ohata K, Sakai N, Sakamoto H, Shiokawa Y, Sonoda Y, Takahashi JC, Ueki K, Wakabayashi T, Yamamoto T, Yoshida K, Kayama T, Arai H; Japan Neurosurgical Society. The Japan Neurosurgical Database: Overview and Results of the First-year Survey. Neurol Med Chir (Tokyo) 60(4):165-190, 2020 | |||
| 有賀 正 | 社会医療法人母恋 理事長、北海道大学 名誉教授 | ||
| 小児科学、原発性免疫不全症、遺伝子治療、臨床遺伝学 | |||
| Okura Y, Kobayashi I, Yamada M, Sasaki S, Yamada Y, Kamioka I, Kanai R, Takahashi Y, Ariga T. Clinical characteristics and genotype-phenotype correlations in C3 deficiency. J Allergy Clin Immunol. 2016 Feb;137(2):640-644. | |||
| Cho K, Yamada M, Agematsu K, Kanegane H, Miyake N, Ueki M, Akimoto T, Kobayashi M, Ikemoto S, Tanino M, Fujita A, Hayasaka I, Miyamoto S, Tanaka-Kubota M, Nakata K, Shiina M, Ogata K, Minakami H, Matsumoto N, Ariga T. Heterozygous Mutations in OAS1 Cause Infantile-onset Pulmonary Alveolar Proteinosis with Hypogammaglobulinemia. Am J Hum Genet 102, 480-486, 2018. | |||
| Tozawa Y, Nogawa-Chida N, Abdrabou S, Nishiuchi R, Ishida T, Suzuki Y, Sano H, Kobayashi R, Kishimoto K, Ohara O, Imai K, Naruto T, Kobayashi K, Ariga T, Yamada M. A deep intronic mutation of c.1166-285T>G in SLC46A1 is shared by four unrelated Japanese patients with hereditary folate malabsorption (HFM) including one with delayed-onset HFM. Clin Immunol. 2019 Sep 5;208:108256. | |||
| 池田 康夫 | 学校法人根津育英会武蔵学園 学園長 早稲田大学 総長室参与、 慶應義塾大学名誉教授 |
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| 血液学 | |||
| （業績・実績その１） Kuwana M, Okazaki Y, Ikeda Y. Detection of circulating B cells producing anti-GPIb autoantibodies in patients with immune thrombocytopenia. PLoS One. 2014 Jan 22;9(1):e86943. doi: 10.1371/journal.pone.0086943. eCollection 2014. |
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| （業績・実績その２） Ikeda Y, Shimada K, Teramoto T, Uchiyama S, Yamazaki T, Oikawa S, Sugawara M, Ando K, Murata M, Yokoyama K, Ishizuka N. Low-dose aspirin for primary prevention of cardiovascular events in Japanese patients 60 years or older with atherosclerotic risk factors: a randomized clinical trial. JAMA. 2014 Dec 17;312(23):2510-20. doi: 10.1001/jama.2014.15690. |
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| （業績・実績その３） Platelet production using adipose-derived mesenchymal stem cells: Mechanistic studies and clinical application. Y Uruga-Ono, Y Ikeda, Y Matsubara, Journal of Thrombosis & Haemostasis, 2021 Feb, Vol19(2), 342-350. Cf. First Pub @20 Nov 2020 |
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| 磯部光章 | 榊原記念病院 院長・東京医科歯科大学 名誉教授 | ||
| 循環器内科 | |||
| Isobe M, Yagita H, Okumura K, Ihara A: Specific acceptance of cardiac allograft after treatment with anti-ICAM-1 and anti-LFA-1. Science, 255: 1125-1127, 1992 |
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| Isobe M, Maejima Y, Saji M, Tateishi U: Evaluation of tocilizumab for intractable Takayasu arteritis and 18 F-fluorodeoxyglucose-positron emission tomography for detecting inflammation under tocilizumab treatment. J Cardiol 2021 May;77(5):539-544. | |||
| Isobe M, Tezuka D: Isolated Cardiac Sarcoidosis: Clinical Characteristics, Diagnosis and Treatment. Int J Cardiol 182: 132-140, 2015. |
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| 江口 勝美 | 社会医療法人財団白十字会佐世保中央病院 顧問 | ||
| リウマチ・膠原病・免疫学 | |||
| 1 | Real-world comparative effectiveness and safety of tofacitinib and baricitinib in patients with rheumatoid arthritis. Iwamoto N, Sato S, Eguchi K,et al. Arthritis Res Ther.2021 Jul23;23(1):197. doi:10.1186/s13075-021-02582-z. |
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| 2 | Clinical features and human T-cell leukemia virus type-1(HTLV-1) proviral load in HTLV-1-positive patients with rheumatoid arthritis: Baseline date in a single cohort study. Eguchi K, Iwanaga M, Terada K, et al. Mod Rheumatol.30(3):471-480, 2020. |
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| 3 |
Next-generation sequencing of the whole MEFV gene in Japanese patients with familial Mediterranean fever: a case-control association study. Koga T, Sato S, Eguchi K, et al. Cli Exp Rheumatol.38(Suppl.127): S35-S41,2020. |
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| 大澤真木子 | 東京女子医科大学名誉教授、立教女学院理事長 | ||
| 小児神経学 | |||
| Sato T, Murakami T, Ishiguro K, Shichiji M, Saito K, Osawa M, Nagata S, Ishigaki K. Respiratory management of patients with Fukuyama congenital muscular dystrophy. Brain Dev. 2016, 38(3):324-30. | |||
| Nationwide survey (incidence, clinical course, prognosis) of Rasmussen's encephalitis．Muto, A., Oguni, H., Takahashi, Y., Shirasaka, Y., Sawaishi, Y., Yano, T., Hoshida, T., Osaka, H., Nakasu, S., Akasaka, N., Sugai, K., Miyamoto, A., Takahashi, S., Suzuki, M., Ohmori, I., Nabatame, S., Osawa, M.：Brain & Dev．2010 32（6）；445–53 |
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| Hino N, Kobayashi M, Shibata N ，Yamamoto T,Saito K ,Osawa M Clinicopathological study on eyes from cases of Fukuyama type congenital muscular dystrophy. Brain Dev. 2001 23:97-107. | |||
| 片山一朗 | 大阪市立大学大学院医学研究科 特任教授 | ||
| 皮膚科学 | |||
| The two faces of mast cells in vitiligo pathogenesis. Katayama I, Yang L, Takahashi A, Yang F, Wataya-Kaneda M. Explor Immunol.1(4)269-284.2021 | |||
| Morphological Alterations and Increased S100B Expression in Epidermal Langerhans Cells Detected in Skin from Patients with Progressive Vitiligo.Yang F, Yang L, Teng L, Zhang H, Katayama I.Life(Basel).11(6)579. 2021 | |||
| Local Epidermal Endocrine Estrogen Protects Human Melanocytes against Oxidative Stress, a Novel Insight into Vitiligo Pathology. Yamamoto A, Yang L, Kuroda Y, Guo J, Teng L, Tsuruta D, Katayama I. Int J Mol Sci. 22(1)269. 2020 | |||
| 加藤 義治 | 東京女子医科大学整形外科 前教授・講座主任 | ||
| 整形外科学 運動器学 | |||
| 研究論文 Katoh Y. Effects of Ethane-1-hydroxy-1,1-diphospho-nate on cell differentiation, and proteoglycan and calcium metabolism in the proximal tibia of young rats. Bone.12: 59-65、1991 |
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| 著作 「CKD・透析に併発する運動器疾患」 加藤 義治、稲葉 雅章 編, 加藤 義治, 透析と骨関節障害の病態と治療、108-120, 透析患者の椎体骨折, 195-209, 医薬ジャーナル社, 2018 |
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| Itoh Tatsuo，Kato Yoshiharu：Posterior decompression for cervical ossfication of the posterior longitudinal ligament．「Ossification of the Posterior Longitudinal Ligament」（Yonenobu K, Sako T, Ono K eds）Springer，Tokyo：pp218①143-152，1997 | |||
| 黒岩 義之 | 財務省診療所長、横浜市立大学 名誉教授 | ||
| 脳神経内科学 | |||
| Toh T, Urata R, Nakawatase A, Yamazaki T, Kuroiwa Y, Baba Y, Fujino K, Kurokawa T: Sensor-level- and ECDL-based brain functional connectivity networks using scalp-recorded EEGs: A comparison of AD and FTD patients and healthy subjects. Computational Neuroscience 9(2):38-44, 2016. | |||
| Kimura K, Inoue KI, Kuroiwa Y, Tanaka F, Takada M: Propagated but topologically distributed forebrain neurons expressing alpha-synuclein in aged macaques. Plos one 11(11):e0166861. Nov.2016. doi:10.1371/journal.pone. 0166861 |
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| Omoto S, Kuroiwa Y, Fujino S, Fujino K, Kurokawa T, Baba Y: Greater N1 potential during centrifugal saccades as compared to centripetal saccades in humans: A scalp-recorded electroencephalographic study. The Autonomic Nervous System (Journal of the Japan Society of Neurovegetative Research)，54(4):306-315, Dec. 2017. | |||
| 澤 倫太郎 | 日本医師会総合政策研究機構 主席研究員 | ||
| 胎児生理学、産科学、医療経済学 | |||
| Sawa R, Asakura H, Power GG. Changes in plasma adenosine during simulated birth of fetal sheep. J Appl Physiol 70(4): 1524-1528, 1991 |
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| Sawa R, Yoneyama Y, Otsubo Y, Suzuki S, Kubonoya K, Power GG, Araki T. Fetal plasma hypoxanthine level in growth-retarded fetuses before labor. J Clin Endocrinol Metab 82: 4028-4033, 1997 |
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| Ishihara O, Seung Chik Jwa, Kuwabara A, Ishikawa T, Kugu K, Sawa R, Banno K,Saito H Assisted reproductive technology inJapan: a summary report for 2016 by the Ethics committee of the Japan society of obstetrics and gynecology. Reprod Med Biol.1-10,2018 |
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| 清野 裕 | 関西電力病院 総長 | ||
| 糖尿病学、内分泌代謝学 | |||
| Dose-response, efficacy, and safety of oral semaglutide monotherapy in Japanese patients with type 2 diabetes(PIONEER 9):a 52-week, phase 2/3a, randomised, controlled trial. Yamada Y, Katagiri H, Hamamoto Y, Deenadayalan S, Navarria A, Nishijima K, Seino Y;PIONEER 9 investigators. Lancet Diabetes Endocrinol. 2020May;8(5):377-391.doi:10.1016/S2213-8587(20)30075-9. |
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| Inactivation of the Glucose-Dependent Insulinotropic Polypeptide Receptor Improves Outcomes following Experimental Myocardial Infarction. Ussher JR, Campbell JE, Mulvihill EE, Baggio LL, Bates HE, McLean BA, Gopal K, Capozzi M, Yusta B, Cao X, Ali S, Kim M, Kabir MG, Seino Y, Suzuki J, Drucker DJ. Cell Metab. 2018 Feb 6;27(2):450-460.e6. doi: 10.1016/j.cmet. 2017.11.003. Epub 2017 Dec 21. | |||
| Stromal cell-derived factor-1 is upregulated by dipeptidyl peptidase-4 inhibition and has protective roles in progressive diabetic nephropathy. Takashima S, Fujita H, Fujishima H, Shimizu T, Sato T, Morii T, Tsukiyama K, Narita T, Takahashi T, Drucker DJ, Seino Y, Yamada Y. Kidney Int. 2016 Oct;90(4):783-96. doi: 10.1016/j.kint. 2016.06.012. Epub 2016 Jul 27. | |||
| 竹中 洋 | 京都府立医科大学 学長 | ||
| 耳鼻咽喉科学 | |||
| Enhanced human IgE production results from exposure to the aromaticHydrocarbons from diesel exhaust;direct effects on B-cell IgE production, Takenaka H,et al J Allery CLin Immunol;1998.95:103-115. |
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| コア・ローテイション 耳鼻咽喉科・頭頸部外科 編集 竹中洋、高橋姿、久育男 金芳堂、2004年1月5日 |
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| 気道アレルギーの成立とその制御：竹中 洋 第110回日本耳鼻咽喉科学術総会宿題報告 東京、2009.05.14. |
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| 富野 康日己 | 医療法人社団松和会 理事長 順天堂大学 名誉教授 |
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| 腎臓内科学 | |||
| Utility of remission criteria for the renal prognosis of IgA nephropathy. Keiichi Matsuzaki, Hitoshi Suzuki, Tetsuya Kawamura, Yasuhiko Tomino, Yusuke Suzuki. Clinical and Experimental Nephrology, 25(9):988-995. Sep.2021. Epub: 11 May 2021 DOI: 10.1007/s10157-021-02069-w | |||
| Recent Understanding of Peritoneal Pathology in Peritoneal Dialysis Patients in Japan. Chieko Hamada, Yasuhiko Tomino. Blood Purification, 2021 Feb 10; 1-10 DOI: 10.1159/000510282 |
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| 必携！ 外来での腎臓病診療アプローチ」富野康日己、中外医学社 2021年9月20日 |
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| 永井 正規 | 埼玉医科大学 名誉教授 | ||
| 疫学 | |||
| Prevalence and Incidence of Polymyositis and Dermatomyositis in Japan. Ohta A, Nagai M, Nishina M, Tomimitsu H, Kohsaka H.Mod Rheumatol 24:477-480, 2013. | |||
| A case control study of female systemic lupus erythematosus in Japan. MASAKI NAGAI,TOMIO HIROHATA,YOSHIFUJI MATSUMOTO,HIROSHI HASHIMOTO,MASAKAZU KONDO,KOTARO OZASA,MITSURU MORI,TSUTOMU HASHIMOTO,HIDEAKI NAKAGAWA,TOSHITAKA OMURA,MASAKI MORI,TAKESHI TOJO,HIROSHI YANAGAWA,European Journal of Public Health, Volume 3, Issue 3:172-176, 1992 | |||
| 「新しい疫学」永井正規他共著，日本公衆衛生協会，（1995）． | |||
| 貫和 敏博 | 東北大学 名誉教授 | ||
| 呼吸器内科 | |||
| Gefitinib Alone Versus Gefitinib Plus Chemotherapy for Non-Small-Cell Lung Cancer With Mutated Epidermal Growth Factor Receptor: NEJ009 Study. Hosomi Y, Morita S, Sugawara S, Kato T, Fukuhara T, Gemma A, Takahashi K, Fujita Y, Harada T, Minato K, Takamura K, Hagiwara K, Kobayashi K, Nukiwa T, Inoue A; North-East Japan Study Group. J Clin Oncol. 2020 Jan 10;38(2):115-123. |
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| 貫和敏博、肺がん. がん生物学イラストレイテッド、第2版、渋谷正史・湯浅保仁編集、羊土社、2019. | |||
| Safety and pharmacokinetics of Alpha-1 MP (Prolastin®-C) in Japanese patients with alpha1-antitrypsin (AAT) deficiency. Seyama K, Nukiwa T, Sato T, Suzuki M, Konno S, Takahashi K, Nishimura M, Steinmann K, Sorrells S, Chen J, Hayashi KI. Respir Investig. 2019 Jan;57(1):89-96. |
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| 日比 紀文 | 北里大学北里研究所病院 炎症性腸疾患先進治療センター 特別顧問、慶應義塾大学 名誉教授 | ||
| 専門分野消化器内科学、消化器免疫学、臨床腫瘍学 | |||
| AJM300 (carotegrast methyl), an oral antagonist of α4-integrin, as induction therapy for patients with moderately active ulcerative colitis: a multicentre, randomised, double-blind, placebo-controlled, phase 3 study. Matsuoka K, Watanabe M, Ohmori T, Nakajima K, Ishida T, Ishiguro Y, Kanke K, Kobayashi K, Hirai F, Watanabe K, Mizusawa H, Kishida S, Miura Y, Ohta A, Kajioka T, Hibi T; AJM300 Study Group.Lancet Gastroenterol Hepatol. 2022 Jul;7(7):648-657. doi: 10.1016/S2468-1253(22)00022-X. Epub 2022 Mar 30.PMID: 35366419 Clinical Trial |
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| Efficacy of Biologic Drugs in Short-Duration Versus Long-Duration Inflammatory Bowel Disease: A Systematic Review and an Individual-Patient Data Meta-Analysis of Randomized Controlled Trials. Ben-Horin S, Novack L, Mao R, Guo J, Zhao Y, Sergienko R, Zhang J, Kobayashi T, Hibi T, Chowers Y, Peyrin-Biroulet L, Colombel JF, Kaplan GG, Chen MH.Gastroenterology. 2022 Feb;162(2):482-494. doi: 10.1053/j.gastro.2021.10.037. Epub 2021 Oct 29.PMID: 34757139 Free article. |
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| Risankizumab for Crohn's disease. Hibi T.Lancet. 2022 May 28;399(10340):1992-1993. doi: 10.1016/S0140-6736(22)00628-6.PMID: 35644143 No abstract available. |
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| 福島 雅典 | 京都大学名誉教授 一般財団法人LHS(ラーニングヘルスソサエティー)研究所代表理事 |
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| トランスレーションナルリサーチ、臨床試験管理学、腫瘍内科学 | |||
| Titanium bridge modification for type 2 thyroplasty to improve device mechanical & safety performance. Sanuki T, Nishimura T, Aburada T, Fukushima M. AurisNasusLarynx.2021Nov3:S0385-8146(21)00252-2. doi: 10.1016/j.anl.2021.10.011. Epub ahead of print. PMID: 34742621. |
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| Multicenter phase III trial of regenerative treatment for chronic tympanic membrane perforation. Kanemaru SI, Kanai R, Omori K, Yamamoto N, Okano T, Kishimoto I, Ogawa K, Kanzaki S, Fujioka M, Oishi N, Naito Y, Kakehata S, Nakamura H, Yamada S, Omae K, Kawamoto A, Fukushima M. Auris Nasus Larynx. 2021 Dec;48(6):1054-1060. doi: 10.1016/j.anl.2021.02.007. Epub 2021 Mar 26. PMID |
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| Long-term outcome of cultivated oral mucosal epithelial transplantation for fornix reconstruction in chronic cicatrising diseases. Komai S, Inatomi T, Nakamura T, Ueta M, Horiguchi G, Teramukai S, Kimura Y, Kagimura T, Fukushima M, Kinoshita S, Sotozono C. Br J Ophthalmol. 2022 Oct;106(10):1355-1362. doi: 10.1136/bjophthalmol-2020-318547. Epub 2021 May 18. |
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| 宮﨑 久義 | 特定非営利活動法人日本医療マネジメント学会 理事長 | ||
| 麻酔、病院管理、地域医療、生活習慣病 | |||
| 癌末期痛に対するモリッカの下垂体破壊術−1.経鼻的下垂体穿刺に必要な基礎的と方法−.宮崎久義,後藤倶子,岡元和文,宇都宮高賢,森岡亨,山室誠,麻酔27:1606-1612.1978 | |||
| 癌末期痛に対するモリッカの下垂体破壊術−2.その成績と作用機序に対する考察−.宮崎久義,後藤倶子,岡元和文,宇都宮高賢,森岡亨,山室誠,麻酔28(1):77-82.1979 |
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| Critical Pathway: Practical applications and its development in Japan. Hisayoshi Miyazaki,Teruhiko Matsushima. JMAJ48(11):568-571.2005 |
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| 山下英俊 | 山形市保健所・保健医療監 | ||
| 眼科学、公衆衛生 | |||
| Tanaka Y, Katoh S, Hori S, Miura M, and Yamashita H: Vascular endothelial growth factor in diabetic retinopathy. Lancet 349: 1520, 1997 | |||
| ten Dijke P, Yamashita H, Ichijo H, Franzen P, Laiho M, Miyazono K, and Heldin C-H: Characterization of type I receptors for transforming growth factor-β and activin. Science 264: 101-104, 1994 | |||
| Nishi K, Nishitsuka K, Yamamoto T, Yamashita H: Factors correlated with visual outcomes at two and four years after vitreous surgery for proliferative diabetic retinopathy. PLOS ONE 2021 Jan 14;16(1):e0244281. doi: 10.1371/journal.pone.0244281. eCollection 2021. | |||
