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| 内海 英雄 |
独立行政法人医薬品医療機器総合機構 理事 |
| 薬学 |
| Simultaneous imaging of tumor oxygenation and microvascular permeability using Overhauser enhanced MRI., Matsumoto S, Yasui H, Batra S, Kinoshita Y, Bernardo M, Munasinghe JP, Utsumi H, Choudhuri R, Devasahayam N, Subramanian S, Mitchell JB, Krishna MC., Proc Natl Acad Sci USA, 106(42): 17898-17903, 2009 |
| Noninvasive assessment of the brain redox status after transient middle cerebral artery occlusion using Overhauser-enhanced magnetic resonance imaging., Yamato M, Shiba T, Yamada KI, Watanabe T, Utsumi H., J Cereb Blood Flow Metab., 29(10):1655-64, 2009 |
| Whole-body kinetic image of a redox probe in mice using Overhauser-enhancesd MRI., Kosem N., Naganuma T., Ichikawa K., Morales N. P., Yasukawa K., Hyodo F., Yamada KI., Utsumi H., Free Radic Biol Med., 53:328-336, 2012 |
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| 高坂 新一 |
国立精神・神経医療研究センター神経研究所 所長 |
| 神経科学 |
Namba T, Ming GL, Song H, Waga C, Enomoto A, Kaibuchi K, Kohsaka S, and Uchino S.:
NMDA receptor regulates migration of newly generated neurons in the adult hippocampus via /Disrupted-In-Schizophrenia 1/ (DISC1).
J Neurochem 118 (2011) 34-44. |
Sanagi T, Nakamura Y, Suzuki E, Uchino S, Aoki M, Warita H, Itoyama Y, Kohsaka S, Ohsawa K.:
Involvement of activated microglia in increased vulnerability of motoneurons after facial nerve avulsion in presymptomatic amyotrophic lateral sclerosis model rats.
Glia. 60(2012) 782-793. |
Ohsawa K, Sanagi T, Nakamura Y, Suzuki E, Inoue K, Kohsaka S.:
Adenosine A3 receptor is involved in ADP-induced microglial process extension and migration.
J Neurochem. 121 (2012) 217-227. |
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| 猿田 享男 |
財団法人医療研修推進財団 理事長 |
| 内分泌 |
| Ichihara A, Hayashi M, Kaneshiro Y, Suzuki F, Nakagawa T, Tada Y, Koura Y, Nishiyama A, Okada H, Uddin MN, Nabi AHMN, Ishida Y, Inagami T, Saruta T.: Inhibition of diabetic nephropathy by a decoy peptide corresponding to the handle region for nonproteolytic activation of prorenin. J Clin Invest. 2004;114:1128–1135. |
| Kurihara I, Shibata H, Kobayashi S, Suda N, Ikeda Y, Yokota K, Murai A, Saito I, Rainey WE, Saruta T.:Ubc9 and Protein Inhibitor of Activated STAT 1 Activate Chicken Ovalbumin Upstream Promoter-Transcription Factor I-mediated Human CYP11B2 Gene Transcription. J Biol Chem 2005;280:6721-6730. |
| Hayashi K, Wakino S, Sugano N, Ozawa Y, Homma K, Saruta T: Ca++ channel subtypes and pharmacology in the kindney. Circ Res 2007;100:342-353. |
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| 西島 正弘 |
昭和薬科大学・学長 |
| 生化学 |
Molecular machinery for non-vesicular trafficking of ceramide
K. Hanada, K. Kumagai, S. Yasuda, Y. Miura, M. Kawano, M. Fukasawa, and M. Nishijima
Nature (Article), 426, 803-809, 2003 |
A Potent Adjuvant Monophosphoryl Lipid A Triggers Various Immune Response, but Not Secretion of lL-1・ or Activation of Caspase-1
K. Okemoto, K. Kawasaki, K. Hanada, M. Miura, and M. Nishijima
J. Immunol., 176, 1203-1208, 2006 |
Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide
N. Kudo, K. Kumagai, N. Tomishige, T. Yamaji, S. Wakatsuki, M. Nishijima, K. Hanada, and R. Kato
Proc. Natl. Acad. Sci.USA., 105, 488-493, 2008 |
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| 早川 堯夫 |
近畿大学薬学総合研究所長 |
| 生物化学、薬学 |
| バイオ医薬品開発の主流を占める糖タンパク質.バイオ医薬品開発における糖鎖技術（早川堯夫、掛樋一晃、平林 淳監修）、早川堯夫、シーエムシー出版、pp.1-21（2011） |
| Human adipose tissue-derived multilineage progenitor cells exposed to oxidative stress induce neurite outgrowth in PC12 cells through p38 MAPK signaling. Moriyama M, Moriyama H, Ueda A, Nishibata Y, Okura H, Ichinose A, Matsuyama A, Hayakawa T. BMC Cell Biol. 13(1):21（2012） |
| Efficient Generation of Functional Hepatocytes From Human Embryonic Stem Cells and Induced Pluripotent Stem Cells by HNF4α Transduction. Takayama K, Inamura M, Kawabata K, Katayama K, Higuchi M, Tashiro K, Nonaka A, Sakurai F, Hayakawa T, Kusuda Furue M, Mizuguchi H. Mol Ther. 20(1) 127-137 (2012). |
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| 堀田 知光 |
国立がん研究センター 理事長 |
| 血液・腫瘍内科学 |
| Phase II/III study of R-CHOP-21 versus R-CHOP-14 for untreated indolent B-cell non-Hodgkin's lymphoma: JCOG 0203 trial. Watanabe T, Tobinai K, Shibata T, Tsukasaki K, Morishima Y, Maseki N, Kinoshita T, Suzuki T, Yamaguchi M, Ando K, Ogura M, Taniwaki M, Uike N, Takeuchi K, Nawano S, Terauchi T, Hotta T. J Clin Oncol 2011, 29(30): 3990-3998 |
| Phase I and phase II study of azacitidine in Japanese patients with myelodysplastic syndromes. Uchida T, Ogawa Y, Kobayashi Y, Ishikawa T, Ohashi H, Hata T, Usui N, Taniwaki M, Ohnishi K, Akiyama H, Ozawa K, Ohyashiki K, Okamoto S, Tomita A, Nakao S, Tobinai K, Ogura M, Ando K, Hotta T. Cancer Sci. 2011,102(9): 1680-1686 |
| Randomized phase II dose-finding study of weekly administration of darbepoetin alfa in anemic patients with lung or ovarian cancer receiving multicycle platinum-containing chemotherapy. Ichinose Y, Steo T, Nishiwaki Y, Ohe Y, Yamada Y, Takeda K, Saijo N, Hotta T. J Clin Oncol 2010,40(6): 521-529 |
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| 村井 安 |
Meiji Seika ファルマ
執行役員医薬研究開発本部長 |
| 医薬品開発 |
| 当該年度は該当なし。 |
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| 渡邉 治雄 |
国立感染症研究所 所長 |
| 細菌学 |
| Interferon-γ-producing immature myeloid cells confer protection against severe invasive group A Streptococcus infections. Takayuki Matsumura, Manabu Ato, Tadayoshi Ikebe, Makoto Ohnishi, Haruo Watanabe and Kazuo Kobayashi. Nature Communication. DOI:10.1038/ncomms1677. 2012 |
| Coordinate control of the locus of enterocyte effacement and enterohemolysin genes by multiple common virulence regulators in enterohemorrhagic Escherichia coli. Iyoda S, Honda N, Saitoh T, Shimuta K, Terajima J, Watanabe H, Ohnishi M. Infect Immun. 79:4628-4637.2011 |
| Bacterial cytoskeleton protein RodZ is involved in post-transcriptional processing of Shigella type III secretion system. Jiro Mitobe, Itaru Yanagihara, Kiyouhisa Ohnishi, Shoji Yamamoto, Makoto Ohnishi, Akira Ishihama and Haruo Watanabe. EMBO. Rep.12:911-916.2011 |
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