【照会先】
医薬・生活衛生局
監視指導・麻薬対策課
課長補佐 小池 紘一郎(2763)
主査 蒲池 稔(2766)
(直通電話) 03-3595-2436
医薬・生活衛生局
安全対策課
課長補佐 塩川 智規(2752)
専門官 松永 雄亮(2750)
(直通電話)03-3595-2435
報道関係者各位
ニザチジン製剤に係るNDMAの分析結果について
現在市場に流通する胃潰瘍等治療薬であるニザチジン製剤※1中の発がん性物質N‐ニトロソジメチルアミン(NDMA)の量を各製造販売業者が分析したところ、全て暫定基準値※2以下であることが確認できましたのでお知らせします。
分析結果の詳細については、下記のとおりです。
※1 暫定基準値を超えたロットの製品についてはすでに自主回収を行っており、現在、市場流通
されておりません。
※2 0.32ppm(NDMAの一日許容摂取量0.0959㎍/日を基に算出)
記
![各社分析結果](data:image/png;base64,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)
※3令和元年10月23日、自主回収着手(クラスI)
※4令和元年12月3日、自主回収着手(クラスI)
参考:
アメリカ食品医薬品局(FDA)及び欧州医薬品庁(EMA)より、ヒスタミンH2受容体拮抗薬であるラニチジン塩酸塩の製剤及び原薬から発がん性物質であるNDMAが検出されたことに伴い、「ラニチジン塩酸塩等における発がん性物質に関する分析について(依頼)」(令和元年9月17日付事務連絡)を発出し、ニザチジンを製造販売する事業者に対し、有効期限内の製品及び当該製品に使用されている原薬についてNDMAの分析を実施するよう依頼をしていた。
参考:
○ラニチジン塩酸塩における発がん物質の検出に対する対応について
https://www.mhlw.go.jp/content/11120000/000560997.pdf
○令和元年10月23日 医薬品自主回収のお知らせ(クラスⅠ)
https://www.mhlw.go.jp/stf/newpage_07461.html
○令和元年12月3日 医薬品自主回収のお知らせ(クラスⅠ)
https://www.mhlw.go.jp/stf/newpage_08207.html
○平成30年度第9回医薬品等安全対策部会安全対策調査会 資料3-1
https://www.mhlw.go.jp/content/11121000/000378171.pdf
○令和元年度第9回医薬品等安全対策部会安全対策調査会 資料4-1
https://www.mhlw.go.jp/content/11120000/000560996.pdf
分析結果の詳細については、下記のとおりです。
※1 暫定基準値を超えたロットの製品についてはすでに自主回収を行っており、現在、市場流通
されておりません。
※2 0.32ppm(NDMAの一日許容摂取量0.0959㎍/日を基に算出)
記
※3令和元年10月23日、自主回収着手(クラスI)
※4令和元年12月3日、自主回収着手(クラスI)
参考:
アメリカ食品医薬品局(FDA)及び欧州医薬品庁(EMA)より、ヒスタミンH2受容体拮抗薬であるラニチジン塩酸塩の製剤及び原薬から発がん性物質であるNDMAが検出されたことに伴い、「ラニチジン塩酸塩等における発がん性物質に関する分析について(依頼)」(令和元年9月17日付事務連絡)を発出し、ニザチジンを製造販売する事業者に対し、有効期限内の製品及び当該製品に使用されている原薬についてNDMAの分析を実施するよう依頼をしていた。
参考:
○ラニチジン塩酸塩における発がん物質の検出に対する対応について
https://www.mhlw.go.jp/content/11120000/000560997.pdf
○令和元年10月23日 医薬品自主回収のお知らせ(クラスⅠ)
https://www.mhlw.go.jp/stf/newpage_07461.html
○令和元年12月3日 医薬品自主回収のお知らせ(クラスⅠ)
https://www.mhlw.go.jp/stf/newpage_08207.html
○平成30年度第9回医薬品等安全対策部会安全対策調査会 資料3-1
https://www.mhlw.go.jp/content/11121000/000378171.pdf
○令和元年度第9回医薬品等安全対策部会安全対策調査会 資料4-1
https://www.mhlw.go.jp/content/11120000/000560996.pdf