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難治性疾患克服研究事業

(○:委員長)

 
池田 康夫 早稲田大学理工学術院先進理工学研究科教授
血栓止血学
Ikeda, Y., Handa, M., Kawano, K., Kamata, T., Murata, M., Araki, Y., Ambo, H., Kawai, Y., Watanabe, K., Itagaki, I., Sakai, K., and Ruggeri, Z.M.:
The role of von Willebrand factor and fibrinogen in platelet aggregation under varying shear stress.
J. Clin. Invest. 87: 1234-1240, 1991
Bhatt DL., Steg PG., Ohman EM., Hirsch AT., Ikeda, Y., Mas JL., Goto S., Liau CS., Richard AJ., Rother J., Wilson PWF., for the REACH Registry Investigators. :
International prevalence, recognition, and treatment of cardiovascular risk factors in outpatients with atherothrombosis.
JAMA 295 (2): 180-189, 2006 (1).
Ikeda Y and Miyakawa Y: Development of thrombopoietin receptor agonists for clinical use. J Thromb Haemost 7 (sup.1) 239-244, 2009
 
石橋 達朗 九州大学病院病院長
眼科
Genome-wide association study identifies two susceptibility loci for exudative age-related macular degeneration in the Japanese population. Arakawa S, Ishibashi T, et al. Nat Genet. 43: 1001-1004, 2011
Photoreceptor cell death and rescue in retinal detachment and degenerations. Murakamia Y, Notomi S, Hisatomi T, Nakazawa T, Ishibashi T, Miller JW, Vavvas DG. Prog Retin Eye Res 37:114-140, 2013
Periostin promotes the generation of fibrous membranes in proliferative
vitreoretinopathy. Ishikawa K, Yoshida S, Nakao S, Nakama T, Kita T, Asato R, Sassa Y,Arita R, Miyazaki M, Enaida H, Oshima Y, Murakami N, Niiro H, Ono J, Matsuda A, Goto Y, Akashi K, Izuhara K, Kudo A, Kono T, Hafezi-Moghadam A, Ishibashi T. FASEB J 28: 131-142, 2014
 
大澤 真木子 東京女子医科大学名誉教授
小児科、小児神経学、臨床遺伝
Nationwide survey (incidence, clinical course, prognosis) of Rasmussen's encephalitis。Muto, A., Oguni, H., Takahashi, Y., Shirasaka, Y., Sawaishi, Y., Yano, T., Hoshida, T., Osaka, H., Nakasu, S., Akasaka, N., Sugai, K., Miyamoto, A., Takahashi, S., Suzuki, M., Ohmori, I., Nabatame, S., Osawa, M.:Brain & Development(Elsebia)32,(6),2010, pp. 445 - 453
Efficacy of Intravenous Midazolam for Status Epilepticus in Childhood 。Hayashi, K., Osawa, M., Aihara, M., Izumi, T., Ohtsuka, Y., Haginoya, K., Kato, I., Kaneko, K., Sugai, K., Takahashi, T., Hamano, S.-i., Matsukura, M., Miura, H., Minagawa, K., Yamano, T., Yamamoto, H., Yamanouchi, H., Yoshikawa, H.

Pediatric Neurology 36, ( 6), 2007, pp. 366 - 372
著作
医の未来 矢澤義雄 編著 岩波書店
 
岡上 武 大阪府済生会吹田病院長
消化器(肝臓)
Genetic polymorphisms of the human PNPLA3 gene are strongly associated with severity of nonalcoholic fatty liver disease in Japanese. Kawaguchi T, Sumida Y, Umemura A, Matsuo K, Takahashi M, Takamura T, Yasui K, Saibara T, Hashimoto E, Kawanaka M, Watanabe S, Kawata S, Imai Y, Kokubo M, Shima T, Park H, Tanaka H, Tajima K, Yamada R, Matsuda F, Okanoue T for Japan Study Group of Nonalcoholic Fatty Liver Disease (JSG-NAFLD). PLoS One 7(6): e38322, 2012
Chapter 19 Non-alcoholic fatty liver disease in Japan. Okanoue T, Yasui K, Itoh Y. In. Farrell GC, McCullough AJ, Day CP. NON-ALCOHOLIC FATTY LIVER DISEASE A Practical Guide, Wiley-Blackwell, United Kingdom, pp217-227, 2013
Simeprevir with peginterferon/ribavirin for treatment-naive heoatitis C genotype 1 patients in Japan: the CONCERT-1. A phase V trial. Hayashi N, Izumi N, Kumada H, Okanoue T, Tsubouchi H, Yatsuhashi H, Kato M, Ki R, Komada Y, Seto C, Goto S. J Hepatol 2014 Apr 12. Pil: S0168-8278(14)00221-9. Doi; 10.1026
葛原 茂樹 鈴鹿医療科学大学保健衛生学部医療福祉学科教授
神経変性疾患、痴呆性疾患、医原性神経疾患、脳血管障害
Kuzuhara S, Kokubo Y, Sasaki R, Narita Y, Yabana T, Hasegawa M, Iwatsubo
T: Familial amyotrophic lateral sclerosis and parkinsonism-dementia complex
of the Kii peninsula of Japan: clinical and neuropathological study and tau
analysis. Ann Neurol 49:501-511, 2001
Morimoto S, Kuzuhara S, Kokubo Y: Increased oxidative stress in patients
with amyotrophic lateral sclerosis/parkinsonism-dementia comlex in the
Kii Peninsula, Japan. Mov Disord 24:123-126, 2008
Tomiyama H, Kokubo Y, Sasaki R, Li Y, Imamichi Y, Funayama M, Mizuno Y,
Hattori N, Kuzuhara S: Mutation analyses in amyotrophic lateral
sclerosis/parkinsonism-dementia complex of the Kii peninsula, Japan. Mov
Disord 23:2344-2348, 2008
 
斉藤 延人 東京大学脳神経外科教授
脳神経外科
Kin T, Oyama H, Kamada K, Aoki S, Ohtomo K, Saito N. Prediction of surgical view of neurovascular decompression using interactive computer graphics. Neurosurgery 65:121-128, 2009.
Tanaka Y, Imai H, Konno K, Miyagishima T, Kubota C, Puentes S, Aoki T, Hata H, Takata K, Yoshimoto Y, Saito N. Experimental Model of Lacunar Infarction in the Gyrencephalic Brain of the Miniature Pig: Neurological Assessment and Histological, Immunohistochemical, and Physiological Evaluation of Dynamic Corticospinal Tract Deformation. Stroke 39: 205-212, 2008.
Saito N, Okada Y, Noda Y, Kinoshita Y, Kondo S, Hirokawa N. KIFC2 is a novel neuron-specific C-terminal type kinesin superfamily motor for dendritic transport of multivesicular body-like organelles. Neuron 18: 425-438, 1997.
 
澤 倫太郎 公益社団法人日本医師会総合政策研究機構研究部長
産科婦人科・周産期学
Fetal plasma hypoxanthine level in growth-retarded fetuses before labor.
Sawa R, Yoneyama Y, Otsubo Y, Suzuki S, Kubonoya K, Power GG, Araki T.
J Clin Endocrinol Metab 82:4028-4033.1997
Changes in plasma adenosine during simulated birth of fetal sheep.
Sawa R, Asakura H, Power GG.Changes in plasma adenosine during simulated birth of fetal sheep.J Appl Physiol 70(4): 1524-1528.1991
Suzuki K, Sawa R, Muto K, Kusuda S, Banno K, Yamagata Z.
Risk perception of Pregnancy Promotes Disapproval of Gestational Surrogacy: Analysis of a Nationally Representative Opinion Survey in Japan.International Journal of Fertility & Sterility; 5(2), 78-85, 2011
国家主導の生命工学がもたらした悲劇―韓国ES細胞事件から見えてみるもの.澤倫太郎 岩波書店・世界,3月号、73-61、2006
県立大野病院事件から見えてくるもの. 澤倫太郎、岩波書店・世界,8月号、195-209、2008
胎児血管特性を応用したアデノシン誘導型DESの開発―羊成獣血管におけるlong acting adenosineによるステント内再狭窄抑制効果についてー. 澤倫太郎、五十嵐美和、峯克也、桑原慶充、里見操緒、竹下俊行,第64回日産婦学術講演会,2012.4.13
 
清野 裕 関西電力病院長
糖尿病学
Inhibition of gastric inhibitory polypeptide signaling prevents obesity
Miyawaki K, Yamada Y, Ban N, Ihara Y, Tsukiyama K, Zhou H, Fujimoto S, Oku A, Tsuda K, Toyokuni S, Hiai H, Mizunoya W, Fushiki T, Holst JJ, Makino M, Tashita A, Kobara Y, Tsubamoto Y, Jinnouchi T, Jomori T, Seino Y.
Nat Med. 2002 Jul;8(7):738-42. Epub 2002 Jun 17.
Glucose intolerance caused by a defect in the entero-insular axis: a study in gastric inhibitory polypeptide receptor knockout mice
Miyawaki K, Yamada Y, Yano H, Niwa H, Ban N, Ihara Y, Kubota A, Fujimoto S, Kajikawa M, Kuroe A, Tsuda K, Hashimoto H, Yamashita T, Jomori T, Tashiro F, Miyazaki J, Seino Y.  Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):14843-7.
Overexpression of inducible cyclic AMP early repressor inhibits transactivation of genes and cell proliferation in pancreatic beta cells
Inada A, Hamamoto Y, Tsuura Y, Miyazaki J, Toyokuni S, Ihara Y, Nagai K, Yamada Y, Bonner-Weir S, Seino Y 
Mol Cell Biol. 2004 Apr;24(7):2831-41
 
竹中 洋 大阪医科大学長
耳鼻咽喉科学
Enhanced human IgE production results from exposure to the aromaticHydrocarbons from diesel exhaust;direct effects on B-cell IgE production, Takenaka H,et al
J Allery CLin Immunol;1998.95:103-115.
コア・ローテイション 耳鼻咽喉科・頭頸部外科
編集 竹中洋、高橋姿、久育男
金芳堂、2004年1月5日
気道アレルギーの成立とその制御:竹中 洋
第110回日本耳鼻咽喉科学術総会宿題報告
東京、2009.05.14.
 
富野 康日己 順天堂大学医学部腎臓内科学講座教授
腎臓内科学
Tomino Y: Leesons from the KK-Ay mouse, a spontaneous animal model for the treatment of human type 2 diabetic nephropathy, Nephrourol Mon, 4:524-529, 2012
Nakata J, Ohsawa I, Onda K, Tanimoto M, Kusaba G, Takeda Y, Kobayashi N, Asanuma K, Tanaka Y, Sato M, Inami Y, Suzuki H, Suzuki H, Masuda A, Nonaka K, Sasaki Y, Hisada A, Hamada C, Horikoshi S, Tomino Y: Risk of Overestimation of Kidney Function Using GFR-Estimating Equations in Patients with Low Inulin Clearance, J Clin Lab Anal. 26(4):248-53, 2012
富野康日己:ここが知りたい生活習慣病・腎臓病・高血圧対策Q&A100、中外医学社、東京、2012
 
友池 仁暢 公益財団法人日本心臓血圧研究振興会附属榊原記念病院長
循環器内科学
Kawai T, Ito T, Ohwada K, Mera Y, Matsushita M, Tomoike H. Hereditary postprandial hypertriglyceridemic rabbit exhibits insulin resistance and central obesity. A novel model of metabolic syndrome. Arterioscler Thromb Vasc Biol 2006;26:2752-2757.
Kitakaze M, Asakura M, Kim J, Shintani Y, Asanuma H, Hamasaki T, Tomoike H, et al. Human atrial natriuretic peptide and nicorandil as adjuncts to reperfusion treatment for acute myocardial infarction (J-WIND): two randomised trials. Lancet 2007;370:1483-1493.
Harada-Shiba M, Sugisawa T, Makino H, Abe M, Tsushima M, Yoshimasa T, Yamashita T, Miyamoto Y, Yamamoto A, Tomoike H, Yokoyama S. Impact of statin treatment on the clinical fate of heterozygous familial hypercholesterolemia. J Atheroscler Thromb 2010;17:667-674.
 
永井 正規 埼玉医科大学公衆衛生学教授
疫学
Prevalence and Incidence of Polymyositis and Dermatomyositis in Japan. Ohta A, Nagai M, Nishina M, Tomimitsu H, Kohsaka H.Mod Rheumatol 24:477-480, 2013.
A case control study of female systemic lupus erythematosus in Japan
MASAKI NAGAI,TOMIO HIROHATA,YOSHIFUJI MATSUMOTO,HIROSHI HASHIMOTO,MASAKAZU KONDO,KOTARO OZASA,MITSURU MORI,TSUTOMU HASHIMOTO,HIDEAKI NAKAGAWA,TOSHITAKA OMURA,MASAKI MORI,TAKESHI TOJO,HIROSHI YANAGAWA European Journal of Public Health, Volume 3, Issue 3:172-176, 1992
「新しい疫学」永井正規他共著,日本公衆衛生協会,(1995).
 
中村 耕三 国立障害者リハビリテーションセンター総長
リハビリテーション
Prevalence of cervical cord compression and its association with physical performance in a population-based cohort in Japan: the Wakayama Spine Study. Nagata K, Nakamura K, et al.: Spine (Phila Pa 1976). 2012, 37(22): 1892-1898.
Reference values for hand grip strength, muscle mass, walking time, and one-leg standing time as indices for locomotive syndrome and associated disability: the second survey of the ROAD study. Yoshimura N, Nakamura K, et al. J Orthop Sci. 2011, 16(6): 768-77.
Acute cervical spinal cord injury complicated by preexisting ossification of the posterior longitudinal ligament: a multicenter study. Chikuda H, Nakamura K, et al. Spine (Phila Pa 1976). 2011, 36(18): 1453-1458.
 
西岡 清 大阪警察病院顧問
皮膚科学・免疫アレルギー学
Hepatocyte growth factor both prevents and ameliorates the symptoms of dermal sclerosis in a mouse model of scleroderma.  Wu MH, Yokozeki H, Takagawa S, Yamamoto T, Satoh T, Kaneda Y, Katayama I, Nishioka K  Gene Therapy 11: 170-180, 2004
Synthesis of α(1,3) fucosyltransferases IV- and VII-dependent eosinophil selectin ligand and recruitment to the skin. Satoh T, Kanai Y, Wu M-H, Yokozeki H, Kannagi R, Lowe JB, Nishioka K Am J Pathol 167: 787-796, 2005
Prostaglandin D2 plays an essential role in chronic allergic inflammation of the skin via CRTH2 receptor.  Satoh T, Moroi R, Akitake K, Urade Y, Kanai Y, Sumi K, Yokozeki H, Nagata K, Hara T, Utsuyama M, Hirokawa K, Suganuma K, Nishioka K, Nakamura M  J Immunology 177: 2621-2629, 2006
 
貫和 敏博 公益財団法人結核予防会常務理事
内科学(呼吸器内科学)
Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. Maemondo M, Inoue A, Kobayashi K, Sugawara S, Oizumi S, Isobe H, Gemma A, Harada M, Yoshizawa H, Kinoshita I, Fujita Y, Okinaga S, Hirano H, Yoshimori K, Harada T, Ogura T, Ando M, Miyazawa H, Tanaka T, Saijo Y, Hagiwara K, Morita S, Nukiwa T; North-East Japan Study Group. N Engl J Med. 2010 Jun 24;362(25):2380-8.
First-line gefitinib for patients with advanced non-small-cell lung cancer harboring epidermal growth factor receptor mutations without indication for chemotherapy. Inoue A, Kobayashi K, Usui K, Maemondo M, Okinaga S, Mikami I, Ando M, Yamazaki K, Saijo Y, Gemma A, Miyazawa H, Tanaka T, Ikebuchi K, Nukiwa T, Morita S, Hagiwara K; North East Japan Gefitinib Study Group. J Clin Oncol. 2009 Mar 20;27(9):1394-400.
OX40 ligand expressed by DCs costimulates NKT and CD4+ Th cell antitumor immunity in mice. Zaini J, Andarini S, Tahara M, Saijo Y, Ishii N, Kawakami K, Taniguchi M, Sugamura K, Nukiwa T, Kikuchi T. J Clin Invest. 2007 Nov;117(11): 3330-8
 
福島 雅典 公益財団法人先端医療振興財団臨床研究情報センター長
腫瘍内科学、臨床試験デザイン・管理・評価、薬剤疫学、医科学
Nakatani E, Nishimura T, Zhou B, Kaneda H, Teramukai S, Nagai Y, Fukushima M, Kanatani Y. Temporal and regional variations in sporadic Creutzfeldt-Jakob disease in Japan, 2001-2010. Epidemiol. Infect.
Suzuki Y, Ishikawa N, Omae K, Hirai T, Ohnishi K, Nakano N, Nishida H, Nakatani T, Fukushima M, Ide C. Bone marrow-derived mononuclear cell transplantation in spinal cord injury patients by lumbar puncture. Restor Neurol Neurosci. 2014 Mar 26. [Epub ahead of print]
Fujita Y, Kinoshita M, Furukawa Y, Nagano T, Hashimoto H, Hirami Y, Kurimoto Y, Arakawa K, Yamazaki K, Okada Y, Katakami N, Uno E, Matsubara Y, Fukushima M, Nada A, Losordo DW, Asahara T, Okita Y, Kawamoto A. Phase II clinical trial of CD34+ cell therapy to explore endpoint selection and timing in patients with critical limb ischemia. Circ J. 2014;78(2):490-501.
 
水野 美邦 順天堂大学名誉教授 順天堂越谷病院長
神経内科学
Kitada T, Asakawa S, Hattori N, Matsumine H, Yamamura Y, Minoshima S, Yokochi M, Mizuno Y, Shimizu N: Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature, 1998;392:605-608
Mizuno Y, Nomoto M, Kondo T, Hasegawa K, Murata M, Ikeda J, Tomida T, Hattori N, on behalf of the Rotigotine Trial Group. Transdermal rotigotine in early-stage Parkinson’s disease: A randomized, double-blind, placebo-controlled trial. Mov Disord 2013;28:1447-1450.
水野美邦.パーキンソン病とともに楽しく生きる.中外医薬,東京,pp 1-212
 
宮坂 信之 東京医科歯科大学名誉教授
内科学(膠原病)、臨床免疫学
Drug retention rates and relevant risk factors for drug discontinuation due to adverse events in rheumatoid arthritis patients receiving anti-cytokine therapy with different target molecules. R. Sakai, M. Tanaka, T. Nanki, K. Watanabe, H. Yamazaki, R. Koike, H. Nagasawa, K. Amano, K. Saito, Y. Tanaka, S. Ito, T. Sumida, A. Ihata, Y. Ishigatsubo, T. Atsumi, T. Koike, A. Nakajima, N. Tamura, T. Fujii, H. Dobashi, S. Tohma, T. Sugihara, Y. Ueki, A. Hashiramoto, A. Kawakami, N. Hagino, N. Miyasaka, M. Harigai, for the REAL Study Group Ann. Rheum. Dis. 71:1820-1826, 2012
Incidence and risk factors for serious infection in patients with rheumatoid arthritis treated with tumor necrosis factor inhibitors: a report from the registry of Japanese rheumatoid arthritis patients for longterm safety. Y. Komano, M. Tanaka, T. Nanki, R. Koike, R. Sakai, H. Kameda, A. Nakajima, K. Saito, M. Takeno, T. Atsumi, S. Tohma, S. Ito, N. Tamura, T. Fujii, T. Sawada, H. Ida, A. Hashiramoto, T. Koike, Y. Ishigatsubo, K. Eguchi, Y. Tanaka, T. Takeuchi, N. Miyasaka, M. Harigai, for the REAL Study Group J. Rheumatol. 38(7):1258-1264, 2011
 
宮崎 久義 特定非営利活動法人日本医療マネジメント学会理事長
麻酔、病院管理、地域医療、生活習慣病
「地域医療支援病院と医療連携のありかた」宮崎久義他共著.じほう.(2004).
地域連携とクリティカルパス.宮崎久義.綜合臨牀.2009.3月
「クリティカルパスの新たな展開VII クリティカルパスと電子カルテ−原点に返って電子カルテ時代のクリティカルパスを考える−」宮崎久義企画.ライフサイエンス.(2011).

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