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肝炎等克服緊急対策研究事業中間・事後評価委員名簿

肝炎等克服緊急対策研究事業中間・事後評価委員名簿

(○:委員長)

宮村 達男 国立感染症研究所 所長
ウイルス学
Detection of antibody against antigen expressed by molecularly cloned hepatitis C virus cDNA: Application to diagnosis and blood screening for post transfusion hepatitis. Miyamura T, Saito I, Katayama T, Kikuchi S, Tateda A, Houghton M, Choo Q-L, Kuo G. Proc Natl Acad Sci USA. 1990; 87:983-987.
Hepatitis C virus infection is associated with the development of hepatocellular carcinoma. Saito I, Miyamura T, Ohbayashi A, Harada H, Katayama T, Kikuchi S, Watanabe Y, Koi S, Onji M, Ohta Y, Choo Q-L, Houghton M, Kuo G. Proc Natl Acad Sci USA. 1990; 87:6547-6549.
The HBx gene of hepatitis B virus induces liver cancer. Kim C-M, Koike K, Saito I, Miyamura T, Jay G. Nature. 1991; 351:317-320.

 

幕内 雅敏 日本赤十字社医療センター 院長
肝胆膵外科学、肝移植
Ultrasonically guided subsegmentectomy. Makuuchi M, Hasegawa H, Yamazaki S. Surg Gynecol Obstet. 1985 Oct;161(4):346-50.
Safety of hemihepatic vascular occlusion during resection of the liver. Makuuchi M, Mori T, Gunven P, Yamazaki S, Hasegawa H. Surg Gynecol Obstet. 1987 Feb;164(2):155-8.
Preoperative portal embolization to increase safety of major Hepatectomy for hilar bile duct carcinoma: a preliminary report. Makuuchi M, Thai BL, Takayasu K, Takayama T, Kosuge T, Gunven P, Yamazaki S, Hasegawa H, Ozaki H. Surgery 1990 May;107(5):521-7.

 

秋澤忠男 昭和大学医学部内科学講座腎臓内科学部門 教授
血液浄化医学、透析医学、腎臓学
Extracorporeal albumin dialysis. Abe T, Akizawa T, et al. Ther Apher Dial. 2004 Jun;8(3):217-22
「急性血液浄化法」秋澤忠男他・編著、総合医学社、2006
Plasma exchange in hepatic failure. Abe T, Akizawa T, et al.
International Society for Apheresis 4th International Congress, 2003

 

岡崎 勲 国際医療福祉大学臨床医学研究センター・教授
肝線維化機序、肝硬変、肝癌
Bone marrow-derived cells express matrix metalloproteinases and contribute to regression of liver fibrosis in mice. Higashiyama R, Inagaki Y, Watanabe T, Okano H, Matsuzaki Y, Shiota G, Okazaki I. Hepatology 2007 Jan; 45(1): 213-222.
Difference in gene expression for matrix metalloproteinase-1 between early and advanced hepatocellular carcinoma. Okazaki I, Wada N, Nakano M, Saito A, Takasaki K, Doi M, Kameyama K, Otani Y, Kubochi K, Niioka M, Watanabe T, Maruyama K. Hepatology 1997 Mar; 25(3): 580-584.
"Extracellular Matrix and the Liver -approach to gene therapy"Okazaki I, Ninomiya Y, Friedman SL, Tanikawa K (editors), Academic Press, Amsterdam, Boston, London, New York, 1-467 (2003).

 

小菅 智男 国立がんセンター中央病院・副院長
外科学
Serum bile acid profile in thyroid dysfunction and effect of medical treatment. Tomoo Kosuge, Tomoe Beppu, Takao Kodama, Koh Hidai, Yasuo Idezuki. Clin Sci.73:425-429,1987.
An isolated, complete resection of the caudate lobe, including the paracaval portion, for hepatocellular carcinoma. Tomoo Kosuge, Junji Yamamoto, Tadatoshi Takayama, Kazuaki Shimada, Susumu Yamasaki, Masatoshi Makuuchi, Hiroshi Hasegawa. Arch Surg.129:280-284,1994.
Improved surgical results for hilar cholangiocarcinoma with procedures including major hepatic resection. Tomoo Kosuge, Junji Yamamoto, Kazuaki Shimada, Susumu Yamasaki, Masatoshi Makuuchi. Ann Surg.230(5):663-671,1999.

 

齋藤 英彦 名古屋セントラル病院・院長
血液病学
Life-threatening human parvovirus B19 infection transmitted by intravenous immune globulin.  Hayakawa F, Imada K, Towatari M, Saito H 
Br J Haematol 118: 1187-1189, 2002.
Safety and complication of interventional radiology for hepatocellular carcinoma in patients with haemophilia and cirrhosis.  Toyoda, H., Fukuda, Y., Yokozaki, S, Hayashi, K., Saito, H., Takamatsu, J. 
Brit J Haematol 112: 1071-1073, 2001
TT virus genotype change frequently in multiply transfused patients with hemophilia but rarely in patients with chronic hepatitis C and healthy subjects.  Toyoda, H., Fukuda, Y., Nakano, I., Katano, Y., Yokozaki, S., Hayashi, K., Ito, Y., Suzuki, K., Nakano, H., Saito, H., Takamatsu,
J Transfusion 41: 1130-1135, 2001

 

村上 清史 金沢大学 名誉教授
分子遺伝
The transcriptional transactivation function of HBx protein is important for its augmentation role in hepatitis B virus replication. Tang H, Delgermaa L, Huang F, Oishi N, Liu L, He L, Zhao L, *Murakami S., J. Virol., 2005, 79(9): 5548-5556.
Effect of Hepatitis C Virus (HCV) NS5B-Nucleolin Interaction on HCV Replication with HCV Subgenomic Replicon. Shimakami T, Honda M, Kusakawa T, Murata T, Shimotohno K, Kaneko S *Murakami S. J. Virol., 2006, 80 (7): 3332-334.
Hepatitis B Virus X protein overcomes oncogenic RAS-induced senescence in human immortalized cells. Cancer Science, Oishi N, Khurts S, Nakamoto Y, Honda M, Kaneko S, *Murakami S. Cancer Science, 2007, 98(10): 1540-1548.

 

吉澤 浩司 広島大学名誉教授
ウイルス肝炎の疫学
Hepatitis B virus(HBV) screening strategy to ensure the safety of blood for transfusion through a combination of immunological testing and nucleic acid amplification testing -Japanese experience-
H.Yugi, M.Mizui, J.Tanaka and H.Yoshizawa
J.clin.virol , 2006 36;(1) 56-64
Titeration of hepatitis B virus infectivity in the sera of pre-acute and late acute phase of HBV infection : Transmission experiments to chimeric mice with human liver repopulated hepatocytes.
A.Tabuchi , J.Tanaka , K.Katayama , M.Mizui , H.Matsukura , H.Yugi , T.Shimada , Y.Miyakawa and H.Yoshizawa
J.Med.virol , 2008 80:2064-2068
A novel hepatitis B virus surface antigen immunoassary as sensitive as hepatitis B virus nuleic acid testing in detecting early infection.
N.Matsubara , O.Kusano , Y.Sugiyama , T.Itoh , M.Mizui, J.Tanaka and H.Yoshizawa Transfusion , 2009 March ; 49:585-595

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