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地球規模保健課題推進研究事業(国際医学協力研究)中間・事後評価委員名簿

(○:委員長)

 
笹月 健彦 国立国際医療研究センター 名誉総長
九州大学高等研究院  特別主幹教授
免疫遺伝学
Sasazuki T, Juji T, Morishima Y, Kinukawa N, Kashiwabara H, Inoko H, Yoshida T, Kimura A, Akaza T, Kamikawaji N, Kodera Y, Takaku F.  Effect of matching of class I HLA alleles on clinical outcome after transplantation of hematopoietic stem cells from an unrelated donor.  New Engl. J. Med., 339:1177-1185, 1998
Fukui Y, Hashimoto O, Sanui T, Oono T, Koga H, Abe M, Inayoshi A, Noda M, Oike M, Shirai T, Sasazuki T.  Hematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration.  Nature, 412: 826-831, 2001
Sasawatari S, Yoshizaki M, Taya C, Tazawa A, Furuyama-Tanaka K, Yonekawa H, Dohi T, Makrigiannis AP, Sasazuki T, Inaba K, Toyama-Sorimachi N. The Ly49Q receptor plays a crucial role in neutrophil polarization and migration by regulating raft trafficking. Immunity, 32: 200-213. 2010
清野 裕 関西電力病院 病院長
糖尿病学
GIP and GLP-1, the two incretin hormones: Similaities and differences.
Y. Seino, M.Fukushima, D.Yabe
Journal of Diabetes Investigation 2010;1(1-2):56-59
Understanding the incretin effect.
Y. Seino.
J Clin Endocrinol Metab 2011; 96(4):934-5
GPR119 regulates murine glucose homeostasis through incretin receptor-dependent and independent mechanisms.
Flock G, Holland D, Y. Seino, Drucker DJ.
Endocrinology 2011;152(2):374-83
 
島 郁夫 北海道大学大学院獣医学研究科 名誉教授
天使大学看護栄養学部栄養学科 教授
ウイルス学
Takashima I, Watanabe T, Ouchi N, Hashimoto N. Ecological studies of Japanese encephalitis virus in Hokkaido: interepidemic outbreaks of swine abortion and evidence for the virus to overwinter locally. Am J Trop Med Hyg. 38: 420-427. 1988
Takashima I, Morita K, Chiba M, Hayasaka D, Sato T, Takezawa C, Igarashi A, Kariwa H, Yoshimatsu K, Arikawa J, Hashimoto N. A case of tick-borne encephalitis in Japan and isolation of the the virus. J Clin Microbiol. 35:1943-1947. 1997
Hayasaka D, Suzuki Y, Kariwa H, Ivanov L, Volkov V, Demenev V, Mizutani T, Gojobori T, Takashima I. Phylogenetic and virulence analysis of tick-borne encephalitis viruses from Japan and far-Eastern Russia. J Gen Virol. 80:3127-3135. 1999
 
廣橋 説雄 慶應義塾大学医学部 特任教授
腫瘍病理学
Tatsuya Oda, Yae Kanai, Tsukasa Oyama, Kenta Yoshiura, Yutaka Shimoyama, Walter Birchmeier, Takashi Sugimura, Setsuo Hirohashi. E-cadherin gene mu tations in human gastric carcinoma cell lines. Proc. Natl. Acad. Sci. USA, 91: 1858-1862, 1994.
Kenta Yoshiura, Yae Kanai, Atsushi Ochiai, Yutaka Shimoyama, Takashi Sugimura, Setsuo Hirohashi. Silencing of the E- cadherin invasion-suppressor Gene by CpG methylation in human carcinomas. Proc. Natl. Acad. Sci. 92(16): 7416-7419, 1995.
Yoshinori Ino, Masahiro Gotoh, Michiie Sakamoto, Kiyomi Tsukagoshi, Setsuo Hirohashi. Dysadherin, a cancer-associated cell membrane glycoprotein, down-regulates E-cadherin and promotes metastasis. Proc. Natl. Acad. Sci. USA, 99(1): 365-370, 2002.
 
三浦 総一郎 防衛医科大学校長
消化器内科学
Higashiyama M, Hokari R, Hozumi H, Kurihara C, Ueda T, Watanabe C, Tomita K, Nakamura M, Komoto S, Okada Y, Kawaguchi A, Nagao S, Suematsu M, Goda N, Miura S. HIF-1 in T cells ameliorated dextran sodium sulfate-induced murine colitis.
J Leukoc Biol. 91(6): 901-909. 2012
Teratani T, Tomita K, Suzuki T, Oshikawa T, Yokoyama H, Shimamura K, Tominaga S, Hiroi S, Irie R, Okada Y, Kurihara C, Ebinuma H, Saito H, Hokari R, Sugiyama K, Kanai T, Miura S, Hibi T. A high-cholesterol diet exacerbates liver fibrosis in mice via accumulation of free cholesterol in hepatic stellate cells.
Gastroenterology. 142(1): 152-164. 2012
Matsunaga H, Hokari R, Ueda T, Kurihara C, Hozumi H, Higashiyama M, Okada Y, Watanabe C, Komoto S, Nakamura M, Kawaguchi A, Nagao S, Sekiyama A, Miura S.  Physiological stress exacerbates murine colitis by enhancing proinflammatory cytokine expression that is dependent on IL-18.
Am J Physiol Gastrointest Liver Physiol. 301(3): G555-G564, 2011
 
森 亨 (公財)結核予防会結核研究所 名誉所長
結核病学・公衆衛生学
Mori T, Leung CC: Tuberculosis in the Global Aging Population. Infect Dis Clin N Am 24: 751–768, 2010. doi:10.1016/j.idc.2010.04.011
Lange C, Mori T: Advances in the diagnosis of tuberculosis. Respirology 15: 220–240, 2010, doi: 10.1111/j.1440-1843.2009.01692.x
Mori T.; Harada, N.; Higuchi, K.; Sekiya, Y.; Uchimura, K.; Shimao, T: Waning of the specific interferon-gamma response after years of tuberculosis infection. Int J Tuberc Lung Dis 2007; 11(9): 1021-1025
 
山本 直樹 国立シンガポール大学医学部 微生物講座教授
ウイルス学
Yamamoto N, zur Hausen H. Tumour promoter TPA enhances transformation of human leukocytes by Epstein-Barr virus. Nature. 1979 Jul 19;280(5719):244-5.
Yamamoto N, Okada M, Koyanagi Y, Kannagi M, Hinuma Y. Transformation of human leukocytes by cocultivation with an adult T cell leukemia virus producer cell line. Science. 1982 Aug 20;217(4561):737-9.
Harada S, Koyanagi Y, Yamamoto N.  Infection of HTLV-III/LAV in HTLV-I-carrying cells MT-2 and MT-4 and application in a plaque assay. Science. 1985 Aug 9;229(4713):563-6.

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