| |
| 内海 英雄 |
独立行政法人医薬品医療機器総合機構 理事
|
| 生体磁気共鳴画像学 |
| Simultaneous imaging of tumor oxygenation and microvascular permeability using Overhauser enhanced MRI., Matsumoto S, Yasui H, Batra S, Kinoshita Y, Bernardo M, Munasinghe JP, Utsumi H, Choudhuri R, Devasahayam N, Subramanian S, Mitchell JB, Krishna MC., Proc Natl Acad Sci USA, 106(42): 17898-17903, 2009 |
| Noninvasive assessment of the brain redox status after transient middle cerebral artery occlusion using Overhauser-enhancesd magnetic resonance imaging., Yamato M, Shiba T, Yamada KI, Watanabe T, Utsumi H., J Cereb Blood Flow Metab., 29(10):1655-64, 2009 |
| Whole-body kinetic image of a redox probe in mice using Overhauser-enhancesd MRI., Kosem N., Naganuma T., Ichikawa K., Morales N. P., Yasukawa K., Hyodo F., Yamada KI., Utsumi H., Free Radic Biol Med., 53:328-336, 2012 |
|
| |
| 大石 道夫 |
公益財団法人かずさDNA研究所･理事長 |
| 分子生物学、分子遺伝学、バイオテクノロジー |
Oishi, M.: An ATP-dependent deoxyribonuclease from Escherichia coli with a possible role in genetic recombination.
Proc. Natl. Acad. Sci. USA 64, 1292-1299 (1969). |
Oishi, M. and Cosloy, S. D.: Specialized transformation in Escherichia coli K12.
Nature 248, 112-116 (1974). |
Oishi, M., Smith, C. L. and Friefeld, B.: Molecular events and molecules that lead to induction of prophage and SOS functions.
Cold Spring Harbor Symp. Quant. Biol. XLIII, 897-907 (1979). |
|
| |
| 梶谷 文彦 |
川崎医療福祉大学・特任教授
|
| 循環器ナノメディシン、生体フィジオーム、 医用工学 |
| Hydrogen peroxide, an endogenous EDHF, plays an important role in coronary autoregulation in vivo.,T.Yada, H.Shimokawa, O.Hiramatsu, T.Kajita, F.Shigeto, M.Goto, Y.Ogasawara, F.Kajiya.: Circulation,107(7):1040-1045,2003 |
| Evaluation of bioavailability of nitric oxide in coronary circulation by direct measurement of plasma nitric oxide concentration., Y.Neishi, S.Mochizuki, T.Miyasaka, T.Kawamoto, T.Kume, R.Sukmawan, M.Tsukiji, Y.Ogasawara, F.Kajiya, T.Akasaka, K.Yoshida, M.Goto.,Proc Natl Acad Sci.,102(32) :11456-11461,2005 |
| F.Kajiya, T.Yada, O.Hiramatsu, Y.Ogasawara, Y.Inai, M.Kajiya, Coronary microcirculation in the beating heart.,Med Biol Eng Comput.,46(5):411-419,2008 |
|
| |
| 白井 智之 |
名古屋市総合リハビリテーションセンター事業団 センター長 |
| 毒性病理学、人体病理学 |
| Matsumoto, H., Yakabe, Y., Saito, K., Sumida, K., Sekijima, M., Nakayama, K., Miyaura, H., Saito, F., Otsuka, M., Shirai, T.: Discrimination of carcinogens by hepatic transcript profiling in rats following 28-day a administration. Cancer Informatics, 7: 253-269 2009. |
| Matsumoto, H., Yakabe, Y., Saito, F., Saito, K., Sumida, K., Sekijima, M., Nakayama, K., Miyaura, H., Otsuka, M., Shirai, T.: New Short Term Prediction Method for Chemical Carcinogenicity by Hepatic Transcript Profiling Following 28-Day Toxicity Tests in Rats. Cancer Informatics, 10: 259-271, 2011. |
| Suzuki, S., Pitchakarn, P., Takeshita, K., Asamoto, M., Takahashi, S., Sato, S., Shirai, T.: Roles for Rat Hepatocyte Malignant Transforming Factor(HMTF) in Late Stage of Hepatocarcinogenesis. Toxicol. Pathol., 39: 1084-1090, 2011. |
|
| ○ |
| 髙久 史麿 |
日本医学会会長 自治医科大学理事長 |
| 内科学（血液,腫瘍） |
Improved gene expression in resting macrophages using an oligopeptide
derived from Vpr of human immunodeficiency virus type-1. Mizoguchi I, Ooe Y,
Hoshino S, Shimura M, Kasahara T, Kano S, Ohta T, Takaku F, Nakayama Y, Ishizaka Y,
Biochemical And Biophysical Research Communications [Biochem Biophys Res Commun];
Vol. 338 (3), pp. 1499-506, 2005 Dec 23 |
Nuclear trafficking of macromolecules by an oligopeptide derived from Vpr of
human immunodeficiency virus type-1. Taguchi T, Shimura M, Osawa Y, Suzuki Y,
Mizoguchi I, Niino K, Takaku F, Ishizaka Y, Biochemical And Biophysical Research
Communications [Biochem Biophys Res Commun]; Vol. 320 (1), pp. 18-26, 2004 Jul 16 |
Analysis of gene expression profiles in an imatinib-resistant cell line, KCL22/SR.
Ohmine K, Nagai T, Tarumoto T, Miyoshi T, Muroi K, Mano H, Komatsu N, Takaku F, Ozawa
K, Stem Cells (Dayton, Ohio) [Stem Cells]; Vol. 21 (3), pp. 315-21, 2003 |
|
|
| 中村 和市 |
日本製薬工業協会 医薬品評価委員会 基礎研究部会 部会長
|
| 毒性学 |
| Establishment and intra-/inter-laboratory validation of a standard protocol of reactive oxygen species assay for chemical photosafety evaluation. Onoue S, Hosoi K, Wakuri S, Iwase Y, Yamamoto T, Matsuoka N, Nakamura K, Toda T, Takagi H, Osaki N, Matsumoto Y, Kawakami S, Seto Y, Kato M, Yamada S, Ohno Y, Kojima H. J Appl Toxicol. 2012 Jun 13. doi: 10.1002/jat.2776. |
| Perspective on non-clinical safety evaluation of drug metabolites through the JSOT workshop. Minagawa T, Nakano K, Furuta S, Iwasa T, Takekawa K, Minato K, Koga T, Sato T, Kawashima K, Kurahashi Y, Onodera H, Naito S, Nakamura K. J Toxicol Sci. 2012 Aug; 37(4): 667-673. |
| Concordance between non-clinical and clinical toxicity data determined by a survey of approved pharmaceuticals in Japan. Nakamura K, Hisada S, Ohkura T, Yoneta Y, Hattori K, Ogino Y, Tamaki C, Takashima Y, Yasugi D, Hashiba M, Matsumura M, Nagayama T. The Society of Toxicology 51st Annual Meeting, Mar 2012. |
|
| |
| 森下 竜一 |
大阪大学大学院医学系研究科寄付講座 教授 |
| 遺伝子治療、創薬、循環器、核酸医薬 |
| Morishita R, Makino H, Aoki M, Hashiya N, Yamasaki K, Azuma J, Taniyama Y, Sawa Y, Kaneda Y, Ogihara T. Phase I/IIa Clinical Trial of Therapeutic Angiogenesis Using Hepatocyte Growth Factor Gene Transfer to Treat Critical Limb Ischemia. Arteriosclerosis, Thrombosis, & Vascular Biology. 2011;31:713-720 |
| Miyake T, Aoki M, Osako MK, Shimamura M, Nakagami H, Morishita R. Development of ribbon-type decoy oligodeoxynucleotides (ODN): systemic administration of ribbon-type decoy ODN against NFκB and Ets binding sites prevented abdominal aortic aneurysm in rat model. Molecular Therapy 2011;19:181-187 |
| Shigematsu H, Yasuda K, Iwai T, Sasajima T, Ishimaru S, Ohashi Y, Yamaguchi T, Ogihara T, Morishita R. Randomized, double-blind, placebo-controlled clinical trial of hepatocyte growth factor plasmid for critical limb ischemia. Gene Therapy. 2010;17:1152-1161 |
|
| |
| 山田 弘 |
（独）医薬基盤研究所 創薬基盤研究部
トキシコゲノミクス・インフォマティクスプロジェクト
プロジェクトリーダー
|
| 分子毒性学 |
| Gao W, Mizukawa Y, Nakatsu N, Minowa Y, Yamada H, Ohno Y, Urushidani T. Mechanism-based biomarker gene sets for glutathione depletion-related hepatotoxicity in rats. Toxicol Appl Pharmacol. 2010; 247: 211-221. |
| 「非臨床試験 創薬段階での非臨床安全性評価―ハイスループット・トキシコロジー／分子毒性学的アプローチ」山田弘他共著，pp419-479，エル・アイ・シー（2008） |
| 医薬品安全性評価に用いるMechanistic Tool Boxの充実，山田弘，第39回日本毒性学会学術年会，シンポジウム：臨床副作用と非臨床毒性の相関－種差を乗り越えて－，2012 |
|
| |
| 吉田 武美 |
公益社団法人薬剤師認定制度認証機構執行理事
昭和大学名誉教授
|
| 毒性学 |
Involvement of Interleukin-1 in Lead Nitrate-Induced Hypercholesterolemia in Mice
M.Kojima, T. Ashino, T. Yoshida, Y. Iwakura and M. Degawa
Biol. Pharm. Bull., 2012,35,246-250. |
６－Mercaptopurine-induced histopathological changes and xanhtine oxidase expression in rat placenta、K. Taki, T. Fukushima, R. Ise, I. Horii and T. Yoshida
J. Toxicol. Sci., 37, 607-615 (2012) |
| Tanaka S, Kondo H, Kanda K, Ashino T, Nakamachi T, Sekikawa K, Iwakura Y, Shioda S, Numazawa S, Yoshida T. Involvement of interleukin-1 in lipopolysaccaride-induced microglial activation and learning and memory deficits. J Neurosci Res. 2011 89, 506-514. |
|
