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難治性疾患等政策研究事業(難治性疾患政策研究事業)事前評価委員会名簿

(○:委員長)

 
池田康夫 早稲田大学 特命教授 
慶應義塾大学 名誉教授
血液学
(業績・実績その1)
Kuwana M, Okazaki Y, Ikeda Y.
Detection of circulating B cells producing anti-GPIb autoantibodies in patients with immune thrombocytopenia.
PLoS One. 2014 Jan 22;9(1):e86943. doi: 10.1371/journal.pone.0086943. eCollection 2014.
(業績・実績その2)
Ikeda Y, Shimada K, Teramoto T, Uchiyama S, Yamazaki T, Oikawa S, Sugawara M, Ando K, Murata M, Yokoyama K, Ishizuka N.
Low-dose aspirin for primary prevention of cardiovascular events in Japanese patients 60 years or older with atherosclerotic risk factors: a randomized clinical trial.
JAMA. 2014 Dec 17;312(23):2510-20. doi: 10.1001/jama.2014.15690.
(業績・実績その3)
Y. Ono-Uruga, K. Tozawa, T. Horiuchi, M. Murata, S. Okamoto, Y. Ikeda, T. Suda & Y. Matsubara
Human adipose tissue-derived stromal cells can differentiate into megakaryocytes and platelets by secreting endogenous thrombopoietin
Journal of Thrombosis and Haemostasis, Vol.14 (6) p. 1285-1297, June 2016
 
石橋 達朗 九州大学病院 病院長
眼科
Ishikawa K, Yoshida S, Nakao S, Nakama T, Kita T, Asato R, Sassa Y, Arita R, Miyazaki M, Enaida H, Oshima Y, Murakami N, Niiro H, Ono J, Matsuda A, Goto Y, Akashi K, Izuhara K, Kudo A,Kono T, Hafezi-Moghadam A, Ishibashi T:
Periostin promotes the generation of fibrous membranes in proliferative vitreoretinopathy. FASEB J 28(1):131-142, 2014
Nakama T, Yoshida S, Ishikawa K, Kobayashi Y, Zhou Y, Nakao S, Sassa Y, Oshima Y, Takao K, Shimahara A, Yoshikawa K, Hamasaki T, Ohgi T, Hayashi H, Matsuda A, Kudo A, Nozaki M, Ogura Y, Kuroda M, Ishibashi T:
Inhibition of choroidal fibrovascular membrane formation by new class of RNA interference therapeutic agent targeting periostin.
Gene Ther 22(2):127-137, 2015
Ishibashi T, Li X, Koh A, Lai, Lee F-L, Lee W-K, Ma Z, Ohji M,Tan N,
Cha S B, Shamsazar J, Yau C L, on behalf of the REVEAL Study
Group:The REVEAL Study : Ranibizumab Monotherapy or Combined with Laser versus Laser Monotherapy in Asian Patients with Diabetic Macular Edema.
Ophthalmology 122(7):1402-1415, 2015
 
江口 勝美 佐世保中央病院リウマチ膠原病センター・顧問
リウマチ・膠原病
Effects of HLA-DRB1 alleles on susceptibility and clinical manifestations in Japanese patients with adult onset Still's disease.
Asano T, Furukawa H, Sato S, Yashiro M, Kobayashi H, Watanabe H, Suzuki E, Ito T, Ubara Y, Kobayashi D, Iwanaga N, Izumi Y, Fujikawa K, Yamasaki S, Nakamura T, Koga T, Shimizu T, Umeda M, Nonaka F, Yasunami M, Ueki Y, Eguchi K, Tsuchiya N, Tohma S, Yoshiura KI, Ohira H, Kawakami A, Migita K.
Arthritis Res Ther. 2017 Sep 12;19(1):199.
Comparison of serum inflammatory cytokine concentrations in familial Mediterranean fever and rheumatoid arthritis patients.
Koga T, Kawashiri SY, Migita K, Sato S, Umeda M, Fukui S, Nishino A, Nonaka F, Iwamoto N, Ichinose K, Tamai M, Nakamura H, Origuchi T, Ueki Y, Masumoto J, Agematsu K, Yachie A, Eguchi K, Kawakami A.
Scand J Rheumatol. 2017 Sep 2:1-3. doi: 10.1080/03009742.2017.1363281. [Epub ahead of print]
Anti-citrullinated peptide antibodies are the strongest predictor of clinically relevant radiographic progression in rheumatoid arthritis patients achieving remission or low disease activity: A post hoc analysis of a nationwide cohort in Japan.
Koga T, Okada A, Fukuda T, Hidaka T, Ishii T, Ueki Y, Kodera T, Nakashima M, Takahashi Y, Honda S, Horai Y, Watanabe R, Okuno H, Aramaki T, Izumiyama T, Takai O, Miyashita T, Sato S, Kawashiri SY, Iwamoto N, Ichinose K, Tamai M, Origuchi T, Nakamura H, Aoyagi K, Eguchi K, Kawakami A; Japanese RA Patients with RRP Study Group.
PLoS One. 2017 May 15;12(5):e0175281. doi: 10.1371/journal.pone.0175281. eCollection 2017.
 
大澤眞木子 東京女子科大学名誉教授/大塚駅前診療所 所長
小児神経学、(神経筋疾患 てんかん学、先天奇形症候群など)
Osawa M, Sumida S, Suzuki N et al. Fukuyama type congenital muscular dystrophy. In: Fukuyama Y, Osawa M, Saito K (eds). Congenital Muscular Dystrophies. Elsevier Science, Amsterdam; 1997, p31-68
Osawa M, Wang ZP, Saito K, et al . Clinico pathological study of transient ambulant Fukuyama type congenital musucular dystrophy cases :Acta Myol 2001 20 96-103.
Makiko Osawa and Keiko Shishikura: Chapter 5 Werdnig-Hoffmann disease and variants. Handbook of Clinical neurology Vol15(59)
DISEASEA OF THE MOTOR SYSTEM. J.M.B.V De Jong.editor Elsevier Science Publishers B. V. 1991 pp51-pp80.
 
河田 純男 兵庫県立西宮病院 院長
消化器内科学
1. Matsuda A, Makino N, Tozawa T, Shirahata N, Honda T, Ikeda Y, Sato H, Ito M, Kakizaki Y, Akamatsu M, Ueno Y, Kawata S: Pancreas fat accumulation, fibrosis, and acinar cell injury in the Zucker Diabetic fatty rat fed a chronic high-fat diet. Pancreas 2014; 43: 735-43.
1. Ikeda Y, Tanji E, Makino N, Kawata S, Furukawa T: MicroRNAs associated with mitogen-activated protein kinase in human pancreatic cancer. Mol Cancer Res 2012; 10: 259-269.
1. Sasaki Y, Takeda H, Sato T, Orii T, Nishise S, Nagino K, Yaoita T, Yoshizawa K, Saito H, Tanaka Y, Kawata S: Serum interleukin-6, insulin, and HOMA-IR in male individuals with colorectal adenoma. Clin Cancer Res 2012; 18: 392-399.
葛原茂樹 鈴鹿医療科学大学 大学院医療科学研究科・研究科長、看護学部看護学科・特任教授
神経内科学
Mimuro M, Yoshida M, Kuzuhara S, Kokubo Y. Amyotrophic lateral sclerosis and parkinsonism-dementia complex of the Hohara focus of the Kii Peninsula: a multiple proteinopathy? Neuropathology 2018;38:98-104.
葛原茂樹.日本の難病対策の歴史と新たな難病対策.公衆衛生2016;80(6):390-399.
Kuzuhara S, Kokubo Y. Amyotrophic lateral sclerosis-pakinsonism -dementia complex in the Kii peninsula of Japan (Muro disease): a review on recent research and new concept In: Amyotrophic Lateral Sclerosis and the Frontotemporal Dementias, Edited by Michael J. Strong, Oxford University Press, Oxford,2012, p39-54.
 
黒岩 義之 財務省診療所長、横浜市立大学名誉教授
神経内科学
Propagated but topologically distributed forebrain neurons expressing alpha-synuclein in aged macaques. Kimura K, Inoue KI, Kuroiwa Y, Tanaka F, Takada M. Plos one. 2016 Nov; 11(11):e0166861.
doi:10.1371/journal.pone. 0166861
A study of brain metabolism in fibromyalgia by positron emission tomography. Usui C, Soma T, Hatta K, Aratani S, Fujita H, Nishioka K, Machida Y, Kuroiwa Y, Nakajima T, Nishioka K. Prog Neuropsychopharmacol Biol Psychiatry. 2017 Apr;75:120-127. doi:10.1016/j.pnpbp.2017.01.012. Epub 2017Jan30.
Greater N1 potential during centrifugal saccades as compared to centripetal saccades in humans: A scalp-recorded electroencephalographic study. Omoto S, Kuroiwa Y, Fujino S, Fujino K, Kurokawa T, Baba Y. 2017 Dec; The Autonomic Nervous System (Journal of the Japan Society of Neurovegetative Research),54(4):306-315.
 
澤倫太郎 日本医師会総合政策研究機構・研究部長
胎児生理学、産科学、医療経済学
Sawa R, Asakura H, Power GG.           
Changes in plasma adenosine during simulated birth of fetal sheep.
J Appl Physiol 70(4): 1524-1528, 1991
Sawa R, Yoneyama Y, Otsubo Y, Suzuki S, Kubonoya K, Power GG,
Araki T.
Fetal plasma hypoxanthine level in growth-retarded fetuses before labor. J Clin Endocrinol Metab 82: 4028-4033, 1997
Suzuki K, Sawa R, Muto K, Kusuda S, Banno K, Yamagata Z.
Risk perception of Pregnancy Promotes Disapproval of Gestational Surrogacy: Analysis of a Nationally Representative Opinion Survey in Japan. International Journal of Fertility & Sterility; 5(2), 78-85, 2011
 
清野 裕 関西電力病院・院長 
糖尿病学
Dipeptidyl peptidase 4 (DPP-4) is expressed in mouse and human islets and its activity is decreased in human islets from individuals with type 2 diabetes.
Omar BA, Liehua L, Yamada Y, Seino Y, Marchetti P, Ahre'n B.
Diabetologia. 2014 Sep;57(9):1876-83. doi: 10.
1007/s00125-014-3299-4. Epub 2014 Jun 18.
Dipeptidyl peptidase-4 inhibitors and sulfonylureas for type 2 diabetes: Friend or foe?
Yabe D, Seino Y.
J Diabetes Investig. 2014 Sep;5(5):475-7. doi: 10.1111/jdi.12229.
Use of the Japanese health insurance claims database to assess the risk of acute pancreatitis in patients with diabetes: comparison of DPP-4 inhibitors with other oral antidiabetic drugs.
Yabe D, Kuwata H, Kaneko M, Ito C, Nishikino R, Murorani K, Kurose T, Seino Y.
Diabetes Obes Metab. 2015 Apr;17(4):430-4. doi: 10.1111/dom.12381. Epub 2014 Sep 17.
 
竹中 洋 大阪医科大学名誉教授
耳鼻咽喉科学
Enhanced human IgE production results from exposure to the aromaticHydrocarbons from diesel exhaust;direct effects on B-cell IgE production, Takenaka H,et al
J Allery CLin Immunol;1998.95:103-115.
コア・ローテイション 耳鼻咽喉科・頭頸部外科
編集 竹中洋、高橋姿、久育男
金芳堂、2004年1月5日
気道アレルギーの成立とその制御:竹中 洋
第110回日本耳鼻咽喉科学術総会宿題報告
東京、2009.05.14.
 
富野 康日己 医療法人社団松和会 常務理事
腎臓内科学
Diabetic Nephropathy: Review” The Prevalence and Management of Diabetic Nephropathy in Asia, Diabetic Nephropathy”. Yasuhiko Tomino, Tomohito Gohda. Kidney Dis 2015;1:52-60 (DOI: 10.1159/000381757) April 30, 2015
Juntendo Research Profiles “Division of Nephrology, Department of Internal Medicine”. Yasuhiko Tomino. Juntendo Medical Journal 2015, 61(3), 320-321
“Case Studies on Kidney Diseases -20 Typical Cases-(2nd revised edition)”. Yasuhiko Tomino. Karger, 2017
 
友池仁暢 榊原記念病院・顧問
循環器内科学
(業績・実績その1)
Incidence of cancers in patients with atherosclerotic cardiovascular diseases. Suzuki M, Tomoike H, Sumiyoshi T, et al. IJC Heart & Vaculature 17:11-16, 2017
(業績・実績その2)
Nationwide distribution of cardiovascular Practice in Japan- Results of Japanese Circulation Society 2010 Annual Survey- Tomoike H, Yokoyama H, Sumita Y, Hanai S, Kada A, Okamura T, Yoshikawa J, Doi Y, Hori M, Tei C. Circulation J 79(5); 1058-1067, 2015
(業績・実績その3)
社会課題を解く視点からの提言‐人の尊重される健康と医療のデザイン‐友池仁暢、塚田信吾、江崎禎英、山口類、井元清哉、宮野悟 電子情報通信学会誌100(1)・3−12、2017
 
中村耕三 国立障害者リハビリテーションセンター・顧問
リハビリテーション
<研究論文例>
Prevalence of cervical cord compression and its association with physical performance in a population-based cohort in Japan: the Wakayama Spine Study. Nagata K, Nakamura K, et al.: Spine (Phila Pa 1976). 2012, 37(22): 1892-1898
<研究論文例>
Reference values for hand grip strength, muscle mass, walking time, and one-leg standing time as indices for locomotive syndrome and associated disability: the second survey of the ROAD study. Yoshimura N, Nakamura K, et al. J Orthop Sci. 2011, 16(6): 768-77.
<研究論文例>
Acute cervical spinal cord injury complicated by preexisting ossification of the posterior longitudinal ligament: a multicenter study. Chikuda H, Nakamura K, et al. Spine (Phila Pa 1976). 2011, 36(18): 1453-1458.
 
永井正規 桐生大学医療保健学部看護学科教授
疫学
Prevalence and Incidence of Polymyositis and Dermatomyositis in Japan. Ohta A, Nagai M, Nishina M, Tomimitsu H, Kohsaka H.Mod Rheumatol 24:477-480, 2013.
A case control study of female systemic lupus erythematosus in Japan
MASAKI NAGAI,TOMIO HIROHATA,YOSHIFUJI MATSUMOTO,HIROSHI HASHIMOTO,MASAKAZU KONDO,KOTARO OZASA,MITSURU MORI,TSUTOMU HASHIMOTO,HIDEAK
I NAKAGAWA,TOSHITAKA OMURA,MASAKI MORI,TAKESHI TOJO,HIROSHI YANAGAWA European Journal of Public Health, Volume 3, Issue 3:172-176, 1992
「新しい疫学」永井正規他共著,日本公衆衛生協会,(1995).
 
西岡 清 兵庫医科大学・常務理事
皮膚科学、アレルギー免疫学
Hepatocyte growth factor both prevents and ameliorates the symptoms of dermal sclerosis in a mouse model of scleroderma. Wu MH, Yokozeki H, Takagawa S, Yamamoto T, Satoh T, Kaneda Y, Katayama I, Nishioka K. Gene Therapy 2004; 11: 170-180
In vivo transfection of a cis element “decoy” against signal transducers and activators of transcription 6 (STAT6)-binding site ameliorates IgE-mediated late phase reaction in an atopic dermatitis mouse model. Yokozeki H, Wu MH, Sumi K, Awad S, Satoh T, Katayama I, Takeda K, Akira A, Kaneda Y, Nishioka K. Gene Therapy 2004; 11: 1753-1762
「原著に学ぶ英米皮膚科学の古典」西岡清監修、片山一朗、岩月啓氏、横関博雄監訳、大阪大学皮膚科学教室刊、株式会社A・M・S(2016)
 
貫和敏博 公益財団法人結核予防会・常務理事
呼吸器内科
EGFR Mutation Analysis of Circulating Tumor DNA Using an Improved PNA-LNA PCR Clamp Method. Watanabe K, Fukuhara T, Tsukita Y, Morita M, Suzuki A, Tanaka N, Terasaki H, Nukiwa T, Maemondo M. Can Respir J. 2016; 2016: 5297329.
最新医学 診断と治療のABC 124.糖尿病の合併症.第4章その他の関連疾患.糖尿病と結核症.貫和敏博、最新医学社、2017.
OX40 ligand newly expressed on bronchiolar progenitors mediates influenza infection and further exacerbates pneumonia. Hirano T, Kikuchi T, et al, Nukiwa T, Watanabe A, Ichinose M. EMBO Mol Med. 2016 Apr 1;8(4):422-36.
 
福島 雅典 公益財団法人神戸医療産業都市推進機構
医療イノベーション推進センター長
腫瘍内科学、臨床試験デザイン・管理・評価、薬剤疫学、医科学
Predictive Factors associated with Acute Ocular Involvement in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.
Sotozono C, Ueta M, Nakatani E, Kitami A, Watanabe H, Sueki H, Iijima M, Aihara M, Ikezawa Z, Aihara Y, Kano Y, Shiohara T, Tohyama M, Shirakata Y, Kaneda H, Fukushima M, Kinoshita S, Hashimoto K; Japanese Research Committee on Severe Cutaneous Adverse Reaction.
Am J Ophthalmol. 2015;160(2):228-37.
Prediction of prognosis of ALS: Importance of active denervation findings of the cervical-upper limb area and trunk area.
Sato Y, Nakatani E, Watanabe Y, Fukushima M, Nakashima K, Kannagi M, Kanatani Y, Mizushima H.
Intractable Rare Dis Res. 2015;4(4):181-9.
Specific clinical signs and symptoms are predictive of clinical course in sporadic Creutzfeldt-Jakob disease.
Nakatani E, Kanatani Y, Kaneda H, Nagai Y, Teramukai S, Nishimura T, Zhou B, Kojima S, Kono H, Fukushima M, Kitamoto T, Mizusawa H.
Eur J Neurol. 2016;23(9):1455-62.
 
宮ア 久義 特定非営利活動法人
日本医療マネジメント学会理事長
麻酔、病院管理、地域医療、生活習慣病
癌末期痛に対するモリッカの下垂体破壊術 1.経鼻的下垂体穿刺に必要な基礎的と方法 .宮崎久義,後藤倶子,岡元和文,宇都宮高賢,森岡亨,山室誠,麻酔27:1606-1612.1978
癌末期痛に対するモリッカの下垂体破壊術 2.その成績と作用機序に対する考察 .宮崎久義,後藤倶子,岡元和文,宇都宮高賢,森岡亨,山室誠,麻酔28(1):77-82.1979
Critical Pathway: Practical applications and its development in Japan.Hisayoshi Miyazaki,Teruhiko Matsushima. JMAJ48(11):568-571.2005
 
吉峰俊樹 大阪大学国際医工情報センター・特任教授
脳神経外科
Yanagisawa T, Fukuma R, Seymour B, Hosomi K, Kishima H, Shimizu T, Yokoi H, Hirata M, Yoshimine T, Kamitani Y, Saitoh Y, Induced sensorimotor brain plasticity controls pain in phantom limb patients, Nature Communications, 7:13209 (2016)
Edakawa K, Yanagisawa T, Kishima H, Fukuma R, Oshino S, Khoo HM, Kobayashi M, Tanaka M, Yoshimine T. Detection of epileptic seizures using phase-amplitude coupling in intracranial electroencephalography. Sci Rep, 6:25422. (2016)
Kishima H, Yanagisawa T, Goto Y, Oshino S, Maruo T, Tani N, Khoo HM, Hosomi K, Hirata M, Yoshimine T. Respiratory function under intrathecal baclofen therapy in patients with spastic tetraplegia, Neuromodulation. 19(6):650-654. (2016)

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