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難治性疾患克服研究事業中間・事後評価委員名簿

(○:委員長)

 
浅香正博 北海道医療大学 学長
消化器内科学、がん予防学
Vonoprazan, a novel potassium-competitive acid blocker, as a component of first-line and second-line triple therapy for Helicobacter pylori eradication: a phase III, randomised, double-blind study. Gut. 65:1439-1446,2016
Murakami K, Sakurai Y, Shiino M, Funao N, Nishimura A, Asaka M.
消化器病学-基礎と臨床-
浅香正博、菅野健太郎、千葉勉編集、浅香正博:消化器疾患診断への手順:2-7p、西村書店、2013
Special lecture: Roadmap to eliminate gastric cancer in Japan. Asaka M 15th Congress of Gastroenterology in China. Tianjin, China 2015
 
五十嵐 隆 国立成育医療研究センター理事長
小児科学
Seki M, Nishimura R, Yoshida K, Shimamura T, Shiraishi Y, Sato Y, Kato M, Chiba K, Tanaka H, Hoshino N, Nagae G, Shiozawa Y, Okuno Y, Hosoi H, Tanaka Y, Okita H, Miyachi M, Souzaki R, Taguchi T, Koh K, Hanada R, Kato K, Nomura Y, Akiyama M, Oka A, Igarashi T, Miyano S, Aburatani H, Hayashi Y, Ogawa S, Takita J: Integrated genetic and epigenetic analysis defines novel molecular subgroups in rhabdomyosaracoma. Nature Commu 6: 7557, 2015
五十嵐 隆、石川冬木、阿久津英憲、石井哲也、岡野英之、佐藤文彦、建石真公子、柘植あづみ、町野朔、松原洋一、苛原稔、金田安史、高橋智、藤井知行(医学・医療領域におけるゲノム編集技術のあり方検討委員会):提言:我が国の医学・医療領域におけるゲノム編集技術のあり方、平成29年(2017年)9月27日 日本学術会議
五十嵐隆:小児腎疾患の臨床、診断と治療社、改訂第6版、東京、2015
 
石橋 達朗 九州大学病院 病院長
眼科
Ishikawa K, Yoshida S, Nakao S, Nakama T, Kita T, Asato R, Sassa Y, Arita R, Miyazaki M, Enaida H, Oshima Y, Murakami N, Niiro H, Ono J, Matsuda A, Goto Y, Akashi K, Izuhara K, Kudo A,Kono T, Hafezi-Moghadam A, Ishibashi T:
Periostin promotes the generation of fibrous membranes in proliferative vitreoretinopathy. FASEB J 28(1):131-142, 2014
Nakama T, Yoshida S, Ishikawa K, Kobayashi Y, Zhou Y, Nakao S, Sassa Y, Oshima Y, Takao K, Shimahara A, Yoshikawa K, Hamasaki T, Ohgi T, Hayashi H, Matsuda A, Kudo A, Nozaki M, Ogura Y, Kuroda M, Ishibashi T:
Inhibition of choroidal fibrovascular membrane formation by new class of RNA interference therapeutic agent targeting periostin.
Gene Ther 22(2):127-137, 2015
Ishibashi T, Li X, Koh A, Lai, Lee F-L, Lee W-K, Ma Z, Ohji M,Tan N,
Cha S B, Shamsazar J, Yau C L, on behalf of the REVEAL Study
Group:The REVEAL Study : Ranibizumab Monotherapy or Combined with Laser versus Laser Monotherapy in Asian Patients with Diabetic Macular Edema.
Ophthalmology 122(7):1402-1415, 2015
 
岡本 幸市 公益財団法人老年病研究所所長
神経内科学
An autopsy case of familial amyotrophic lateral sclerosis with a TARDBP Q343R mutation. Okamoto K, Fujita Y, Hoshino E, Tamura Y, Fukuda T, Hasegawa M, Takatama M. Neuropathology, 2015 Oct;35(5):462-468.
Anti-MuSK antibody-positive myasthenia gravis mimicking amyotrophic lateral sclerosis. Furuta N, Ishizawa K, Shibata M, Tsukagoshi S, Nagamine S, Makioka K, Fujita Y, Ikeda M, Yoshimura S, Motomura M, Okamoto K, Ikeda Y. Intern Med, 2015 Oct;54(19):2497-2501.
Ectopic germinoma involving multiple midline and paramedian structures outside the pineal gland or hypophyseal region of the brain prior to tumor development. Hayashi S, Okamoto K. J Neurol Sci, 2015 Nov 15;358(1-2):512-514.
 
長村義之 国際医療福祉大学大学院教授
病理学、内分泌学、腫瘍学
Hirohata T, Asano K, Ogawa Y, Takano S, Amano K, Isozaki O, Iwai Y, Sakata K, Fukuhara N, Nishioka H, Osamura RY, et al: DNA mismatch repair protein (MSH6) correlated with the responses of atypical pituitary adenomas and pituitary carcinomas to temozolomide: the national cooperative study by the Japan Society for Hypothalamic and Pituitary Tumors. J Clin Endocrinol Metab 2013, 98:1130-1136.
Egashira N, Takekoshi S, Takei M, Teramoto A, Osamura RY: Expression of FOXL2 in human normal pituitaries and pituitary adenomas. Mod Pathol 2011, 24:765-773.
WHO Classification of Tumours of Endocrine Organs, WHO/IARC Classification of Tumours, 4th Edition, Volume 10, 2017, Edited by Lloyd RV, Osamura RY, Kloppel G, Rosai J,
 
小池 隆夫 NTT東日本札幌病院院長・北海道大学名誉教授
リウマチ学・臨床免疫学・内分泌学・糖尿病学
Koike T.
Antiphospholipid syndrome: 30 years and our contribution.
Int J Rheum Dis.18(2):233-41, 2015.
Koike T.
My contribution, my dream a look at the future of APS.Lupus. 23(12):1332-1334, 2014.
Koike T.
The new era of autoimmune disease research.
Arthritis Res Ther. 13(3):113.2011
 
齊藤 延人 東京大学大学院医学系研究科教授
脳神経外科学
Differences in genetic and epigenetic alterations between von Hippel-Lindau disease-related and sporadic hemangioblastomas of the central nervous system. Takayanagi S, Mukasa A, Tanaka S, Nomura M, Omata M, Yanagisawa S, Yamamoto S, Ichimura K, Nakatomi H, Ueki K, Aburatani H, and Saito N. Neuro Oncol. 2017 Sep;19(9):1228-1236.
The importance of encephalo-Myo-synangiosis in surgical revascularization strategies for moyamoya disease in children and adults. Imai H, Miyawaki S, Ono H, Nakatomi H, Yoshimoto Y, Saito N. World Neurosurg. 2015 May;83(5):691-699
Identification of agenetic variant common to moyamoya disease and intracranial major artery stenosis/occlusion. Miyawaki S, Imai H, Takayanagi S, Mukasa A, Nakatomi H, Saito N. Stroke 2012 Dec;43(12):3371-3374
 
堺 秀人 医療法人仁泉会理事
腎臓病学
Shiiki, H., Saito, T., Nishitani, Y., Mitarai, T., Yorioka, N., Yoshimura, A.,Hitoshi Yokoyama, H., Nishi, S., Tomino, Y., Kiyoshi Kurokawa,K., Sakai, H.:Prognosis and risk factors for idiopathic membranousnephropathy with nephrotic syndrome in Japan. Kidney Int 65(4): 1400-1407,2004
AMEDとともに進む日本の腎臓研究、堺秀人、腎臓39:30-33, 2017
AMED腎疾患実用化研究事業の説明、堺秀人、平成28年度日本腎臓学会総会、2016年6月17日
 
澤倫太郎 日本医師会総合政策研究機構・研究部長
胎児生理学、産科学、医療経済学
Sawa R, Asakura H, Power GG.           
Changes in plasma adenosine during simulated birth of fetal sheep.
J Appl Physiol 70(4): 1524-1528, 1991
Sawa R, Yoneyama Y, Otsubo Y, Suzuki S, Kubonoya K, Power GG,
Araki T.
Fetal plasma hypoxanthine level in growth-retarded fetuses before labor. J Clin Endocrinol Metab 82: 4028-4033, 1997
Suzuki K, Sawa R, Muto K, Kusuda S, Banno K, Yamagata Z.
Risk perception of Pregnancy Promotes Disapproval of Gestational Surrogacy: Analysis of a Nationally Representative Opinion Survey in Japan. International Journal of Fertility & Sterility; 5(2), 78-85, 2011
嶋 幸男 国際医療福祉大学大学院教授、柳川療育センター施設長
小児神経学、神経病理学
Neuronal plasticity in the developing and aging cerebral cortices of patients with Down syndrome.Takashima M, Takahashi S, Yokoo M, Iwata O, Iwata S, Takashima S・International Journal of Neuro- rehabilitation, 1:2, 2014
A history of our understanding of cerebral vascular development and pathogenesis of perinatal brain damage over the past 30 years, and further prospective.Takashima S, Itoh M, Oka A・Seminars in Pediatric Neurology 16:226-36, 2009
Pediatric Neuropathology- a text and atlas.Armstrong D, Halliday W, Hawkins C, Takashima S、Springer, Tokyo, 2007.
 
竹中 洋 大阪医科大学名誉教授
耳鼻咽喉科学
Enhanced human IgE production results from exposure to the aromaticHydrocarbons from diesel exhaust;direct effects on B-cell IgE production, Takenaka H,et al
J Allery CLin Immunol;1998.95:103-115.
コア・ローテイション 耳鼻咽喉科・頭頸部外科
編集 竹中洋、高橋姿、久育男
金芳堂、2004年1月5日
気道アレルギーの成立とその制御:竹中 洋
第110回日本耳鼻咽喉科学術総会宿題報告
東京、2009.05.14.
 
坪内博仁 鹿児島市立病院 病院長
消化器内科、肝臓病
Purification and Partial Characterization of Hepatocyte Growth Factor from Plasma of a Patient with Fulminant Hepatic Failure. Gohda E, Tsubouchi H, Nakayama H, Hirono S, Sakiyama O, Takahashi K, Miyazaki H, Hashimoto S, and Daikuhara Y. J.Clin.Invest.1988 Feb; 81: 414-419.
Molecular Cloning and Sequence Analysis of cDNA for Human Hepatocyte Growth Factor. Miyazawa K, Tsubouchi H, Naka D, Takahashi K, Okigaki M, Arakaki N Nakayama H, Hirono S, Sakiyama O, Takahashi K, Gohda E, Daikuhara Y, and Kitamura N. Biochemical and Biophysical Research Communications. 1989 Sep; 163(2): 967-973
Safety and pharmacokinetics of recombinant human hepatocyte growth factor(rh-HGF)in patients with fulminant hepatitis: a phase I/II clinical trial, following preclinical studies to ensure safety. Ido A, Moriuchi A, Numata M, Murayama T, Teramukai S, Marusawa H, Yamaji N, Setoyama H, Kim I, Chiba T, Higuchi S, Yokode M, Fukushima M, Shimizu A and Tsubouchi H. Journal of Translational Medicine. 2011; 9: 55.
 
永井正規 埼玉医科大学公衆衛生学教授
疫学
Prevalence and Incidence of Polymyositis and Dermatomyositis in Japan. Ohta A, Nagai M, Nishina M, Tomimitsu H, Kohsaka H.Mod Rheumatol 24:477-480, 2013.
A case control study of female systemic lupus erythematosus in Japan
MASAKI NAGAI,TOMIO HIROHATA,YOSHIFUJI MATSUMOTO,HIROSHI HASHIMOTO,MASAKAZU KONDO,KOTARO OZASA,MITSURU MORI,TSUTOMU HASHIMOTO,HIDEAK
I NAKAGAWA,TOSHITAKA OMURA,MASAKI MORI,TAKESHI TOJO,HIROSHI YANAGAWA European Journal of Public Health, Volume 3, Issue 3:172-176, 1992
「新しい疫学」永井正規他共著,日本公衆衛生協会,(1995)
 
中村耕三 国立障害者リハビリテーションセンター総長
整形外科学 リハビリテーション医学
Dyggve-Melchior-Clausen syndrome without mental retardation (Smith-McCort dysplasia): morphological findings in the growth plate of the iliac crest. Nakamura K, Kurokawa T, Nagano A, Nakamura S, Taniguchi K, Hamazaki M. Am J Med Genet. 1997 Oct 3;72(1):11-7.
Benign form of congenital angulation of long bones associated with shortening of soft tissues. Nakamura K, Haga N, Manabe N, Iizuka T: Clin Dysmorphol 1998;7: 1-10.
A large-scale genetic association study of ossification of the posterior longitudinal ligament of the spine. Horikoshi T, Maeda K, Kawaguchi Y, Chiba K, Mori K, Koshizuka Y, Hirabayashi S, Sugimori K, Matsumoto M, Kawaguchi H,Takahashi M, Inoue H, Kimura T, Matsusue Y, Inoue I, Baba H, Nakamura K, Ikegawa S: Hum Genet. 2006; 119: 611-616.
 
西岡 清 大阪警察病院顧問
皮膚科学、アレルギー・免疫学
<研究論文>
Hepatocyte growth factor both prevents and ameliorates the symptoms of dermal sclerosis in a mouse model of scleroderma. Wu MH, Yokozeki H, Takagawa S, Yamamoto T, Satoh T, Kaneda Y, Katayama I, Nishioka K.
Gene Therapy 2004; 11: 170-180
<学術論文>
In vivo transfection of a cis element “decoy” against signal transducers and activators of transcription 6 (STAT6)-binding site ameliorates IgE-mediated late phase reaction in an atopic dermatitis mouse model. Yokozeki H, Wu MH, Sumi K, Awad S, Satoh T, Katayama I, Takeda K, Akira A, Kaneda Y, Nishioka K, Gene Therapy 2004; 11: 1753-1762
<著書>
「原著に学ぶ英米皮膚科学の古典」西岡清監修、片山一朗、岩月啓氏、横関博雄監訳、大阪大学皮膚科学教室刊、株式会社AMS(2016)
 
貫和敏博 公益財団法人結核予防会・常務理事
呼吸器内科
Randomized phase II study of concurrent versus sequential alternating gefitinib and chemotherapy in previously untreated non-small cell lung cancer with sensitive EGFR mutations: NEJ005/TCOG0902. Sugawara S, Oizumi S, et al Nukiwa T; Ann Oncol. 2015 May;26(5):888-94.
Risk factors for acute exacerbation of idiopathic pulmonary fibrosis--Extended analysis of pirfenidone trial in Japan.
Kondoh Y, et al. Sugiyama Y, Kudoh S, Nukiwa T. Respir Investig. 2015 Nov;53(6):271-8.
Efficacy of pirfenidone and disease severity of idiopathic pulmonary fibrosis: Extended analysis of phase III trial in Japan.
Taguchi Y, Ebina M, et al. Sugiyama Y, Kudoh S, Nukiwa T; Respir Investig. 2015 Nov;53(6):279-87.
 
平田結喜緒 (公財)先端医療振興財団・先端医療センター病院長、東京医科歯科大学名誉教授
内分泌代謝学、糖尿病、高血圧、心血管分子生物学
1.Regulation of growth hormone secretion by (pro)renin receptor.Tani,Y,Yamada,S,Inoshita,N,Hirata,Y,Schichiri,M. Sci Rep 5:100878/DOI:10.1038/strep10878
2.Salusin-b as a powerful endogenous antidispogenic neuropeptide.Suzuki-Kemuriyama,N,Nakano-Tataeno,T,Tani,Y,Hirata,Y, Schichiri,M. Sci Rep 6:20988/DOI:10.1038/strep20988
3.Transcriptome analysis of aldosterone- regulated genes in human vascular endothelial cell lines stably expressing mineralocorticoid receptor.Sekizawa,N,Yoshimoto,T,Hayakawa,E,Suzuki,N,Sugiyama,T,
Hirata,Y.MolCelEndocrinol2011,341:78-88/doi:10.1016/j.mce.2011.05.029
 
福島 雅典 公益財団法人先端医療振興財団 臨床研究情報センター長
腫瘍内科学、臨床試験デザイン・管理・評価、薬剤疫学、医科学
Cultivated oral mucosal epithelial transplantation for persistent epithelial defect in severe ocular surface diseases with acute inflammatory activity.
Sotozono C, Inatomi T, Nakamura T, Koizumi N, Yokoi N, Ueta M, Matsuyama K, Kaneda H, Fukushima M, Kinoshita S.
Acta Ophthalmol. 2014 Sep;92(6):e447-53. doi: 10.1111/aos.12397. Epub 2014 May 19.
Temporal and regional variations in sporadic Creutzfeldt-Jakob disease in Japan, 2001-2010.
Nakatani E, Nishimura T, Zhou B, Kaneda H, Teramukai S, Nagai Y, Fukushima M, Kanatani Y.
Epidemiol Infect. 2015 Apr;143(5):1073-8.
Tanaka S, Fukushima M. Size of Creutzfeldt-Jakob Disease Epidemic Associated with Cadaveric Dura Transplantation. Neuroepidemiology 2010; 34:2, 32-237.
 
宮ア 久義 特定非営利活動法人
日本医療マネジメント学会理事長
麻酔、病院管理、地域医療、生活習慣病
癌末期痛に対するモリッカの下垂体破壊術-1.経鼻的下垂体穿刺に必要な基礎的と方法-.宮崎久義,後藤倶子,岡元和文,宇都宮高賢,森岡亨,山室誠,麻酔27:1606-1612.1978
癌末期痛に対するモリッカの下垂体破壊術-2.その成績と作用機序に対する考察-.宮崎久義,後藤倶子,岡元和文,宇都宮高賢,森岡亨,山室誠,麻酔28(1):77-82.1979
Critical Pathway: Practical applications and its development in Japan.Hisayoshi Miyazaki,Teruhiko Matsushima. JMAJ48(11):568-571.2005
 
吉栖 正生 広島大学大学院医歯薬保健学研究科教授
循環器病学
Osteoprotegerin Prevents Development of Abdominal Aortic Aneurysms. Bumdelger B, Kokubo H, Kamata R, Fujii M, Yoshimura K, Aoki H, Orita Y, Ishida T, Ohtaki M, Nagao M, Ishida M, Yoshizumi M. PLoS One. 2016 Jan 19;11(1):e0147088.
Smoking cessation reverses DNA double-strand breaks in human mononuclear cells. Ishida M, Ishida T, Tashiro S, Uchida H, Sakai C, Hironobe N, Miura K, Hashimoto Y, Arihiro K, Chayama K, Kihara Y, Yoshizumi M. PLoS One. 2014 Aug 5;9(8):e103993.
腹部大動脈瘤検出装置
吉栖 正生,辻 敏夫,藤田 悦則,小倉 由美,前田 慎一郎
  日本国特許出願 2009-118095  2009

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