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第3次対がん総合戦略研究事業

(○:委員長)

上田 龍三 愛知医科大学医学部・教授
腫瘍免疫
Defucosylated anti-CCR4 monoclonal antibody (KW-0761) for relapsed adult T-cell leukemia-lymphoma: a multicenter phase II study. Ishida T, Joh T, Uike N, Yamamoto K, Utsunomiya A, Yoshida S, Saburi Y, Miyamoto T, Takamoto S, Suzushima H, Tsukasaki K, Nosaka K, Fujiwara H, Ishitsuka K, Inagaki H, Ogura M, Akinaga S, Tomonaga M, Tobinai K, Ueda R: J Clin Oncol,; 30(8):837-42, 2012
Autologous Tax-Specific CTL Therapy in a Primary Adult T Cell Leukemia/Lymphoma Cell-Bearing NOD/Shi-scid, IL-2Rγnull Mouse Model. Masaki A, Ishida T, Suzuki S, Ito A, Mori F, Sato F, Narita T, Yamada T, Ri M, Kusumoto S, Komatsu H, Tanaka Y, Niimi A, Inagaki H, Iida S, Ueda R.
J Immunol,; 191(1):135-44. 2013
Strategy for preventing hepatitis B reactivation in patients with resolved HBV infection following rituximab-containing chemotherapy. Kusumoto S, Tanaka Y, Mizokami M, Ueda R.; Hepatology; 60(2):765-6, 2014.
 
前原 喜彦 九州大学大学院消化器・総合外科 教授
消化器(消化管、肝・胆・膵、脾・門脈)移植 肺 乳腺 血管
A gp130-Src-YAP module links inflammation to epithelial regeneration.
Taniguchi K, Wu LW, Grivennikov SI, de Jong PR, Lian I, Yu FX, Wang K, Ho SB, Boland BS, Chang JT, Sandborn WJ, Hardiman G, Raz E, Maehara Y, Yoshimura A, Zucman-Rossi J, Guan KL, Karin M.
Nature. 2015 Mar 5;519(7541):57-62.
Suppression of Autophagy During Liver Regeneration Impairs Energy Charge and Hepatocyte Senescence in Mice.
Toshima T1, Shirabe K, Fukuhara T, Ikegami T, Yoshizumi T, Soejima Y, Ikeda T, Okano S, Maehara Y.
Hepatology. 2014 Jul;60(1):290-300.
Frequent plasma cell hepatitis during telaprevir-based triple therapy for hepatitis C after liver transplantation.
Ikegami T, Yoshizumi T, Shirabe K, Maehara Y
J Hepatol. 2014 Apr;60(4):894-6.
 
加藤 治文 東京医科大学名誉教授
新座志木中央総合病院名誉院長
国際医療福祉大学大学院教授
呼吸器外科学
Our Experience With Photodynamic Diagnosis and Photodynamic Therapy for Lung Cancer. Kato H. Journal of the National Comprehensive Cancer Network. 2012 Oct; 10 Sup.2: 3-8.
A Clinician View and Experience of Proteomic Studies in the Light of Lung Cancer in Japanese Healthcare. Kato H, Nishimura T, Hirano T, Nomura M, Tojo H, Fujii K, Kawamura T, Mikami S, Kihara M, Bando Y, Tsuboi M, Ikeda N, Marko-Varga G. Journal of Proteome Research. 2011 Jan; 10(1): 51-57.
Developments for a growing Japanese patient population: Facilitating new technologies for future health care. Kato H, Nishimura T, Ikeda N, Yamada T, Kondo T, Saijo N, Nishio K, Fujimoto J, Nomura M, Oda Y, Lindmark B, Maniwa J, Hibino H, Unno M, Ito T, Sawa Y, Tojo H, Egawa S, Edula G, Lopez M, Wigmore M, Inase N, Yoshizawa Y, Nomura F, Marko-Varga G. Journal of Proteomics. 2011 May; 74(6): 759-64.
 
澁谷 正史 上武大学 学長
腫瘍学、分子生物学、血管生物学
(業績・実績その1 学術総説論文)
VEGFR and Type-V RTK Activation and Signaling. Shibuya M. In the Receptor Tyrosine Kinase Book, Edited by Y. Schlessinger et al. Cold Spring Harb Perspect Biol. 2013 Oct 1;5(10). doi:pii: a009092
(業績・実績その2 学術論文)
Inhibition of histone demethylase JMJD1A improves anti-angiogenic therapy and reduces tumor associated macrophages. Osawa T, Tsuchida R, Muramatsu M, Shimamura T, Wang F, Suehiro JI, Kanki Y, Wada Y, Yuasa Y, Aburatani H, Miyano S, Minami T, Kodama T, Shibuya M. Cancer Res. 73:3019-28, 2013.
(業績・実績その3 学術総説論文)
Involvement of Flt-1 (VEGFR-1) in cancer and preeclampsia. Shibuya, M. Proc Jpn Acad Ser B Phys Biol Sci. 87:167-78, 2011.
 
新海 哲 湘南東部総合病院 副院長・がん治療センター長
腫瘍内科
Phase I clinical trial of irinotecan (CPT-11), 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothecin, and cisplatin in combination with fixed dose of vindesine in advanced non-small cell lung cancer. Shinkai T, Arioka H, Kunikane H, Eguchi K, Sasaki Y, Tamura T, Ohe Y, Oshita F, Nishio M, Karato A, Okamoto H, Nakashima H, Ohmatsu H, Shiraishi J, Nomura N, Saijo N. Cancer Res. 1994, 54:2636-2642.
Quality of life and disease-related symptoms in previously treated Japanese patients with non-small-cell lung cancer: results of a randomized phase III study ‘V-15-32) of gefitinib versus docetaxel. Sekine I, Ichinose Y, Nishiwaki Y, Yamamoto N, Tsuboi M, Nakagawa K., Shinkai T, Negoro S, Imamura F, Eguchi K, Takeda K, Itoh Y, Tamura T, Sijo N, Fukuoka M. Annals of Oncology. 2009, 20: 1483-1488.
Etoposide and cisplatin versus irinotecan and cisplatin in patients with limited-stage small-cell lung cancer treated with etoposide and cisplatin plus concurrent accelerated hyperfractionated thoracic radiotherapy (JCOG0202): a randomized phase 3 study. Kubota K, Hida T, Ishikura S, Mizusawa J, Nishio M, Kawahara M, Yokoyama A, Imamura F, Takeda K, Negoro S, Harada M, Okamoto H, Yamamoto N, Shinkai T, Sakai H, Matsui K, Nakagawa K, Shibata T, Saijo N, Tamura T, on behalf of the Japan Clinical Oncology Group. Lancet Oncol, 2014, 15: 106-113.
 
田島 和雄 三重大学医学部公衆衛生・産業医学分野 客員教授
疫学、公衆衛生学
現代の五大病「がん」Q&A 田島和雄 監修
毎日ムック(毎日新聞社)・完全保存版・30-63頁・2013年
Ethnoepidemiology of HTLV-1 related diseases: Ethnic determinants of HTLV-1 susceptibility and its worldwide dispersal. Sonoda. S., Li, H.C., Tajima, K., Cancer Sci., 2011, 102:295-301.
2q36.3 is associated with prognosis for estorogen receptor-negative breast cancer patients treated with chemotherapy. Li, J., Matsuo, K., Ito, H., Iwata, H., Tajima, K. et al., Nat. Commun., 2014, 5: 4051.
 
中釜 斉 独立行政法人国立がん研究センター
理事(兼)研究所長
専門分野:分子腫瘍学、翻訳制御機構の異常と消化器発がん、環境発がん、比較ゲノミクス
Onuma K, Ochiai M, Orihashi K, Takahashi M, Imai T, Nakagama H, Hippo Y. Genetic reconstitution of tumorigenesis in primary intestinal cells. Proc Natl Acad Sci U S A, 110(27):11127-32, 2013
Okamoto K, Ishiguro T, Midorikawa Y, Ohata H, Izumiya M, Tsuchiya T, Sato A, Sakai H, and Nakagama H. miR-493 induction during carcinogenesis blocks metastatic settlement of colon cancer cells in liver. EMBO J, 31(7):1752-63, 2012
Tsuchiya N, Izumiya M, Ogata-Kawata H, Okamoto K, Fujiwara Y, Nakai M, Okabe A, Schetter AJ, Bowman ED, Midorikawa Y, Sugiyama Y, Aburatani H, Harris CC, Nakagama H. Tumor Suppressor miR-22 Determines p53-Dependent Cellular Fate through Post-transcriptional Regulation of p21. Cancer Res,
 
平岡 真寛 京都大学大学院医学研究科・教授
放射線腫瘍学・画像応用治療学
Nakamura M, Akimoto M, Mukumoto N, Yamada M, Tanabe H, Ueki N, Matsuo Y, Mizowaki T, Kokubo M, Hiraoka M: Influence of the correlation modeling period on the prediction accuracy of infrared marker-based dynamic tumor tracking using a gimbaled X-ray head. Phys Med. 2015 May;31(3):204-9. doi: 10.1016/j.ejmp.2015.01.004. Epub 2015 Jan 30.
Matsuo Y, Ueki N, Takayama K, Nakamura M, Miyabe Y, Ishihara Y, Mukumoto N, Yano S, Tanabe H, Kaneko S, Mizowaki T, Monzen H, Sawada A, Kokubo M, Hiraoka M.: Evaluation of dynamic tumour tracking radiotherapy with real-time monitoring for lung tumours using a gimbal mounted linac. Radiother Oncol. 2014 Sep;112(3):360-4. doi: 10.1016/j.radonc.2014.08.003. Epub 2014 Aug 22.
Mampuya WA, Matsuo Y, Ueki N, Nakamura M, Mukumoto N, Nakamura A, Iizuka Y, Kishi T, Mizowaki T, Hiraoka M. The impact of abdominal compression on outcome in patients treated with stereotactic body radiotherapy for primary lung cancer. J Radiat Res. 2014 Sep;55(5):934-9. doi: 10.1093/jrr/rru028. Epub 2014 May 6.

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