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難治性疾患政策研究事業事前評価委員名簿

(○:委員長)

 
新井 一 順天堂大学 学長
脳神経外科学
Mori E, Ishikawa M, Kato T, Kazui H, Miyake H, Miyajima M, Nakajima M, Hashimoto M, Kuriyama N, Tokuda T, Ishii K, Kaijima N, Hirata Y, Saito M, Arai H: Guidelines for management of idiopathic normal pressure hydrocephalus: Second edition. Neurol Med Chir (Tokyo) 52:775-809, 2012
Sugano H, Nakanishi H, Nakajima M, Higo T, Iimura Y, Tanaka K, Hosozawa M, Niijima S, Arai H. Posterior quadrant disconnection surgery for Sturge-Weber syndrome. Epilepsia 55(5):683-9, 2014
Iihara K, Tominaga T, Saito N, Suzuki M, Date I, Fujii Y, Hongo K, Houkin K, Kato A, Kato Y, Kawamata T, Kim P, Kinouchi H, Kohmura E, Kurisu K, Maruyama K, Mikuni N, Miyamoto S, Morita A, Nakase H, Narita Y, Nishikawa R, Nozaki K, Ogasawara K, Ohata K, Sakai N, Sakamoto H, Shiokawa Y, Sonoda Y, Takahashi JC, Ueki K, Wakabayashi T, Yamamoto T, Yoshida K, Kayama T, Arai H; Japan Neurosurgical Society. The Japan Neurosurgical Database: Overview and Results of the First-year Survey. Neurol Med Chir (Tokyo) 60(4):165-190, 2020
 
有賀 正 社会医療法人母恋 理事長、北海道大学 名誉教授
小児科学、原発性免疫不全症、遺伝子治療、臨床遺伝学
Okura Y, Kobayashi I, Yamada M, Sasaki S, Yamada Y, Kamioka I, Kanai R, Takahashi Y, Ariga T. Clinical characteristics and genotype-phenotype correlations in C3 deficiency. J Allergy Clin Immunol. 2016 Feb;137(2):640-644.
Cho K, Yamada M, Agematsu K, Kanegane H, Miyake N, Ueki M, Akimoto T, Kobayashi M, Ikemoto S, Tanino M, Fujita A, Hayasaka I, Miyamoto S, Tanaka-Kubota M, Nakata K, Shiina M, Ogata K, Minakami H, Matsumoto N, Ariga T. Heterozygous Mutations in OAS1 Cause Infantile-onset Pulmonary Alveolar Proteinosis with Hypogammaglobulinemia. Am J Hum Genet 102, 480-486, 2018.
Tozawa Y, Nogawa-Chida N, Abdrabou S, Nishiuchi R, Ishida T, Suzuki Y, Sano H, Kobayashi R, Kishimoto K, Ohara O, Imai K, Naruto T, Kobayashi K, Ariga T, Yamada M. A deep intronic mutation of c.1166-285T>G in SLC46A1 is shared by four unrelated Japanese patients with hereditary folate malabsorption (HFM) including one with delayed-onset HFM. Clin Immunol. 2019 Sep 5;208:108256.
 
池田康夫 早稲田大学 特命教授 
慶應義塾大学 名誉教授
血液学
Kuwana M, Okazaki Y, Ikeda Y.
Detection of circulating B cells producing anti-GPIb autoantibodies in patients with immune thrombocytopenia.
PLoS One. 2014 Jan 22;9(1):e86943. doi: 10.1371/journal.pone.0086943. eCollection 2014.
Ikeda Y, Shimada K, Teramoto T, Uchiyama S, Yamazaki T, Oikawa S, Sugawara M, Ando K, Murata M, Yokoyama K, Ishizuka N.
Low-dose aspirin for primary prevention of cardiovascular events in Japanese patients 60 years or older with atherosclerotic risk factors: a randomized clinical trial.
JAMA. 2014 Dec 17;312(23):2510-20. doi: 10.1001/jama.2014.15690.
Tozawa K, Ono-Uruga Y, Yazawa M, Mori T, Murata M, Okamoto S, Ikeda Y, Matsubara Y.
Megakaryocytes and platelets from a novel human adipose tissue-derived mesenchymal stem cell line.
Blood. 2019 Feb 14;133(7):633-643.
doi: 10.1182/blood-2018-04-842641. Epub 2018 Nov 28
 
石橋 達朗 九州大学 理事、副学長
眼科
Ishikawa K, Yoshida S, Nakao S, Nakama T, Kita T, Asato R, Sassa Y, Arita R, Miyazaki M, Enaida H, Oshima Y, Murakami N, Niiro H, Ono J, Matsuda A, Goto Y, Akashi K, Izuhara K, Kudo A,Kono T, Hafezi-Moghadam A, Ishibashi T:
Periostin promotes the generation of fibrous membranes in proliferative vitreoretinopathy. FASEB J 28(1):131-142, 2014
Nakama T, Yoshida S, Ishikawa K, Kobayashi Y, Zhou Y, Nakao S, Sassa Y, Oshima Y, Takao K, Shimahara A, Yoshikawa K, Hamasaki T, Ohgi T, Hayashi H, Matsuda A, Kudo A, Nozaki M, Ogura Y, Kuroda M, Ishibashi T:
Inhibition of choroidal fibrovascular membrane formation by new class of RNA interference therapeutic agent targeting periostin.
Gene Ther 22(2):127-137, 2015
Ishibashi T, Li X, Koh A, Lai, Lee F-L, Lee W-K, Ma Z, Ohji M,Tan N,
Cha S B, Shamsazar J, Yau C L, on behalf of the REVEAL Study
Group:The REVEAL Study : Ranibizumab Monotherapy or Combined with Laser versus Laser Monotherapy in Asian Patients with Diabetic Macular Edema.
Ophthalmology 122(7):1402-1415, 2015
 
磯部 光章 公益財団法人日本心臓血圧研究振興会附属榊原記念病院 院長
循環器内科
Isobe M, Yagita H, Okumura K, Ihara A: Specific acceptance of cardiac
allograft after treatment with anti-ICAM-1 and anti-LFA-1. Science, 255:1125-1127, 1992
Isobe M: Takayasu Arteritis Revisited: Current Diagnosis and Treatment. IntJ Cardiol 168 (Sept): 3-10, 2013
Isobe M, Tezuka D: Isolated Cardiac Sarcoidosis: Clinical Characteristics,Diagnosis and Treatment. Int J Cardiol 182: 132-140, 2015.
 
江口 勝美 社会医療法人財団白十字会佐世保中央病院 顧問
リウマチ・免疫学
1 Clinical features and human T-cell leukemia virus type-1(HTLV-1)
proviral load in HTLV-1-positive patients with rheumatoid arthritis: Baseline data in a single cohort study. Eguchi K, Iwanaga M, Terada K, et al. Mod Rheumatol.2020;30(3):471-480.
2 Hepatitis B virus reactivation in patients with rheumatoid arthritis. A single-center study. Matsuzaki T, Eguchi K, Nagao N, Tuji S, Aramaki T, et al. Mod Rheumatol.2018; 28(5):808-813.
3 Attenuated effectiveness of tumor necrosis factor inhibitors for ant-human T lymphotropic virus type 1 antibody-positive rheumatoid arthritis. Suzuki T, Fukui S, Eguchi k, et al. Arthritis Rheumatol.2018; 70(7): 1014-1021.
大澤 真木子 東京女子医科大学 名誉教授
小児神経学
Sato T, Murakami T, Ishiguro K, Shichiji M, Saito K, Osawa M, Nagata S, Ishigaki K. Respiratory management of patients with Fukuyama congenital muscular dystrophy. Brain Dev. 2016, 38(3):324-30.
Nationwide survey (incidence, clinical course, prognosis) of Rasmussen's encephalitis.Muto, A., Oguni, H., Takahashi, Y., Shirasaka, Y., Sawaishi, Y., Yano, T., Hoshida, T., Osaka, H., Nakasu, S., Akasaka, N., Sugai, K., Miyamoto, A., Takahashi, S., Suzuki, M., Ohmori, I., Nabatame, S., Osawa, M.:Brain & Development(Elsebia)32,(6),2010, pp. 445 - 453
Hino N, Kobayashi M, Shibata N et al (2001) Clinicopathological study on eyes from cases of Fukuyama type congenital muscular dystrophy. Brain Dev. 23:97-107.
 
片山 一朗 大阪市立大学大学院医学研究科 特任教授
皮膚科学
Sweat glucose and GLUT2 expression in atopic dermatitis: Implication for clinical manifestation and treatment. Ono E, Murota H, Mori Y, Yoshioka Y, Nomura Y, Munetsugu T, Yokozeki H, Katayama I.
PLoS One. 2018 Apr 20;13(4):e0195960. d56
Local Glucocorticoid Activation by 11β-Hydroxysteroid Dehydrogenase 1 in Keratinocytes: The Role in Hapten-Induced Dermatitis. Terao M, Itoi S, Matsumura S, Yang L, Murota H, Katayama I Am J Pathol. 2016;186(6):1499-510.
Dose-dependent role of claudin-1 in vivo in orchestrating features of atopic dermatitis. )Tokumasu R, Yamaga K, Yamazaki Y, Murota H, Suzuki K, Tamura A, Bando K, Furuta Y, Katayama I ,Tsukita S Proc Natl Acad Sci U S A. 2016;113(28): E4061-8.
 
加藤 義治 東京女子医科大学整形外科 前教授・講座主任
整形外科学 運動器学
研究論文
Katoh Y. Effects of Ethane-1-hydroxy-1,1-diphospho-nate on cell differentiation, and proteoglycan and calcium metabolism in the proximal tibia of young rats. Bone.12: 59-65、1991
「CKD・透析に併発する運動器疾患」 加藤 義治、稲葉 雅章 編, 加藤 義治, 透析と骨関節障害の病態と治療、108-120, 透析患者の椎体骨折, 195-209, 医薬ジャーナル社, 2018
Itoh Tatsuo,Kato Yoshiharu:Posterior decompression for cervical ossfication of the posterior longitudinal ligament.「Ossification of the Posterior Longitudinal Ligament」(Yonenobu K, Sako T, Ono K eds)Springer,Tokyo:pp218@143-152,1997
葛原茂樹 鈴鹿医療科学大学 大学院医療科学研究科・研究科長、看護学部看護学科・特任教授
神経内科学
Mimuro M, Yoshida M, Kuzuhara S, Kokubo Y. Amyotrophic lateral sclerosis and parkinsonism-dementia complex of the Hohara focus of the Kii Peninsula: a multiple proteinopathy? Neuropathology 2018;38:98-104.
葛原茂樹.日本の難病対策の歴史と新たな難病対策.公衆衛生2016;80(6):390-399.
Kuzuhara S, Kokubo Y. Amyotrophic lateral sclerosis-pakinsonism -dementia complex in the Kii peninsula of Japan (Muro disease): a review on recent research and new concept In: Amyotrophic Lateral Sclerosis and the Frontotemporal Dementias, Edited by Michael J. Strong, Oxford University Press, Oxford,2012, p39-54.
 
黒岩 義之 財務省診療所長、横浜市立大学名誉教授
脳神経内科学
Toh T, Urata R, Nakawatase A, Yamazaki T, Kuroiwa Y, Baba Y, Fujino K, Kurokawa T: Sensor-level- and ECDL-based brain functional connectivity networks using scalp-recorded EEGs: A comparison of AD and FTD patients and healthy subjects. Computational Neuroscience 9(2):38-44, 2016.
Kimura K, Inoue KI, Kuroiwa Y, Tanaka F, Takada M: Propagated but topologically distributed forebrain neurons expressing alpha-synuclein in aged macaques. Plos one 11(11):e0166861. Nov.2016.
doi:10.1371/journal.pone. 0166861
Omoto S, Kuroiwa Y, Fujino S, Fujino K, Kurokawa T, Baba Y: Greater N1 potential during centrifugal saccades as compared to centripetal saccades in humans: A scalp-recorded electroencephalographic study. The Autonomic Nervous System (Journal of the Japan Society of Neurovegetative Research),54(4):306-315, Dec. 2017.
 
澤倫太郎 日本医師会総合政策研究機構 研究部長・会長特別補佐
胎児生理学、産科学、医療経済学
Sawa R, Asakura H, Power GG.
Changes in plasma adenosine during simulated birth of fetal sheep.
J Appl Physiol 70(4): 1524-1528, 1991
Sawa R, Yoneyama Y, Otsubo Y, Suzuki S, Kubonoya K, Power GG, Araki T.
Fetal plasma hypoxanthine level in growth-retarded fetuses before labor.
J Clin Endocrinol Metab 82: 4028-4033, 1997
Ishihara O, Seung Chik Jwa, Kuwabara A, Ishikawa T, Kugu K, Sawa R, Banno K,Saito H
Assisted reproductive technology inJapan: a summary report for 2016
by the Ethics committee of the Japan society of obstetrics and gynecology. Reprod Med Biol.1-10,2018
 
清野 裕 関西電力病院 総長
糖尿病学、内分泌代謝学
Dose-response, efficacy, and safety of oral semaglutide monotherapy in Japanese patients with type 2 diabetes(PIONEER 9):a 52-week, phase 2/3a, randomised, controlled trial. Yamada Y, Katagiri H, Hamamoto Y, Deenadayalan S, Navarria A, Nishijima K, Seino Y;PIONEER 9 investigators. Lancet Diabetes Endocrinol.
2020May;8(5):377-391.doi:10.1016/S2213-8587(20)30075-9.
Inactivation of the Glucose-Dependent Insulinotropic Polypeptide Receptor Improves Outcomes following Experimental Myocardial Infarction. Ussher JR, Campbell JE, Mulvihill EE, Baggio LL, Bates HE, McLean BA, Gopal K, Capozzi M, Yusta B, Cao X, Ali S, Kim M, Kabir MG, Seino Y, Suzuki J, Drucker DJ. Cell Metab. 2018 Feb 6;27(2):450-460.e6. doi: 10.1016/j.cmet. 2017.11.003. Epub 2017 Dec 21.
Stromal cell-derived factor-1 is upregulated by dipeptidyl peptidase-4 inhibition and has protective roles in progressive diabetic nephropathy. Takashima S, Fujita H, Fujishima H, Shimizu T, Sato T, Morii T, Tsukiyama K, Narita T, Takahashi T, Drucker DJ, Seino Y, Yamada Y. Kidney Int. 2016 Oct;90(4):783-96. doi: 10.1016/j.kint. 2016.06.012. Epub 2016 Jul 27.
 
竹中 洋 京都府立医科大学 学長
耳鼻咽喉科学
Enhanced human IgE production results from exposure to the aromaticHydrocarbons from diesel exhaust;direct effects on B-cell IgE production, Takenaka H,et al
J Allery CLin Immunol;1998.95:103-115.
コア・ローテイション 耳鼻咽喉科・頭頸部外科
編集 竹中洋、高橋姿、久育男
金芳堂、2004年1月5日
気道アレルギーの成立とその制御:竹中 洋
第110回日本耳鼻咽喉科学術総会宿題報告
東京、2009.05.14.
 
富野 康日己 医療法人社団松和会 理事長
順天堂大学 名誉教授
腎臓内科学
“Inhibition of STAT3 Signaling Reduces IgA1 Autoantigen Production in IgA Nephropathy” Koshi Yamada, Zhi-Qiang Huang, Milan Raska, Colin Reily, Joshua C. Anderson, Hitoshi Suzuki, Hiroyuki Ueda, Zina Moldoveanu, Krzysztof Kiryluk, Yusuke Suzuki, Robert J. Wyatt, Yasuhiko Tomino, Ali G. Gharavi, Amy Weinmann, Bruce A. Julian, Christopher D. Willey and Jan Novak. Kidney Int Rep. 2017 July 19; 2(6): 1194-1207. DOI: 10.1016/j.ekir.2017.07.002.
“Outcomes of the Re-classification of WHO Class IV Lupus Nephritis Using the ISN/RPS Classification: a Single Center Retrospective Observational Study from JUDE Study” Tomoko Miyashita, Shinji Morimoto, Daisuke Honda, Souichiro Nakano, Hirofumi Amano, Isao Osawa, Ken Yamaji, Yasuhiko Tomino, Yoshinari Takasaki, Naoto Tamura. Juntendo Medical Journal 2017. 63(5): 362-369. DOI: 10.14789/jmj.63.362
“Rac1in podocytes promotes glomerular repair and limits the formation of sclerosis” Rin Asao, Takuto Seki, Miyuki Takagi, Hiroyuki Yamada, Fumiko Kodama, Yoshiko Hosoe-Nagai, Eriko Tanaka, Juan Alejandro Oliva Trejo, Kanae, Yamamoto-Nonaka, Yu Sasaki, Teruo Hidaka, Takashi Ueno, Motoko Yanagita, Yusuke Suzuki, Yasuhiko Tomino, Katsuhiko Asanuma. Nature Scientific Reports 8(1):5061 March 2018. DOI: 10.1038/s41598-018-23278-6
 
永井正規 埼玉医科大学名誉教授
疫学
Prevalence and Incidence of Polymyositis and Dermatomyositis in Japan. Ohta A, Nagai M, Nishina M, Tomimitsu H, Kohsaka H.Mod Rheumatol 24:477-480, 2013.
A case control study of female systemic lupus erythematosus in Japan
MASAKI NAGAI,TOMIO HIROHATA,YOSHIFUJI MATSUMOTO,HIROSHI HASHIMOTO,MASAKAZU KONDO,KOTARO OZASA,MITSURU MORI,TSUTOMU HASHIMOTO,HIDEAK
I NAKAGAWA,TOSHITAKA OMURA,MASAKI MORI,TAKESHI TOJO,HIROSHI YANAGAWA European Journal of Public Health, Volume 3, Issue 3:172-176, 1992
「新しい疫学」永井正規他共著,日本公衆衛生協会,(1995).
 
貫和敏博 東北大学 名誉教授
呼吸器内科
Gefitinib Alone Versus Gefitinib Plus Chemotherapy for Non-Small-Cell Lung Cancer With Mutated Epidermal Growth Factor Receptor: NEJ009 Study.
Hosomi Y, Morita S, Sugawara S, Kato T, Fukuhara T, Gemma A, Takahashi K, Fujita Y, Harada T, Minato K, Takamura K, Hagiwara K, Kobayashi K, Nukiwa T, Inoue A; North-East Japan Study Group.
J Clin Oncol. 2020 Jan 10;38(2):115-123.
貫和敏博、肺がん. がん生物学イラストレイテッド、第2版、渋谷正史・湯浅保仁編集、羊土社、2019.
Safety and pharmacokinetics of Alpha-1 MP (Prolastin?-C) in Japanese patients with alpha1-antitrypsin (AAT) deficiency.
Seyama K, Nukiwa T, Sato T, Suzuki M, Konno S, Takahashi K, Nishimura M, Steinmann K, Sorrells S, Chen J, Hayashi KI.
Respir Investig. 2019 Jan;57(1):89-96.
 
日比 紀文 北里大学北里研究所病院 炎症性腸疾患先進治療センター センター長、慶應義塾大学 名誉教授
消化器内科学、消化器免疫学、臨床腫瘍学
Naganuma M, Sugimoto S, Mitsuyama K, Kobayashi T, Yoshimura N, Ohi H, Tanaka S, Andoh A, Ohmiya N, Saigusa K, Yamamoto T, Morohoshi Y, Ichikawa H, Matsuoka K, Hisamatsu T, Watanabe K, Mizuno S, Suda W, Hattori M, Fukuda S, Hirayama A, Abe T, Watanabe M, Hibi T, Suzuki Y, Kanai T; INDIGO Study Group: Efficacy of Indigo Naturalis in a Multicenter Randomized Controlled Trial of Patients With Ulcerative Colitis. Gastroenterology. 154(4):935-947, 2018
Matsuoka K, Kobayashi T, Ueno F, Matsui T, Hirai F, Inoue N, Kato J, Kobayashi K, Kobayashi K, Koganei K, Kunisaki R, Motoya S, Nagahori M, Nakase H, Omata F, Saruta M, Watanabe T, Tanaka T, Kanai T, Noguchi Y, Takahashi KI, Watanabe K, Hibi T, Suzuki Y, Watanabe M, Sugano K, Shimosegawa T: Evidence-based clinical practice guidelines for inflammatory bowel disease. J Gastroenterol. 53(3):305-353,2018
Watanabe K, Matsumoto T, Hisamatsu T, Nakase H, Motoya S, Yoshimura N, Ishida T, Kato S, Nakagawa T, Esaki M, Nagahori M, Matsui T, Naito Y, Kanai T, Suzuki Y, Nojima M, Watanabe M, Hibi T; DIAMOND study group: Clinical and Pharmacokinetic Factors Associated With Adalimumab-Induced Mucosal Healing in Patients With Crohn's Disease. Clin Gastroenterol Hepatol. 16(4):542-549, 2018
 
福島 雅則 公益財団法人神戸医療産業都市推進機構 医療イノベーション推進センター センター長
腫瘍内科学、トランスレーションナルリサーチ、レギュラトリーサイエンス、科学経営学
Yamashita S, Arai H, Bujo H, Masuda D, Ohama T, Ishibashi T, Yanagi K, Doi Y, Nakagawa S, Yamashiro K, Tanabe K, Kita T, Matsuzaki M, Saito Y, Fukushima M, Matsuzawa Y; PROSPECTIVE Study Group.Probucol Trial for Secondary Prevention of Atherosclerotic Events in Patients with Coronary Heart Disease (PROSPECTIVE)J Atheroscler Thromb. 2020 Apr 24. doi: 10.5551/jat.55327. Online ahead of print.
Nishizawa S, Kojima S, Okada H, Shinke T, Torizuka T, Teramukai S, Fukushima M.Ten-year prospective evaluation of whole-body cancer screening with multiple modalities including [(18)F]fluorodeoxyglucose positron emission tomography in a healthy populationAnn Nucl Med. 2020 May;34(5):358-368. doi: 10.1007/s12149-020-01456-9. Epub 2020 Mar 21.
Nishimura T, Tsai IJ, Yamauchi H, Nakatani E, Fukushima M, Hsu CY.Association of Geomagnetic Disturbances and Suicide Attempts in Taiwan, 1997-2013: A Cross-Sectional StudyInt J Environ Res Public Health. 2020 Feb 12;17(4):1154. doi: 10.3390/ijerph17041154.
 
宮ア 久義 特定非営利活動法人
日本医療マネジメント学会理事長
麻酔、病院管理、地域医療、生活習慣病
癌末期痛に対するモリッカの下垂体破壊術 1.経鼻的下垂体穿刺に必要な基礎的と方法 .宮崎久義,後藤倶子,岡元和文,宇都宮高賢,森岡亨,山室誠,麻酔27:1606-1612.1978
癌末期痛に対するモリッカの下垂体破壊術 2.その成績と作用機序に対する考察 .宮崎久義,後藤倶子,岡元和文,宇都宮高賢,森岡亨,山室誠,麻酔28(1):77-82.1979
Critical Pathway: Practical applications and its development in Japan.Hisayoshi Miyazaki,Teruhiko Matsushima. JMAJ48(11):568-571.2005

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