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難治性疾患等政策研究事業中間・事後評価委員名簿

(○:委員長)

 
浅香正博 北海道医療大学 学長
消化器病学、がん予防学
Effect on Helicobacter pylori eradication therapy against gastric cancer in Japan. Tsuda M, Asaka M, Kato M, Matsushima R,. Fujimori K, Akino K, Kikuchi S, Lin Y, Sakamoto N. Helicobacter 2017 22: e12415
Vonoprazan, a novel potassium-competitive acid blocker, as a component of first-line and second-line triple therapy for Helicobacter pylori eradication: a phase III, randomised, double-blind study. Murakami K, Sakurai Y, Shiino M, Funao N, Nishimura A, Asaka M. Gut. 65:1439-1446,2016
Increased ghrelin signaling prolongs survival in mouse models of human aging through activation of sirtuin1. Fujitsuka N, Asakawa A, Morinaga A, Amitani MS, Amitani H, Katsuura G, Sawada Y, Sudo Y, Uezono Y, Mochiki E, Sakata I, Sakai T, Hanazaki K, Yada T, Yakabi K, Sakuma E, Ueki T, Niijima A, Nakagawa K, Okubo N, Takeda H, Asaka M, Inui A Mol Psychiatry. 2016 21:1613-1623.
 
五十嵐 隆 国立成育医療研究センター理事長
国立成育医療研究センター理事長
<研究論文>
Igarashi T, Gu:nter W, Sekine T, Inatomi J, Shiraga H, Takahashi S, Suzuki J, Tsuru N, Yanagihara T, Shimazu M, Jentsch TJ, Thakker RV: Functional characterization of renal chloride channel, CLCN5, mutations associated with Dent’s Japan disease. Kidney Int 54: 1850-1856, 1998
<研究論文>
Igarashi T, Inatomi J, Sekine T, Cha SH, Kanai Y, Kunimi M, Tsukamoto K, Satoh H, Shimadzu M, Tozawa F, Mori T, Shiobara M, Seki G, Endou H: Mutations in SLC4A4 cause permanent isolated proximal renal tubular acidosis with ocular abnormalities. Nature Genet 23:264-266, 1999
<研究論文>
Enomoto A, Kimura H, Chairoungdua A, Shigeta Y, Jutabha P, Cha SH, Hosoyamada M, Takeda M, Sekine T, Igarashi T, Matsuo H, Kikuchi Y, Oda T, Ichida K, Hosoya T, Shimokata K, Niwa T, Kanai Y, Endou H: Molecular identification of a renal/urate/anion exchanger that regulates blood urate levels. Nature 417: 447-452, 2002
 
石橋 達朗 九州大学 理事・副学長
眼科
Ishikawa K, Yoshida S, Nakao S, Nakama T, Kita T, Asato R, Sassa Y, Arita R, Miyazaki M, Enaida H, Oshima Y, Murakami N, Niiro H, Ono J, Matsuda A, Goto Y, Akashi K, Izuhara K, Kudo A,Kono T, Hafezi-Moghadam A, Ishibashi T:
Periostin promotes the generation of fibrous membranes in proliferative vitreoretinopathy. FASEB J 28(1):131-142, 2014
Nakama T, Yoshida S, Ishikawa K, Kobayashi Y, Zhou Y, Nakao S, Sassa Y, Oshima Y, Takao K, Shimahara A, Yoshikawa K, Hamasaki T, Ohgi T, Hayashi H, Matsuda A, Kudo A, Nozaki M, Ogura Y, Kuroda M, Ishibashi T:
Inhibition of choroidal fibrovascular membrane formation by new class of RNA interference therapeutic agent targeting periostin.
Gene Ther 22(2):127-137, 2015
Ishibashi T, Li X, Koh A, Lai, Lee F-L, Lee W-K, Ma Z, Ohji M,Tan N,
Cha S B, Shamsazar J, Yau C L, on behalf of the REVEAL Study
Group:The REVEAL Study : Ranibizumab Monotherapy or Combined with Laser versus Laser Monotherapy in Asian Patients with Diabetic Macular Edema.
Ophthalmology 122(7):1402-1415, 2015
 
内野 誠 くまもと南部広域病院 理事長・病院長
脳神経内科
Localization and characterization of dystrophin in the central nervous system of normal controls and Duchenne muscular dystrophy. Uchino M, Teramoto H, Naoe H, Yoshioka K, Miike T, Ando M. J. Neurol. Neurosurg. Psych. 57 : 426-429, 1994.
Long-term outcome of polymyositis treated with high single-dose alteranate-day prednisolone therapy. Uchino M, Yamashita S, Uchino K, Hara H , Koide T, Suga T, Hirahara T, Kimura E, Yamashita T, Ueda A, Kurisaki R, Suzuki J, Honda S, Maeda Y, Hirano T. Europ Neurol, 68:117-121, 2012.
Muscle biopsy findings predictive of malignancy in rare infiltrative dermatomyositis. Uchino M, Yamashita S, Uchino K, Mori A, Hara H , Suga T, Hirahara T, Koide T, Kimura E, Yamashita T, Ueda A, Kurisaki R, Suzuki J, Honda S, Maeda Y, Hirano T., Ando Y. Clinc Neurol Neurosurg 115:603-606, 2013.
 
長村義之 慶應義塾大学医学部客員教授/日本鋼管病院
病理学 ゲノム病理学
WHO Classification of Tumours of Endocrine Organs, WHO/IARC Classification of Tumours, 4th Edition, Volume 10, 2017, Edited by Lloyd RV, Osamura RY, Klo:ppel G, Rosai J,
Histopathology and Cytopathology of Neuroendocrine Tumors and Carcinomas of the Breast: A Review. Osamura RY, Matsui N, Okubo M, et al. Acta Cytol 2019;63:340-346.
The International Academy of Cytology Yokohama System for Reporting Breast Fine-Needle Aspiration Biopsy Cytopathology. Field AS, Raymond WA, Rickard M, Arnold L, Brachtel EF, Chaiwun B, Chen L, Di Bonito L, Kurtycz DFI, Lee AHS, Lim E, Ljung BM, Michelow P, Osamura RY, et al. Acta Cytol 2019;63:257-273.
 
片山一朗 大阪市大大学院共同研究講座特任教授
皮膚科学
Sweat glucose and GLUT2 expression in atopic dermatitis: Implication for clinical manifestation and treatment. Ono E, Murota H, Mori Y, Yoshioka Y, Nomura Y, Munetsugu T, Yokozeki H, Katayama I. PLoS One. 2018 Apr 20;13(4):e0195960. d56
Local Glucocorticoid Activation by 11β-Hydroxysteroid Dehydrogenase 1 in Keratinocytes: The Role in Hapten-Induced Dermatitis. Terao M, Itoi S, Matsumura S, Yang L, Murota H, Katayama I Am J Pathol. 2016;186(6):1499-510.
Dose-dependent role of claudin-1 in vivo in orchestrating features of atopic dermatitis. )Tokumasu R, Yamaga K, Yamazaki Y, Murota H, Suzuki K, Tamura A, Bando K, Furuta Y, Katayama I ,Tsukita S Proc Natl Acad Sci U S A. 2016;113(28): E4061-8.
 
加藤 義治 東京女子医科大学整形外科 前教授・講座主任
運動器学、骨代謝学、整形外科学
研究論文
Katoh Y. Effects of Ethane-1-hydroxy-1,1-diphospho-nate on cell differentiation, and proteoglycan and calcium metabolism in the proximal tibia of young rats.、Bone.12: 59-65、1991
Yoshiharu Kato, Tatsuo Itoh, Koichi Kanaya, Motoya Kubota, Shunnichi Ito: Relationship between atlantoaxial (C1/2) and cervical Alignment (C2-C7) angles with Magerl and Brooks techniques for atlantoaxial subluxation in rheumatoid Arthritis. J Orthop Sei. 11:347-352, 2006
・Itoh Tatsuo,Kato Yoshiharu:Posterior decompression for cervical ossfication of the posterior longitudinal ligament.「Ossification of the Posterior Longitudinal Ligament」(Yonenobu K, Sako T, Ono K eds)Springer,Tokyo:pp218@143-152,1997
学術的発表 ・Kato Y, T.Itoh T.、 Atlantoaxial dislocation、Current Orthopaedics 12(1), 20-27, 1998
 
小池 髟v 医療法人清仁会 北海道内科リウマチ科病院・最高顧問
リウマチ学・臨床免疫学・内分泌学・糖尿病学
Koike T.
Antiphospholipid syndrome: 30 years and our contribution.
Int J Rheum Dis. 18(2):233-41, 2015.
Koike T.
My contribution, my dream a look at the future of APS.Lupus. 23(12):1332-1334, 2014.
Koike T.
The new era of autoimmune disease research.
Arthritis Res Ther. 13(3):113.2011
 
堺 秀人 医療法人仁泉会理事
腎臓病学
AMED腎疾患実用化研究事業の説明、堺秀人、
平成28年度日本腎臓学会総会、2016年6月17日
 
澤倫太郎 日本医師会総合政策研究機構・研究部長
胎児生理学、産科学、医療経済学
Sawa R, Asakura H, Power GG.
Changes in plasma adenosine during simulated birth of fetal sheep.
J Appl Physiol 70(4): 1524-1528, 1991
Sawa R, Yoneyama Y, Otsubo Y, Suzuki S, Kubonoya K, Power GG,
Araki T.
Fetal plasma hypoxanthine level in growth-retarded fetuses before labor. J Clin Endocrinol Metab 82: 4028-4033, 1997
Ishihara O, Seung Chik Jwa, Kuwabara A, Ishikawa T,
Kugu K, Sawa R, Banno K,Saito H
Assisted reproductive technology inJapan: a summary report for 2016
by the Ethics committee of the Japan society of obstetrics and gynecology. Reprod Med Biol.1-10,2018
嶋 幸男 柳川療育センター名誉センター長
小児神経学、神経病理学
Neuronal plasticity in the developing and aging cerebral cortices of patients with Down syndrome.Takashima M, Takahashi S, Yokoo M, Iwata O, Iwata S, Takashima S・International Journal of Neuro- rehabilitation, 1:2, 2014
A history of our understanding of cerebral vascular development and pathogenesis of perinatal brain damage over the past 30 years, and further prospective.Takashima S, Itoh M, Oka A・Seminars in Pediatric Neurology 16:226-36, 2009
Pediatric Neuropathology- a text and atlas.Armstrong D, Halliday W, Hawkins C, Takashima S、Springer, Tokyo, 2007.
 
竹中 洋 京都府立医科大学 学長
耳鼻咽喉科学
Enhanced human IgE production results from exposure to the aromaticHydrocarbons from diesel exhaust;direct effects on B-cell IgE production, Takenaka H,et al
J Allery CLin Immunol;1998.95:103-115.
コア・ローテイション 耳鼻咽喉科・頭頸部外科
編集 竹中洋、高橋姿、久育男
金芳堂、2004年1月5日
気道アレルギーの成立とその制御:竹中 洋
第110回日本耳鼻咽喉科学術総会宿題報告
東京、2009.05.14.
 
坪内博仁 鹿児島市立病院 病院長
消化器内科、肝臓病
Purification and Partial Characterization of Hepatocyte Growth Factor from Plasma of a Patient with Fulminant Hepatic Failure. Gohda E, Tsubouchi H, Nakayama H, Hirono S, Sakiyama O, Takahashi K, Miyazaki H, Hashimoto S, and Daikuhara Y. J.Clin.Invest.1988 Feb; 81: 414-419.
Molecular Cloning and Sequence Analysis of cDNA for Human Hepatocyte Growth Factor. Miyazawa K, Tsubouchi H, Naka D, Takahashi K, Okigaki M, Arakaki N Nakayama H, Hirono S, Sakiyama O, Takahashi K, Gohda E, Daikuhara Y, and Kitamura N. Biochemical and Biophysical Research Communications. 1989 Sep; 163(2): 967-973
Safety and pharmacokinetics of recombinant human hepatocyte growth factor(rh-HGF)in patients with fulminant hepatitis: a phase I/II clinical trial, following preclinical studies to ensure safety. Ido A, Moriuchi A, Numata M, Murayama T, Teramukai S, Marusawa H, Yamaji N, Setoyama H, Kim I, Chiba T, Higuchi S, Yokode M, Fukushima M, Shimizu A and Tsubouchi H. Journal of Translational Medicine. 2011; 9: 55.
 
永井正規 埼玉医科大学名誉教授
疫学
Prevalence and Incidence of Polymyositis and Dermatomyositis in Japan. Ohta A, Nagai M, Nishina M, Tomimitsu H, Kohsaka H.Mod Rheumatol 24:477-480, 2013.
A case control study of female systemic lupus erythematosus in Japan
MASAKI NAGAI,TOMIO HIROHATA,YOSHIFUJI MATSUMOTO,HIROSHI HASHIMOTO,MASAKAZU KONDO,KOTARO OZASA,MITSURU MORI,TSUTOMU HASHIMOTO,HIDEAK
I NAKAGAWA,TOSHITAKA OMURA,MASAKI MORI,TAKESHI TOJO,HIROSHI YANAGAWA European Journal of Public Health, Volume 3, Issue 3:172-176, 1992
「新しい疫学」永井正規他共著,日本公衆衛生協会,(1995).
 
貫和敏博 東北大学・名誉教授
呼吸器内科
EGFR Mutation Analysis of Circulating Tumor DNA Using an Improved PNA-LNA PCR Clamp Method. Watanabe K, Fukuhara T, Tsukita Y, Morita M, Suzuki A, Tanaka N, Terasaki H, Nukiwa T, Maemondo M. Can Respir J. 2016; 2016: 5297329.
最新医学 診断と治療のABC 124.糖尿病の合併症.第4章その他の関連疾患.糖尿病と結核症.貫和敏博、最新医学社、2017.
OX40 ligand newly expressed on bronchiolar progenitors mediates influenza infection and further exacerbates pneumonia. Hirano T, Kikuchi T, et al, Nukiwa T, Watanabe A, Ichinose M. EMBO Mol Med. 2016 Apr 1;8(4):422-36.
 
平田結喜緒 兵庫県予防医学協会理事、東京医科歯科大学名誉教授
内分泌代謝学、糖尿病、高血圧、心血管分子生物学
Regulation of growth hormone secretion by (pro)renin receptor. Tani Y., Yamada S., Inoshita N., Hirata Y., Shichiri M. Sci. Rep. 5, 10878; doi: 10.1038/strep10878(2015)
Validation of an ion torrent sequencing platform for the detection of gene mutations in biopsy specimens from patients with non-small-cell lung cancer. Fujita S., Masago K., Takeshita J., Okuda C., Otsuka K., Hata A., Kaji R., Katabami N., Hirata Y. PLOS One doi: 10.1371/journal.phone.0130219; June 15, 2015
Next generation sequencing of tyrosine kinase inhibitor-resistant non-small-cell lung cancers in patients harboring epidermal growth factor-activating mutations. Masago K., Fujita S., Muraki M., Hata A., Okuda C., Otsuka K., Kaji R., Takeshita J., Kato R., Katakami N., Hirata Y. BMC Cancer 15:008,2015; doi 10.1186/s12885-015-1925-2
 
福島 雅則 公益財団法人先端医療振興財団臨床研究情報センター長
腫瘍内科学、臨床試験デザイン・管理・評価、薬剤疫学、医科学
Predictive Factors associated with Acute Ocular Involvement in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.
Sotozono C, Ueta M, Nakatani E, Kitami A, Watanabe H, Sueki H, Iijima M, Aihara M, Ikezawa Z, Aihara Y, Kano Y, Shiohara T, Tohyama M, Shirakata Y, Kaneda H, Fukushima M, Kinoshita S, Hashimoto K; Japanese Research Committee on Severe Cutaneous Adverse Reaction.
Am J Ophthalmol. 2015;160(2):228-37.
Prediction of prognosis of ALS: Importance of active denervation findings of the cervical-upper limb area and trunk area.
Sato Y, Nakatani E, Watanabe Y, Fukushima M, Nakashima K, Kannagi M, Kanatani Y, Mizushima H.
Intractable Rare Dis Res. 2015;4(4):181-9.
Specific clinical signs and symptoms are predictive of clinical course in sporadic Creutzfeldt-Jakob disease.
Nakatani E, Kanatani Y, Kaneda H, Nagai Y, Teramukai S, Nishimura T, Zhou B, Kojima S, Kono H, Fukushima M, Kitamoto T, Mizusawa H.
Eur J Neurol. 2016;23(9):1455-62.
 
宮ア 久義 特定非営利活動法人
日本医療マネジメント学会理事長
麻酔、病院管理、地域医療、生活習慣病
癌末期痛に対するモリッカの下垂体破壊術 1.経鼻的下垂体穿刺に必要な基礎的と方法 .宮崎久義,後藤倶子,岡元和文,宇都宮高賢,森岡亨,山室誠,麻酔27:1606-1612.1978
癌末期痛に対するモリッカの下垂体破壊術 2.その成績と作用機序に対する考察 .宮崎久義,後藤倶子,岡元和文,宇都宮高賢,森岡亨,山室誠,麻酔28(1):77-82.1979
Critical Pathway: Practical applications and its development in Japan.Hisayoshi Miyazaki,Teruhiko Matsushima. JMAJ48(11):568-571.2005
 
宮下 俊之 北里大学医学部 教授 医学部長
小児科学、分子遺伝学、分子生物学
Miyashita, T. and Reed, J.C. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 1995, 80, 293-299.
Nagao, K., Iwai, Y. and Miyashita, T. RCAN1 is an important mediator of glucocorticoid-induced apoptosis in human leukemic cells. PLOS ONE 2012, 7, e49926
Ikemoto, Y., Takayama, Y., Fujii, K., Masuda, M., Kato, C., Hatsuse, H., Fujitani, K., Nagao, K., Kameyama, K., Ikehara, H., Toyoda, M., Umezawa, A. and Miyashita, T. Somatic mosaicism containing double mutations in PTCH1 revealed by generation of induced pluripotent stem cells from nevoid basal cell carcinoma syndrome. J. Med. Genet. 2017, 54, 579-584
 
吉栖 正生 広島大学大学院医歯薬保健学研究科教授
循環器病学
EPA Prevents the Development of Abdominal Aortic Aneurysms through Gpr-120/Ffar-4. Kamata R, Bumdelger B, Kokubo H, Fujii M, Yoshimura K, Ishida T, Ishida M, Yoshizumi M. PLoS One. 11(10):e0165132, 2016.
Protective Effects of Japanese Soybean Paste (Miso) on Stroke in Stroke-Prone Spontaneously Hypertensive Rats (SHRSP). Watanabe H, Sasatani M, Doi T, Masaki T, Satoh K, Yoshizumi M. Am J Hypertens. 31(1):43-47, 2017.
Assessment of Lower-limb Vascular Endothelial Function Based on Enclosed Zone Flow-mediated Dilation. Hirano H, Takama R, Matsumoto R, Tanaka H, Hirano H, Soh Z, Ukawa T, Takayanagi T, Morimoto H, Nakamura R, Saeki N, Hashimoto H, Matsui S, Kishimoto S, Oda N, Kajikawa M, Maruhashi T, Kawamoto M, Yoshizumi M, Higashi Y, Tsuji T. Sci Rep. 8(1):9263, 2018.
 
吉峰俊樹 大阪大学国際医工情報センター・特任教授
脳神経外科
Yanagisawa T, Fukuma R, Seymour B, Hosomi K, Kishima H, Shimizu T, Yokoi H, Hirata M, Yoshimine T, Kamitani Y, Saitoh Y, Induced sensorimotor brain plasticity controls pain in phantom limb patients, Nature Communications, 7:13209 (2016)
Edakawa K, Yanagisawa T, Kishima H, Fukuma R, Oshino S, Khoo HM, Kobayashi M, Tanaka M, Yoshimine T. Detection of epileptic seizures using phase-amplitude coupling in intracranial electroencephalography. Sci Rep, 6:25422. (2016)
Kishima H, Yanagisawa T, Goto Y, Oshino S, Maruo T, Tani N, Khoo HM, Hosomi K, Hirata M, Yoshimine T. Respiratory function under intrathecal baclofen therapy in patients with spastic tetraplegia, Neuromodulation. 19(6):650-654. (2016)

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