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難治性疾患等政策研究事業事前評価委員名簿

(○:委員長)

 
有賀 正 北海道大学名誉教授/社会医療法人母恋 理事長
小児科学、原発性免疫不全症、小児感染免疫学
Onodera M, Ariga T, Kawamura N, Kobayashi I, Ohtsu M, Yamada M, Tame A, Furuta H, Okano M, Matsumoto S, Kotani H, McGarrity G J, Blaese R M, and Sakiyama Y: Successful Peripheral T-Lymphocyte-Directed Gene Transfer for a Patient with Severe Combined Immune Deficiency Caused by Adenosine Deaminase Deficiency. Blood 1997, 91: 30-36.
Ariga T, Kondoh T, Yamaguchi K, Yamada M, Sasaki S, Nelson DL, Ikeda H, Kobayashi K, Moriuchi H, Sakiyama Y: Spontaneous in vivo reversion of an inherited mutation in the Wiskott-Aldrich syndrome. J Immunol 2001, 166: 5245-5249.
Cho K, Yamada M, Agematsu K, Kanegane H, Miyake N, Ueki M, Akimoto T, Kobayashi M, Ikemoto S, Tanino M, Fujita A, Hayasaka I, Miyamoto S, Tanaka-Kubota M, Nakata K, Shiina M, Ogata K, Minakami H, Matsumoto N, Ariga T. Heterozygous Mutations in OAS1 Cause Infantile-onset Pulmonary Alveolar Proteinosis with Hypogammaglobulinemia. Am J Hum Genet 2018, 102: 480-486.
 
池田康夫 早稲田大学 特命教授 
慶應義塾大学 名誉教授
血液学
(業績・実績その1)
Kuwana M, Okazaki Y, Ikeda Y.
Detection of circulating B cells producing anti-GPIb autoantibodies in patients with immune thrombocytopenia.
PLoS One. 2014 Jan 22;9(1):e86943. doi: 10.1371/journal.pone.0086943. eCollection 2014.
(業績・実績その2)
Ikeda Y, Shimada K, Teramoto T, Uchiyama S, Yamazaki T, Oikawa S, Sugawara M, Ando K, Murata M, Yokoyama K, Ishizuka N.
Low-dose aspirin for primary prevention of cardiovascular events in Japanese patients 60 years or older with atherosclerotic risk factors: a randomized clinical trial.
JAMA. 2014 Dec 17;312(23):2510-20. doi: 10.1001/jama.2014.15690.
(業績・実績その3)
Y. Ono-Uruga, K. Tozawa, T. Horiuchi, M. Murata, S. Okamoto, Y. Ikeda, T. Suda & Y. Matsubara
Human adipose tissue-derived stromal cells can differentiate into megakaryocytes and platelets by secreting endogenous thrombopoietin
Journal of Thrombosis and Haemostasis, Vol.14 (6) p. 1285-1297, June 2016
 
石橋 達朗 九州大学 理事・副学長
眼科
Ishikawa K, Yoshida S, Nakao S, Nakama T, Kita T, Asato R, Sassa Y, Arita R, Miyazaki M, Enaida H, Oshima Y, Murakami N, Niiro H, Ono J, Matsuda A, Goto Y, Akashi K, Izuhara K, Kudo A,Kono T, Hafezi-Moghadam A, Ishibashi T:
Periostin promotes the generation of fibrous membranes in proliferative vitreoretinopathy. FASEB J 28(1):131-142, 2014
Nakama T, Yoshida S, Ishikawa K, Kobayashi Y, Zhou Y, Nakao S, Sassa Y, Oshima Y, Takao K, Shimahara A, Yoshikawa K, Hamasaki T, Ohgi T, Hayashi H, Matsuda A, Kudo A, Nozaki M, Ogura Y, Kuroda M, Ishibashi T:
Inhibition of choroidal fibrovascular membrane formation by new class of RNA interference therapeutic agent targeting periostin.
Gene Ther 22(2):127-137, 2015
Ishibashi T, Li X, Koh A, Lai, Lee F-L, Lee W-K, Ma Z, Ohji M,Tan N,
Cha S B, Shamsazar J, Yau C L, on behalf of the REVEAL Study
Group:The REVEAL Study : Ranibizumab Monotherapy or Combined with Laser versus Laser Monotherapy in Asian Patients with Diabetic Macular Edema.
Ophthalmology 122(7):1402-1415, 2015
 
江口 勝美 社会医療法人財団白十字会佐世保中央病院
リウマチ免疫学
Clinical features and human T-cell leukemia virus type 1(HTLV-1) proviral load in HTLV-1-positive patients with rheumatoid arthritis : Baseline data in a single center cohort study.
Eguchi K, Iwanaga M, Terada K, et al.
Mod Rheumatol.2019 Apr2:1-10.
Development of adult T-cell leukaemia/lymphoma during the treatment of rheumatoid arthritis. Okamoto M, Eguchi K, Hida A, et al. Mod Rheumatol Case Reports. https://doi.org/10.1080/24725625.2018.1549932
Brief report: Attenuated effectiveness of tumor necrosis factor inhibitors for anti-human T lymphotropic virus type 1 antibody-positive rheumatoid arthritis.
Suzuki T, Fukui S, Eguchi K, et al.
Arthritis Rheumatol. 2018;70:1014-1021
 
大澤 真木子 東京女子科大学名誉教授/大塚駅前診療所 所長
小児神経学、(神経筋疾患 てんかん学、先天奇形症候群など)
Osawa M, Sumida S, Suzuki N et al. Fukuyama type congenital muscular dystrophy. In: Fukuyama Y, Osawa M, Saito K (eds). Congenital Muscular Dystrophies. Elsevier Science, Amsterdam; 1997, p31-68
Osawa M, Wang ZP, Saito K, et al . Clinico pathological study of transient ambulant Fukuyama type congenital musucular dystrophy cases :Acta Myol 2001 20 96-103.
Makiko Osawa and Keiko Shishikura: Chapter 5 Werdnig-Hoffmann disease and variants. Handbook of Clinical neurology Vol15(59)
DISEASEA OF THE MOTOR SYSTEM. J.M.B.V De Jong.editor Elsevier Science Publishers B. V. 1991 pp51-pp80.
 
片山 一朗 大阪市大大学院共同研究講座特任教授
皮膚科学
Sweat glucose and GLUT2 expression in atopic dermatitis: Implication for clinical manifestation and treatment. Ono E, Murota H, Mori Y, Yoshioka Y, Nomura Y, Munetsugu T, Yokozeki H, Katayama I.
PLoS One. 2018 Apr 20;13(4):e0195960. d56
Local Glucocorticoid Activation by 11β-Hydroxysteroid Dehydrogenase 1 in Keratinocytes: The Role in Hapten-Induced Dermatitis. Terao M, Itoi S, Matsumura S, Yang L, Murota H, Katayama I Am J Pathol. 2016;186(6):1499-510.
Dose-dependent role of claudin-1 in vivo in orchestrating features of atopic dermatitis. )Tokumasu R, Yamaga K, Yamazaki Y, Murota H, Suzuki K, Tamura A, Bando K, Furuta Y, Katayama I ,Tsukita S Proc Natl Acad Sci U S A. 2016;113(28): E4061-8.
葛原茂樹 鈴鹿医療科学大学 大学院医療科学研究科・研究科長、看護学部看護学科・特任教授
神経内科学
Mimuro M, Yoshida M, Kuzuhara S, Kokubo Y. Amyotrophic lateral sclerosis and parkinsonism-dementia complex of the Hohara focus of the Kii Peninsula: a multiple proteinopathy? Neuropathology 2018;38:98-104.
葛原茂樹.日本の難病対策の歴史と新たな難病対策.公衆衛生2016;80(6):390-399.
Kuzuhara S, Kokubo Y. Amyotrophic lateral sclerosis-pakinsonism -dementia complex in the Kii peninsula of Japan (Muro disease): a review on recent research and new concept In: Amyotrophic Lateral Sclerosis and the Frontotemporal Dementias, Edited by Michael J. Strong, Oxford University Press, Oxford,2012, p39-54.
 
黒岩 義之 財務省診療所長、横浜市立大学名誉教授
脳神経内科学
Toh T, Urata R, Nakawatase A, Yamazaki T, Kuroiwa Y, Baba Y, Fujino K, Kurokawa T: Sensor-level- and ECDL-based brain functional connectivity networks using scalp-recorded EEGs: A comparison of AD and FTD patients and healthy subjects. Computational Neuroscience 9(2):38-44, 2016.
Kimura K, Inoue KI, Kuroiwa Y, Tanaka F, Takada M: Propagated but topologically distributed forebrain neurons expressing alpha-synuclein in aged macaques. Plos one 11(11):e0166861. Nov.2016.
doi:10.1371/journal.pone. 0166861
Omoto S, Kuroiwa Y, Fujino S, Fujino K, Kurokawa T, Baba Y: Greater N1 potential during centrifugal saccades as compared to centripetal saccades in humans: A scalp-recorded electroencephalographic study. The Autonomic Nervous System (Journal of the Japan Society of Neurovegetative Research),54(4):306-315, Dec. 2017.
 
澤倫太郎 日本医師会総合政策研究機構・研究部長
胎児生理学、産科学、医療経済学
Sawa R, Asakura H, Power GG.
Changes in plasma adenosine during simulated birth of fetal sheep.
J Appl Physiol 70(4): 1524-1528, 1991
Sawa R, Yoneyama Y, Otsubo Y, Suzuki S, Kubonoya K, Power GG, Araki T.
Fetal plasma hypoxanthine level in growth-retarded fetuses before labor.
J Clin Endocrinol Metab 82: 4028-4033, 1997
Ishihara O, Seung Chik Jwa, Kuwabara A, Ishikawa T, Kugu K, Sawa R, Banno K,Saito H
Assisted reproductive technology inJapan: a summary report for 2016
by the Ethics committee of the Japan society of obstetrics and gynecology. Reprod Med Biol.1-10,2018
 
清野 裕 関西電力病院・総長 
糖尿病学
Inactivation of the Glucose-Dependent Insulinotropic Polypeptide Receptor Improves Outcomes following Experimental Myocardial Infarction.
Ussher JR, Campbell JE, Mulvihill EE, Baggio LL, Bates HE, McLean BA, Gopal K, Capozzi M, Yusta B, Cao X, Ali S, Kim M, Kabir MG, Seino Y, Suzuki J, Drucker DJ.
Cell Metab. 2018 Feb 6;27(2):450-460.e6. doi: 10.1016/j.cmet.
2017.11.003. Epub 2017 Dec 21.
Stromal cell-derived factor-1 is upregulated by dipeptidyl peptidase-4 inhibition and has protective roles in progressive diabetic nephropathy.
Takashima S, Fujita H, Fujishima H, Shimizu T, Sato T, Morii T, Tsukiyama K, Narita T, Takahashi T, Drucker DJ, Seino Y, Yamada Y.
Kidney Int. 2016 Oct;90(4):783-96. doi: 10.1016/j.kint.
2016.06.012. Epub 2016 Jul 27.
The protective roles of GLP-1R signaling in diabetic nephropathy: possible mechanism and therapeutic potential.
Fujita H, Morii T, Fujishima H, Sato T, Shimizu T, Hosoba M, Tsukiyama K, Narita T, Takahashi T, Drucker DJ, Seino Y, Yamada Y.
Kidney Int. 2014 Mar;85(3):579-89. doi: 10.1038/ki.2013.427. Epub 2013 Oct 23.
 
竹中 洋 京都府立医科大学 学長
耳鼻咽喉科学
Enhanced human IgE production results from exposure to the aromaticHydrocarbons from diesel exhaust;direct effects on B-cell IgE production, Takenaka H,et al
J Allery CLin Immunol;1998.95:103-115.
コア・ローテイション 耳鼻咽喉科・頭頸部外科
編集 竹中洋、高橋姿、久育男
金芳堂、2004年1月5日
気道アレルギーの成立とその制御:竹中 洋
第110回日本耳鼻咽喉科学術総会宿題報告
東京、2009.05.14.
 
富野 康日己 医療法人社団松和会 常務理事
腎臓内科学
Diminished capacity of opsonization and immune complex solubilization, and detection of anti-C1q antibodies in sera from patients with hereditary angioedema. Honda D, Ohsawa I, Sato N, Inoshita H, Mano S, Tomino Y, Suzuki Y. Allergol Int. 2017 Oct;66(4):603-609. doi:10.1016/j.alit.2017.03.008. Epub 2017 Apr 20.
Inhibition of STAT3 Signaling Reduces IgA1 Autoantigen Production in IgA Nephropathy. Koshi Yamada, Zhi-Qiang Huang, Milan Raska, Colin Reily, Joshua C. Anderson, Hitoshi Suzuki, Hiroyuki Ueda, Zina Moldoveanu, Krzysztof Kiryluk, Yusuke Suzuki, Robert J. Wyatt, Yasuhiko Tomino, Ali G. Gharavi, Amy Weinmann, Bruce A. Julian, Christopher D. Willey and Jan Novak. Kidney Int Rep. 2017 July 19; 2(6): 1194-1207.
doi: 10.1016/j.ekir.2017.07.002.
Outcomes of the Re-classification of WHO Class IV Lupus Nephritis Using the ISN/RPS Classification: a Single Center Retrospective Observational Study from JUDE Study. Tomoko Miyashita, Shinji Morimoto, Daisuke Honda, Souichiro Nakano, Hirofumi Amano, Isao Osawa, Ken Yamaji, Yasuhiko Tomino, Yoshinari Takasaki, Naoto Tamura. Juntendo Medical Journal 2017. 63(5): 362-369. doi: 10.14789/jmj.63.362
 
友池仁暢 公益財団法人日本心臓血圧研究振興会附属榊原記念病院 顧問
循環器内科学
(業績・実績その1)
Incidence of cancers in patients with atherosclerotic cardiovascular diseases. Suzuki M, Tomoike H, Sumiyoshi T, et al. IJC Heart & Vaculature 17:11-16, 2017
(業績・実績その2)
Nationwide distribution of cardiovascular Practice in Japan- Results of Japanese Circulation Society 2010 Annual Survey- Tomoike H, Yokoyama H, Sumita Y, Hanai S, Kada A, Okamura T, Yoshikawa J, Doi Y, Hori M, Tei C. Circulation J 79(5); 1058-1067, 2015
(業績・実績その3)
社会課題を解く視点からの提言‐人の尊重される健康と医療のデザイン‐友池仁暢、塚田信吾、江崎禎英、山口類、井元清哉、宮野悟 電子情報通信学会誌100(1)・3−12、2017
 
中村耕三 国立障害者リハビリテーションセンター顧問
リハビリテーション医学
Prevalence of cervical cord compression and its association with physical performance in a population-based cohort in Japan: the Wakayama Spine Study. Nagata K, Nakamura K, et al.: Spine (Phila Pa 1976). 2012, 37(22): 1892-1898
Reference values for hand grip strength, muscle mass, walking time, and one-leg standing time as indices for locomotive syndrome and associated disability: the second survey of the ROAD study. Yoshimura N, Nakamura K, et al. J Orthop Sci. 2011, 16(6): 768-77.
Acute cervical spinal cord injury complicated by preexisting ossification of the posterior longitudinal ligament: a multicenter study. Chikuda H, Nakamura K, et al. Spine (Phila Pa 1976). 2011, 36(18): 1453-1458.
 
永井正規 埼玉医科大学名誉教授
疫学
Prevalence and Incidence of Polymyositis and Dermatomyositis in Japan. Ohta A, Nagai M, Nishina M, Tomimitsu H, Kohsaka H.Mod Rheumatol 24:477-480, 2013.
A case control study of female systemic lupus erythematosus in Japan
MASAKI NAGAI,TOMIO HIROHATA,YOSHIFUJI MATSUMOTO,HIROSHI HASHIMOTO,MASAKAZU KONDO,KOTARO OZASA,MITSURU MORI,TSUTOMU HASHIMOTO,HIDEAK
I NAKAGAWA,TOSHITAKA OMURA,MASAKI MORI,TAKESHI TOJO,HIROSHI YANAGAWA European Journal of Public Health, Volume 3, Issue 3:172-176, 1992
「新しい疫学」永井正規他共著,日本公衆衛生協会,(1995).
 
貫和敏博 公益財団法人結核予防会・常務理事
呼吸器内科
EGFR Mutation Analysis of Circulating Tumor DNA Using an Improved PNA-LNA PCR Clamp Method. Watanabe K, Fukuhara T, Tsukita Y, Morita M, Suzuki A, Tanaka N, Terasaki H, Nukiwa T, Maemondo M. Can Respir J. 2016; 2016: 5297329.
最新医学 診断と治療のABC 124.糖尿病の合併症.第4章その他の関連疾患.糖尿病と結核症.貫和敏博、最新医学社、2017.
OX40 ligand newly expressed on bronchiolar progenitors mediates influenza infection and further exacerbates pneumonia. Hirano T, Kikuchi T, et al, Nukiwa T, Watanabe A, Ichinose M. EMBO Mol Med. 2016 Apr 1;8(4):422-36.
 
日比 紀文 北里大学北里研究所病院 炎症性腸疾患先進治療センター長
慶應義塾大学 名誉教授
消化器内科学、消化器免疫学、臨床腫瘍学
Naganuma M, Sugimoto S, Mitsuyama K, Kobayashi T, Yoshimura N, Ohi H, Tanaka S, Andoh A, Ohmiya N, Saigusa K, Yamamoto T, Morohoshi Y, Ichikawa H, Matsuoka K, Hisamatsu T, Watanabe K, Mizuno S, Suda W, Hattori M, Fukuda S, Hirayama A, Abe T, Watanabe M, Hibi T, Suzuki Y, Kanai T; INDIGO Study Group: Efficacy of Indigo Naturalis in a Multicenter Randomized Controlled Trial of Patients With Ulcerative Colitis. Gastroenterology. 154(4):935-947, 2018
Matsuoka K, Kobayashi T, Ueno F, Matsui T, Hirai F, Inoue N, Kato J, Kobayashi K, Kobayashi K, Koganei K, Kunisaki R, Motoya S, Nagahori M, Nakase H, Omata F, Saruta M, Watanabe T, Tanaka T, Kanai T, Noguchi Y, Takahashi KI, Watanabe K, Hibi T, Suzuki Y, Watanabe M, Sugano K, Shimosegawa T: Evidence-based clinical practice guidelines for inflammatory bowel disease. J Gastroenterol. 53(3):305-353,2018
Watanabe K, Matsumoto T, Hisamatsu T, Nakase H, Motoya S, Yoshimura N, Ishida T, Kato S, Nakagawa T, Esaki M, Nagahori M, Matsui T, Naito Y, Kanai T, Suzuki Y, Nojima M, Watanabe M, Hibi T; DIAMOND study group: Clinical and Pharmacokinetic Factors Associated With Adalimumab-Induced Mucosal Healing in Patients With Crohn's Disease. Clin Gastroenterol Hepatol. 16(4):542-549, 2018
 
福島 雅則 公益財団法人先端医療振興財団臨床研究情報センター長
腫瘍内科学、臨床試験デザイン・管理・評価、薬剤疫学、医科学
Predictive Factors associated with Acute Ocular Involvement in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.
Sotozono C, Ueta M, Nakatani E, Kitami A, Watanabe H, Sueki H, Iijima M, Aihara M, Ikezawa Z, Aihara Y, Kano Y, Shiohara T, Tohyama M, Shirakata Y, Kaneda H, Fukushima M, Kinoshita S, Hashimoto K; Japanese Research Committee on Severe Cutaneous Adverse Reaction.
Am J Ophthalmol. 2015;160(2):228-37.
Prediction of prognosis of ALS: Importance of active denervation findings of the cervical-upper limb area and trunk area.
Sato Y, Nakatani E, Watanabe Y, Fukushima M, Nakashima K, Kannagi M, Kanatani Y, Mizushima H.
Intractable Rare Dis Res. 2015;4(4):181-9.
Specific clinical signs and symptoms are predictive of clinical course in sporadic Creutzfeldt-Jakob disease.
Nakatani E, Kanatani Y, Kaneda H, Nagai Y, Teramukai S, Nishimura T, Zhou B, Kojima S, Kono H, Fukushima M, Kitamoto T, Mizusawa H.
Eur J Neurol. 2016;23(9):1455-62.
 
宮ア 久義 特定非営利活動法人
日本医療マネジメント学会理事長
麻酔、病院管理、地域医療、生活習慣病
癌末期痛に対するモリッカの下垂体破壊術 1.経鼻的下垂体穿刺に必要な基礎的と方法 .宮崎久義,後藤倶子,岡元和文,宇都宮高賢,森岡亨,山室誠,麻酔27:1606-1612.1978
癌末期痛に対するモリッカの下垂体破壊術 2.その成績と作用機序に対する考察 .宮崎久義,後藤倶子,岡元和文,宇都宮高賢,森岡亨,山室誠,麻酔28(1):77-82.1979
Critical Pathway: Practical applications and its development in Japan.Hisayoshi Miyazaki,Teruhiko Matsushima. JMAJ48(11):568-571.2005
 
吉峰俊樹 大阪大学国際医工情報センター・特任教授
脳神経外科
Yanagisawa T, Fukuma R, Seymour B, Hosomi K, Kishima H, Shimizu T, Yokoi H, Hirata M, Yoshimine T, Kamitani Y, Saitoh Y, Induced sensorimotor brain plasticity controls pain in phantom limb patients, Nature Communications, 7:13209 (2016)
Edakawa K, Yanagisawa T, Kishima H, Fukuma R, Oshino S, Khoo HM, Kobayashi M, Tanaka M, Yoshimine T. Detection of epileptic seizures using phase-amplitude coupling in intracranial electroencephalography. Sci Rep, 6:25422. (2016)
Kishima H, Yanagisawa T, Goto Y, Oshino S, Maruo T, Tani N, Khoo HM, Hosomi K, Hirata M, Yoshimine T. Respiratory function under intrathecal baclofen therapy in patients with spastic tetraplegia, Neuromodulation. 19(6):650-654. (2016)

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