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内海 英雄 |
独立行政法人医薬品医療機器総合機構 理事 |
| 物理薬学 |
| Whole-body kinetic image of a redox probe in mice using Overhauser-enhancesd MRI., Kosem N., Naganuma T., Ichikawa K., Morales N. P., Yasukawa K., Hyodo F., Yamada KI., Utsumi H., Free Radic Biol Med., 53:328-336,（2012） |
| In vivo imaging of mitochondrial function in methamphetamine- treated rats., Shiba, T., Yamato, M., Kudo, W., Watanabe, T., Utsumi, H., Yamada, K.. Neuroimage, 57 (3), 866-872. (2011) |
In vivo evaluation of nobel nitroxyl radicals with reduction stability., Kinoshita,Y.; Yamada,K.; Yamasaki,T.; Mito,F.; Yamato,M.; Kosem,N.; Deguchi,H.; Shirahama,C.; Ito,Y.; Kitagawa,K.; Okukado,N.; Sakai,K.; Utsumi,H., Free Radic Biol Med; 49(11):1703-9, (2010)
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稲垣 治 |
日本製薬工業協会 医薬品評価委員会 委員長 |
| 医薬品開発 |
治験の空洞化を防ぐための早期探索的臨床試験の推進 −企業の立場から−
稲垣 治
Jpn. J. Clin Pharmacol. Ther., 42(2), 85-86 (2011)
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大野 泰雄 |
木原記念横浜生命科学振興財団 理事長 |
| トキシコロジー |
| Uehara T, Kondo C, Morikawa Y, Hanafusa H, Ueda S, Minowa Y, Nakatsu N, Ono A, Maruyama T, Kato I, Yamate J, Yamada H, Ohno Y, Urushidani T. Toxicogenomic biomarkers for renal papillary injury in rats. Toxicology. 303:1-8, 2013. |
| Establishment and intra-/inter-laboratory validation of a standard protocol of reactive oxygen species assay for chemical photosafety evaluation. Onoue S, Hosoi K, Wakuri S, Iwase Y, Yamamoto T, Matsuoka N, Nakamura K, Toda T, Takagi H, Osaki N, Matsumoto Y, Kawakami S, Seto Y, Kato M, Yamada S, Ohno Y, and Kojima H, J Appl Toxicol. 2012 Jun 13. doi: 10.1002/jat.2776. |
| Effect of nuclear receptor downregulation on hepatic expression of cytochrome P450 and transporters in chronic hepatitis C in association with fibrosis development. Hanada K, Nakai K, Tanaka H, Suzuki F, Kumada H, Ohno Y, Ozawa S, Ogata H., Drug Metab Pharmacokinet. 2011, 27: 301-306. |
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高坂 新一 |
国立精神・神経医療研究センター 理事
(兼)神経研究所長
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| 神経化学 |
Gonda Y, Andrews W. D, Tabata H, Namba T, Parnavelas J. G, Nakajima K, Kohsaka S, Hanashima C, Uchino S.:
Robo1 Regulates the Migration and Laminar Distribution of Upper-Layer Pyramidal Neurons of the Cerebral Cortex.
Cerebral Cortex 23 (2013) 1495-1508.
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Sanagi T, Nakamura Y, Suzuki E, Uchino S, Aoki M, Warita H, Itoyama Y, Kohsaka S, Ohsawa K.:
Involvement of activated microglia in increased vulnerability of motoneurons after facial nerve avulsion in presymptomatic amyotrophic lateral sclerosis model rats.
Glia. 60(2012) 782-793.
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Ohsawa K, Sanagi T, Nakamura Y, Suzuki E, Inoue K, Kohsaka S.:
Adenosine A3 receptor is involved in ADP-induced microglial process extension and migration.
J Neurochem. 121 (2012) 217-227.
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佐竹元吉 |
お茶の水女子大学 生活環境教育研究センター
客員教授
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| 専門分野：薬用植物学 |
| 日本の有毒植物 株）学研教育出版(2012年 5月) |
Hiroko Shimomura, Hiroko Tokumoto, Setsuko Sekita, Motoyoshi Satake, Maki Tokugawa, Narimasa Tokugawa, and Yukihiro Goda, Identification of Components in “Usaien” Preparation :Contents of the Heirloom Gallipot of the Mito-Tokugawa Family 生薬学雑誌67 (2). 41-58 (2013)
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| Kanami Mori-Yasumoto, Ryoko Izumoto, Hiroyuki Fuchino, Takashi Ooi, Yutaka Agatsuma, Takenori Kusumi, Motoyoshi Satake, Setsuko Sekita, Leishmanicidal activities and cytotoxicities of bisnaphthoquinone analogues and naphthol derivatives from Burman Diospyros burmanica, Bioorganic & Medicinal Chemistry Vol. 20 (2012)5215-5219 |
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田澤 義明 |
一般社団法人 日本臨床検査薬協会 |
| コンパニオン診断薬ワーキング |
| 当該年度は該当なし。 |
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中西 聡 |
日本製薬工業協会研究開発委員会 委員 |
| 低分子創薬 |
Kiyotoshi Mori, Kotaro Takasaki, Yoshimitsu Kato, Hiroshi Yano, Kimihisa Ueno, Michiaki Ichimura, Hideki Kusaka, Yuji Nomoto, Katsuya Higo, Satoshi Nakanishi: GLUCOSE CONCENTRATION-DEPENDENT POTENTIATION OF INSULIN SECRETION BY A NEW CHEMICAL ENTITY, KCP256.
Eur. J. Pharmacol. 528, 176-182 (2005)
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Fumito Kozumi, Atsuhiro Hasegawa, Keiko Ochiai, Katsuhiko Ando, Hidemasa Kondo, Mayumi Yoshida, Yuzuru Matsuda, and Satoshi Nakanishi: EI-2346, A NOVEL INTERLEUKIN-1BETA CONVERTING ENZYME INHIBITOR PRODUCED BY STREPTOMYCES SP. E-2346. I. TAXONOMY OF PRODUCING STRAIN, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL PRPERTIES, AND BIOLOGICAL PROPERTIES
J. Antibiot. 56, 985-992 (2003)
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| 特願2000-557834 糖尿病治療剤 |
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服部 征雄 |
放送大学富山学習センター 所長 |
| 薬用植物学 |
Natural products and their derivatives,having anti-HIV protease
Activity. Chao‐mei Ma,Norio Nakamura and Masao Hattori,Current Topics in Medicinal Chemistry,
3, 77-99 (2003).
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Bitter principles from the fruiting bodies,cultural mycelia and
spores of Ganoderma lucidum.
Byung Sun MinIP,Jiang Jing Caol and Masao Hattoril, Current Topics in Phytochemistry, 7,35-60 (2005).
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Survey of Anti-HIV and Anti-HCV Compounds from Natural Sources, , Masao Hattori, Chao-Mei Ma, Ying Wei, Riham Salah El Dine, Naoto Sato, Canadian Chemical Transactions（Licensee Borderless Science Publishing, Canada.）, 1, 116-140 (2013).
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矢守 隆夫 |
独立行政法人医薬品医療機器総合機構 センター長 |
| 分子薬理学 |
JFCR39, a panel of 39 human cancer cell lines, and its application in the discovery and development of anticancer drugs.
Kong D, Yamori T.
Bioorg Med Chem. 20(6) 1947-51 2012年
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AMF-26, a Novel Inhibitor of the Golgi System, Targeting ADP-ribosylation Factor 1 (Arf1) with Potential for Cancer Therapy.
Ohashi Y, Iijima H, Yamaotsu N, Yamazaki K, Sato S, Okamura M, Sugimoto K, Dan S, Hirono S, Yamori T.
J Biol Chem. 287(6) 3885-97 2012年
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Antitumor activity of ZSTK474, a new phosphatidylinositol 3-kinase inhibitor.
Yaguchi S1, Fukui Y, Koshimizu I, Yoshimi H, Matsuno T, Gouda H, Hirono S, Yamazaki K, Yamori T.
J Natl Cancer Inst. 2006 Apr 19;98(8):545-56.
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渡邉 治雄 |
国立感染症研究所 所長 |
| 細菌学 |
| Morita-Ishihara T, Miura M, Iyoda S, Izumiya H, Watanabe H, Ohnishi M, Terajima J. EspO1-2 Regulates EspM2-Mediated RhoA Activity to Stabilize Formation of Focal Adhesions in Enterohemorrhagic Escherichia coli-Infected Host Cells. PLoS One. 8(2):e55960. doi:2013 |
| Izumiya H, Terajima J, Yamamoto S, Ohnishi M, Watanabe H, Kai A, Kurazono T, Taguchi M, Asai T, Akiba M, Matsumoto Y, Tamura Y. Genomic analysis of Salmonella enterica serovar Typhimurium definitive phage type 104.. Emerg Infect Dis.19(5):823-235. 2013 |
| Takayuki Matsumura, Manabu Ato, Tadayoshi Ikebe, Makoto Ohnishi, Haruo Watanabe and Kazuo Kobayashi. Interferon-γ-producing immature myeloid cells confer protection against severe invasive group A Streptococcus infections. Nature Communication:3:678. 2012 (DOI:10.1038/ncomms1677) |
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