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肝炎等克服緊急対策研究事業

(○:委員長)

宮村 達男 国立感染症研究所 名誉所員
ウイルス学
An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis. Kuo,G., Choo,Q-L., Alter,H.J., Gitnick,G.L., Redeker,A.G., Purcell,R.H., Miyamura,T. Dienstag J.L., Alter,M.J., Stevens,C.E., Tegtmeier,G.E., Bonino,F., Colombo,M., Lee,W-S., Kuo,C., Berger,K., Shuster,J.R., Overby,L.R., Bradley,D.W., and Houghton,M. Science 244: 362-364, 1989.
Detection of antibody against antigen expressed by molecularly cloned hepatitis C virus cDNA: Application to diagnosis and blood screening for post transfusion hepatitis. Miyamura,T., Saito,I., Katayama,T., Kikuchi,S., Tateda,A., Houghton,M., Choo,Q-L., and Kuo,G. Proc.Natl.Acad.Sci.USA, 87: 983-987, 1990.
A cDNA fragment of hepatitis C virus isolated from an implicated donor of post-transfusion non-A, non-B hepatitis in Japan. Kubo,Y., Takeuchi,K., Boonmar,S., Katayama,T., Choo,Q-L., Kuo,G., Weiner,A.W., Bradley,D.W., Houghton,M., Saito,I., and Miyamura,T.  Nucl.Acids Res. 17:10367-10372, 1989.
 
清澤 研道 社会医療法人城西医療財団 城西病院
消化器病・肝臓病・ウイルス肝炎
Yoshizawa K, Matsumoto A, Ichijo T, Umemura T, Joshita S, Komatsu M, Tanaka N, Tanaka E, Ota M, Katsuyama Y, Kiyosawa K, Abe M, Onji M.  Long-term outcome of japanese patients with type 1 autoimmune hepatitis. Hepatology 2012 Aug;56(2):668-76
Yokosuka O, Takaguchi K, Fujioka S, Shindo M, Chayama K, Kobashi H, Hayashi N, Sato C, Kiyosawa K, Tanikawa K, Ishikawa H, Masaki N, Seriu T, Omata M. Long-term use of entecavir in nucleoside-naive Japanese patients with chronic hepatitis B infection. J Hepatol. 2010 Jun;52(6):791-9.
Kiyosawa K, Sodeyama T, Tanaka E, Gibo Y, Yoshizawa K, Nakano Y, Furuta S, Akahane Y, Nishioka K, Purcell RH, et al.: Interrelationship of blood transfusion, non-A, non-B hepatitis and hepatocellular carcinoma: analysis by detection of antibody to hepatitis C virus. Hepatology 1990;12: 671-675.
 
井廻 道夫 新百合ケ丘総合病院 消化器・肝臓病研究所 所長
肝臓病学
Perforin, Fas/Fas ligand, TNF-a pathways as specific and bystander killing mechanisms of hepatitis C virus-specific human CTL. Ando K, Hiroishi K, Kaneko T, Moriyama T, Muto Y, Kayagaki N, Yagita H, Okumura K, Imawari M. J Immunol 1997;158:5283-5291.
Strong CD8+ T-cell responses against tumor-associated antigens prolong the recurrence-free interval after tumor treatment in patients with hepatocellular carcinoma. Hiroishi K, Eguchi J, Baba T, Shimazaki T, Ishii S, Hiraide A, Sasaki M, Doi H, Uozumi S, Omori R, Matsumura T, Yanagawa T, Ito T, Imawari M. J Gastroenterol 2010;45:451-458.
25-hydroxyvitamin D3 suppresses hepatitis C virus production. Matsumura T, Kato T, Sugiyama N, Tasaka-Fujita M, Murayama A, Masaki T, Wakita T, Imawari M. Hepatology 2012;56:1231-1239.
 
遠藤弘良 東京女子医科大学国際環境・熱帯医学講座主任教授
国際保健、熱帯医学
(業績その1)
Hang NT, Maeda S., Lien LT, Thuong.PH, Hung NV, Thuy TR, Keicho, Endo H et.al, Primary drug-resistant tuberculosis in Hanoi, Viet Nam: present status and risk factors, Plos One, 2013 Aug 13:8(8): e71867
(業績その2)
Nguyen Thi-Le Hang, Ikumi Matsushita, Takuro Shimbo, Le Thi Hong,Do Bang Tam, Luu Thi Lien, Pham Huu Thuong, Vu Cao Cuong,Minako Hijikata, Nobuyuki Kobayashi, Shinsaku Sakurada,Kazue Higuchi, Nobuyuki Harada, Hiroyoshi Endo, Naoto Keicho, Association between tuberculosis recurrence and interferon-gamma response during treatment Original Research Article In Press, Accepted Manuscript, Available online 21 June 2014
(業績その3)
Kenji Murai, Richard Culleton, Teruhiko Hisaoka, Hiroyoshi Endo, Toshihiro Mita, Global distribution of polymorphism associated with Delayed Plasmodium falciparum parasite clearance following artemisinin Treatment: Genotyping of archive blood samples, Parasitology International,2014
 
恩地 森一 済生会今治医療福祉センター長
消化器内科学
MeetingReport自己免疫性肝炎の診断指針・治療方針(2)
恩地森一 肝臓Vol.54 no10 69:723-725,2013
Tokumoto Y,Hiasa Y,Uesugi K,Watanabe T,Mashiba T,Abe M,Kumagi T,Ikeda Y,Matsuura B,Onji M:Ribavirin regulates hepatitis C virus replication through enhancing interferon-stimulated genes and interleukin 8.J Infect Dis 205:1121-1130,2012.
Michitaka K,Hiraoka A,Imai Y,Utsunomiya H,Tatsukawa H,Shimizu Y,Ninomiya K,Yamago H,Tanihara T,Hasebe A,Ninomiya T,Horiike N,Abe M,Hiasa Y,Onji M,Abe E,Ochi H:Clinical features and hepatitis B virus(HBV)genotypes in pregnant woman chronically infected with HBV.Intern Med.51:3317-22,2012.
 
戸田 剛太郎 独立行政法人地域医療機能推進機構(JCHO)東京高輪病院
内科学(消化器・肝臓病学)
A large-scale, double-blind trial of ursodoxycholic acid in patients eith chronic hepatitis C.
Omata M, Yoshida H, Toyota J, Tomita E, Nishiguchi S, Hayashi N, Iino S, Makino I, Okita K, Toda G, Tanikawa K, Kumada H; Japanese C-Viral Hepatitis Network
Gut 56:1747-53.2007
Antitumor activity mediated by CD4+ cytotoxic T lymphocyte against MHC class II-negative mouse hepatocellular carcinoma induced by dendritic cell vaccine and interleukin-12.
Homma S, Komita H, Sagawa Y, Ohno T, Toda G
Immunology 115:451-61,2005
Analysis of factors affecting the appearance of hepatocellular carcinoma in patients with chronic hepatitis C. A long term follow-up study after histologic diagnosis.
Aizawa Y, Shibamoto Y, Takagi Y, Zeniya M, Toda G
Cancer 89:53-9,2000
 
矢野 右人 国立病院機構長崎医療センター名誉院長
ウイルス性肝炎
Quantitative immunoelectrophoresis as a method for determination of hepatitis B antigen
Standardization and comparison with other methods
M. Yano and I. Tripatzis    Z.Immun.-Forsch Bd. 146 : S174-186, 1973.
Prevention of HBV Mother-Infant Transmission
Michitami Yano, Heiichiro Tajim  Acta Paediatrica Japonica 28 (3) : 300-305, 1986
The Long-term Pathological Evolution of Chronic Hepatitis C
Michitami Yano, Hiromitsu Kumada, Masayoshi Kage, Kenji Ikeda, Kazuhide Shimamatsu, Osami Inoue, Etsuko Hashimoto, Jay H. Lefkowitch, Jurgen Ludwig and Kunio Okuda
HEPATOLOGY 23 (6) : 1334-1340, 1996.6
 
吉澤 浩司 広島大学 名誉教授
ウイルス肝炎の疫学
Natural histories of hepatitis C virus infection in men and women simulated by the Markov model. Tanaka J. Kumada H. Ikeda K. Mizui M. Hino K. Katayama K. kumagai J. Kamiya Y . Miyakawa Y. Yoshizawa H. J.Med.Virol.2003,70.378-386.
Livir disease in hepatitis C vinus carriers identified at blood donation and their outcomes with or without interferon treatment:Study on 1019 carriers followed for 5-10 years. Mizui M. Yokoyama T. Tsuji K. Arataki K. Yamaguchi S. Miura T. Kitamoto M. Takezaki E. Orimen S. Sakata T. Kamada K. Maruhashi A. Tamura T. Nakamura T. Ishida K. Teramen K. Miyakawa Y. Yoshizawa H. Hepatology Reserch 2007,37.994-1001.
Minimum infectious dose of hepatitis B virus in chimpanzees and difference in dynamics of viremia between genotype A and genotype C. Komiya Y. Katayama K. Yugi H. Mizui M. Matsukura H. Tomoguri T. Miyakawa Y. Tabuchi A. Tanaka J. Yoshizawa H. Transfusion. 2008,48.286-294.

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