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難治性疾患克服研究事業 中間・事後評価委員名簿

(○:委員長)

 
稲葉 裕 実践女子大学生活科学部 教授
疫学
「疫学調査における地域および年令因子に関する研究」稲葉 裕、高木廣文、柳井晴夫、松原純子.日本公衛誌 22(2),83-90. 1975
Recent statistical data book of intractable diseases in Japan.
Inaba Y, Minowa M, Osaki Y, Nagai M, Aizawa S, Ohno Y(Eds)
Research Committee on Epidemiology of Intractable Diseases, the Ministry of Health and Welfare of Japan.1996
「難病とその他の疾患」稲葉裕編著.所収「疫学ハンドブック:重要疾患の疫学と予防」日本疫学会編.1998
 
江藤 文夫 国立障害者リハビリテーションセンター自立支援局長
リハビリテーション医学
Eto F, Saotome I, Furuichi T, Ogasawara M: Effects of long-term use of benzodiazepines on gait and standing balance in the elderly. Annals of New York Academy of Sciences 860: 543-545, 1998.
Eto F, Wada N, Maeno T, Miyake N, Saotome I: The effect of heel elevation in Parkinsonian gait. Geriatrics Gerontology International 2004; 4: S202-S204.
Saotome T, Sekino M, Eto F, Ueno S: Evaluation of diffusional anisotropy and microscopic structure in skeletal muscles using magnetic resonance. Magn Reson Imaging 2006; 24: 19-25.
 
長村 義之 国際医療福祉大学教授
病理学、内分泌学、腫瘍学
Pathology, pathogenesis and therapy of growth hormone (GH)-producing pituitary adenomas: technical advances in histochemistry and their contribution. Osamura RY, Egashira N, Kajiya H, Takei M, Tobita M, Miyakoshi T, Inomoto C, Takekoshi S, Teramoto A: Acta Histochem Cytochem 2009, 42:95-104.
The Expression of Wnt4 Is Regulated by Estrogen via an Estrogen Receptor Alpha-dependent Pathway in Rat Pituitary Growth Hormone-producing Cells. Miyakoshi T, Kajiya H, Miyajima K, Takei M, Tobita M, Takekoshi S, Osamura RY: Acta Histochem Cytochem 2009, 42:205-213.
Selection of buffer pH by the isoelectric point of the antigen for the efficient heat-induced epitope retrieval: Kajiya H, Takekoshi S, Takei M, Egashira N, Miyakoshi T, Serizawa A, Teramoto A, Osamura RY: re-appraisal for nuclear protein pathobiology. Histochem Cell Biol 2009, 132:659-667.
 
越智 隆弘 大阪警察病院・院長
整形外科
Mesenchymal stromal cells. Nurse-like cells reside in the synovial tissue and bone marrow in rheumatoid arthritis.
Ochi T, Yoshikawa H, Toyosaki-Maeda T, Lipsky PE.
Arthritis Res Ther. 2007;9(1):201. Review.
Fondaparinux prevents venous thromboembolism after joint replacement surgery in Japanese patients.
Fuji T, Fujita S, Ochi T.
Int Orthop. 2008 Aug;32(4):443-51. Epub 2007 Apr 28.
患者さんのための関節リウマチ治療ガイドライン
越智 隆弘監修
医歯薬出版株式会社出版 2006年
 
木下 茂 京都府立医科大学・視覚機能再生外科学教授
眼科学
Kinoshita S, Adachi W, Sotozono C, Nishida K, Yokoi N, Quantock A, Okubo K: Characteristics of the human ocular surface epithelium. Prog. Retina Eye Res 20:639-673, 2001.
Sotozono C, Ueta M, Koizumi N, Inatomi T, Ikezawa Z, Shirakata Y, Hashimoto K, Kinoshita S: Diagnosis and Treatment of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis with Ocular Complications. Ophthalmology 116:685-690, 2009.
Nakano M, Ikeda Y, Taniguchi T, Yagi T, Fuwa M, Omi N, Tokuda Y, Tanaka M, Yoshii K, Kageyama M, Naruse S, Matsuda A, Mori K, Kinoshita S, Tashiro K: Three susceptible foci associated with primary-open angle glaucoma identified by genome-wide association study in Japanese population. Proc Natl Acad Sci 106:12838-12842, 2009.
桐野 高明 国立国際医療研究センター・総長
脳神経外科
Nakatomi H, Kuriu T, Okabe S, Yamamoto S, Hatano O, Kawahara N, Tamura A, Kirino T, Nakafuku M: Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors. Cell 110:429-441,2002
Maruyama K, Kawahara N, Shin M, Tago M, Kishimoto J, Kurita H, Kawamoto S, Morita A, Kirino T: The risk of hemorrhage after radiosurgery for cerebral arteriovenous malformations. N Engl J Med 352:146-153,2005
Kirino T: Ischemic tolerance. J Cereb Blood Flow Metab 22:1283-1296,2002 (Invited Review)
 
高嶋 幸男 柳川療育センター施設長
小児科、小児神経科、新生児科、神経病理
Armstrong D, Halliday W, Hawkins C, Takashima S: Pediatric Neuropathology- a text and atlas, Springer, Tokyo, 2007.
Takashima S, Itoh M, Oka A: A history of our understanding of cerebral vascular development and pathogenesis of perinatal brain damage over the past 30 years, and further prospective. Seminars in Pediatric Neurology 16:226-36, 2009.
高嶋幸男、伊藤雅之、水口 雅:ヒト脳の形態形成とその異常、脳神経科学、東京、三輪書店、p.53-62, 2003.
 
竹中 洋 大阪医科大学 学長
耳鼻咽喉科学
Enhanced human IgE production results from exposure to the aromatic Hydrocarbons from diesel exhaust;direct effects on B-cell IgE production, Takenaka H, et al
J Allery CLin Immunol;1998.95:103-115.
コア・ローテイション 耳鼻咽喉科・頭頸部外科
編集 竹中洋、高橋姿、久育男
金芳堂、2004年1月5日
気道アレルギーの成立とその制御:竹中 洋
第110回日本耳鼻咽喉科学術総会宿題報告
東京、2009.05.14.
 
谷口 克 独立行政法人理化学研究所 免疫アレルギー科学総合研究センター・センター長
免疫学
Generation of functional NKT cells in vitro from embryonic stem cells bearing rearranged invariant Valpha14-Jalpha18 TCRalpha gene. Watarai H, Rybouchkin A, Hongo N, Nagata Y, Sakata S, Sekine E, Dashtsoodol N, Tashiro T, Fujii S, Shimizu K, Mori K, Masuda K, Kawamoto H, Koseki H, Taniguchi M. Blood,115:230-7, 2010.
PDC-TREM, a plasmacytoid dendritic cell-specific receptor, is responsible for augmented production of type I interferon. Watarai H, Sekine E, Inoue S, Nakagawa R, Kaisho T, and Taniguchi M. Proc. Natl. Acad. Sci. USA, 105: 2993-2998, 2008.
Va14 NKT cell-triggered IFN-g production by Gr-1+CD11b+ cells mediates early graft loss of syngeneic transplanted islets. Yasunami, Y., Kojo, S., Kitamura, H., Toyofuku, A., Satoh, M., Nakano, M., Nabeyama, K., Nakamura, Y., Matsuoka, N., Ikeda, S., Tanaka, M., Ono, J., Nagata,N., Ohara, S., and Taniguchi, M. J. Exp. Med. 202:913-918, 2005.
 
新津 洋司郎 札幌医科大学分子標的探索講座 特任教授
臨床腫瘍学、消化器病学、血液病学
Resolution of liver cirrhosis using vitamin A-coupled liposomes to deliver siRNA against a collagen-specific chaperone. Sato Y, Murase K, Kato J, Kobune M, Sato T, Kawano Y, Takimoto R, Takada K, Miyanishi K, Matsunaga T, Takayama T, Niitsu Y Nature Biotechnology, 26(4):431-42, 2008
Interaction between leukemic-cell VLA-4 and stromal fibronectin is a decisive factor for minimal residual disease of acute myelogenous leukemia. Matsunaga T, Takemoto N, Sato T, Takimoto R, Tanaka I, Fujimi A, Akiyama T, Kuroda H, Kawano Y, Kobune M, Kato J, Hirayama Y, Sakamaki S, Kohda K, Miyake K, Niitsu Y. Nature Medicine, 9(9):1158-65, 2003
Aberrant crypt foci of the colon as precursors of adenoma and cancer. Takayama T, Katsuki S, Takahashi Y, Ohi M, Nojiri S, Sakamaki S, Kato J, Kogawa K, Miyake H, Niitsu Y. The New England Journal of Medicine, 339(18):1277-84, 1998
 
西岡 清 横浜市立みなと赤十字病院 名誉院長
皮膚科学・免疫アレルギー学
Hepatocyte growth factor both prevents and ameliorates the symptoms of dermal sclerosis in a mouse model of scleroderma.  Wu MH, Yokozeki H, Takagawa S, Yamamoto T, Satoh T, Kaneda Y, Katayama I, Nishioka  K Gene Therapy 11: 170-180, 2004
Synthesis of α(1,3) fucosyltransferases IV- and VII-dependent eosinophil selectin ligand and recruitment to the skin. Satoh T, Kanai Y, Wu M-H, Yokozeki H, Kannagi R, Lowe JB, Nishioka K Am J Pathol 167: 787-796, 2005
Prostaglandin D2 plays an essential role in chronic allergic inflammation of the skin via CRTH2 receptor.  Satoh T, Moroi R, Akitake K, Urade Y, Kanai Y, Sumi K, Yokozeki H, Nagata K, Hara T, Utsuyama M, Hirokawa K, Suganuma K, Nishioka K, Nakamura M  J Immunology 177: 2621-2629, 2006
 
貫和 敏博 東北大学大学院医学系研究科・教授
内科学(呼吸器内科学)
Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. Maemondo M, Inoue A, Kobayashi K, Sugawara S, Oizumi S, Isobe H, Gemma A, Harada M, Yoshizawa H, Kinoshita I, Fujita Y, Okinaga S, Hirano H, Yoshimori K, Harada T, Ogura T, Ando M, Miyazawa H, Tanaka T, Saijo Y, Hagiwara K, Morita S, Nukiwa T; North-East Japan Study Group. N Engl J Med. 2010 Jun 24;362(25):2380-8.
First-line gefitinib for patients with advanced non-small-cell lung cancer harboring epidermal growth factor receptor mutations without indication for chemotherapy. Inoue A, Kobayashi K, Usui K, Maemondo M, Okinaga S, Mikami I, Ando M, Yamazaki K, Saijo Y, Gemma A, Miyazawa H, Tanaka T, Ikebuchi K, Nukiwa T, Morita S, Hagiwara K; North East Japan Gefitinib Study Group. J Clin Oncol. 2009 Mar 20;27(9):1394-400.
OX40 ligand expressed by DCs costimulates NKT and CD4+ Th cell antitumor immunity in mice. Zaini J, Andarini S, Tahara M, Saijo Y, Ishii N, Kawakami K, Taniguchi M, Sugamura K, Nukiwa T, Kikuchi T. J Clin Invest. 2007 Nov;117(11): 3330-8
 
菱田 明 焼津市立総合病院・事業管理者
腎臓内科学
急性腎不全・AKIを理解する・菱田明・東京医学社・2010年
Enhanced intrarenal receptor-mediated prorenin activation in chronic progressive anti-thymocyte serum nephritis rats on high salt intake. Huang Y, Yamamoto T, Misaki T, Suzuki H, Togawa A, Ohashi N, Fukasawa H, Fujigaki Y, Ichihara A, Nishiyama A, Senbonmatsu T, Ikegaya N, Hishida A. Am J Physiol Renal Physiol. 303(1):F130-8, 2012.
Cell division and phenotypic regression of proximal tubular cells in response to uranyl acetate insult in rats.
Fujigaki Y, Sakakima M, Sun Y, Fujikura T, Tsuji T, Yasuda H, Hishida A.  Nephrol Dial Transplant. 24:2686-92,2009.
 
保坂 シゲリ 社団法人日本医師会常任理事
 
棟方 昭博 弘前大学名誉教授
消化器内科,消化器内視鏡,消化器免疫
Dose portal hypertension modify colonic mucosal vasculature? quantification of alteration by image processing and topology. Munakata A. Sasaki Y. Am. J. Gastroenterology 90:1997-2001, 1995
Improved localizing method of radiopill in measurement of entire gastrointestinal pH profiles: Colonic luminal pH in normal subjects and patient with Crohn’s disease. Sasaki Y, Nakajima H, Munakata A. Am. J. Gastroenterology 92:114-118, 1997
Endoscopic ligation by means of clip and detachable snare for management of colonic postpolypectomy hemorrhage. Uno Y, Munakata A. Gstrointestinal Endoscopy 49:113-115, 1999
 
吉栖 正生 広島大学大学院 医歯薬学総合研究科教授
循環器病学
Autologous bone-marrow mononuclear cell implantation improves endothelium-dependent vasodilation in patients with limb ischemia.
Higashi Y, Kimura M, Hara K, Noma K, Jitsuiki D, Nakagawa K, Oshima T, Chayama K, Sueda T, Goto C, Matsubara H, Murohara T, Yoshizumi M.
Circulation 109:1215-1218, 2004
Role of osteoprotegerin in arterial calcification: development of new animal model.
Orita Y, Yamamoto H, Kohno N, Sugihara M, Honda H, Kawamata S, Mito S, Soe NN, Yoshizumi M.
Arterioscler Thromb Vasc Biol 27:2058-2064, 2007
腹部大動脈瘤検出装置
吉栖 正生,辻 敏夫,藤田 悦則,小倉 由美,前田 慎一郎
  日本国特許出願 2009-118095  2009

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