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難治性疾患等政策研究事業(難治性疾患政策研究事業)中間・事後評価委員

(○:委員長)

 
浅香正博 北海道医療大学 学長
内科学、消化器病学、がん予防学
Vonoprazan, a novel potassium-competitive acid blocker, as a component of first-line and second-line triple therapy for Helicobacter pylori eradication: a phase III, randomised, double-blind study. Gut. 65:1439-1446,2016
Murakami K, Sakurai Y, Shiino M, Funao N, Nishimura A, Asaka M.
消化器病学 基礎と臨床
浅香正博、菅野健太郎、千葉勉編集、浅香正博:消化器疾患診断への手順:2-7p、西村書店、2013
Special lecture: Roadmap to eliminate gastric cancer in Japan. Asaka M 15th Congress of Gastroenterology in China. Tianjin, China 2015
 
五十嵐 隆 国立成育医療研究センター理事長
小児科
<研究論文>
Igarashi T, Gu:nter W, Sekine T, Inatomi J, Shiraga H, Takahashi S, Suzuki J, Tsuru N, Yanagihara T, Shimazu M, Jentsch TJ, Thakker RV: Functional characterization of renal chloride channel, CLCN5, mutations associated with Dent’s Japan disease. Kidney Int 54: 1850-1856, 1998
<研究論文>
Igarashi T, Inatomi J, Sekine T, Cha SH, Kanai Y, Kunimi M, Tsukamoto K, Satoh H, Shimadzu M, Tozawa F, Mori T, Shiobara M, Seki G, Endou H: Mutations in SLC4A4 cause permanent isolated proximal renal tubular acidosis with ocular abnormalities. Nature Genet 23:264-266, 1999
<研究論文>
Enomoto A, Kimura H, Chairoungdua A, Shigeta Y, Jutabha P, Cha SH, Hosoyamada M, Takeda M, Sekine T, Igarashi T, Matsuo H, Kikuchi Y, Oda T, Ichida K, Hosoya T, Shimokata K, Niwa T, Kanai Y, Endou H: Molecular identification of a renal/urate/anion exchanger that regulates blood urate levels. Nature 417: 447-452, 2002
 
石橋 達朗 九州大学病院 病院長
眼科
Ishikawa K, Yoshida S, Nakao S, Nakama T, Kita T, Asato R, Sassa Y, Arita R, Miyazaki M, Enaida H, Oshima Y, Murakami N, Niiro H, Ono J, Matsuda A, Goto Y, Akashi K, Izuhara K, Kudo A,Kono T, Hafezi-Moghadam A, Ishibashi T:
Periostin promotes the generation of fibrous membranes in proliferative vitreoretinopathy. FASEB J 28(1):131-142, 2014
Nakama T, Yoshida S, Ishikawa K, Kobayashi Y, Zhou Y, Nakao S, Sassa Y, Oshima Y, Takao K, Shimahara A, Yoshikawa K, Hamasaki T, Ohgi T, Hayashi H, Matsuda A, Kudo A, Nozaki M, Ogura Y, Kuroda M, Ishibashi T:
Inhibition of choroidal fibrovascular membrane formation by new class of RNA interference therapeutic agent targeting periostin.
Gene Ther 22(2):127-137, 2015
Ishibashi T, Li X, Koh A, Lai, Lee F-L, Lee W-K, Ma Z, Ohji M,Tan N,
Cha S B, Shamsazar J, Yau C L, on behalf of the REVEAL Study
Group:The REVEAL Study : Ranibizumab Monotherapy or Combined with Laser versus Laser Monotherapy in Asian Patients with Diabetic Macular Edema.
Ophthalmology 122(7):1402-1415, 2015
 
長村義之 国際医療福祉大学大学院 特任教授
病理学 ゲノム病理学
WHO Classification of Tumours of Endocrine Organs, WHO/IARC Classification of Tumours, 4th Edition, Volume 10, 2017, Edited by Lloyd RV, Osamura RY, Klo:ppel G, Rosai J,
Osamura RY. A Groundbreaking Work Which Laid the Foundation for Mass Screening in Cervical Cytology in Japan. Acta Cytol. 2017, 61, 299-304.
Hanna WM, Ruschoff J, Bilous M, Coudry RA, Dowsett M, Osamura RY, Penault-Llorca F, van de Vijver M, Viale G: HER2 in situ hybridization in breast cancer: clinical implications of polysomy 17 and genetic heterogeneity. Mod Pathol 2014, 27:4-18.
 
片山一朗 大阪大学大学院医学系研究科皮膚科学 教授
アトピー性皮膚炎、膠原病、接触皮膚炎、皮膚免疫学、薬剤アレルギー、皮膚血管炎、光生物学、臨床アレルギー学
Animal model of sclerotic skin. I: Local injections of bleomycin induce sclerotic skin mimicking scleroderma.Yamamoto,T.,Takagawa,S.,Katayama,I.,Yamazaki,K.,Hamasaki,Y.,Shinkai,H.,and Nishioka,K.: J.Invest.Dermatol.,112:456-462,1999
Japanese Society of Allergology:Japanese guideline for atopic dermatitis 2014.Katayama,I.,Kohno,Y.,Akiyama,K.,Aihara,M.,Kondo,N.,Saeki,H.,Shoji,S.,Yamada,H.,and Nakamura,K.: Allergol Int.,63(3):377-398,2014
Detection of self-reactive CD8+ T cells with an anergic phenotype in healthy individuals.Maeda,Y.,Nishikawa,H.,Sugiyama,D.,Ha,D.,Hamaguchi,M.,Saito,T.,Nishioka,M.,Wing,JB.,Adeegbe,D.,Katayama,I.,and Sakaguchi,S.: Science,346(6216):1536-1540,2014
 
小池 隆夫 医療法人清仁会 北海道内科リウマチ科病院・最高顧問
リウマチ学・臨床免疫学・内分泌学・糖尿病学
Koike T.
Antiphospholipid syndrome: 30 years and our contribution.
Int J Rheum Dis. 18(2):233-41, 2015.
Koike T.
My contribution, my dream a look at the future of APS.Lupus. 23(12):1332-1334, 2014.
Koike T.
The new era of autoimmune disease research.
Arthritis Res Ther. 13(3):113.2011
 
堺 秀人 医療法人仁泉会理事
腎臓病学
AMED腎疾患実用化研究事業の説明、堺秀人、
平成28年度日本腎臓学会総会、2016年6月17日
 
澤倫太郎 日本医師会総合政策研究機構・研究部長
胎児生理学、産科学、医療経済学
Sawa R, Asakura H, Power GG.           
Changes in plasma adenosine during simulated birth of fetal sheep.
J Appl Physiol 70(4): 1524-1528, 1991
Sawa R, Yoneyama Y, Otsubo Y, Suzuki S, Kubonoya K, Power GG,
Araki T.
Fetal plasma hypoxanthine level in growth-retarded fetuses before labor. J Clin Endocrinol Metab 82: 4028-4033, 1997
Suzuki K, Sawa R, Muto K, Kusuda S, Banno K, Yamagata Z.
Risk perception of Pregnancy Promotes Disapproval of Gestational Surrogacy: Analysis of a Nationally Representative Opinion Survey in Japan. International Journal of Fertility & Sterility; 5(2), 78-85, 2011
嶋 幸男 柳川療育センター名誉センター長
小児神経学、神経病理学
Neuronal plasticity in the developing and aging cerebral cortices of patients with Down syndrome.Takashima M, Takahashi S, Yokoo M, Iwata O, Iwata S, Takashima S・International Journal of Neuro- rehabilitation, 1:2, 2014
A history of our understanding of cerebral vascular development and pathogenesis of perinatal brain damage over the past 30 years, and further prospective.Takashima S, Itoh M, Oka A・Seminars in Pediatric Neurology 16:226-36, 2009
Pediatric Neuropathology- a text and atlas.Armstrong D, Halliday W, Hawkins C, Takashima S、Springer, Tokyo, 2007.
 
竹中 洋 京都府立医科大学 学長
耳鼻咽喉科学
Enhanced human IgE production results from exposure to the aromaticHydrocarbons from diesel exhaust;direct effects on B-cell IgE production, Takenaka H,et al
J Allery CLin Immunol;1998.95:103-115.
コア・ローテイション 耳鼻咽喉科・頭頸部外科
編集 竹中洋、高橋姿、久育男
金芳堂、2004年1月5日
気道アレルギーの成立とその制御:竹中 洋
第110回日本耳鼻咽喉科学術総会宿題報告
東京、2009.05.14.
 
坪内博仁 鹿児島市立病院 病院長
消化器内科、肝臓病
Purification and Partial Characterization of Hepatocyte Growth Factor from Plasma of a Patient with Fulminant Hepatic Failure. Gohda E, Tsubouchi H, Nakayama H, Hirono S, Sakiyama O, Takahashi K, Miyazaki H, Hashimoto S, and Daikuhara Y. J.Clin.Invest.1988 Feb; 81: 414-419.
Molecular Cloning and Sequence Analysis of cDNA for Human Hepatocyte Growth Factor. Miyazawa K, Tsubouchi H, Naka D, Takahashi K, Okigaki M, Arakaki N Nakayama H, Hirono S, Sakiyama O, Takahashi K, Gohda E, Daikuhara Y, and Kitamura N. Biochemical and Biophysical Research Communications. 1989 Sep; 163(2): 967-973
Safety and pharmacokinetics of recombinant human hepatocyte growth factor(rh-HGF)in patients with fulminant hepatitis: a phase I/II clinical trial, following preclinical studies to ensure safety. Ido A, Moriuchi A, Numata M, Murayama T, Teramukai S, Marusawa H, Yamaji N, Setoyama H, Kim I, Chiba T, Higuchi S, Yokode M, Fukushima M, Shimizu A and Tsubouchi H. Journal of Translational Medicine. 2011; 9: 55.
 
永井正規 埼玉医科大学名誉教授
疫学
Prevalence and Incidence of Polymyositis and Dermatomyositis in Japan. Ohta A, Nagai M, Nishina M, Tomimitsu H, Kohsaka H.Mod Rheumatol 24:477-480, 2013.
A case control study of female systemic lupus erythematosus in Japan
MASAKI NAGAI,TOMIO HIROHATA,YOSHIFUJI MATSUMOTO,HIROSHI HASHIMOTO,MASAKAZU KONDO,KOTARO OZASA,MITSURU MORI,TSUTOMU HASHIMOTO,HIDEAK
I NAKAGAWA,TOSHITAKA OMURA,MASAKI MORI,TAKESHI TOJO,HIROSHI YANAGAWA European Journal of Public Health, Volume 3, Issue 3:172-176, 1992
「新しい疫学」永井正規他共著,日本公衆衛生協会,(1995).
 
中村耕三 国立障害者リハビリテーションセンター顧問
リハビリテーション医学
<研究論文例>
Prevalence of cervical cord compression and its association with physical performance in a population-based cohort in Japan: the Wakayama Spine Study. Nagata K, Nakamura K, et al.: Spine (Phila Pa 1976). 2012, 37(22): 1892-1898
<研究論文例>
Reference values for hand grip strength, muscle mass, walking time, and one-leg standing time as indices for locomotive syndrome and associated disability: the second survey of the ROAD study. Yoshimura N, Nakamura K, et al. J Orthop Sci. 2011, 16(6): 768-77.
<研究論文例>
Acute cervical spinal cord injury complicated by preexisting ossification of the posterior longitudinal ligament: a multicenter study. Chikuda H, Nakamura K, et al. Spine (Phila Pa 1976). 2011, 36(18): 1453-1458.
 
貫和敏博 公益財団法人結核予防会・常務理事
呼吸器内科
EGFR Mutation Analysis of Circulating Tumor DNA Using an Improved PNA-LNA PCR Clamp Method. Watanabe K, Fukuhara T, Tsukita Y, Morita M, Suzuki A, Tanaka N, Terasaki H, Nukiwa T, Maemondo M. Can Respir J. 2016; 2016: 5297329.
最新医学 診断と治療のABC 124.糖尿病の合併症.第4章その他の関連疾患.糖尿病と結核症.貫和敏博、最新医学社、2017.
OX40 ligand newly expressed on bronchiolar progenitors mediates influenza infection and further exacerbates pneumonia. Hirano T, Kikuchi T, et al, Nukiwa T, Watanabe A, Ichinose M. EMBO Mol Med. 2016 Apr 1;8(4):422-36.
 
平田結喜緒 兵庫県予防医学協会・参与、
東京医科歯科大学名誉教授
内分泌代謝学、糖尿病、高血圧、心血管分子生物学
1.1. Regulation of growth hormone secretion by (pro)renin receptor. Tani Y., Yamada S., Inoshita N., Hirata Y., Shichiri M. Sci. Rep. 5, 10878; doi: 10.1038/strep10878(2015)
2.Validation of an ion torrent sequencing platform for the detection of gene mutations in biopsy specimens from patients with non-small-cell lung cancer. Fujita S., Masago K., Takeshita J., Okuda C., Otsuka K., Hata A., Kaji R., Katabami N., Hirata Y. PLOS One doi: 10.1371/journal.phone.0130219; June 15, 2015
3.3. Next generation sequencing of tyrosine kinase inhibitor-resistant non-small-cell lung cancers in patients harboring epidermal growth factor-activating mutations. Masago K., Fujita S., Muraki M., Hata A., Okuda C., Otsuka K., Kaji R., Takeshita J., Kato R., Katakami N., Hirata Y. BMC Cancer 15:008,2015; doi 10.1186/s12885-015-1925-2
 
福島 雅典 公益財団法人神戸医療産業都市推進機構
医療イノベーション推進センター長
腫瘍内科学、臨床試験デザイン・管理・評価、薬剤疫学、医科学
Predictive Factors associated with Acute Ocular Involvement in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.
Sotozono C, Ueta M, Nakatani E, Kitami A, Watanabe H, Sueki H, Iijima M, Aihara M, Ikezawa Z, Aihara Y, Kano Y, Shiohara T, Tohyama M, Shirakata Y, Kaneda H, Fukushima M, Kinoshita S, Hashimoto K; Japanese Research Committee on Severe Cutaneous Adverse Reaction.
Am J Ophthalmol. 2015;160(2):228-37.
Prediction of prognosis of ALS: Importance of active denervation findings of the cervical-upper limb area and trunk area.
Sato Y, Nakatani E, Watanabe Y, Fukushima M, Nakashima K, Kannagi M, Kanatani Y, Mizushima H.
Intractable Rare Dis Res. 2015;4(4):181-9.
Specific clinical signs and symptoms are predictive of clinical course in sporadic Creutzfeldt-Jakob disease.
Nakatani E, Kanatani Y, Kaneda H, Nagai Y, Teramukai S, Nishimura T, Zhou B, Kojima S, Kono H, Fukushima M, Kitamoto T, Mizusawa H.
Eur J Neurol. 2016;23(9):1455-62.
 
宮ア 久義 特定非営利活動法人
日本医療マネジメント学会理事長
麻酔、病院管理、地域医療、生活習慣病
癌末期痛に対するモリッカの下垂体破壊術 1.経鼻的下垂体穿刺に必要な基礎的と方法 .宮崎久義,後藤倶子,岡元和文,宇都宮高賢,森岡亨,山室誠,麻酔27:1606-1612.1978
癌末期痛に対するモリッカの下垂体破壊術 2.その成績と作用機序に対する考察 .宮崎久義,後藤倶子,岡元和文,宇都宮高賢,森岡亨,山室誠,麻酔28(1):77-82.1979
Critical Pathway: Practical applications and its development in Japan.Hisayoshi Miyazaki,Teruhiko Matsushima. JMAJ48(11):568-571.2005
 
宮下 俊之 北里大学医学部 教授 医学部長
小児科学、分子遺伝学、分子生物学
Miyashita, T. and Reed, J.C. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 1995, 80, 293-299.
Nagao, K., Iwai, Y. and Miyashita, T. RCAN1 is an important mediator of glucocorticoid-induced apoptosis in human leukemic cells. PLOS ONE 2012, 7, e49926
Ikemoto, Y., Takayama, Y., Fujii, K., Masuda, M., Kato, C., Hatsuse, H., Fujitani, K., Nagao, K., Kameyama, K., Ikehara, H., Toyoda, M., Umezawa, A. and Miyashita, T. Somatic mosaicism containing double mutations in PTCH1 revealed by generation of induced pluripotent stem cells from nevoid basal cell carcinoma syndrome. J. Med. Genet. 2017, 54, 579-584
 
吉栖 正生 広島大学大学院医歯薬保健学研究科教授
循環器病学
EPA Prevents the Development of Abdominal Aortic Aneurysms through Gpr-120/Ffar-4. Kamata R, Bumdelger B, Kokubo H, Fujii M, Yoshimura K, Ishida T, Ishida M, Yoshizumi M. PLoS One. 11(10):e0165132, 2016.
Protective Effects of Japanese Soybean Paste (Miso) on Stroke in Stroke-Prone Spontaneously Hypertensive Rats (SHRSP). Watanabe H, Sasatani M, Doi T, Masaki T, Satoh K, Yoshizumi M. Am J Hypertens. 31(1):43-47, 2017.
Assessment of Lower-limb Vascular Endothelial Function Based on Enclosed Zone Flow-mediated Dilation. Hirano H, Takama R, Matsumoto R, Tanaka H, Hirano H, Soh Z, Ukawa T, Takayanagi T, Morimoto H, Nakamura R, Saeki N, Hashimoto H, Matsui S, Kishimoto S, Oda N, Kajikawa M, Maruhashi T, Kawamoto M, Yoshizumi M, Higashi Y, Tsuji T. Sci Rep. 8(1):9263, 2018.
 
吉峰俊樹 大阪大学国際医工情報センター・特任教授
脳神経外科
Yanagisawa T, Fukuma R, Seymour B, Hosomi K, Kishima H, Shimizu T, Yokoi H, Hirata M, Yoshimine T, Kamitani Y, Saitoh Y, Induced sensorimotor brain plasticity controls pain in phantom limb patients, Nature Communications, 7:13209 (2016)
Edakawa K, Yanagisawa T, Kishima H, Fukuma R, Oshino S, Khoo HM, Kobayashi M, Tanaka M, Yoshimine T. Detection of epileptic seizures using phase-amplitude coupling in intracranial electroencephalography. Sci Rep, 6:25422. (2016)
Kishima H, Yanagisawa T, Goto Y, Oshino S, Maruo T, Tani N, Khoo HM, Hosomi K, Hirata M, Yoshimine T. Respiratory function under intrathecal baclofen therapy in patients with spastic tetraplegia, Neuromodulation. 19(6):650-654. (2016)

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