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革新的がん医療実用化研究事業

(○:委員長)

堀田 知光 国立がん研究センター 理事長・総長
血液腫瘍内科
Phase II/III Study of R-CHOP-21 Versus R-CHOP-14 for Untreated Indolent B-Cell Non-Hodgkin’s Lymphoma: JCOG 0203 Trial
Watanabe T, Tobinai K, Shibata T, Tsukasaki K, Morishima Y, Maseki N, Kinoshita T, Suzuki T, Yamaguchi M, Ando K, Ogura M, Taniwaki M, Uike N, Takeuchi K, Nawano S, Terauchi T and Hotta T
J Clinical Oncol 29(30):3990-3998, Oct 2011
Phase II Study of cyclophosphamide, doxorubicin, vincristine, prednisolone (CHOP) therapy for newly diagnosed patients with low- and low-intermediate risk, aggressive non-Hodgkin’s lymphoma: final results of the japan Clinical Oncology Group Study, JCOG9508
Kagami Y, Itoh K, Tobinai K, Fukuda H, Mukai K, Chou T, Mikuni C, Kinoshita T, Fukushima N, Kiyama Y, Suzuki T, Sasaki T, Watanabe Y, Tsukasaki K, Shimoyama M, Ogura M and Hotta T
Intl J of Hematology 96:74-83, Jun 2012
Phase I study of BCX1777 (forodesine) in patients with relapsed or refractory peripheral T/natural killer-cell malignancies
Ogura M, Tsukasaki K, Nagai H, Uchida T, Oyama T, Suzuki T, Taguchi J, Maruyama D, Hotta T and Tobinai K
Cancer Science 103(7):1290-1295, Jul 2012
 
澁谷 正史 上武大学 学長
腫瘍学、分子生物学、血管生物学
(業績・実績その1 学術総説論文)
VEGFR and Type-V RTK Activation and Signaling. Shibuya M. In the Receptor Tyrosine Kinase Book, Edited by Y. Schlessinger et al. Cold Spring Harb Perspect Biol. 2013 Oct 1;5(10). doi:pii: a009092
(業績・実績その2 学術論文)
Inhibition of histone demethylase JMJD1A improves anti-angiogenic therapy and reduces tumor associated macrophages. Osawa T, Tsuchida R, Muramatsu M, Shimamura T, Wang F, Suehiro JI, Kanki Y, Wada Y, Yuasa Y, Aburatani H, Miyano S, Minami T, Kodama T, Shibuya M. Cancer Res. 73:3019-28, 2013.
(業績・実績その3 学術総説論文)
Involvement of Flt-1 (VEGFR-1) in cancer and preeclampsia. Shibuya, M. Proc Jpn Acad Ser B Phys Biol Sci. 87:167-78, 2011.
 
宮園 浩平 東京大学大学院医学系研究科分子病理学 教授
分子病理学、分子腫瘍学
Smad3 and TTF-1/NKX2-1 complex regulates Smad4-independent gene expression. Isogaya K, *Koinuma D, Tsutsumi S, Saito RA, Miyazawa K, Aburatani H, *Miyazono K. Cell Res. 2014, 24 (8): 994-1008.
Bone morphogenetic protein-9 inhibits lymphatic vessel formation via activin receptor-like kinase 1 during development and cancer progression. Yoshimatsu Y, Lee YG, Akatsu Y, Taguchi L, Suzuki HI, Cunha SI, Maruyama K, Suzuki Y, Yamazaki T, Katsura A, Oh SP, Zimmers TA, Lee SJ, Pietras K, Koh GY, *Miyazono K, Watabe T. Proc Natl Acad Sci USA. 2013, 110 (47): 18940-18945.
MCPIP1 ribonuclease antagonizes dicer and terminates microRNA biogenesis through precursor microRNA degradation. Suzuki HI, Arase M, Matsuyama H, Choi YL, Ueno T, Mano H, Sugimoto K, *Miyazono K. Mol Cell. 2011, 44 (3): 424-436.
 
中釜 斉 独立行政法人国立がん研究センター
理事(兼)研究所長
 
Ohki R, Saito K, Chen Y, Kawase T, Hiraoka N, Saigawa R, Minegishi M, Aita Y, Yanai G, Shimizu H, Yachida S, Sakata N, Doi R, Kosuge T, Shimada K, Tycko B, Tsukada T, Kanai Y, Sumi S, Namiki H, Taya Y, Shibata T, Nakagama H. PHLDA3 is a novel tumor suppressor of pancreatic neuroendocrine tumors. Proc Natl Acad Sci U S A., 111(23):E2404-13, 2014
Onuma K, Ochiai M, Orihashi K, Takahashi M, Imai T, Nakagama H, Hippo Y. Genetic reconstitution of tumorigenesis in primary intestinal cells. Proc Natl Acad Sci U S A, 110(27):11127-32, 2013
Tsuchiya N, Izumiya M, Ogata-Kawata H, Okamoto K, Fujiwara Y, Nakai M, Okabe A, Schetter AJ, Bowman ED, Midorikawa Y, Sugiyama Y, Aburatani H, Harris CC, Nakagama H. Tumor Suppressor miR-22 Determines p53-Dependent Cellular Fate through Post-transcriptional Regulation of p21. Cancer Res, 71(13):4628-4639, 2011
 
清木 元治 高知大学・特任教授
がんの分子生物学
Seiki, M., Eddy, R., Shows, T.B., and Yoshida, M. (1984). Nonspecific integration of the HTLV provirus genome into adult T-cell leukaemia cells. Nature 309, 640-642.
Seiki, M., Hikikoshi, A., Taniguchi, T., and Yoshida, M. (1985). Expression of the pX gene of HTLV-I: general splicing mechanism in the HTLV family. Science 228, 1532-1534.
Sato, H., Takino, T., Okada, Y., Cao, J., Shinagawa, A., Yamamoto, E., and Seiki, M. (1994). A matrix metalloproteinase expressed on the surface of invasive tumour cells. Nature 370, 61-65.
 
祖父江 友孝 大阪大学大学院医学系研究科教授
がん疫学
Cigarette smoking and subsequent risk of lung cancer by histologic type in middle-aged Japanese men and women: the JPHC study. Sobue T, Yamamoto S, Hara M, Sasazuki S, Sasaki S, Tsugane S. Int J Cancer. 2002; 99: 245-251.
Screening for lung cancer with low-dose helical computed tomography: Anti-Lung Cancer Association Project. Sobue T, Moriyama N, Kaneko M, Kusumoto M, Kobayashi T, Tsuchiya R, Kakinuma R, Ohmatsu H, Nagai K, Nishiyama H, Matsui E, Eguchi K. J Clin Oncol. 2002; 20: 911-20.
A case-control study for evaluating lung-cancer screening in Japan. Sobue T, Suzuki T, Naruke T. Int J Cancer. 1992; 50:230-7.
 
田島 和雄 三重大学医学部公衆衛生・産業医学分野 客員教授
疫学、公衆衛生学
現代の五大病「がん」Q&A 田島和雄 監修
毎日ムック(毎日新聞社)・完全保存版・30-63頁・2013年
Ethnoepidemiology of HTLV-1 related diseases: Ethnic determinants of HTLV-1 susceptibility and its worldwide dispersal. Sonoda. S., Li, H.C., Tajima, K., Cancer Sci., 2011, 102:295-301.
2q36.3 is associated with prognosis for estorogen receptor-negative breast cancer patients treated with chemotherapy. Li, J., Matsuo, K., Ito, H., Iwata, H., Tajima, K. et al., Nat. Commun., 2014, 5: 4051.
 
吉田 稔 国立研究開発法人理化学研究所 環境資源科学研究センター 創薬・医療技術基盤連携部門・部門長
化学遺伝学
Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A
Yoshida, M; Kijima, M; Akita, M; Beppu, T.
Journal of Biological Chemistry, 265 (28): 17174-17179 (1990)
Times Cited: 1361
CRM1 is an export receptor for leucine-rich nuclear export signals
Fornerod, M; Ohno, M; Yoshida, M; Mattaj, IW.
Cell, 90 (6): 1051-1060 (1997)
Times Cited: 1361
Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA
Kaida, D; Motoyoshi, H; Tashiro, E; Nojima, T; Hagiwara, M; Ishigami, K; Watanabe, H; Kitahara, T; Yoshida, T; Nakajima, H; Tani, T; Horinouchi, S; Yoshida, M.
 
大津 敦 国立がん研究センター先端医療開発センター長
腫瘍内科
Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Bang YJ, Van Cutsem E, Ohtsu A, et al, Lancet 376: 687-697, 2010
TAS-102 monotherapy for pretreated metastatic colorectal cancer: a double-blind, randomised, placebo-controlled phase 2 trial. Yoshino T, Mizunuma N, Yamazaki K, Nishina T, Komatsu Y, Baba H, Tsuji A, Yamaguchi K, Muro K, Sugimoto N, Tsuji Y, Moriwaki T, Esaki T, Hamada C, Tanase T, Ohtsu A. Lancet Oncol. 13(10):993-1001, 2012
Randomized phase III trial of 5-fluorouracil alone versus 5-fluorouracil plus cisplatin versus uracil and tegafur plus mitomycin C in patients with unresectable advanced gastric cancer: the Japan Clinical Oncology Group Study (JCOG9205). Ohtsu A, Shimada Y, Shirao K, et al. J Clin Oncol, 21: 54-59, 2003
 
野田 哲生 公益財団法人がん研究会
代表理事・常務理事 がん研究所 所長
分子遺伝学
H. Takeshima, M. Iino, H. Takekura, M. Nishi, J. Kuno, O. Minowa, H. Takano and T. Noda. (1994) Excitation-contraction uncoupling and muscular degeneration in mice lacking functional skeletal muscle ryanodine-receptor gene. Nature, 369: 556-559.
H. Shibata, K. Toyama, H. Shioya, M. Ito, M. Hirota, S. Hasegawa, H. Matsumoto, H. Takano, T. Akiyama, K. Toyoshima, R. Kanamaru, Y. Kanegae, I. Saito, Y. Nakamura, K. Shiba and T. Noda. (1997) Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene. Science, 278: 120-123.
R. Yao, Y. Kondoh, Y. Natsume, H. Yamanaka, M. Inoue, H. Toki, R. Takagi, T. Shimizu, T. Yamori, H. Osada and T. Noda. (2014) A small compound targeting TACC3 revealed its different spatiotemporal contributions for spindle assembly in cancer cells. Oncogene, 33: 4242-4252.
 
米田 悦啓 国立研究開発法人 医薬基盤・健康・栄養研究所
理事長
分子細胞生物学・生化学
Antibodies to Asp-Asp-Glu-Asp can inhibit transport of nuclear proteins into the nucleus. Yoneda, Y., Imamoto-Sonobe, N., Matsuoka, Y., Iwamoto, R., Kiho, Y., and Uchida, T.
Science, 242: 275-278 (1988)
The structure of importin-? bound to SREBP-2: Insights into nuclear import of a transcription factor. Lee, S. J., Sekimoto, T., Yamashita, E., Nagoshi, E., Nakagawa, A., Imamoto, N., Yoshimura, M., Sakai, H., Chong, K. T., Tsukihara, T. and Yoneda, Y.
Science, 302: 1571-1575 (2003)
Triggering neural differentiation of ES cells by subtype switching of importin-?. Yasuhara, N., Shibazaki, N., Tanaka, S., Nagai, M., Kamikawa, Y., Oe, S., Kamachi, Y., Kondoh, H. and Yoneda, Y.
Nature Cell Biol., 9: 72-79 (2007)
 
杉山 雄一 理化学研究所 イノベーション推進センター
杉山特別研究室
薬物動態学
Aida K, Hayashi H, Inamura K, Mizuno T and Sugiyama Y. Differential roles of ubiquitination in the degradation mechanism of cell surface-resident bile salt export pump and multidrug
resistance-associated protein 2. Mol Pharmacol 85:482-491 (2014).
Izumi S, Nozaki Y, Komori T, Maeda K, Takenaka O, Kusano K, Yoshimura T, Kusuhara H and Sugiyama Y. Substrate-dependent inhibition of organic anion transporting polypeptide 1B1: comparative analysis with prototypical probe substrates estradiol-17beta-glucuronide,
estrone-3-sulfate, and sulfobromophthalein. Drug Metab Dispos 41:1859-1866 (2013).
Yoshida K, Maeda K and Sugiyama Y. Hepatic and intestinal drug transporters: prediction of pharmacokinetic effects caused by drug-drug interactions and genetic polymorphisms.
Annu Rev Pharmacol Toxicol. ;53: 581-612 (2013).
 
橋爪 誠 九州大学大学院医学研究院先端医療医学講座・教授
消化器外科 コンピュータ外科 ロボット手術
Murata M, Narahara S, Umezaki K, Toita R, Tabata S, Piao J, Abe K, Kang J, Ohuchida K, Cui L, Hashizume M: Liver cell specific targeting by the preS1 domain of hepatitis B virus surface antigen displayed on protein nanocages.
International Journal of Nanomedicine. 7:4353-62, 2012
Hashizume M:
MR image-guided surgical robotic system.
International Journal of Computer Assisted Radiology and Surgery 1(1): 203-205, 2006
Arata J, Kenmotsu H, Takagi M, Hori T, Miyagi T, Fujimoto H, Kajita Y, Hayashi Y, Chinzei K, Hashizume M:
Surgical bedside master console for neurosurgical robotic system.
Int J CARS 8(1): 75-86, 2013
 
佐久間 一郎 東京大学大学院工学系研究科
生体医工学、精密工学
Junchen Wang, Etsuko Kobayashi, Ichiro Sakuma, Coarse-to-fine dot array marker detection with accurate edge localization for stereo visual tracking, Biomedical Signal Processing and Control 15,pp49-59, 2015
Kuan Luan, Takashi Ohya, Hongen Liao, Etsuko Kobayashi, Ichiro Sakuma: Vessel bifurcation localization based on intraoperative three-dimensional ultrasound and catheter path for image-guided catheter intervention of oral cancers, Computerized Medical Imaging and Graphics 37, pp:113-122, 2013
岸宏亮、藤江正克、橋爪誠、佐久間一郎、土肥健純:ロッド駆動型多関節術具とこれを用いたMRI環境対応小型マスタスレーブマニピュレータ、日本ロボット学会誌 Vol.27 No.6:pp652-660、2009
 
赤堀 眞 東京大学医学部附属病院臨床研究支援センター 特任専門員
医療機器レギュラトリーサイエンス
厚生労働科学研究費補助金医療技術実用化総合研究事業「東日本大震災が治験等に及ぼした影響の調査と今後の対策に関する研究」平成23年度総括研究報告書 平成24年5月
「文部科学省・厚生労働省平成25年度成果報告会:企業の立場から見る早期・探索的臨床試験拠点及び臨床研究中核病院 -企業経験者からの視点」赤堀眞,臨床薬理,42 (Suppl XXXIII): 247-249 (2014)
「薬事法改正がもたらす医療機器開発の促進に対するアカデミアの期待」赤堀眞,レギュラトリーサイエンス学会誌,4(3): 231-235(2014)
 
横山 晶 公益財団法人新潟県保健衛生センター・副理事長
臨床腫瘍学・呼吸器内科学
Randomized phase III trial comparing weekly docetaxel plus cisplatin versus docetaxel monotherapy every 3 weeks in elderly patients with advanced non-small-cell lung cancer: the intergroup trial JCOG0803/WJOG4307L. Abe T, Takeda K, Ohe Y, Kudoh S, Ichinose Y, Okamoto H, Yamamoto N, Yoshioka H, Minato K, Sawa T, Iwamoto Y, Saka H, Mizusawa J, Shibata T, Nakamura S, Ando M, Yokoyama A, Nakagawa K, Saijo N, Tamura T. J Clin Oncol. 2015 Feb 20;33(6):575-81.
Randomized controlled trial comparing docetaxel-cisplatin combination with weekly docetaxel alone in elderly patients with advanced non-small-cell lung cancer: Japan Clinical Oncology Group (JCOG) 0207. Tsukada H, Yokoyama A, Goto K, Shinkai T, Harada M, Ando M, Shibata T, Ohe Y, Tamura T, Saijo N; Lung Cancer Study Group of the Japan Clinical Oncology Group(JCOG). Jpn J Clin Oncol. 2015
Jan;45(1):88-95.
Thoracic radiotherapy with or without daily low-dose carboplatin in elderly patients with non-small-cell lung cancer: a randomised, controlled, phase 3 trial by the Japan Clinical Oncology Group (JCOG0301). Atagi S, Kawahara M, Yokoyama A, Okamoto H, Yamamoto N, Ohe Y, Sawa T, Ishikura S, Shibata T, Fukuda H, Saijo N, Tamura T; Japan Clinical Oncology Group Lung Cancer Study Group. Lancet Oncol. 2012 Jul;13(7):671-8.
 
篠田 雅幸 愛知県がんセンター中央病院・名誉院長
消化器外科学
Masayuki Shinoda, Nobutoshi Ando, Ken Kato, Satoshi Ishikura, Hoichi Kato, Yasuhiro Tsubosa, Keiko Minashi, Hiroshi Okabe, Yusuke Kimura, Tatsuyuki Kawano, Shin-Ichi Kosugi, Yasushi Toh, Kenichi Nakamura, Haruhiko Fukuda and Japan Clinical Oncology Group:Randomized study of low-dose versus standard-dose chemoradiotherapy for unresectable esophageal squamous cell carcinoma (JCOG0303).Cancer Science 106; 407-412, 2015
Isao Oze, Keitaro Matsuo, Stoyo Hosono, Hidemi Ito, Miki Watanabe, Shunzo Hatooka, Yasushi Hasegawa, Masayuki Shinoda, Kazuo Tajima and Hideo Tanaka: Coffee and green tea consumption is associated with upper aerodigestive tract cancer in Japan. Int J Cancer 135(2): 391-400, 2014
Naoko Sanuki, Satoshi Ishikura, Masayuki Shinoda, Yoshinori Ito, Kzushige Hayakawa, Nobutoshi Ando: Radiotherapy quality assurance review for a multi-center randomized trial of locally advanced esophageal cancer: the Japan Clinical Oncology Group (JCOG) trial 0303. Int Clin Oncol 17; 105-111,2011
 
佐野 武 がん研有明病院消化器外科部長
消化器外科学、胃腫瘍学
Surgery for cancer of the stomach. Sano T. In: Oesophagogastric Surgery, Saunders, London, 2013
D2 lymphadenectomy alone or with para-aortic nodal dissection for gastric cancer. 74. Sasako M, Sano T, Yamamoto S, Kurokawa Y, Nashimoto A, Kurita A, Hiratsuka M, Tsujinaka T, Kinoshita T, Arai K, Yamamura Y, Okajima K. N Engl J Med. 2008;95:1495-1500
New Japanese classifications and treatment guidelines for gastric cancer: revision concepts and major revised points. Sano T, Aiko T. Gastric Cancer. 2011;14:97-100
 
直江 知樹 独立行政法人国立病院機構名古屋医療センター
院長
血液内科学
Tamibarotene as maintenance therapy for acute promyelocytic leukemia: results from a randomized controlled trial. Shinagawa K, Yanada M, Sakura T, Ueda Y, Sawa M, Miyatake J, Dobashi N, Kojima
M, Hatta Y, Emi N, Tamaki S, Gomyo H, Yamazaki E, Fujimaki K, Asou N, Matsuo K, Ohtake S, Miyazaki Y, Ohnishi K, Kobayashi Y, Naoe T.
J Clin Oncol. 2014 Nov 20;32(33):3729-35.
Diagnosis and management of acute myeloid leukemia in adults:
recommendations from an international expert panel, on behalf of the European LeukemiaNet. Dohner H, Estey EH, Amadori S, Appelbaum FR, Buchner T, Burnett AK, Dombret H,Fenaux P, Grimwade D, Larson RA, Lo-Coco F, Naoe T, Niederwieser D, Ossenkoppele GJ, Sanz MA, Sierra J, Tallman MS, Lowenberg B, Bloomfield CD; European LeukemiaNet. Blood. 2010 Jan 21;115(3):453-74.
Prognostic implication of FLT3 and N-RAS gene mutations in acute
myeloid leukemia. Kiyoi H, Naoe T, Nakano Y, Yokota S, Minami S, Miyawaki S, Asou N, Kuriyama K,Jinnai I, Shimazaki C, Akiyama H, Saito K, Oh H, Motoji T, Omoto E, Saito H, Ohno R, Ueda R.
Blood. 1999 May 1;93(9):3074-80.
 
水谷 修紀 東京医科歯科大学名誉教授/特任教授
小児血液・腫瘍
Incidence and survival rates of hematological malignancies in Japanese children and adolescents (2006-2010): based on registry data from the Japanese Society of Pediatric Hematology.
Horibe K, Mizutani S, et al.
Int J Hematol. 2013;98(1):74-88.
Process for immune defect and chromosomal translocation during early thymocyte development lacking ATM.
Isoda T, Mizutani S, et al.
Blood. 2012;120(4):789-99.
Immunologically silent cancer clone transmission from mother to offspring.
Isoda T, Mizutani S, et al.
Proc Natl Acad Sci U S A. 2009;106(42):17882-5.?
 
望月 一男 伊豆東部総合病院・顧問(杏林大学医学部客員教授)
整形外科(整形腫瘍学)
<研究論文>
1. Kazuo Mochizuki, Yoshiaki Ishii, Hiroshi Yamaguchi, Toshiharu Minabe: Vascularized tissue transplantation in limb salvage procedures for musculoskeletal sarcoma. J Orthop Surg 7(2): 23-32, 1999.
2. Kazuo Mochizuki, Hiroshi Yamaguchi, Tohru Umeda, Japanese Musculo-Skeletal Oncology Group: The management of pelvic chondrosarcoma in Japan. Int Orthop (SICOT) 24(2): 65-70, 2000.
3. Takashi Tajima, Takeshi Morii, Fumihito Kikuchi, Akihiko Matsumine, Hiroaki Murata, Hiroo Nobuto, Kazuo Mochizuki: Significance of the expression of LRP and PPAR-gamma in lipomatous soft tissue tumors. Open Orthop J 4: 48-55, 2010.
<著作>
1. 望月一男(分担執筆):軟部腫瘍.臨床病態学3・北村聖総編集、11運動器疾患.松下隆編集・ヌーヴェルヒロカワ・東京・191-204, 2006.
2. 望月一男(分担執筆):悪性線維性組織球腫. 吉川秀樹編集・20巻骨軟部腫瘍および関連疾患.越智隆弘総編集・最新整形外科学体系.中山書店・東京・316-319, 2007.
3. 望月一男(編集顧問):臨床医のための最新整形外科. 平澤泰介、三浪明男、戸山芳昭編集主幹・先端医療シリーズ44.先端医療技術研究所・東京, 2013.
<学術的発表>
1. Kazuo Mochizuki (Faculty Member): Limb salvage surgery for distal femur osteosarcoma using extendable Kotz prosthesis in children -Video of operation, extension and function. Reconstruction using vascularized tissue transplantation following resection of musculoskeletal sarcomas. Advanced International Course on Lower Extremity Limb Salvage Surgery, Kuala Lumpur, Malaysia, 11-12 June 2007.
2. Kazuo Mochizuki (Invited Lecture): Importance of postoperative managements for malignant musculoskeletal tumors. The 22nd Annual meeting of the Korean Bone and Joint Tumor Society, DaeJeon, Korea, 19-21 April 2012.
望月一男(会長講演):悪性軟部腫瘍に対するunplanned resectionの問題点. 第45回日本整形外科学会骨・軟部腫瘍学術集会、東京都、2012年7月15日.
 
堀部 敬三 国立病院機構名古屋医療センター臨床研究センター長
小児血液腫瘍学
Incidence and survival rates of hematological malignancies in Japanese children and adolescents (2006-2010): based on registry data from the Japanese Society of Pediatric Hematology. Horibe K, Saito AM, Takimoto T, Tsuchida M, Manabe A, Shima M, Ohara A, Mizutani S. Int J Hematol. 2013 Jul;98(1):74-88.
Vinblastine in Children and Adolescents With High-Risk Anaplastic Large-Cell Lymphoma: Results of the Randomized ALCL99-Vinblastine Trial. Le Deley MC, Rosolen A, Williams DM, Horibe K, Wrobel G, Attarbaschi A, Zsiros J, Uyttebroeck A, Marky IM, Lamant L, Woessmann W, Pillon M, Hobson R, Mauguen A, Reiter A, Brugieres L. J Clin Oncol. 2010 Sep 1;28(25):3987-93.
「小児がん診療ハンドブック〜実地診療に役立つ診断・治療の理念と実践〜」 堀部敬三 編集 他共著 医薬ジャーナル社 大阪 2011

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