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難治性疾患等克服研究事業(難治性疾患克服研究事業)中間・事後評価委員名簿

(○:委員長)

 
浅香 正博 国立大学法人北海道大学がん予防内科講座特任教授
消化器病学、臨床腫瘍学
Recent development of gastric cancer prevention. Jpn J Clin Oncol. Kato M, Asaka M. 2012:42:987-94.
A new approach for elimination of gastric cancer deaths in Japan. Int J Cancer. Asaka M. 2013:132:1272-6.
Roadmap to eliminate gastric cancer with Helicobacter pylori eradication and consecutive surveillance in Japan. Asaka M, Kato M, Sakamoto N. J Gastroenterol. 2014:249:1-8.
 
江藤 文夫 国立障害者リハビリテーションセンター総長
リハビリテーション医学
Eto F, Saotome I, Furuichi T, Ogasawara M: Effects of long-term use of benzodiazepines on gait and standing balance in the elderly. Annals of New York Academy of Sciences 860: 543-545, 1998.
Eto F, Wada N, Maeno T, Miyake N, Saotome I: The effect of heel elevation in Parkinsonian gait. Geriatrics Gerontology International 2004; 4: S202-S204.
Saotome T, Sekino M, Eto F, Ueno S: Evaluation of diffusional anisotropy and microscopic structure in skeletal muscles using magnetic resonance. Magn Reson Imaging 2006; 24: 19-25.
 
木下 茂 京都府立医科大学眼科学教室教授
眼科学
Kinoshita S, Adachi W, Sotozono C, Nishida K, Yokoi N, Quantock A, Okubo K: Characteristics of the human ocular surface epithelium. Prog. Retina Eye Res 20:639-673, 2001.
Sotozono C, Ueta M, Koizumi N, Inatomi T, Ikezawa Z, Shirakata Y, Hashimoto K, Kinoshita S: Diagnosis and Treatment of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis with Ocular Complications. Ophthalmology 116:685-690, 2009.
Nakano M, Ikeda Y, Taniguchi T, Yagi T, Fuwa M, Omi N, Tokuda Y, Tanaka M, Yoshii K, Kageyama M, Naruse S, Matsuda A, Mori K, Kinoshita S, Tashiro K: Three susceptible foci associated with primary-open angle glaucoma identified by genome-wide association study in Japanese population. Proc Natl Acad Sci 106:12838-12842, 2009.
 
小池 隆夫 NTT東日本札幌病院長
臨床免疫学
Anticardiolipin cofactor(s) and differential diagnosis of
autoimmune disease. Matsuura E,Igarashi Y,Fujimoto M.Ichikawa
K. Koike, T. (1990). Lancet 336, 177-178.
Multiple autoimmune diseases after autologous stem-cell transplantation. Bohgaki T, Atsumi T, Koike, T. (2007). N Engl J Med. 357, 495-497
Antiphospholipid syndrome;pathogenesis. Atsumi T,Amengual O, Koike T. (2011) In: Lahita, RG, Tsokos, G, Buyon, J, Koike, T (eds), Systemic Lupus Erythematosus 5th ed, Academic Press; 945-965
 
斉藤 延人 国立大学法人東京大学大学院医学系研究科教授
脳神経外科
Kin T, Oyama H, Kamada K, Aoki S, Ohtomo K, Saito N. Prediction of surgical view of neurovascular decompression using interactive computer graphics. Neurosurgery 65:121-128, 2009.
Tanaka Y, Imai H, Konno K, Miyagishima T, Kubota C, Puentes S, Aoki T, Hata H, Takata K, Yoshimoto Y, Saito N. Experimental Model of Lacunar Infarction in the Gyrencephalic Brain of the Miniature Pig: Neurological Assessment and Histological, Immunohistochemical, and Physiological Evaluation of Dynamic Corticospinal Tract Deformation. Stroke 39: 205-212, 2008.
Saito N, Okada Y, Noda Y, Kinoshita Y, Kondo S, Hirokawa N. KIFC2 is a novel neuron-specific C-terminal type kinesin superfamily motor for dendritic transport of multivesicular body-like organelles. Neuron 18: 425-438, 1997.
 
堺 秀人 慶應義塾大学病院 病院長補佐
腎臓病、糖尿病
Glomerular expression of platelet-derived growth factor (PDGF)-A,-B chain and PDGF
receptor-α, -β in human diabetic nephropathy 
Goro Uehara, Daisuke Suzuki, Masao Toyoda, Tomoya Umezono, Hideto Sakai
Division of Nephrology and Metabolism, Department of Internal Medicine, Tokai University School of Medicine
Clin Exp Nephrol 2004;8:36-42
糖尿病腎症患者の腎生検標本における分子生物学的解析。堺 秀人、糖尿病合併症 22:13-23, 2008.
Expression of human nephrin mRNA in diabetic nephropathy. Masao Toyoda, Daisuke Suzuki, Tomoya Umezono, Masashi Honma, Takako Sakai and Hideto Sakai.
Newphrol. Dial. Transplant. 19:380-385, 2004.
 
澤 倫太郎 社団法人日本医師会総合政策研究機構研究部長
産科婦人科・周産期学
Fetal plasma hypoxanthine level in growth-retarded fetuses before labor.
Sawa R, Yoneyama Y, Otsubo Y, Suzuki S, Kubonoya K, Power GG, Araki T.
J Clin Endocrinol Metab 82:4028-4033.1997
Changes in plasma adenosine during simulated birth of fetal sheep.
Sawa R, Asakura H, Power GG.Changes in plasma adenosine during simulated birth of fetal sheep.J Appl Physiol 70(4): 1524-1528.1991
Suzuki K, Sawa R, Muto K, Kusuda S, Banno K, Yamagata Z.
Risk perception of Pregnancy Promotes Disapproval of Gestational Surrogacy: Analysis of a Nationally Representative Opinion Survey in Japan.International Journal of Fertility & Sterility; 5(2), 78-85, 2011
国家主導の生命工学がもたらした悲劇―韓国ES細胞事件から見えてみるもの.澤倫太郎 岩波書店・世界,3月号、73-61、2006
県立大野病院事件から見えてくるもの. 澤倫太郎、岩波書店・世界,8月号、195-209、2008
胎児血管特性を応用したアデノシン誘導型DESの開発―羊成獣血管におけるlong acting adenosineによるステント内再狭窄抑制効果についてー. 澤倫太郎、五十嵐美和、峯克也、桑原慶充、里見操緒、竹下俊行,第64回日産婦学術講演会,2012.4.13
 
高岡 邦夫 阪和人工関節センター顧問
整形外科学
Poor bone quality or hip structure as risk factors affecting survival of total hip arthroplasty.
Kobayashi,S., Saito,N,. Horiuchi,H. Iorio,R and Takaoka,K.
The Lancet. 355: 1499-1504, 2000.
A biodegradable polymer as a cytokine delivery system for inducing boneformation.
Saitou.N., Okada,T., Horiuchi,H., Murakami,N., Takahashi,J.,Nawata,
M., Ota, H., Nozaki,K. and Takaoka,K.
Nature Biotechnology, 19; 332-335, 2001
Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts.
Nakamura,T., Imai,Y., Matsumoto,T., Sato,S., Takeuchi,K., Igarashi, K., Harada,Y., Azuma,Y., Krust,A.,Yamamoto,Y., Nishiura, H., Takeda,S., Takayanagi,H, Metzger,D., Kanno,J., Takaoka,K., Martin. TJ, Chambon P. and Kato,S.
Cell 130:811-823, 2007.
高嶋 幸男 柳川療育センター施設長
小児科、小児神経科、新生児科、神経病理
Armstrong D, Halliday W, Hawkins C, Takashima S: Pediatric Neuropathology- a text and atlas, Springer, Tokyo, 2007.
Takashima S, Itoh M, Oka A: A history of our understanding of cerebral vascular development and pathogenesis of perinatal brain damage over the past 30 years, and further prospective. Seminars in Pediatric Neurology 16:226-36, 2009.
高嶋幸男、伊藤雅之、水口 雅:ヒト脳の形態形成とその異常、脳神経科学、東京、三輪書店、p.53-62, 2003.
 
永井 正規 埼玉医科大学公衆衛生学教授
疫学
Prevalence and Incidence of Polymyositis and Dermatomyositis in Japan. Ohta A, Nagai M, Nishina M, Tomimitsu H, Kohsaka H.Mod Rheumatol 24:477-480, 2013.
A case control study of female systemic lupus erythematosus in Japan
MASAKI NAGAI,TOMIO HIROHATA,YOSHIFUJI MATSUMOTO,HIROSHI HASHIMOTO,MASAKAZU KONDO,KOTARO OZASA,MITSURU MORI,TSUTOMU HASHIMOTO,HIDEAKI NAKAGAWA,TOSHITAKA OMURA,MASAKI MORI,TAKESHI TOJO,HIROSHI YANAGAWA European Journal of Public Health, Volume 3, Issue 3:172-176, 1992
「新しい疫学」永井正規他共著,日本公衆衛生協会,(1995).
 
長村 義之 国際医療福祉大学三田病院病理診断センター長
病理学、内分泌学、腫瘍学
Pathology, pathogenesis and therapy of growth hormone (GH)-producing pituitary adenomas: technical advances in histochemistry and their contribution. Osamura RY, Egashira N, Kajiya H, Takei M, Tobita M, Miyakoshi T, Inomoto C, Takekoshi S, Teramoto A: Acta Histochem Cytochem 2009, 42:95-104.
The Expression of Wnt4 Is Regulated by Estrogen via an Estrogen Receptor Alpha-dependent Pathway in Rat Pituitary Growth Hormone-producing Cells. Miyakoshi T, Kajiya H, Miyajima K, Takei M, Tobita M, Takekoshi S, Osamura RY: Acta Histochem Cytochem 2009, 42:205-213.
Selection of buffer pH by the isoelectric point of the antigen for the efficient heat-induced epitope retrieval: Kajiya H, Takekoshi S, Takei M, Egashira N, Miyakoshi T, Serizawa A, Teramoto A, Osamura RY: re-appraisal for nuclear protein pathobiology. Histochem Cell Biol 2009, 132:659-667.
 
新津 洋司郎 札幌医科大学分子標的探索講座 特任教授
臨床腫瘍学、消化器病学、血液病学
Resolution of liver cirrhosis using vitamin A-coupled liposomes to deliver siRNA against a collagen-specific chaperone. Sato Y, Murase K, Kato J, Kobune M, Sato T, Kawano Y, Takimoto R, Takada K, Miyanishi K, Matsunaga T, Takayama T, Niitsu Y Nature Biotechnology, 26(4):431-42, 2008
Interaction between leukemic-cell VLA-4 and stromal fibronectin is a decisive factor for minimal residual disease of acute myelogenous leukemia. Matsunaga T, Takemoto N, Sato T, Takimoto R, Tanaka I, Fujimi A, Akiyama T, Kuroda H, Kawano Y, Kobune M, Kato J, Hirayama Y, Sakamaki S, Kohda K, Miyake K, Niitsu Y. Nature Medicine, 9(9):1158-65, 2003
Aberrant crypt foci of the colon as precursors of adenoma and cancer. Takayama T, Katsuki S, Takahashi Y, Ohi M, Nojiri S, Sakamaki S, Kato J, Kogawa K, Miyake H, Niitsu Y. The New England Journal of Medicine, 339(18):1277-84, 1998
 
西岡 清 大阪警察病院皮膚科顧問
皮膚科学・免疫アレルギー学
Hepatocyte growth factor both prevents and ameliorates the symptoms of dermal sclerosis in a mouse model of scleroderma.  Wu MH, Yokozeki H, Takagawa S, Yamamoto T, Satoh T, Kaneda Y, Katayama I, Nishioka K  Gene Therapy 11: 170-180, 2004
Synthesis of α(1,3) fucosyltransferases IV- and VII-dependent eosinophil selectin ligand and recruitment to the skin. Satoh T, Kanai Y, Wu M-H, Yokozeki H, Kannagi R, Lowe JB, Nishioka K Am J Pathol 167: 787-796, 2005
Prostaglandin D2 plays an essential role in chronic allergic inflammation of the skin via CRTH2 receptor.  Satoh T, Moroi R, Akitake K, Urade Y, Kanai Y, Sumi K, Yokozeki H, Nagata K, Hara T, Utsuyama M, Hirokawa K, Suganuma K, Nishioka K, Nakamura M  J Immunology 177: 2621-2629, 2006
 
貫和 敏博 みやぎ県南中核病院企業長
内科学(呼吸器内科学)
Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. Maemondo M, Inoue A, Kobayashi K, Sugawara S, Oizumi S, Isobe H, Gemma A, Harada M, Yoshizawa H, Kinoshita I, Fujita Y, Okinaga S, Hirano H, Yoshimori K, Harada T, Ogura T, Ando M, Miyazawa H, Tanaka T, Saijo Y, Hagiwara K, Morita S, Nukiwa T; North-East Japan Study Group. N Engl J Med. 2010 Jun 24;362(25):2380-8.
First-line gefitinib for patients with advanced non-small-cell lung cancer harboring epidermal growth factor receptor mutations without indication for chemotherapy. Inoue A, Kobayashi K, Usui K, Maemondo M, Okinaga S, Mikami I, Ando M, Yamazaki K, Saijo Y, Gemma A, Miyazawa H, Tanaka T, Ikebuchi K, Nukiwa T, Morita S, Hagiwara K; North East Japan Gefitinib Study Group. J Clin Oncol. 2009 Mar 20;27(9):1394-400.
OX40 ligand expressed by DCs costimulates NKT and CD4+ Th cell antitumor immunity in mice. Zaini J, Andarini S, Tahara M, Saijo Y, Ishii N, Kawakami K, Taniguchi M, Sugamura K, Nukiwa T, Kikuchi T. J Clin Invest. 2007 Nov;117(11): 3330-8
 
平田 結喜緒 公益財団法人先端医療振興財団先端医療センター病院長
内分泌代謝学
Nakano-Tateno T,Shichiri M,Suzuki-Kemuriyama N,Tani Y,Izumiyama H, Hirata
Y:Prolonged effects of intracerebroventricular angiotensin II on drinking, eating and locomotor behavior in mice. Reg Peptide 173:86-92, 2012
Hayakawa E,Yoshimoto T,Sekizawa N,Sugiyama T,Hirata Y:Overexpression of
Receptor for advanced glycolation end products induces monocyte chemoattractant protein-1expression in rat vascular smooth muscle cells.
J Atheroscler Thromb 19:13-22, 2012
Tateishi Y,KOuyama R,Mihara M, Doi M,Yoshimoto T,Hirata Y:Evaluation of salivary cortisol measurements for the diagnosis of subclinical Cushing’s
Syndrome. Endocr J 59:283-289, 2012
 
福島 雅典 財団法人先端医療振興財団臨床研究情報センター長
腫瘍内科学、臨床試験デザイン・管理・評価、薬剤疫学、医科学
Kubota K, Kawahara M, Ogawara M, Nishiwaki Y, Komuta K, Minato K, Fujita Y, Teramukai S, Fukushima M, Furuse K, on behalf of the Japan Multi-National Trial Organisation. Vinorelbine plus gemcitabine fo1lowed by docetaxe1 versus carbop 1atin p1us pac1itaxe1 in patients with advanced non-small-cell lung cancer: A randomised, open-label, phase III study. Lancet Oncol 2008;9:1135-1142.
Tanaka S, Fukushima, M. Size of Creutzfeldt-Jakob Disease Epidemic Associated with Cadaveric Dura Transplantation. Neuroepidemiology 2010;34:232-237.
Sotozono C, Inatomi T, Nakamura T, Koizumi N, Yokoi N, Ueta M, Matsuyama K, Miyakoda K, Kaneda H, Fukushima M, Kinoshita S. Visual improvement after cultivated oral mucosal epithelial transplantation. Ophthalmology 2013 Jan;120(1):193-200.
 
宮崎 久義 日本医療マネジメント学会理事長
麻酔、病院管理、地域医療、生活習慣病
「地域医療支援病院と医療連携のありかた」宮崎久義他共著.じほう.(2004).
地域連携とクリティカルパス.宮崎久義.綜合臨牀.2009.3月
「クリティカルパスの新たな展開VII クリティカルパスと電子カルテ−原点に返って電子カルテ時代のクリティカルパスを考える−」宮崎久義企画.ライフサイエンス.(2011).
 
吉栖 正生 広島大学大学院医歯薬学総合研究科創成医科学専攻教授
循環器病学
Autologous bone-marrow mononuclear cell implantation
improves endothelium-dependent vasodilation in patients with limb
ischemia.
Higashi Y, Kimura M, Hara K, Noma K, Jitsuiki D, Nakagawa K,
Oshima T, Chayama K, Sueda T, Goto C, Matsubara H, Murohara T,
Yoshizumi M.
Circulation 109:1215-1218, 2004
Role of osteoprotegerin in arterial calcification:
development of new animal model.
Orita Y, Yamamoto H, Kohno N, Sugihara M, Honda H, Kawamata
S, Mito S, Soe NN, Yoshizumi M.
Arterioscler Thromb Vasc Biol 27:2058-2064, 2007
腹部大動脈瘤検出装置
吉栖 正生,辻 敏夫,藤田 悦則,小倉 由美,前田 慎一郎
  日本国特許出願 2009-118095  2009

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