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創薬基盤推進研究事業

(○:委員長)

 
内海 英雄 独立行政法人医薬品医療機器総合機構 理事
物理薬学
Whole-body kinetic image of a redox probe in mice using Overhauser-enhancesd MRI., Kosem N., Naganuma T., Ichikawa K., Morales N. P., Yasukawa K., Hyodo F., Yamada KI., Utsumi H., Free Radic Biol Med., 53:328-336,(2012)
In vivo imaging of mitochondrial function in methamphetamine- treated rats., Shiba, T., Yamato, M., Kudo, W., Watanabe, T., Utsumi, H., Yamada, K.. Neuroimage, 57 (3), 866-872. (2011)
In vivo evaluation of nobel nitroxyl radicals with reduction stability., Kinoshita,Y.; Yamada,K.; Yamasaki,T.; Mito,F.; Yamato,M.; Kosem,N.; Deguchi,H.; Shirahama,C.; Ito,Y.; Kitagawa,K.; Okukado,N.; Sakai,K.; Utsumi,H., Free Radic Biol Med; 49(11):1703-9, (2010)
高坂 新一 国立精神・神経医療研究センター 理事
(兼)神経研究所長
神経化学
Gonda Y, Andrews W. D, Tabata H, Namba T, Parnavelas J. G, Nakajima K, Kohsaka S, Hanashima C, Uchino S.:
Robo1 Regulates the Migration and Laminar Distribution of Upper-Layer Pyramidal Neurons of the Cerebral Cortex.
Cerebral Cortex 23 (2013) 1495-1508.
Sanagi T, Nakamura Y, Suzuki E, Uchino S, Aoki M, Warita H, Itoyama Y, Kohsaka S, Ohsawa K.:
Involvement of activated microglia in increased vulnerability of motoneurons after facial nerve avulsion in presymptomatic amyotrophic lateral sclerosis model rats.
Glia. 60(2012) 782-793.
Ohsawa K, Sanagi T, Nakamura Y, Suzuki E, Inoue K, Kohsaka S.:
Adenosine A3 receptor is involved in ADP-induced microglial process extension and migration.
J Neurochem. 121 (2012) 217-227.
 
佐竹元吉 お茶の水女子大学 生活環境教育研究センター
客員教授
専門分野:薬用植物学
日本の有毒植物 株)学研教育出版(2012年 5月)
Hiroko Shimomura, Hiroko Tokumoto, Setsuko Sekita, Motoyoshi Satake, Maki Tokugawa, Narimasa Tokugawa, and Yukihiro Goda, Identification of Components in “Usaien” Preparation :Contents of the Heirloom Gallipot of the Mito-Tokugawa Family 生薬学雑誌67 (2). 41-58 (2013)



Kanami Mori-Yasumoto, Ryoko Izumoto, Hiroyuki Fuchino, Takashi Ooi, Yutaka Agatsuma, Takenori Kusumi, Motoyoshi Satake, Setsuko Sekita, Leishmanicidal activities and cytotoxicities of bisnaphthoquinone analogues and naphthol derivatives from Burman Diospyros burmanica, Bioorganic & Medicinal Chemistry Vol. 20 (2012)5215-5219

 
中西 聡 日本製薬工業協会研究開発委員会 委員
低分子創薬
Kiyotoshi Mori, Kotaro Takasaki, Yoshimitsu Kato, Hiroshi Yano, Kimihisa Ueno, Michiaki Ichimura, Hideki Kusaka, Yuji Nomoto, Katsuya Higo, Satoshi Nakanishi: GLUCOSE CONCENTRATION-DEPENDENT POTENTIATION OF INSULIN SECRETION BY A NEW CHEMICAL ENTITY, KCP256.
Eur. J. Pharmacol. 528, 176-182 (2005)
Fumito Kozumi, Atsuhiro Hasegawa, Keiko Ochiai, Katsuhiko Ando, Hidemasa Kondo, Mayumi Yoshida, Yuzuru Matsuda, and Satoshi Nakanishi: EI-2346, A NOVEL INTERLEUKIN-1BETA CONVERTING ENZYME INHIBITOR PRODUCED BY STREPTOMYCES SP. E-2346. I. TAXONOMY OF PRODUCING STRAIN, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL PRPERTIES, AND BIOLOGICAL PROPERTIES
J. Antibiot. 56, 985-992 (2003)
特願2000-557834 糖尿病治療剤
 
中村 和市 日本製薬工業協会 医薬品評価委員会 基礎研究部会 部会長
毒性学
Perspective on non-clinical safety evaluation of drug metabolites through the JSOT workshop. Minagawa T, Nakano K, Furuta S, Iwasa T, Takekawa K, Minato K, Koga T, Sato T, Kawashima K, Kurahashi Y, Onodera H, Naito S, Nakamura K. J Toxicol Sci. Aug 2012. 37(4): 667-673.
Potentials and limitations of nonclinical safety assessment for predicting clinical adverse drug reactions: correlation analysis of 142 approved drugs in Japan. Tamaki C, Nagayama T, Hashiba M, Fujiyoshi M, Hizue M, Kodaira H, Nishida M, Suzuki K, Takashima Y, Ogino Y, Yasugi D, Yoneta Y, Hisada S, Ohkura T and Nakamura K. J Toxicol Sci. Aug 2013. 38(4): 581-591.
Establishment and intra-/inter-laboratory validation of a standard protocol of reactive oxygen species assay for chemical photosafety evaluation. Onoue S, Hosoi K, Wakuri S, Iwase Y, Yamamoto T, Matsuoka N, Nakamura K, Toda T, Takagi H, Osaki N, Matsumoto Y, Kawakami S, Seto Y, Kato M, Yamada S, Ohno Y, Kojima H. J Appl Toxicol. Nov 2013. 33(11): 1241-1250.
 
早川 尭夫 近畿大学薬学総合研究所 所長
生物化学、薬学
ヒト幹細胞を用いた細胞・組織加工医薬品等の品質・安全性確保に関する指針整備と主なポイント.(その1)−(その8).早川堯夫、青井貴之、梅澤明弘、小澤敬也、佐藤陽治、澤 芳樹、松山晃文、大和雅之、山中伸弥、再生医療、10(3), 86-152 (2011)
Japanese Regulatory Perspective on Immunogenicity. Detection and Quantification of Antibodies to Biopharmaceuticals : Practical and Applied Considerations (ed. by Michael G. Tovey), Takao Hayakawa and Akiko Ishii: John Wiley & Sons, Inc., New Jersey, USA, August 2011
A Possible Role for Protein Phosphorylation in the Activation of the Respiratory Burst in Human Neutrophils: Evidence from studies with cells from patients with chronic granulomatous disease, T. Hayakawa, K. Suzuki, S. Suzuki, P.C. Andrews and B.M. Babior: J. Biol. Chem., 261(20), 9109-9115 (1986)
 
山口 一成 熊本大学発生学研究所 学術研究員
血液学
Takizawa K, Nakashima T, Mizukami T, Kuramitsu M, Endoh D, Kawauchi S, Sasaki K, Momose H, Kiba Y, Mizutani T, Furuta RA, Yamaguchi K, Hamaguchi I: Degenerate PCR strategy with DNA microarray for detection of multiple and various subtypes of virus during blood screening. Transfusion 53:2545-2555,2013
Odaka C, Kato H, Otsubo H, Takamoto S, Okada Y, Taneichi M, Okuma K, Sagawa K, Hoshi Y, Tasaki T, Fujii Y, Yonemura Y, Iwao N, Tanaka A, Okazaki H, Momose S, Kitazawa J, Mori H, Matsushita A, Nomura H, Yasoshima H, Ohkusa Y, Yamaguchi K, Hamaguchi I: Online reporting system for transfusion-related adverse events to enhance recipient haemovigilance in Japan: a pilot study. Transfusion and Apheresis Science 48:95-102,2013
Iwanaga M, Watanabe T, Yamaguchi K.: Adult T-cell leukemia: a review of epidemiological evidence. Front Microbiol. 3:322. 2012
 
矢守 隆夫 独立行政法人医薬品医療機器総合機構 審査センター長
分子薬理学
JFCR39, a panel of 39 human cancer cell lines, and its application in the discovery and development of anticancer drugs.
Kong D, Yamori T.
Bioorg Med Chem. 20(6) 1947-51 2012年
AMF-26, a Novel Inhibitor of the Golgi System, Targeting ADP-ribosylation Factor 1 (Arf1) with Potential for Cancer Therapy.
Ohashi Y, Iijima H, Yamaotsu N, Yamazaki K, Sato S, Okamura M, Sugimoto K, Dan S, Hirono S, Yamori T.
J Biol Chem. 287(6) 3885-97 2012年
Antitumor activity of ZSTK474, a new phosphatidylinositol 3-kinase inhibitor.
Yaguchi S1, Fukui Y, Koshimizu I, Yoshimi H, Matsuno T, Gouda H, Hirono S, Yamazaki K, Yamori T.
J Natl Cancer Inst. 2006 Apr 19;98(8):545-56.
 
渡部 一人 日本製薬工業協会 医薬品評価委員会
基礎研究部会 副部会長
毒性学
Investigation of the mechanism of drug induced autoimmune hemolytic anemia in cynomolgus monkeys elucidated by a repeated-dose of a humanized monoclonal antibody drug. Kazuto WATANABE , Ryosuke WATANABE , Akihumi SHIODA , Keiji MIZOGUCHI , Tetsuro SUGIMOTO and Keiji TERAO: J. Toxicol. Sci., 28(3), 123-138, 2003
先端バイオ医薬品の評価技術,バイオ医薬品の非臨床安全性試験.櫻井貴之,渡部一人:シーエムシー出版,p227-238,2010
Collaborative work to evaluate toxicity on male reproductive organs by repeated dose studies in rats 11) testicular toxicity of 2- or 4-week repeated or single-dose administration of a novel platinum complex. Yasuyuki MISAWA、 Kazuto WATANABE et al: J. Toxicol. Sci., 25, Special Issue, 117-127, 2000
 
渡邉 治雄 国立感染症研究所 所長
細菌学
Morita-Ishihara T, Miura M, Iyoda S, Izumiya H, Watanabe H, Ohnishi M, Terajima J. EspO1-2 Regulates EspM2-Mediated RhoA Activity to Stabilize Formation of Focal Adhesions in Enterohemorrhagic Escherichia coli-Infected Host Cells. PLoS One. 8(2):e55960. doi:2013
Izumiya H, Terajima J, Yamamoto S, Ohnishi M, Watanabe H, Kai A, Kurazono T, Taguchi M, Asai T, Akiba M, Matsumoto Y, Tamura Y. Genomic analysis of Salmonella enterica serovar Typhimurium definitive phage type 104.. Emerg Infect Dis.19(5):823-235. 2013
Takayuki Matsumura, Manabu Ato, Tadayoshi Ikebe, Makoto Ohnishi, Haruo Watanabe and Kazuo Kobayashi. Interferon-γ-producing immature myeloid cells confer protection against severe invasive group A Streptococcus infections. Nature Communication:3:678. 2012 (DOI:10.1038/ncomms1677)

(官職指定)
医政局研究開発振興課長

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