難治性疾患克服研究事業事前評価委員名簿
（○：委員長）
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| 猿田享男 | 慶應義塾大学 名誉教授・医療研修推進財団 理事長 |
| 高血圧症、内分泌代謝疾患、腎臓病 | |
| Saruta T, Suzuki H, Handa M, Igarashi Y, Kondo K, Senba S : Multiple factors contribute to the pathogenesis of hypertension in Cushing's syndrome. J Clin Endocrinol Metab 1986;62:275-279. | |
| Saruta T, Kanno Y, Hayashi K, Konishi K : Antihypertensive agents and renal protection : calcium channel blockers. Kidney International Suppl.1996 ;55 :s52-s56. | |
| Saruta T, Kageyama S, Ogihara T, Hiwada K, Ogawa M, Tawara K, Gatlin M, Garthwaite S, Bittman R, Patrick J: Efficacy and safety of the selective aldosterone blockers Eplerenone in Japanese patients with hypertension. J Clin Hypertens 2004;6:175-185. | |
| 朝倉 均 | 新潟大学名誉教授 医療法人社団こうかん会 こうかんクリニック 院長 |
| 消化器内科学分野 | |
| Is there a link between food and intestinal microbes and the occurrence of Crohn's disease and ulcerative colitis? Asakura,H., Suzuki K., Kitahora T., Morizane T. Journal of Gastroenterology and Hepatology 23巻 (12号): 1794-1801, 2008 | |
| Rectal administration of tranilast ameliorated acute colitis in mice through increase expression of heme oxygenase-1. Sun X., Suzuki K., Nagata M., Kawauchi Y., Yano., Ohkoshi S., Matsuda Y., Kawachi H., Watanabe K., Asakura H., Aoyagi Y. Pathology International 60巻 (2号): 93-101, 2010 | |
| 日本のIBD研究の歴史と展望を概説してください。 IBD Research,3巻（4号）：320-323、2009 | |
| 内田 健夫 | （社）日本医師会 常任理事 |
| 外科 | |
| 【どうなる 特定健診・特定保健指導】【特定健診・特定保健指導への対応】日本医師会の立場から．内田健夫．病院．67（7）．609-611.2008 | |
| 【特定健診・特定保健指導の実際】保健指導の実際 地域における特定保健指導．内田健夫．綜合臨床．57（5）．1612-1617．2008 | |
| ヘルスサービスの中のジェネリック医薬品 医療政策から臨床の場まで ジェネリック医薬品の問題点について．内田健夫．薬理と治療．35（3）．1047-1050.2007 | |
| 大野 良之 | （独）労働者健康福祉機構 旭労災病院 顧問 |
| 疫学 | |
| Epidemiology of intractable diseases in Japan. Ohno Y, Kawamura T,Tamakoshi A, Wakai K, Aoki R, Kojima M, Lin Y, Hashimoto T, Nagai M, Minowa M. J Epidemiol. 1996; 6(Suppl): s99-s109. | |
| 「難病の患者数と臨床疫学像把握のための全国疫学調査マニュアル」大野良之、川村孝、玉腰暁子、橋本修二 編、厚生省特定疾患難病の調査研究班（1994） | |
| 「難病の最新情報−疫学から臨床・ケアまで−」、大野良之 編、東京：南山堂（2000） | |
| 神崎 仁 | 慶應大学名誉教授、国際医療福祉大学教授 |
| 耳鼻咽喉科学、耳科学、神経耳科学 | |
| Ogawa K,Takei S, Inoue Y, Kanzaki J: Effect of Prostagrandin E1 on idiopathic sudden sensorineural hearing loss. A double-blinded clinical study.Otology & Neurotology 23:665-668,2002 |
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| Kanzaki J, Inoue Y, Ogawa K, et al: Effect of single-drug treatment on idiopathic sensorineural hearing loss.Auris Nasus Larynx 30:123-127,2003 | |
| Kanzaki J, Kanzaki S, Ogawa K: Long-term prognosis of steroid dependent Sensorineural hearing loss. Audiool Neurotol 14:26-34, 2009 |
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| 桐野高明 | 国立国際医療センター・総長 |
| 脳神経外科 | |
| Nakatomi H, Kuriu T, Okabe S, Yamamoto S, Hatano O, Kawahara N, TamuraA, Kirino T, Nakafuku M: Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors.Cell 110:429-441,2002 | |
| Maruyama K, Kawahara N, Shin M, Tago M, Kishimoto J, Kurita H,Kawamoto S, Morita A, Kirino T: The risk of hemorrhage after radiosurgery for cerebral arteriovenous malformations. N Engl J Med 352:146-153,2005 | |
| Kirino T: Ischemic tolerance. J Cereb Blood Flow Metab 22:1283-1296,2002(Invited Review) | |
| 葛原茂樹 | 国立精神・神経センター病院 院長 |
| 神経変性疾患、痴呆性疾患、医原性神経疾患、脳血管障害 | |
| Kuzuhara S, Kokubo Y, Sasaki R, Narita Y, Yabana T, Hasegawa M, Iwatsubo T: Familial amyotrophic lateral sclerosis and parkinsonism-dementia complex of the Kii peninsula of Japan: clinical and neuropathological study and tau analysis. Ann Neurol 49:501-511, 2001 | |
| Morimoto S, Kuzuhara S, Kokubo Y: Increased oxidative stress in patients with amyotrophic lateral sclerosis/parkinsonism-dementia comlex in the Kii Peninsula, Japan. Mov Disord 24:123-126, 2008 | |
| Tomiyama H, Kokubo Y, Sasaki R, Li Y, Imamichi Y, Funayama M, Mizuno Y,Hattori N, Kuzuhara S: Mutation analyses in amyotrophic lateral sclerosis/parkinsonism-dementia complex of the Kii peninsula, Japan. Mov Disord 23:2344-2348, 2008 | |
| 笹月健彦 | 九州大学高等研究院特別主幹教授 国立国際医療センター名誉総長 |
| 免疫遺伝学 | |
| Sasazuki T, Juji T, Morishima Y, Kinukawa N, Kashiwabara H, Inoko H, Yoshida T, Kimura A, Akaza T, Kamikawaji N, Kodera Y, Takaku F. Effect of matching of class I HLA alleles on clinical outcome after transplantation of hematopoietic stem cells from an unrelated donor. New Engl. J. Med., 339:1177-1185, 1998 | |
| Fukui Y, Hashimoto O, Sanui T, Oono T, Koga H, Abe M, Inayoshi A, Noda M, Oike M, Shirai T, Sasazuki T. Hematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration. Nature, 412: 826-831, 2001 | |
| Modulation of TNF-?-converting enzyme by the spike protein of SARS-CoV and ACE2 induces TNF-?? production and facilitates viral entry. Haga S, Yamamoto N, Nakai-Murakami C, Osawa Y, Tokunaga K, Sata T, Yamamoto N, Sasazuki T, Ishizaka Y. Proc Natl Acad Sci USA, 105:7809-7814, 2008 | |
| 清野 裕 | 関西電力病院 院長 |
| 糖尿病学 | |
| Inhibition of gastric inhibitory polypeptide signaling prevents obesity Miyawaki K, Yamada Y, Ban N, Ihara Y, Tsukiyama K, Zhou H, Fujimoto S, Oku A, Tsuda K, Toyokuni S, Hiai H, Mizunoya W, Fushiki T, Holst JJ, Makino M, Tashita A, Kobara Y, Tsubamoto Y, Jinnouchi T, Jomori T, Seino Y. Nat Med. 2002 Jul;8(7):738-42. Epub 2002 Jun 17. |
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| Glucose intolerance caused by a defect in the entero-insular axis: a study in gastric inhibitory polypeptide receptor knockout mice Miyawaki K, Yamada Y, Yano H, Niwa H, Ban N, Ihara Y, Kubota A, Fujimoto S, Kajikawa M, Kuroe A, Tsuda K, Hashimoto H, Yamashita T, Jomori T, Tashiro F, Miyazaki J, Seino Y. Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):14843-7. |
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| Overexpression of inducible cyclic AMP early repressor inhibits transactivation of genes and cell proliferation in pancreatic beta cells Inada A, Hamamoto Y, Tsuura Y, Miyazaki J, Toyokuni S, Ihara Y, Nagai K, Yamada Y, Bonner-Weir S, Seino Y Mol Cell Biol. 2004 Apr;24(7):2831-41 |
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| 田中靖彦 | 東京医療センター名誉院長 |
| 眼科、網膜色素上皮細胞、網膜変性症 | |
| Tanaka Y,Utsumi J,etal:Purification,Molecular cloning, and expression of a novel growth -promoting factor for retinal pigment epitherial cells,REF-1/TFPI-2:Invest Ophthalmol Vis Sci45:245-252,2004 | |
| Umeda,S,Tanaka,Y,etal:Macular Degeneration with Drusen in a Cynomolgus Monkey (Macaca fascicularis) Pedigree:Exclusion of 13 Candidate Gene and Loci :Invest Oohthalmol Vis Sci 46:683-691,2005 | |
| Tanaka Y,Valle D,Uemura Y:Leber's congenital Amaurosis and Taurine. 2nd ISGED and ISPO,1984.5 | |
| 津田冨康 | 国家公務員共済新別府病院・顧問 |
| 内科・呼吸器内科 | |
| サルコイドーシスとその他の肉芽腫性疾患、監修安藤正幸、四元秀毅、サルコイドーシスの治療、サルコイドーシスの診断基準と診断の手引き−２００６、著者:津田冨康、克誠堂出版、東京、１９０−２００、２９０−２９４、２００６． | |
| 西岡 清 | 横浜市立みなと赤十字病院 院長 |
| 皮膚科学、免疫アレルギー学 | |
| Hepatocyte growth factor both prevents and ameliorates the symptoms of dermal sclerosis in a mouse model of scleroderma. Wu MH, Yokozeki H, Takagawa S, Yamamoto T, Satoh T, Kaneda Y, Katayama I, Nishioka K Gene Therapy 11: 170-180, 2004 | |
| Synthesis of α(1,3) fucosyltransferases IV- and VII-dependent eosinophil selectin ligand and recruitment to the skin. Satoh T, Kanai Y, Wu M-H, Yokozeki H, Kannagi R, Lowe JB, Nishioka K Am J Pathol 167: 787-796, 2005 | |
| Prostaglandin D2 plays an essential role in chronic allergic inflammation of the skin via CRTH2 receptor. Satoh T, Moroi R, Akitake K, Urade Y, Kanai Y, Sumi K, Yokozeki H, Nagata K, Hara T, Utsuyama M, Hirokawa K, Suganuma K, Nishioka K, Nakamura M J Immunology 177: 2621-2629, 2006 | |
| 秦 順一 | 常磐大学教授、国立成育医療センター名誉総長 慶應義塾大学名誉教授 |
| 病理学、成育医療 | |
| 成育医療（単著）・悠飛社・2008 | |
| 標準病理学（共著）・医学書院・2004 | |
| 臨床工学技士標準テキスト（共著）・金原出版・医学書院・2004 | |
| 廣橋説雄 | 国立がんセンター・総長 |
| 腫瘍病理学 | |
| Genetic variation in PSCA is associated with susceptibility to diffuse-type gastric cancer. Study Group of Millennium Genome Project for Cancer, Sakamoto H, Yoshimura K, Saeki N, Katai H, Shimoda T, Matsuno Y, Saito D, Sugimura H, Tanioka F, Kato S, Matsukura N, Matsuda N, Nakamura T, Hyodo I, Nishina T, Yasui W, Hirose H, Hayashi M, Toshiro E, Ohnami S, Sekine A, Sato Y, Totsuka H, Ando M, Takemura R, Takahashi Y, Ohdaira M, Aoki K, Honmyo I, Chiku S, Aoyagi K, Sasaki H, Ohnami S, Yanagihara K, Yoon KA, Kook MC, Lee YS, Park SR, Kim CG, Choi IJ, Yoshida T, Nakamura Y, Hirohashi S. Nat Genet. 40(6): 730-740, 2008. | |
| Dysadherin, a cancer-associated cell membrane glycoprotein, down-regulates E-cadherin and promotes metastasis. Ino Y, Gotoh M, Sakamoto M, Tsukagoshi K, Hirohashi S. Proc Natl Acad Sci U S A. 8;99(1):365-370, 2002. Epub 2001. | |
| E-cadherin gene mutations in human gastric carcinoma cell lines.Oda T, Kanai Y, Oyama T, Yoshiura K, Shimoyama Y, Birchmeier W, Sugimura T, Hirohashi S. Proc Natl Acad Sci U S A. 91(5): 1858-1862, 1994. | |
| 溝口秀昭 | 東京女子医科大学 名誉教授 |
| 血液内科 | |
| The effect of erythropoietin on human bone marrow cells in vitro I.Studies do nine cases of bone marrow failure. Mizoguchi H, Miura Y, Takaku F, Sassa s, Chiba S, Nakao K. Blood 37(6):624-633, 1971 |
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| A point mutation at codon 13 of the N-ras oncogene in myelodys-plastic syndrome. Hirai H, Mano Y, Hagiwara H, Maru Y, Omine M,Mizoguchi H, Nishida J, Takaku F Nature 327;430-434, 1987 |
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| Treatment of severe aplastic anemia with antithymocyte globulin and cyclosporine A with or whithout G-CSF in adults:a multicenter randomized study in Japan. Teramura M, Kimura A Iwase S, Yonemura Y, Nakao S, Urabe A, Omine、M, Mizoguchi H Blood 110(6):1756-1761, 2007 |
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