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難病・がん等の疾患分野の医療の実用化研究事業(肝炎関係研究分野)

(○:委員長)

宮村 達男 国立感染症研究所 名誉所員
ウイルス学
An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis. Kuo,G., Choo,Q-L., Alter,H.J., Gitnick,G.L., Redeker,A.G., Purcell,R.H., Miyamura,T. Dienstag J.L., Alter,M.J., Stevens,C.E., Tegtmeier,G.E., Bonino,F., Colombo,M., Lee,W-S., Kuo,C., Berger,K., Shuster,J.R., Overby,L.R., Bradley,D.W., and Houghton,M. Science 244: 362-364, 1989.
Detection of antibody against antigen expressed by molecularly cloned hepatitis C virus cDNA: Application to diagnosis and blood screening for post transfusion hepatitis. Miyamura,T., Saito,I., Katayama,T., Kikuchi,S., Tateda,A., Houghton,M., Choo,Q-L., and Kuo,G. Proc.Natl.Acad.Sci.USA, 87: 983-987, 1990.
A cDNA fragment of hepatitis C virus isolated from an implicated donor of post-transfusion non-A, non-B hepatitis in Japan. Kubo,Y., Takeuchi,K., Boonmar,S., Katayama,T., Choo,Q-L., Kuo,G., Weiner,A.W., Bradley,D.W., Houghton,M., Saito,I., and Miyamura,T.  Nucl.Acids Res. 17:10367-10372, 1989.
 
清澤 研道 社会医療法人城西医療財団 城西病院
消化器病・肝臓病・ウイルス肝炎
Yoshizawa K, Matsumoto A, Ichijo T, Umemura T, Joshita S, Komatsu M, Tanaka N, Tanaka E, Ota M, Katsuyama Y, Kiyosawa K, Abe M, Onji M.  Long-term outcome of japanese patients with type 1 autoimmune hepatitis. Hepatology 2012 Aug;56(2):668-76
Yokosuka O, Takaguchi K, Fujioka S, Shindo M, Chayama K, Kobashi H, Hayashi N, Sato C, Kiyosawa K, Tanikawa K, Ishikawa H, Masaki N, Seriu T, Omata M. Long-term use of entecavir in nucleoside-naive Japanese patients with chronic hepatitis B infection. J Hepatol. 2010 Jun;52(6):791-9.
Kiyosawa K, Sodeyama T, Tanaka E, Gibo Y, Yoshizawa K, Nakano Y, Furuta S, Akahane Y, Nishioka K, Purcell RH, et al.: Interrelationship of blood transfusion, non-A, non-B hepatitis and hepatocellular carcinoma: analysis by detection of antibody to hepatitis C virus. Hepatology 1990;12: 671-675.
 
遠藤弘良 東京女子医科大学国際環境・熱帯医学講座主任教授
国際保健、熱帯医学
(業績その1)
Takahashi, N., Tanabe, K., Tsukahara, T., Dzodzomenyo, M.,Dysoley, L., Khamlome, B., Sattabongkot, J., Nakamura, M., Sakurai, M., Kobayashi, J., Endo, H., Hombhanje, F., Tsuboi, T., * Mita, T. A large scale survey for novel genotypes of the Plasmodium falciparum chloroquine-resistant pfcrt gene Malaria J 2012 11:92
(業績その2)
Kitamura,T., Obara,H., Takashima,Y., Takahashi,K., Inaoka,K., Nagai,M., Endo,H., Jimba,M., Sugiura,Y., World Health Assembly Agendas and trends of international health issues for the last 43 years: Analysis of World Health assembly Agendas between 1970 and 2012, Health Policy, 2013
(業績・実績その3)
Shunsuke Miyano, Samba Muvuma, Naoko Ishikawa, Hiroyoshi Endo, Charles Msiska, Gardner Syakantu, Healthcare provision for HIV co-infected tuberculosis patients in rural Zambia: an observational Cohort study at primary care centres, BMC Health Services Research, 2013, 13:397
 
神代 正道 久留米大学理事長
病理学
Pathologic diagnosis of early hepatocellular carcinoma: report of the international consensus group for hepatocellular neoplasia.
International Consensus Group for Hepatocellular Neoplasia (Corresponding author: Kojiro, M).Hepatology 2009,49(2):658-664.
Pathology of Hepatocellular Carcinoma. Blackwell Publishing,Oxford, England. Kojiro, M, 2006.
Role of liver biopsy in HCC. Masamichi Kojiro, Post-graduate Course, International Association of Study of the Liver, San Francisco, USA, October 31, 2008.
 
戸田 剛太郎 船員保険会せんぽ東京高輪病院名誉院長、東京慈恵会医科大学客員教授
内科学(消化器・肝臓病学)
A large-scale, double-blind trial of ursodoxycholic acid in patients eith chronic hepatitis C.
Omata M, Yoshida H, Toyota J, Tomita E, Nishiguchi S, Hayashi N, Iino S, Makino I, Okita K, Toda G, Tanikawa K, Kumada H; Japanese C-Viral Hepatitis Network
Gut 56:1747-53.2007
Antitumor activity mediated by CD4+ cytotoxic T lymphocyte against MHC class II-negative mouse hepatocellular carcinoma induced by dendritic cell vaccine and interleukin-12.
Homma S, Komita H, Sagawa Y, Ohno T, Toda G
Immunology 115:451-61,2005
Analysis of factors affecting the appearance of hepatocellular carcinoma in patients with chronic hepatitis C. A long term follow-up study after histologic diagnosis.
Aizawa Y, Shibamoto Y, Takagi Y, Zeniya M, Toda G
Cancer 89:53-9,2000
 
矢野 右人 国立病院機構長崎医療センター名誉院長
ウイルス性肝炎
Quantitative immunoelectrophoresis as a method for determination of hepatitis B antigen
Standardization and comparison with other methods
M. Yano and I. Tripatzis    Z.Immun.-Forsch Bd. 146 : S174-186, 1973.
Prevention of HBV Mother-Infant Transmission
Michitami Yano, Heiichiro Tajim  Acta Paediatrica Japonica 28 (3) : 300-305, 1986
The Long-term Pathological Evolution of Chronic Hepatitis C
Michitami Yano, Hiromitsu Kumada, Masayoshi Kage, Kenji Ikeda, Kazuhide Shimamatsu, Osami Inoue, Etsuko Hashimoto, Jay H. Lefkowitch, Jurgen Ludwig and Kunio Okuda
HEPATOLOGY 23 (6) : 1334-1340, 1996.6
 
山田 剛太郎 川崎医科大学総合内科学2 特任教授
肝臓内科学
Hepatitis B core and surface antigens in liver tissue. Light and electron microscopic localization by the peroxidase -labeled antibody method. Yamada G and Nakane PK. Laboratory Investigation. 1977; 36(6):646-659
Electron and immunoelectron microscopic study of Dane particle formation in chronic hepatitis B. Yamada G, Sakamoto Y, Mizuno M, Nishihara T, Kobayashi T, Takahshi T, Nagashima H. Gastroenterology 1982; 83(2):348-356
Efficacy of interferon alfa therapy in chronic hepatitis C patients depends primarily on hepatitis C virus RNA level. Yamada G, Takatani M, Kishi F, Takahashi M, Doi T, Tsuji T, Shin S, Tanno M, Ureda MS, Kolberg JA. Hepatology 1995; 22(5):1351-1354
 
吉澤 浩司 広島大学 名誉教授
ウイルス肝炎の疫学
Natural histories of hepatitis C virus infection in men and women simulated by the Markov model. Tanaka J. Kumada H. Ikeda K. Mizui M. Hino K. Katayama K. kumagai J. Kamiya Y . Miyakawa Y. Yoshizawa H. J.Med.Virol.2003,70.378-386.
Livir disease in hepatitis C vinus carriers identified at blood donation and their outcomes with or without interferon treatment:Study on 1019 carriers followed for 5-10 years. Mizui M. Yokoyama T. Tsuji K. Arataki K. Yamaguchi S. Miura T. Kitamoto M. Takezaki E. Orimen S. Sakata T. Kamada K. Maruhashi A. Tamura T. Nakamura T. Ishida K. Teramen K. Miyakawa Y. Yoshizawa H. Hepatology Reserch 2007,37.994-1001.
Minimum infectious dose of hepatitis B virus in chimpanzees and difference in dynamics of viremia between genotype A and genotype C. Komiya Y. Katayama K. Yugi H. Mizui M. Matsukura H. Tomoguri T. Miyakawa Y. Tabuchi A. Tanaka J. Yoshizawa H. Transfusion. 2008,48.286-294.

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