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難治性疾患等克服研究事業(難治性疾患克服研究事業)事前評価委員会名簿

(○:委員長)

 
池田 康夫 早稲田大学 特命教授
血栓止血学
Ikeda Y, Shimada K, Teramoto T, Uchiyama S, Yamazaki T, Oikawa S, Sugawara M, Ando K, Murata M, Yokoyama K, Ishizuka N.
Low-dose aspirin for primary prevention of cardiovascular events in Japanese patients 60 years or older with atherosclerotic risk factors: a randomized clinical trial.
JAMA. 2014 Dec 17;312(23):2510-20. doi: 10.1001/jama.2014.15690.
Bhatt DL., Steg PG., Ohman EM., Hirsch AT., Ikeda, Y., Mas JL., Goto S., Liau CS., Richard AJ., Rother J., Wilson PWF., for the REACH Registry Investigators. :
International prevalence, recognition, and treatment of cardiovascular risk factors in outpatients with atherothrombosis.
JAMA 295 (2): 180-189, 2006 (1).
Ikeda, Y., Handa, M., Kawano, K., Kamata, T., Murata, M., Araki, Y., Ambo, H., Kawai, Y., Watanabe, K., Itagaki, I., Sakai, K., and Ruggeri, Z.M.:
The role of von Willebrand factor and fibrinogen in platelet aggregation under varying shear stress.
J. Clin. Invest. 87: 1234-1240, 1991
 
石橋 達朗 九州大学病院 病院長
眼科
Ishikawa K, Yoshida S, Nakao S, Nakama T, Kita T, Asato R, Sassa Y, Arita R, Miyazaki M, Enaida H, Oshima Y, Murakami N, Niiro H, Ono J, Matsuda A, Goto Y, Akashi K, Izuhara K, Kudo A,Kono T, Hafezi-Moghadam A, Ishibashi T:
Periostin promotes the generation of fibrous membranes in proliferative vitreoretinopathy. FASEB J 28(1):131-142, 2014
Nakama T, Yoshida S, Ishikawa K, Kobayashi Y, Zhou Y, Nakao S, Sassa Y, Oshima Y, Takao K, Shimahara A, Yoshikawa K, Hamasaki T, Ohgi T, Hayashi H, Matsuda A, Kudo A, Nozaki M, Ogura Y, Kuroda M, Ishibashi T:
Inhibition of choroidal fibrovascular membrane formation by new class of RNA interference therapeutic agent targeting periostin.
Gene Ther 22(2):127-137, 2015
Ishibashi T, Li X, Koh A, Lai, Lee F-L, Lee W-K, Ma Z, Ohji M,Tan N,
Cha S B, Shamsazar J, Yau C L, on behalf of the REVEAL Study
Group:The REVEAL Study : Ranibizumab Monotherapy or Combined with Laser versus Laser Monotherapy in Asian Patients with Diabetic Macular Edema.
Ophthalmology 122(7):1402-1415, 2015
 
大澤眞木子 東京女子科大学名誉教授/大塚駅前診療所 所長
小児神経学、(神経筋疾患 てんかん学、先天奇形症候群など)
Osawa M, Sumida S, Suzuki N et al. Fukuyama type congenital muscular dystrophy. In: Fukuyama Y, Osawa M, Saito K (eds). Congenital Muscular Dystrophies. Elsevier Science, Amsterdam; 1997, p31-68

Osawa M, Wang ZP, Saito K, et al . Clinico pathological study of transient ambulant Fukuyama type congenital musucular dystrophy cases :Acta Myol 2001 20 96-103.

Makiko Osawa and Keiko Shishikura: Chapter 5 Werdnig-Hoffmann disease and variants. Handbook of Clinical neurology Vol15(59)
DISEASEA OF THE MOTOR SYSTEM. J.M.B.V De Jong.editor Elsevier Science Publishers B. V. 1991 pp51-pp80.
 
岡上 武 大阪府済生会吹田病院 名誉院長
消化器病学(肝臓)
Risk estimation model for nonalcoholic fatty liver disease?in the Japanese using multiple genetic markers. KAWAGUCHI T, SHIMA T, MIZUNO M., MITAUMOTO Y, UMEMURA A, KAMBARA Y, TANAKA S, SUMIDA Y, YASUI K, TAKAHASHI M, MATSUO K, ITOH Y, TOKUSHIGE K, HASHIMOTO E, KIYOSAWA K, KAWAGUCHI M, ITOH H, UTO H, KOMORIZAWA Y, SHIRABE K, TAKAMI S, TAKAMURA T, KAWANAKA M, YAMADA R, MATSUDA F, OKANOUE T. PLoS ONE in press
Identification of novel noninvasive markers for diagnosing nonalcoholic steatohepatitis and related fibrosis by data mining. YOSHIMURA K, OKANOUE T, EBISA H, IWASAKI T, MIZUNOI M, SHIMA T, ICHIHARA J, YAMAZAKI K. Hepatology. 2016 Feb;63(2):462-473.
Risk prediction for the development and progression of nonalcoholic fatty liver disease with genetic markers. OKANOUE T, SHIMA T, MIZUNO M, MITSUMOTO Y, KANBARA Y, KAWANAKA M, KAWAGUCHT T, MATSUDA F. AASLD The Liver Meeting 2017(Washington), 2017
 
葛原 茂樹 鈴鹿医療科学大学看護学部 特任教授
神経内科学
Kuzuhara S, Kokubo Y, Sasaki R, Narita Y, Yabana T, Hasegawa M, Iwatsubo T. Familial amyotrophic lateral sclerosis and parkinsonism-dementia complex of the Kii peninsula of Japan: clinical and neuropathological study and tau analysis. Ann Neurol 49:501-11,2001
(著書・分担執筆)Kuzuhara S, Kokubo Y. Amyotrophic lateral sclerosis-pakinsonism-dementia complex in the Kii peninsula of Japan (Muro disease): a review on recent research and new concept, In: .Amyotrophic Lateral Sclerosis and the Frontotemporal Dementias, Edited by Michael J. Strong, Oxford University Press, Oxford 2012, p39-54.
(招待講演)Kuzuhara S. Segawa’s Disease and Parkinsonism-ALS-Dementia Complex of Kii Peninsula, in “Specific movement disorders in AOS” Session of the 4th Asian and Oceanian
Parkinson’s Disease and Movement Disorders Congress/AOPMC, Plenary Session III: Specific movement disorders in Japan: Historical and recent developments. The 4th Asian and Oceanian
Parkinson’s Disease and Movement Disorders Congress/AOPMC, Pathaya (Thailand), Nov 28-30,2014.
 
齊藤 延人 東京大学大学院医学系研究科教授
脳神経外科学
Differences in genetic and epigenetic alterations between von Hippel-Lindau disease-related and sporadic hemangioblastomas of the central nervous system. Takayanagi S, Mukasa A, Tanaka S, Nomura M, Omata M, Yanagisawa S, Yamamoto S, Ichimura K, Nakatomi H, Ueki K, Aburatani H, and Saito N. Neuro Oncol. 2017 Sep;19(9):1228-1236.
The importance of encephalo-Myo-synangiosis in surgical revascularization strategies for moyamoya disease in children and adults. Imai H, Miyawaki S, Ono H, Nakatomi H, Yoshimoto Y, Saito N. World Neurosurg. 2015 May;83(5):691-699
Identification of agenetic variant common to moyamoya disease and intracranial major artery stenosis/occlusion. Miyawaki S, Imai H, Takayanagi S, Mukasa A, Nakatomi H, Saito N. Stroke 2012 Dec;43(12):3371-3374
 
澤倫太郎 日本医師会総合政策研究機構・研究部長
胎児生理学、産科学、医療経済学
Sawa R, Asakura H, Power GG.           
Changes in plasma adenosine during simulated birth of fetal sheep.
J Appl Physiol 70(4): 1524-1528, 1991
Sawa R, Yoneyama Y, Otsubo Y, Suzuki S, Kubonoya K, Power GG,
Araki T.
Fetal plasma hypoxanthine level in growth-retarded fetuses before labor. J Clin Endocrinol Metab 82: 4028-4033, 1997
Suzuki K, Sawa R, Muto K, Kusuda S, Banno K, Yamagata Z.
Risk perception of Pregnancy Promotes Disapproval of Gestational Surrogacy: Analysis of a Nationally Representative Opinion Survey in Japan. International Journal of Fertility & Sterility; 5(2), 78-85, 2011
 
清野 裕 関西電力病院・院長 
糖尿病学
Dipeptidyl peptidase 4 (DPP-4) is expressed in mouse and human islets and its activity is decreased in human islets from individuals with type 2 diabetes.
Omar BA, Liehua L, Yamada Y, Seino Y, Marchetti P, Ahren B.
Diabetologia. 2014 Sep;57(9):1876-83. doi: 10.
1007/s00125-014-3299-4. Epub 2014 Jun 18.
Dipeptidyl peptidase-4 inhibitors and sulfonylureas for type 2 diabetes: Friend or foe?
Yabe D, Seino Y.
J Diabetes Investig. 2014 Sep;5(5):475-7. doi: 10.1111/jdi.12229.
Use of the Japanese health insurance claims database to assess the risk of acute pancreatitis in patients with diabetes: comparison of DPP-4 inhibitors with other oral antidiabetic drugs.
Yabe D, Kuwata H, Kaneko M, Ito C, Nishikino R, Murorani K, Kurose T, Seino Y.
Diabetes Obes Metab. 2015 Apr;17(4):430-4. doi: 10.1111/dom.12381. Epub 2014 Sep 17.
 
竹中 洋 大阪医科大学名誉教授
耳鼻咽喉科学
Enhanced human IgE production results from exposure to the aromaticHydrocarbons from diesel exhaust;direct effects on B-cell IgE production, Takenaka H,et al
J Allery CLin Immunol;1998.95:103-115.
コア・ローテイション 耳鼻咽喉科・頭頸部外科
編集 竹中洋、高橋姿、久育男
金芳堂、2004年1月5日
気道アレルギーの成立とその制御:竹中 洋
第110回日本耳鼻咽喉科学術総会宿題報告
東京、2009.05.14.
 
富野 康日己 順天堂大学医学部腎臓内科学講座教授
腎臓内科学
Significance of urinary full-length megalin in patients with IgA nephropathy. Seki T, Asanuma K, Asao R, Nonaka K, Sasaki Y, Oliva Trejo JA, Kurosawa H, Hirayama Y, Horikoshi S, Tomino Y. PLoS One. 2014 Dec 12:9(12): 4114400.doi
Pathogenesis and treatment of Chronic kidney disease: a review of our recent basic and clinical data. Tomino Y. Kidney Blood Press Res. 39:450-489, 2014
Immunopathological Predictors of Prognosis in IgA Nephropathy. New Insights into Glomerulonephritis -Pathogenesis and Treatment-. Tomino Y. Clen N(ed), Contrib Nephrol.(Ed: C. Ronco)Basel, Karger, 181:65-74,2013
 
友池仁暢 榊原記念病院・院長
循環器内科学
外来診療で診る慢性心不全 友池仁暢 Heart View 2016; 20(8):698-703.
Nationwide distribution of cardiovascular practice in Japan ?Results of Japanese Circulation Society 2010 Annual Survey-. Tomoike H, Yokoyama H, Sumita Y, Hanai S, et al. Circulation J 2015;79:1058-1067.
拡張型心筋症ならびに関連する二次性心筋症の診療に関するガイドライン.(班長)友池仁暢 循環器病の診断と治療に関するガイドライン(日本循環器学会)2011;3-79.
 
永井正規 埼玉医科大学公衆衛生学教授
疫学
Prevalence and Incidence of Polymyositis and Dermatomyositis in Japan. Ohta A, Nagai M, Nishina M, Tomimitsu H, Kohsaka H.Mod Rheumatol 24:477-480, 2013.
A case control study of female systemic lupus erythematosus in Japan
MASAKI NAGAI,TOMIO HIROHATA,YOSHIFUJI MATSUMOTO,HIROSHI HASHIMOTO,MASAKAZU KONDO,KOTARO OZASA,MITSURU MORI,TSUTOMU HASHIMOTO,HIDEAK
I NAKAGAWA,TOSHITAKA OMURA,MASAKI MORI,TAKESHI TOJO,HIROSHI YANAGAWA European Journal of Public Health, Volume 3, Issue 3:172-176, 1992
「新しい疫学」永井正規他共著,日本公衆衛生協会,(1995)
 
中村耕三 国立障害者リハビリテーションセンター総長
整形外科学 リハビリテーション医学
Dyggve-Melchior-Clausen syndrome without mental retardation (Smith-McCort dysplasia): morphological findings in the growth plate of the iliac crest. Nakamura K, Kurokawa T, Nagano A, Nakamura S, Taniguchi K, Hamazaki M. Am J Med Genet. 1997 Oct 3;72(1):11-7.
Benign form of congenital angulation of long bones associated with shortening of soft tissues. Nakamura K, Haga N, Manabe N, Iizuka T: Clin Dysmorphol 1998;7: 1-10.
A large-scale genetic association study of ossification of the posterior longitudinal ligament of the spine. Horikoshi T, Maeda K, Kawaguchi Y, Chiba K, Mori K, Koshizuka Y, Hirabayashi S, Sugimori K, Matsumoto M, Kawaguchi H,Takahashi M, Inoue H, Kimura T, Matsusue Y, Inoue I, Baba H, Nakamura K, Ikegawa S: Hum Genet. 2006; 119: 611-616.
 
西岡 清 大阪警察病院顧問
皮膚科学、アレルギー・免疫学
<学術論文>
Hepatocyte growth factor both prevents and ameliorates the symptoms of dermal sclerosis in a mouse model of scleroderma. Wu MH, Yokozeki H, Takagawa S, Yamamoto T, Satoh T, Kaneda Y, Katayama I, Nishioka K. Gene Therapy 2004; 11: 170-180
<学術論文>
In vivo transfection of a cis element “decoy” against signal transducers and activators of transcription 6 (STAT6)-binding site ameliorates IgE-mediated late phase reaction in an atopic dermatitis mouse model. Yokozeki H, Wu MH, Sumi K, Awad S, Satoh T, Katayama I, Takeda K, Akira A, Kaneda Y, Nishioka K. Gene Therapy 2004; 11: 1753-1762
<著書>
「原著に学ぶ英米皮膚科学の古典」西岡 清監修、片山一朗、岩月啓氏、横関博雄監訳、大阪大学皮膚科学教室刊、株式会社AMS(2016)
 
貫和敏博 公益財団法人結核予防会・常務理事
呼吸器内科
Randomized phase II study of concurrent versus sequential alternating gefitinib and chemotherapy in previously untreated non-small cell lung cancer with sensitive EGFR mutations: NEJ005/TCOG0902. Sugawara S, Oizumi S, et al Nukiwa T; Ann Oncol. 2015 May;26(5):888-94.
Risk factors for acute exacerbation of idiopathic pulmonary fibrosis--Extended analysis of pirfenidone trial in Japan.
Kondoh Y, et al. Sugiyama Y, Kudoh S, Nukiwa T. Respir Investig. 2015 Nov;53(6):271-8.
Efficacy of pirfenidone and disease severity of idiopathic pulmonary fibrosis: Extended analysis of phase III trial in Japan.
Taguchi Y, Ebina M, et al. Sugiyama Y, Kudoh S, Nukiwa T; Respir Investig. 2015 Nov;53(6):279-87.
 
福島 雅典 公益財団法人先端医療振興財団 臨床研究情報センター長
腫瘍内科学、臨床試験デザイン・管理・評価、薬剤疫学、医科学
Cultivated oral mucosal epithelial transplantation for persistent epithelial defect in severe ocular surface diseases with acute inflammatory activity.
Sotozono C, Inatomi T, Nakamura T, Koizumi N, Yokoi N, Ueta M, Matsuyama K, Kaneda H, Fukushima M, Kinoshita S.
Acta Ophthalmol. 2014 Sep;92(6):e447-53. doi: 10.1111/aos.12397. Epub 2014 May 19.
Temporal and regional variations in sporadic Creutzfeldt-Jakob disease in Japan, 2001-2010.
Nakatani E, Nishimura T, Zhou B, Kaneda H, Teramukai S, Nagai Y, Fukushima M, Kanatani Y.
Epidemiol Infect. 2015 Apr;143(5):1073-8.
Tanaka S, Fukushima M. Size of Creutzfeldt-Jakob Disease Epidemic Associated with Cadaveric Dura Transplantation. Neuroepidemiology 2010; 34:2, 32-237.
 
水野美邦 順天堂大学名誉教授
神経内科学
Ohta E, Nihira T, Uchino A, Imaizumi Y, Okada Y, Akamatsu W, Takahashi K, Hayakawa H, Nagai M, Ohyama M, Ryo R, Ogino M, Murayama S, Takashima A, Nishiyama K, Mizuno Y, Mochizuki H, Obata F, Okano H. I2020T mutant LRRK2 iPSC-derived neurons in the Sagamihara family exhibit increased Tau phosphorylation through the AKT/GSK-3β signaling pathway. Hum Mol Genet 2015;24(17):4879-900.
Yoshita M, Arai H, Arai H, Arai T, Asada T, Fujishiro H, Hanyu H, Iizuka O, Iseki E, Kashihara K, Kosaka K, Maruno H, Mizukami K, Mizuno Y, Mori E, Nakajima K, Nakamura H, Nakano S, Nakashima K, Nishio Y, Orimo S, Samuraki M, Takahashi A, Taki J, Tokuda T, Urakami K, Utsumi K, Wada K, Washimi Y, Yamasaki J, Yamashina S, Yamada M. Diagnostic Accuracy of 123I-Meta-Iodobenzylguanidine Myocardial Scintigraphy in Dementia with Lewy Bodies: A Multicenter Study. PLoS One. 2015;10:e0120540.
Hauser RA, Schapira AHV, Bbarone P, Mizuno Y, Rascor O, Busse M, Debieuvre C, Fraessdorf M, Poewe P for the Pramipexole ER Studies Group. Long-term safety and sustained efficacy of extende-relearse pramipexole in eraly and advanced Parkinson’s disease. Eur J Neurol 2014;21:736-743
 
宮坂信之 東京医科歯科大学名誉教授
膠原病内科、臨床免疫学
1. Pulmonary infections following immunosuppressive treatments during hospitalization worsen the short-term vital prognosis for patients with connective tissue disease-associated interstitial pneumonia. Tanaka M, Koike R, Sakai R, Saito K, Hirata S, Nagasawa H, Kameda H, Hara M, Kawaguchi Y, Tohma S, Takasaki Y, Dohi M, Nishioka Y, Yasuda S, Miyazaki Y, Kaneko Y, Nanki T, Watanabe K, Yamazaki H, Miyasaka N, Harigai M. Mod. Rheumatol. 2014 Dec 15:1-6. [Epub ahead of print]
2. Injury and subsequent regeneration of muscles activate local innate immunity to facilitate development and relapse of autoimmune myositis. Kimura N, Hirata S, Miyasaka N, Kawahata K, Kohsaka H. Arthritis Rheumatol. 2015 Jan 7. [Epub ahead of print]
3. Effects of intravenous immunoglobulin therapy in Japanese patients with polymyositis and dermatomyositis resistant to corticosteroids: a randomized double-blind placebo-controlled trial. Miyasaka N, Hara M, Koike T, Saito E, Yamada M, Tanaka Y; Additional Members of the GB-0998 Study Group. Mod. Rheumatol. 22(3):382-393, 2012
 
宮ア 久義 特定非営利活動法人
日本医療マネジメント学会理事長
麻酔、病院管理、地域医療、生活習慣病
癌末期痛に対するモリッカの下垂体破壊術?1.経鼻的下垂体穿刺に必要な基礎的と方法?.宮崎久義,後藤倶子,岡元和文,宇都宮高賢,森岡亨,山室誠,麻酔27:1606-1612.1978
癌末期痛に対するモリッカの下垂体破壊術?2.その成績と作用機序に対する考察?.宮崎久義,後藤倶子,岡元和文,宇都宮高賢,森岡亨,山室誠,麻酔28(1):77-82.1979
Critical Pathway: Practical applications and its development in Japan.Hisayoshi Miyazaki,Teruhiko Matsushima. JMAJ48(11):568-571.2005

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