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難治性疾患等克服研究事業(難治性疾患克服研究事業)事前評価委員名簿

(○:委員長)

 
池田 康夫 早稲田大学理工学術院先進理工学研究科生命理工学研究専攻教授
血栓止血学
Ikeda, Y., Handa, M., Kawano, K., Kamata, T., Murata, M., Araki, Y., Ambo, H., Kawai, Y., Watanabe, K., Itagaki, I., Sakai, K., and Ruggeri, Z.M.:
The role of von Willebrand factor and fibrinogen in platelet aggregation under varying shear stress.
J. Clin. Invest. 87: 1234-1240, 1991
Bhatt DL., Steg PG., Ohman EM., Hirsch AT., Ikeda, Y., Mas JL., Goto S., Liau CS., Richard AJ., Rother J., Wilson PWF., for the REACH Registry Investigators. :
International prevalence, recognition, and treatment of cardiovascular risk factors in outpatients with atherothrombosis.
JAMA 295 (2): 180-189, 2006 (1).
Ikeda Y and Miyakawa Y: Development of thrombopoietin receptor agonists for clinical use. J Thromb Haemost 7 (sup.1) 239-244, 2009
岡上 武 大阪府済生会吹田病院長
消化器(肝臓)
Genetic polymorphisms of the human PNPLA3 gene are strongly associated with severity of nonalcoholic fatty liver disease in Japanese. Kawaguchi T, Sumida Y, Umemura A, Matsuo K, Takahashi M, Takamura T, Yasui K, Saibara T, Hashimoto E, Kawanaka M, Watanabe S, Kawata S, Imai Y, Kokubo M, Shima T, Park H, Tanaka H, Tajima K, Yamada R, Matsuda F, Okanoue T for Japan Study Group of Nonalcoholic Fatty Liver Disease (JSG-NAFLD). PLoS One 7(6): e38322, 2012
Chapter 19 Non-alcoholic fatty liver disease in Japan. Okanoue T, Yasui K, Itoh Y. In. Farrell GC, McCullough AJ, Day CP. NON-ALCOHOLIC FATTY LIVER DISEASE A Practical Guide, Wiley-Blackwell, United Kingdom, pp217-227, 2013
Simeprevir with peginterferon/ribavirin for treatment-naive heoatitis C genotype 1 patients in Japan: the CONCERT-1. A phase III trial. Hayashi N, Izumi N, Kumada H, Okanoue T, Tsubouchi H, Yatsuhashi H, Kato M, Ki R, Komada Y, Seto C, Goto S. J Hepatol 2014 Apr 12. Pil: S0168-8278(14)00221-9. Doi; 10.1026
 
春日 雅人 国立国際医療研究センター研究所長
内科学、内分泌代謝学
Dok1 mediates high-fat diet-induced adipocyte hypertrophy and obesity through modulation of PPAR-γ phosphorylation.  Hosooka, T., Noguchi, T., Kotani, K., Nakamura, T., Sakaue, H., Inoue, H., Ogawa, W., Tobimatsu, K., Takazawa, K., Sakai, M., Matsuki, Y., Hiramatsu, R., Yasuda, T., Lazar, MA., Yamanashi, Y.and Kasuga, M. Nature Med. (2008)14:188-193.
FSP27 Contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets. Nishino, N., Tamori, Y., Tateya, S., Kawaguchi, T., Shibakusa, T., Mizunoya, W., Inoue, K., Kitazawa, R., Kitazawa, S., Matsuki, Y., Hiramatsu, R., Masubuchi, S., Omachi, A., Kimura, K., Saito, M., Amo, T., Ohta, S., Yamaguchi, T., Osumi, T., Cheng, J., Fujimoto, T., Nakao, H., Nakao, K., Aiba, A., Okamura, H., Fushiki, T., and Kasuga, M. J.Clin.Invest.(2008)118:2808-2821.
Ablation of C/EBPb alleviates ER stress and pancreatic b cell failure through induction of GRP78.  Matsuda T, Kido Y, Asahara S, Kaisho T, Tanaka T, Hashimoto N, Shigeyama Y, Takeda A, Inoue T, Shibutani Y, Koyanagi M, Hosooka T, Matsumoto M, Inoue H, Uchida T, Koike M, Uchiyama Y, Akira S, Kasuga M. J. Clin. Invest. (2010)120: 115-126
 
木下 茂 京都府立医科大学眼科学教室教授
眼科学
Kinoshita S, Adachi W, Sotozono C, Nishida K, Yokoi N, Quantock A, Okubo K: Characteristics of the human ocular surface epithelium. Prog. Retina Eye Res 20:639-673, 2001.
Sotozono C, Ueta M, Koizumi N, Inatomi T, Ikezawa Z, Shirakata Y, Hashimoto K, Kinoshita S: Diagnosis and Treatment of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis with Ocular Complications. Ophthalmology 116:685-690, 2009.
Nakano M, Ikeda Y, Taniguchi T, Yagi T, Fuwa M, Omi N, Tokuda Y, Tanaka M, Yoshii K, Kageyama M, Naruse S, Matsuda A, Mori K, Kinoshita S, Tashiro K: Three susceptible foci associated with primary-open angle glaucoma identified by genome-wide association study in Japanese population. Proc Natl Acad Sci 106:12838-12842, 2009.
葛原 茂樹 鈴鹿医療科学大学保健衛生学部医療福祉学科特任教授
神経変性疾患、痴呆性疾患、医原性神経疾患、脳血管障害
Kuzuhara S, Kokubo Y, Sasaki R, Narita Y, Yabana T, Hasegawa M, Iwatsubo
T: Familial amyotrophic lateral sclerosis and parkinsonism-dementia complex
of the Kii peninsula of Japan: clinical and neuropathological study and tau
analysis. Ann Neurol 49:501-511, 2001
Morimoto S, Kuzuhara S, Kokubo Y: Increased oxidative stress in patients
with amyotrophic lateral sclerosis/parkinsonism-dementia comlex in the
Kii Peninsula, Japan. Mov Disord 24:123-126, 2008
Tomiyama H, Kokubo Y, Sasaki R, Li Y, Imamichi Y, Funayama M, Mizuno Y,
Hattori N, Kuzuhara S: Mutation analyses in amyotrophic lateral
sclerosis/parkinsonism-dementia complex of the Kii peninsula, Japan. Mov
Disord 23:2344-2348, 2008
 
斉藤 延人 東京大学教授
脳神経外科
Kin T, Oyama H, Kamada K, Aoki S, Ohtomo K, Saito N. Prediction of surgical view of neurovascular decompression using interactive computer graphics. Neurosurgery 65:121-128, 2009.
Tanaka Y, Imai H, Konno K, Miyagishima T, Kubota C, Puentes S, Aoki T, Hata H, Takata K, Yoshimoto Y, Saito N. Experimental Model of Lacunar Infarction in the Gyrencephalic Brain of the Miniature Pig: Neurological Assessment and Histological, Immunohistochemical, and Physiological Evaluation of Dynamic Corticospinal Tract Deformation. Stroke 39: 205-212, 2008.
Saito N, Okada Y, Noda Y, Kinoshita Y, Kondo S, Hirokawa N. KIFC2 is a novel neuron-specific C-terminal type kinesin superfamily motor for dendritic transport of multivesicular body-like organelles. Neuron 18: 425-438, 1997.
 
澤 倫太郎 社団法人日本医師会総合政策研究機構研究部長
産科婦人科・周産期学
Fetal plasma hypoxanthine level in growth-retarded fetuses before labor.
Sawa R, Yoneyama Y, Otsubo Y, Suzuki S, Kubonoya K, Power GG, Araki T.
J Clin Endocrinol Metab 82:4028-4033.1997
Changes in plasma adenosine during simulated birth of fetal sheep.
Sawa R, Asakura H, Power GG.Changes in plasma adenosine during simulated birth of fetal sheep.J Appl Physiol 70(4): 1524-1528.1991
Suzuki K, Sawa R, Muto K, Kusuda S, Banno K, Yamagata Z.
Risk perception of Pregnancy Promotes Disapproval of Gestational Surrogacy: Analysis of a Nationally Representative Opinion Survey in Japan.International Journal of Fertility & Sterility; 5(2), 78-85, 2011
国家主導の生命工学がもたらした悲劇―韓国ES細胞事件から見えてみるもの.澤倫太郎 岩波書店・世界,3月号、73-61、2006
県立大野病院事件から見えてくるもの. 澤倫太郎、岩波書店・世界,8月号、195-209、2008
胎児血管特性を応用したアデノシン誘導型DESの開発―羊成獣血管におけるlong acting adenosineによるステント内再狭窄抑制効果についてー. 澤倫太郎、五十嵐美和、峯克也、桑原慶充、里見操緒、竹下俊行,第64回日産婦学術講演会,2012.4.13
 
清野 裕 関西電力病院長
糖尿病学
Inhibition of gastric inhibitory polypeptide signaling prevents obesity
Miyawaki K, Yamada Y, Ban N, Ihara Y, Tsukiyama K, Zhou H, Fujimoto S, Oku A, Tsuda K, Toyokuni S, Hiai H, Mizunoya W, Fushiki T, Holst JJ, Makino M, Tashita A, Kobara Y, Tsubamoto Y, Jinnouchi T, Jomori T, Seino Y.
Nat Med. 2002 Jul;8(7):738-42. Epub 2002 Jun 17.
Glucose intolerance caused by a defect in the entero-insular axis: a study in gastric inhibitory polypeptide receptor knockout mice
Miyawaki K, Yamada Y, Yano H, Niwa H, Ban N, Ihara Y, Kubota A, Fujimoto S, Kajikawa M, Kuroe A, Tsuda K, Hashimoto H, Yamashita T, Jomori T, Tashiro F, Miyazaki J, Seino Y.  Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):14843-7.
Overexpression of inducible cyclic AMP early repressor inhibits transactivation of genes and cell proliferation in pancreatic beta cells
Inada A, Hamamoto Y, Tsuura Y, Miyazaki J, Toyokuni S, Ihara Y, Nagai K, Yamada Y, Bonner-Weir S, Seino Y 
Mol Cell Biol. 2004 Apr;24(7):2831-41
 
清野 佳紀 大阪厚生年金病院名誉院長
小児科学、内分泌学
Evaluation of Quality of Life in Children with GH Deficiency and Idiopathic Short Stature Using the Child Behavior Checklist.
Toshiaki Tanaka, ShigeruTai, Yoji Morisaki, Katsuhiko Tachibana,Yasuko Kambayashi, Kazuo Chigara, YoshikiSeino, and Kenji Fujieda. Clin Pediatr Endocrinol 18(1), 15-22. 2009.
PTH has the potential to rescue disturbed bone growth in a achondroplasia. Koso Ueda, Yoshitaka Yamanaka, Daisuke Harada, Emi Yamagami, Hiroyuki Tanaka, Yoshiki Seino. Bone 41.13-18.2007.
「NEW 小児科学 改訂2版」清野佳紀、小林邦彦、原田研介、桃井眞理子.南江堂.2009.
 
高岡 邦夫 阪和人工関節センター顧問
整形外科学
Poor bone quality or hip structure as risk factors affecting survival of total hip arthroplasty.
Kobayashi,S., Saito,N,. Horiuchi,H. Iorio,R and Takaoka,K.
The Lancet. 355: 1499-1504, 2000.
A biodegradable polymer as a cytokine delivery system for inducing boneformation.
Saitou.N., Okada,T., Horiuchi,H., Murakami,N., Takahashi,J.,Nawata,
M., Ota, H., Nozaki,K. and Takaoka,K.
Nature Biotechnology, 19; 332-335, 2001
Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts.
Nakamura,T., Imai,Y., Matsumoto,T., Sato,S., Takeuchi,K., Igarashi, K., Harada,Y., Azuma,Y., Krust,A.,Yamamoto,Y., Nishiura, H., Takeda,S., Takayanagi,H, Metzger,D., Kanno,J., Takaoka,K., Martin. TJ, Chambon P. and Kato,S.
Cell 130:811-823, 2007.
 
竹中 洋 大阪医科大学長
耳鼻咽喉科学
Enhanced human IgE production results from exposure to the aromaticHydrocarbons from diesel exhaust;direct effects on B-cell IgE production, Takenaka H,et al
J Allery CLin Immunol;1998.95:103-115.
コア・ローテイション 耳鼻咽喉科・頭頸部外科
編集 竹中洋、高橋姿、久育男
金芳堂、2004年1月5日
気道アレルギーの成立とその制御:竹中 洋
第110回日本耳鼻咽喉科学術総会宿題報告
東京、2009.05.14.
 
富野 康日己 順天堂大学大学院医学研究科腎臓内科学教授
腎臓内科学
Tomino Y: Leesons from the KK-Ay mouse, a spontaneous animal model for the treatment of human type 2 diabetic nephropathy, Nephrourol Mon, 4:524-529, 2012
Nakata J, Ohsawa I, Onda K, Tanimoto M, Kusaba G, Takeda Y, Kobayashi N, Asanuma K, Tanaka Y, Sato M, Inami Y, Suzuki H, Suzuki H, Masuda A, Nonaka K, Sasaki Y, Hisada A, Hamada C, Horikoshi S, Tomino Y: Risk of Overestimation of Kidney Function Using GFR-Estimating Equations in Patients with Low Inulin Clearance, J Clin Lab Anal. 26(4):248-53, 2012
富野康日己:ここが知りたい生活習慣病・腎臓病・高血圧対策Q&A100、中外医学社、東京、2012
 
友池 仁暢 公益財団法人日本心臓血圧研究振興会附属榊原記念病院長
循環器内科学
Kawai T, Ito T, Ohwada K, Mera Y, Matsushita M, Tomoike H. Hereditary postprandial hypertriglyceridemic rabbit exhibits insulin resistance and central obesity. A novel model of metabolic syndrome. Arterioscler Thromb Vasc Biol 2006;26:2752-2757.
Kitakaze M, Asakura M, Kim J, Shintani Y, Asanuma H, Hamasaki T, Tomoike H, et al. Human atrial natriuretic peptide and nicorandil as adjuncts to reperfusion treatment for acute myocardial infarction (J-WIND): two randomised trials. Lancet 2007;370:1483-1493.
Harada-Shiba M, Sugisawa T, Makino H, Abe M, Tsushima M, Yoshimasa T, Yamashita T, Miyamoto Y, Yamamoto A, Tomoike H, Yokoyama S. Impact of statin treatment on the clinical fate of heterozygous familial hypercholesterolemia. J Atheroscler Thromb 2010;17:667-674.
 
永井 正規 埼玉医科大学公衆衛生学教授
疫学
Prevalence and Incidence of Polymyositis and Dermatomyositis in Japan. Ohta A, Nagai M, Nishina M, Tomimitsu H, Kohsaka H.Mod Rheumatol 24:477-480, 2013.
A case control study of female systemic lupus erythematosus in Japan
MASAKI NAGAI,TOMIO HIROHATA,YOSHIFUJI MATSUMOTO,HIROSHI HASHIMOTO,MASAKAZU KONDO,KOTARO OZASA,MITSURU MORI,TSUTOMU HASHIMOTO,HIDEAKI NAKAGAWA,TOSHITAKA OMURA,MASAKI MORI,TAKESHI TOJO,HIROSHI YANAGAWA European Journal of Public Health, Volume 3, Issue 3:172-176, 1992
「新しい疫学」永井正規他共著,日本公衆衛生協会,(1995).
 
西岡 清 大阪警察病院皮膚科顧問
皮膚科学・免疫アレルギー学
Hepatocyte growth factor both prevents and ameliorates the symptoms of dermal sclerosis in a mouse model of scleroderma.  Wu MH, Yokozeki H, Takagawa S, Yamamoto T, Satoh T, Kaneda Y, Katayama I, Nishioka K  Gene Therapy 11: 170-180, 2004
Synthesis of α(1,3) fucosyltransferases IV- and VII-dependent eosinophil selectin ligand and recruitment to the skin. Satoh T, Kanai Y, Wu M-H, Yokozeki H, Kannagi R, Lowe JB, Nishioka K Am J Pathol 167: 787-796, 2005
Prostaglandin D2 plays an essential role in chronic allergic inflammation of the skin via CRTH2 receptor.  Satoh T, Moroi R, Akitake K, Urade Y, Kanai Y, Sumi K, Yokozeki H, Nagata K, Hara T, Utsuyama M, Hirokawa K, Suganuma K, Nishioka K, Nakamura M  J Immunology 177: 2621-2629, 2006
 
貫和 敏博 みやぎ県南中核病院企業長
内科学(呼吸器内科学)
Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. Maemondo M, Inoue A, Kobayashi K, Sugawara S, Oizumi S, Isobe H, Gemma A, Harada M, Yoshizawa H, Kinoshita I, Fujita Y, Okinaga S, Hirano H, Yoshimori K, Harada T, Ogura T, Ando M, Miyazawa H, Tanaka T, Saijo Y, Hagiwara K, Morita S, Nukiwa T; North-East Japan Study Group. N Engl J Med. 2010 Jun 24;362(25):2380-8.
First-line gefitinib for patients with advanced non-small-cell lung cancer harboring epidermal growth factor receptor mutations without indication for chemotherapy. Inoue A, Kobayashi K, Usui K, Maemondo M, Okinaga S, Mikami I, Ando M, Yamazaki K, Saijo Y, Gemma A, Miyazawa H, Tanaka T, Ikebuchi K, Nukiwa T, Morita S, Hagiwara K; North East Japan Gefitinib Study Group. J Clin Oncol. 2009 Mar 20;27(9):1394-400.
OX40 ligand expressed by DCs costimulates NKT and CD4+ Th cell antitumor immunity in mice. Zaini J, Andarini S, Tahara M, Saijo Y, Ishii N, Kawakami K, Taniguchi M, Sugamura K, Nukiwa T, Kikuchi T. J Clin Invest. 2007 Nov;117(11): 3330-8
 
福島 雅典 財団法人先端医療振興財団臨床研究情報センター長
腫瘍内科学、臨床試験デザイン・管理・評価、薬剤疫学、医科学
Kubota K, Kawahara M, Ogawara M, Nishiwaki Y, Komuta K, Minato K, Fujita Y, Teramukai S, Fukushima M, Furuse K, on behalf of the Japan Multi-National Trial Organisation. Vinorelbine plus gemcitabine fo1lowed by docetaxe1 versus carbop 1atin p1us pac1itaxe1 in patients with advanced non-small-cell lung cancer: A randomised, open-label, phase III study. Lancet Oncol 2008;9:1135-1142.
Tanaka S, Fukushima, M. Size of Creutzfeldt-Jakob Disease Epidemic Associated with Cadaveric Dura Transplantation. Neuroepidemiology 2010;34:232-237.
Sotozono C, Inatomi T, Nakamura T, Koizumi N, Yokoi N, Ueta M, Matsuyama K, Miyakoda K, Kaneda H, Fukushima M, Kinoshita S. Visual improvement after cultivated oral mucosal epithelial transplantation. Ophthalmology 2013 Jan;120(1):193-200.
 
水野 美邦 北里大学医学部客員教授
神経内科学
Kitada T, Asakawa S, Hattori N, Matsumine H, Yamamura Y, Minoshima S, Yokochi M, Mizuno Y, Shimizu N: Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature, 1998;392:605-608
Mizuno Y, Nomoto M, Kondo T, Hasegawa K, Murata M, Ikeda J, Tomida T, Hattori N, on behalf of the Rotigotine Trial Group. Transdermal rotigotine in early-stage Parkinson’s disease: A randomized, double-blind, placebo-controlled trial. Mov Disord 2013;28:1447-1450.
水野美邦.パーキンソン病とともに楽しく生きる.中外医薬,東京,pp 1-212
 
宮坂 信之 東京医科歯科大学大学院膠原病・リウマチ内科学教授
内科学(膠原病)、臨床免疫学
Drug retention rates and relevant risk factors for drug discontinuation due to adverse events in rheumatoid arthritis patients receiving anti-cytokine therapy with different target molecules. R. Sakai, M. Tanaka, T. Nanki, K. Watanabe, H. Yamazaki, R. Koike, H. Nagasawa, K. Amano, K. Saito, Y. Tanaka, S. Ito, T. Sumida, A. Ihata, Y. Ishigatsubo, T. Atsumi, T. Koike, A. Nakajima, N. Tamura, T. Fujii, H. Dobashi, S. Tohma, T. Sugihara, Y. Ueki, A. Hashiramoto, A. Kawakami, N. Hagino, N. Miyasaka, M. Harigai, for the REAL Study Group Ann. Rheum. Dis. 71:1820-1826, 2012
Incidence and risk factors for serious infection in patients with rheumatoid arthritis treated with tumor necrosis factor inhibitors: a report from the registry of Japanese rheumatoid arthritis patients for longterm safety. Y. Komano, M. Tanaka, T. Nanki, R. Koike, R. Sakai, H. Kameda, A. Nakajima, K. Saito, M. Takeno, T. Atsumi, S. Tohma, S. Ito, N. Tamura, T. Fujii, T. Sawada, H. Ida, A. Hashiramoto, T. Koike, Y. Ishigatsubo, K. Eguchi, Y. Tanaka, T. Takeuchi, N. Miyasaka, M. Harigai, for the REAL Study Group J. Rheumatol. 38(7):1258-1264, 2011
 
宮崎 久義 日本医療マネジメント学会理事長
麻酔、病院管理、地域医療、生活習慣病
「地域医療支援病院と医療連携のありかた」宮崎久義他共著.じほう.(2004).
地域連携とクリティカルパス.宮崎久義.綜合臨牀.2009.3月
「クリティカルパスの新たな展開VII クリティカルパスと電子カルテ−原点に返って電子カルテ時代のクリティカルパスを考える−」宮崎久義企画.ライフサイエンス.(2011).

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