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肝炎等克服緊急対策研究事業

(○:委員長)

宮村 達男 国立感染症研究所 名誉所員
ウイルス学
An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis. Kuo,G., Choo,Q-L., Alter,H.J., Gitnick,G.L., Redeker,A.G., Purcell,R.H., Miyamura,T. Dienstag J.L., Alter,M.J., Stevens,C.E., Tegtmeier,G.E., Bonino,F., Colombo,M., Lee,W-S., Kuo,C., Berger,K., Shuster,J.R., Overby,L.R., Bradley,D.W., and Houghton,M. Science 244: 362-364, 1989.
Detection of antibody against antigen expressed by molecularly cloned hepatitis C virus cDNA: Application to diagnosis and blood screening for post transfusion hepatitis. Miyamura,T., Saito,I., Katayama,T., Kikuchi,S., Tateda,A., Houghton,M., Choo,Q-L., and Kuo,G. Proc.Natl.Acad.Sci.USA, 87: 983-987, 1990.
A cDNA fragment of hepatitis C virus isolated from an implicated donor of post-transfusion non-A, non-B hepatitis in Japan. Kubo,Y., Takeuchi,K., Boonmar,S., Katayama,T., Choo,Q-L., Kuo,G., Weiner,A.W., Bradley,D.W., Houghton,M., Saito,I., and Miyamura,T.  Nucl.Acids Res. 17:10367-10372, 1989.
 
幕内 雅敏 日本赤十字社医療センター 院長
肝胆膵外科
Ultrasonically guided subsegmentectomy.Makuuchi M, Hasegawa H, Yamazaki S. Surgery, Gynecology & Obstetrics 161:346-350, 1985
Safety of hemihepatic vascular occlusion during resection of the liver. Makuuchi M, Mori T, Gunven P, Yamazaki S. Surgery, Gynecology & Obstetrics 164:155-158, 1987
Preoperative portal embolization to increase safety of major hepatectomy for hilar bile duct carcinoma: a preliminary report. Makuuchi M, Thai B. L., Takayasu K, Takayama T, Kosuge T, Gunven P, Yamazaki S, Hasegawa H, Ozaki H. Surgery 107:521-527, 1990
 
戸田 剛太郎 独立行政法人地域医療機能推進機構(JCHO)東京高輪病院
内科学(消化器・肝臓病学)
A large-scale, double-blind trial of ursodoxycholic acid in patients eith chronic hepatitis C.
Omata M, Yoshida H, Toyota J, Tomita E, Nishiguchi S, Hayashi N, Iino S, Makino I, Okita K, Toda G, Tanikawa K, Kumada H; Japanese C-Viral Hepatitis Network
Gut 56:1747-53.2007
Antitumor activity mediated by CD4+ cytotoxic T lymphocyte against MHC class II-negative mouse hepatocellular carcinoma induced by dendritic cell vaccine and interleukin-12.
Homma S, Komita H, Sagawa Y, Ohno T, Toda G
Immunology 115:451-61,2005
Analysis of factors affecting the appearance of hepatocellular carcinoma in patients with chronic hepatitis C. A long term follow-up study after histologic diagnosis.
Aizawa Y, Shibamoto Y, Takagi Y, Zeniya M, Toda G
Cancer 89:53-9,2000
 
樋野 興夫 順天堂大学 医学部 病理・腫瘍学 教授
専門分野 病理学・発がん
Hino O., Kitagawa T. and Sugano H.: Relationship between serum and histochemical markers for hepatitis B virus and rate of viral integration in hepatocellular carcinomas in Japan. Int J Cancer 35: 5-10, 1985
Hino O., Shows T. B. and Rogler C. E.: Hepatitis B virus integration site in hepatocellular carcinoma at chromosome 17;18 translocation. Proc Natl Acad Sci U S A 83: 8338-8342, 1986
Hino O., Tabata S. and Hotta Y.: Evidence for increased in vitro recombination with insertion of human hepatitis B virus DNA. Proc Natl Acad Sci U S A 88: 9248-9252, 1991
 
三田村 圭二 昭和大学医学部消化器内科 客員教授
肝臓病学
Mitamura,K., BH.Hoyer, A.Ponzetto, J.Nelson, R.Purcell, and J.Gerin,
Woodchuck hepatitis virus DNA in woodchuck liver tissues. Hepatology 2 47S-50S 1982
Hakozaki,Y., M.Katou, T.Shirahama, O.Yoshii, K.Nakagawa, K.Oba, T.Matsumoto, N.Kuwabara, and Mitamura,K. Long-term prognosis of chronic hepatitis C after treatment with interferon α-2b and relationship of response to proliferative activity of hepatocytes and hepatitis C virus Am J Gastroenterol 91 2144-2149 1996
Ito,T., K.Yasui, J.Mukaigawara, A.Katsume, M.kohara, and K.Mitamura
Acquisition of susceptibility to hepatitis C virus replication in HepG2 cells by fusion with primary human heatocytes:establish-ment of a quantitative assay for hepatitis C virus infectitvity in a cell culture system Hepatology 34 566-572 2001
 
村上 清史 金沢大学名誉教授、金沢学院大教授
北陸ライフサイエンスクラスター統括コーディネーター
分子遺伝
Hepatitis B Virus X protein overcomes oncogenic RAS-induced senescence in human immortalized cells. Oishi N, Khurts S, Nakamoto Y, Honda M, Kaneko S, *Murakami S. Cancer Science, 98(10): 1540-1548, (2007)
Effect of Hepatitis C Virus (HCV) NS5B-Nucleolin Interaction on HCV Replication with HCV Subgenomic Replicon. Shimakami T, Honda M, Kusakawa T, Murata T, Shimotohno K, Kaneko S *Murakami S. J. Virol., 80 (7): 3332-3340, (2006).
The Molecular functions and the biological roles of Hepatitis B Virus X protein (HBx) Tang H, Oishi N, Kaneko S, *Murakami S. Cancer Sci., 97(10):977-983, (2006)
 
矢野 右人 国立病院機構長崎医療センター名誉院長
ウイルス性肝炎
Quantitative immunoelectrophoresis as a method for determination of hepatitis B antigen
Standardization and comparison with other methods
M. Yano and I. Tripatzis    Z.Immun.-Forsch Bd. 146 : S174-186, 1973.
Prevention of HBV Mother-Infant Transmission
Michitami Yano, Heiichiro Tajim  Acta Paediatrica Japonica 28 (3) : 300-305, 1986
The Long-term Pathological Evolution of Chronic Hepatitis C
Michitami Yano, Hiromitsu Kumada, Masayoshi Kage, Kenji Ikeda, Kazuhide Shimamatsu, Osami Inoue, Etsuko Hashimoto, Jay H. Lefkowitch, Jurgen Ludwig and Kunio Okuda
HEPATOLOGY 23 (6) : 1334-1340, 1996.6
 
吉澤 浩司 広島大学 名誉教授
ウイルス肝炎の疫学
Natural histories of hepatitis C virus infection in men and women simulated by the Markov model. Tanaka J. Kumada H. Ikeda K. Mizui M. Hino K. Katayama K. kumagai J. Kamiya Y . Miyakawa Y. Yoshizawa H. J.Med.Virol.2003,70.378-386.
Livir disease in hepatitis C vinus carriers identified at blood donation and their outcomes with or without interferon treatment:Study on 1019 carriers followed for 5-10 years. Mizui M. Yokoyama T. Tsuji K. Arataki K. Yamaguchi S. Miura T. Kitamoto M. Takezaki E. Orimen S. Sakata T. Kamada K. Maruhashi A. Tamura T. Nakamura T. Ishida K. Teramen K. Miyakawa Y. Yoshizawa H. Hepatology Reserch 2007,37.994-1001.
Minimum infectious dose of hepatitis B virus in chimpanzees and difference in dynamics of viremia between genotype A and genotype C. Komiya Y. Katayama K. Yugi H. Mizui M. Matsukura H. Tomoguri T. Miyakawa Y. Tabuchi A. Tanaka J. Yoshizawa H. Transfusion. 2008,48.286-294.

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