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肝炎等克服政策研究事業 事前評価委員名簿

(○:委員長)

脇田 隆字 国立感染症研究所・所長
ウイルス学、肝炎ウイルス学
Wakita T, T Pietschmann, T Kato, T Date, M Miyamoto, Z Zhao, K Murthy, A Habermann, H-G Kra:usslich, M Mizokami, R Bartenschlager, T J Liang. Production of Infectious Hepatitis C Virus in Tissue Culture from a Cloned Viral Genome. Nat Med. 2005 11:791-6.
Wakita T and Wands JR. Specific inhibition of hepatitis C virus expression by antisense oligodeoxy-nucleotides: In vitro model for selection of target sequence. J Biol Chem. 1994 269:14205-10
Wakita T, Kakumu S, Shibayama M, Yoshioka K, Ito Y, Shinagawa T, Ishikawa T, Takayanagi M, Morishima T. Detection of pre-C and core region mutants of hepatitis B virus in chronic hepatitis B virus carriers. J Clin Invest. 1991 88: 1793-801
 
相澤 好治 北里大学・名誉教授
予防医学
Aizawa Y, Kudo Y. Magnetometric evaluation of toxicities of chemicals to the lungs and cells.Environ Health Prev Med. 2010 Jul;15(4):197-202. (Epub 2010 Apr 6.)
Wada K, Yoshikawa T, Hayashi T, Aizawa Y. Emergency response technical work at Fukushima Dai-ichi nuclear power plant: occupational health challenges posed by the nuclear disaster. Occup Environ Med 2012.8, 69(8):599-602. Epub 2012 Apr 12.
Kido T, Sugaya C, Ikeuchi R, Kudo Y, Tsunoda M, Aizawa Y. The increases in mRNA expressions of inflammatory cytokines by adding cleaning solvent or tetrachloroethylene in the murine macrophage cell line J774.1 evaluated by real-time PCR. Ind Health. 2013;51(3):319-25. Epub 2013 Mar 29.
 
井上 真奈美 国立研究開発法人 国立がん研究センター 社会と健康研究センター 予防研究部・部長
疫学、予防医学
Inoue M, et al. Coffee Drinking and Reduced Risk of Liver Cancer: Update on Epidemiological Findings and Potential Mechanisms. Curr Nutr Rep 2019; 8: 182-186.
Inoue M, et al. Attributable causes of cancer in Japan in 2005--systematic assessment to estimate current burden of cancer attributable to known preventable risk factors in Japan. Ann Oncol 2012; 23: 1362-1369.
Inoue M, et al. Metabolic factors and subsequent risk of hepatocellular carcinoma by hepatitis virus infection status: a large-scale population-based cohort study of Japanese men and women (JPHC Study Cohort II). Cancer Causes Control 2009; 20: 741-750.
 
井廻 道夫 新百合ヶ丘総合病院消化器・肝臓病研究所・所長
肝臓病学
Perforin, Fas/Fas ligand, TNF-a pathways as specific and bystander killing mechanisms of hepatitis C virus-specific human CTL. Ando K, Hiroishi K, Kaneko T, Moriyama T, Muto Y, Kayagaki N, Yagita H, Okumura K, Imawari M. J Immunol 1997;158:5283-5291.
Strong CD8+ T-cell responses against tumor-associated antigens prolong the recurrence-free interval after tumor treatment in patients with hepatocellular carcinoma. Hiroishi K, Eguchi J, Baba T, Shimazaki T, Ishii S, Hiraide A, Sasaki M, Doi H, Uozumi S, Omori R, Matsumura T, Yanagawa T, Ito T, Imawari M. J Gastroenterol 2010;45:451-458.
25-hydroxyvitamin D3 suppresses hepatitis C virus production. Matsumura T, Kato T, Sugiyama N, Tasaka-Fujita M, Murayama A, Masaki T, Wakita T, Imawari M. Hepatology 2012;56:1231-1239.
 
遠藤 弘良 聖路加国際大学公衆衛生大学院研究科長
国際保健、熱帯医学
S.Miyano,G.Syakantu, K.Komada, H.Endo, T.Sugishita, Cost-effectiveness analysis of the national decentralization policy of antiretroviral treatment programme in Zambia, Cost Effectiveness and Resource Allocation, 2017, 15:4,
W.Paoin, M.Yuenyongsuwan, Y.Yokobori, H.Endo, S.Kim, Development of the ICD-10 simplified version and field test, Professional practice and innovation, 2017
最新保健学講座7 保健医療福祉行政論、(編集)野村陽子、メヂカルフレンド社、2015年、分担題目「感染症に関する主な法律と制度」
 
恩地 森一 愛媛大学 名誉教授
消化器・代謝内科学
Al Mahtab M, Akbar SMF, Aguilar JC, Onji M, et al; Treatment of chronic hepatitis B naive patients with a therapeutic vaccine containing HBs and HBc antigens (A randomized, open and treartmentr controlled phase III clinical trial). PLoS One. 13:e0201236,2018
Akao T, Morita A, Onji M, et al: Low serum levels of zonulin in patients with HCV-infected chronic liver diseases. Eurasian Journal of Gastroenterology, 2018:8(2); 10.5005/jp-journals-10018-1275
瀧本育子、住村恵、長野可奈子、小池奈緒、竹島美香、成瀬隆弘、利光久美子、恩地森一:がん病態栄養専門管理栄養士による緩和ケア病棟の実態調査と課題の抽出。日本病態栄養学会誌。20(3):237-241、2017
 
清澤 研道 社会医療法人財団慈泉会相澤病院消化器病センター・名誉センター長
消化器病・肝臓病・ウイルス肝炎
Kimura T, Kobayashi A, Tanaka N, Sano K, Komatsu M, Fujimori N, Yamazaki T, Shibata S, Ichikawa Y, Joshita S, Umemura T, Matsumoto A, Horiuchi A, Mori H, Wada S, Kiyosawa K, Miyagawa S, Tanaka E.
Clinicopathological characteristics of non-B non-C hepatocellular carcinoma without past hepatitis B virus infection.
Hepatol Res. 2017 Apr;47(5):405-418.
Kiyosawa K, Umemura T, Ichijo T, Matsumoto A, Yoshizawa K, Gad A, Tanaka E.  Hepatocellular carcinoma: recent trends in Japan. Gastroenterology. 2004 Nov;127(5 Suppl 1):S17-26.
Kiyosawa K, Sodeyama T, Tanaka E, Gibo Y, Yoshizawa K, Nakano Y, Furuta S, Akahane Y, Nishioka K, Purcell RH, et al.: Interrelationship of blood transfusion, non-A, non-B hepatitis and hepatocellular carcinoma: analysis by detection of antibody to hepatitis C virus. Hepatology 1990;12: 671-675.
 
林 紀夫 関西労災病院・院長
肝臓病学
Quantitative analysis of pre-S1 and pre-S2 in relation to HBsAg expression. Yuki N, Hayashi N, Katayama K, Kasahara A, Ueda K, Fusamoto H, Sato N, Kamada T. Hepatology 11:38-43, 1990
Identification of multiple transcription factors, HLF, FTF, and E4BP4, controlling hepatitis B virus enhancer II. Ishida H, Ueda K, Ohkawa K, Kanazawa Y, Hosui A, Nakanishi F, Mita E, Kasahara A, Sasaki Y, Hori M, Hayashi N.
J Virol 74:1241-1251,2000
Supportive role played by precore and preS2 genomic changes in the establishment of lamivudine-resistant hepatitis B virus. Ohkawa K, Takehara T, Kato M, Deguchi M, Kagita M, Hikita H, Sasakawa A, Kohga K, Uemura A, Sakamori R, Yamaguchi S, Miyagi T, Ishida H, Tatsumi T, Hayashi N.
J Infect Dis 198:1150-1159, 2008
 
宮村 達男 国立感染症研究所・名誉所員
ウイルス学
An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis. Kuo,G., Choo,Q-L., Alter,H.J., Gitnick,G.L., Redeker,A.G., Purcell,R.H., Miyamura,T. Dienstag J.L., Alter,M.J., Stevens,C.E., Tegtmeier,G.E., Bonino,F., Colombo,M., Lee,W-S., Kuo,C., Berger,K., Shuster,J.R., Overby,L.R., Bradley,D.W., and Houghton,M. Science 244: 362-364, 1989.
Detection of antibody against antigen expressed by molecularly cloned hepatitis C virus cDNA: Application to diagnosis and blood screening for post transfusion hepatitis. Miyamura,T., Saito,I., Katayama,T., Kikuchi,S., Tateda,A., Houghton,M., Choo,Q-L., and Kuo,G. Proc.Natl.Acad.Sci.USA, 87: 983-987, 1990.
A cDNA fragment of hepatitis C virus isolated from an implicated donor of post-transfusion non-A, non-B hepatitis in Japan. Kubo,Y., Takeuchi,K., Boonmar,S., Katayama,T., Choo,Q-L., Kuo,G., Weiner,A.W., Bradley,D.W., Houghton,M., Saito,I., and Miyamura,T.  Nucl.Acids Res. 17:10367-10372, 1989.

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