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内海 英雄 |
独立行政法人医薬品医療機器総合機構 理事 |
生体磁気共鳴画像学 |
Simultaneous imaging of tumor oxygenation and microvascular permeability using Overhauser enhanced MRI., Matsumoto S, Yasui H, Batra S, Kinoshita Y, Bernardo M, Munasinghe JP, Utsumi H, Choudhuri R, Devasahayam N, Subramanian S, Mitchell JB, Krishna MC., Proc Natl Acad Sci USA, 106(42): 17898-17903, 2009 |
Noninvasive assessment of the brain redox status after transient middle cerebral artery occlusion using Overhauser-enhancesd magnetic resonance imaging., Yamato M, Shiba T, Yamada KI, Watanabe T, Utsumi H., J Cereb Blood Flow Metab., 29(10):1655-64, 2009 |
Whole-body kinetic image of a redox probe in mice using Overhauser-enhancesd MRI., Kosem N., Naganuma T., Ichikawa K., Morales N. P., Yasukawa K., Hyodo F., Yamada KI., Utsumi H., Free Radic Biol Med., 53:328-336, 2012 |
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大石 道夫 |
公益財団法人かずさDNA研究所 理事長 |
分子生物学、分子遺伝学、バイオテクノロジー |
Oishi, M.: An ATP-dependent deoxyribonuclease from Escherichia coli with a possible role in genetic recombination.
Proc. Natl. Acad. Sci. USA 64, 1292-1299 (1969). |
Oishi, M. and Cosloy, S. D.: Specialized transformation in Escherichia coli K12.
Nature 248, 112-116 (1974). |
Oishi, M., Smith, C. L. and Friefeld, B.: Molecular events and molecules that lead to induction of prophage and SOS functions.
Cold Spring Harbor Symp. Quant. Biol. XLIII, 897-907 (1979). |
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白井 智之 |
名古屋市総合リハビリテーションセンター事業団 センター長 |
毒性病理学、人体病理学 |
Matsumoto, H., Yakabe, Y., Saito, K., Sumida, K., Sekijima, M., Nakayama, K., Miyaura, H., Saito, F., Otsuka, M., Shirai, T.: Discrimination of carcinogens by hepatic transcript profiling in rats following 28-day a administration. Cancer Informatics, 7: 253-269 2009. |
Matsumoto, H., Yakabe, Y., Saito, F., Saito, K., Sumida, K., Sekijima, M., Nakayama, K., Miyaura, H., Otsuka, M., Shirai, T.: New Short Term Prediction Method for Chemical Carcinogenicity by Hepatic Transcript Profiling Following 28-Day Toxicity Tests in Rats. Cancer Informatics, 10: 259-271, 2011. |
Suzuki, S., Pitchakarn, P., Takeshita, K., Asamoto, M., Takahashi, S., Sato, S., Shirai, T.: Roles for Rat Hepatocyte Malignant Transforming Factor(HMTF) in Late Stage of Hepatocarcinogenesis. Toxicol. Pathol., 39: 1084-1090, 2011. |
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久 史麿 |
日本医学会会長 自治医科大学 理事長 |
内科学(血液,腫瘍) |
Improved gene expression in resting macrophages using an oligopeptide
derived from Vpr of human immunodeficiency virus type-1. Mizoguchi I, Ooe Y,
Hoshino S, Shimura M, Kasahara T, Kano S, Ohta T, Takaku F, Nakayama Y, Ishizaka Y,
Biochemical And Biophysical Research Communications [Biochem Biophys Res Commun];
Vol. 338 (3), pp. 1499-506, 2005 Dec 23 |
Nuclear trafficking of macromolecules by an oligopeptide derived from Vpr of
human immunodeficiency virus type-1. Taguchi T, Shimura M, Osawa Y, Suzuki Y,
Mizoguchi I, Niino K, Takaku F, Ishizaka Y, Biochemical And Biophysical Research
Communications [Biochem Biophys Res Commun]; Vol. 320 (1), pp. 18-26, 2004 Jul 16 |
Analysis of gene expression profiles in an imatinib-resistant cell line, KCL22/SR.
Ohmine K, Nagai T, Tarumoto T, Miyoshi T, Muroi K, Mano H, Komatsu N, Takaku F, Ozawa
K, Stem Cells (Dayton, Ohio) [Stem Cells]; Vol. 21 (3), pp. 315-21, 2003 |
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中村 和市 |
日本製薬工業協会 医薬品評価委員会 基礎研究部会 部会長 |
毒性学 |
Perspective on non-clinical safety evaluation of drug metabolites through the JSOT workshop. Minagawa T, Nakano K, Furuta S, Iwasa T, Takekawa K, Minato K, Koga T, Sato T, Kawashima K, Kurahashi Y, Onodera H, Naito S, Nakamura K. J Toxicol Sci. Aug 2012. 37(4): 667-673. |
Potentials and limitations of nonclinical safety assessment for predicting clinical adverse drug reactions: correlation analysis of 142 approved drugs in Japan. Tamaki C, Nagayama T, Hashiba M, Fujiyoshi M, Hizue M, Kodaira H, Nishida M, Suzuki K, Takashima Y, Ogino Y, Yasugi D, Yoneta Y, Hisada S, Ohkura T and Nakamura K. J Toxicol Sci. Aug 2013. 38(4): 581-591. |
Establishment and intra-/inter-laboratory validation of a standard protocol of reactive oxygen species assay for chemical photosafety evaluation. Onoue S, Hosoi K, Wakuri S, Iwase Y, Yamamoto T, Matsuoka N, Nakamura K, Toda T, Takagi H, Osaki N, Matsumoto Y, Kawakami S, Seto Y, Kato M, Yamada S, Ohno Y, Kojima H. J Appl Toxicol. Nov 2013. 33(11): 1241-1250. |
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村松 正實 |
埼玉医科大学ゲノム医学研究センター 名誉教授 |
転写、ステロイドホルモン、癌 |
Quantitative aspects of isolation of nucleoli from the walker carcinosarcoma and liver of the rat. Muramatsu, M., Smetana, K. and Busch, H. (1963).
Cancer Res., 23, 510-518. |
Genomic binding-site cloning reveals an estrogen-responsive gene that encodes a RING finger protein. Inoue, S., Orimo, A., Hosoi, T., Kondo, S., Toyoshima, H., Kondo, T., Ikegami, A., Ouchi, Y., Orimo, H. and Muramatsu, M. (1993).
Proc. Natl. Acad. Sci. USA 90, 11117-11121. |
RNA polymerase I associated factor 53 binds to the nucleolar transcription factor UBF and functions in specific rDNA transcription. Hanada, K., Song, C.-Z., Yamamoto, K., Yano, K., Maeda, Y., Yamaguchi, K. and Muramatsu, M. (1996). EMBO J.,15, 2217-2226. |
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山田 弘 |
(独)医薬基盤研究所 創薬基盤研究部
トキシコゲノミクス・インフォマティクスプロジェクト プロジェクトリーダー |
分子毒性学 |
Minowa Y., Kondo C., Uehara1 T., Morikawa Y., Okuno Y., Nakatsu N., Ono A., Maruyama T., Kato I., Yamate J., Yamada H., Ohno Y., Urushidani T., Toxicogenomic multigene biomarker for predicting the future onset of proximal tubular injury in rats, Toxicology, 297, 47-56, 2012 |
Okuno Y, Minowa Y., Yamada H., Ohno Y., Urushidani T., In silico toxicology prediction using toxicogenomics data, In Handbook of Systems Toxicology, Johns Wiley and Sons Ltd., New York (Casciano D.A. and Sahu S.C., Ed.), 591-598, 2011 |
Yamada H., Toxicogenomics and biomaerkers, Folia Pharmacol., Jpn., 140, 221-225, 2012 |
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吉田 武美 |
公益社団法人薬剤師認定制度認証機構執行 理事
昭和大学名誉 教授 |
毒性学 |
Involvement of Interleukin-1 in Lead Nitrate-Induced Hypercholesterolemia in Mice
M.Kojima, T. Ashino, T. Yoshida, Y. Iwakura and M. Degawa
Biol. Pharm. Bull., 2012,35,246-250. |
6−Mercaptopurine-induced histopathological changes and xanhtine oxidase expression in rat placenta、K. Taki, T. Fukushima, R. Ise, I. Horii and T. Yoshida
J. Toxicol. Sci., 37, 607-615 (2012) |
Tanaka S, Kondo H, Kanda K, Ashino T, Nakamachi T, Sekikawa K, Iwakura Y, Shioda S, Numazawa S, Yoshida T. Involvement of interleukin-1 in lipopolysaccaride-induced microglial activation and learning and memory deficits. J Neurosci Res. 2011 89, 506-514. |
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