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肝炎等克服緊急対策研究事業 中間・事後評価委員会

(○:委員長)

 
沖田 極 社会保険下関厚生病院名誉院長・顧問
肝臓病学
Furutani T, Hino K, Okita K, et al.:Hepatic iron overload induces hepatocellular carcinoma in transgenic mice expressing the hepatic C virus polyprotein. Gastroenterology 131:461-469,2006
Nishina S, Hino K, Okita K, et al.:Hepatitis  C virus induced reactive oxygen species raise hepatic iron level in mice by reducing hepcidin transcription. Gastroenterology 134:226-238,2008
特許第4997377号(登録日:平成24年5月25日)
名称:骨髄細胞の遊走・分化・増殖評価モデル動物およびその利用法
発明者:寺井崇二、沖田 極(特許権者:国立大学法人山口大学)
 
樋野 興夫 順天堂大学 医学部 病理・腫瘍学 教授
病理学・発がん
Hino O., Kitagawa T. and Sugano H.: Relationship between serum and histochemical markers for hepatitis B virus and rate of viral integration in hepatocellular carcinomas in Japan. Int J Cancer 35: 5-10, 1985
Hino O., Shows T. B. and Rogler C. E.: Hepatitis B virus integration site in hepatocellular carcinoma at chromosome 17;18 translocation. Proc Natl Acad Sci U S A 83: 8338-8342, 1986
Hino O., Tabata S. and Hotta Y.: Evidence for increased in vitro recombination with insertion of human hepatitis B virus DNA. Proc Natl Acad Sci U S A 88: 9248-9252, 1991
 
幕内 雅敏 日本赤十字社医療センター 院長
肝胆膵外科
Ultrasonically guided subsegmentectomy.Makuuchi M, Hasegawa H, Yamazaki S. Surgery, Gynecology & Obstetrics 161:346-350, 1985
Safety of hemihepatic vascular occlusion during resection of the liver. Makuuchi M, Mori T, Gunven P, Yamazaki S. Surgery, Gynecology & Obstetrics 164:155-158, 1987
Preoperative portal embolization to increase safety of major hepatectomy for hilar bile duct carcinoma: a preliminary report. Makuuchi M, Thai B. L., Takayasu K, Takayama T, Kosuge T, Gunven P, Yamazaki S, Hasegawa H, Ozaki H. Surgery 107:521-527, 1990
 
三田村 圭二 昭和大学 医学部 内科学講座 消化器内か学部門
客員教授
肝臓病学
Mitamura,K., BH.Hoyer, A.Ponzetto, J.Nelson, R.Purcell, and J.Gerin,
Woodchuck hepatitis virus DNA in woodchuck liver tissues. Hepatology 2 47S-50S 1982
Hakozaki,Y., M.Katou, T.Shirahama, O.Yoshii, K.Nakagawa, K.Oba, T.Matsumoto, N.Kuwabara, and Mitamura,K. Long-term prognosis of chronic hepatitis C after treatment with interferon α-2b and relationship of response to proliferative activity of hepatocytes and hepatitis C virus Am J Gastroenterol 91 2144-2149 1996
Ito,T., K.Yasui, J.Mukaigawara, A.Katsume, M.kohara, and K.Mitamura
Acquisition of susceptibility to hepatitis C virus replication in HepG2 cells by fusion with primary human heatocytes:establish-ment of a quantitative assay for hepatitis C virus infectitvity in a cell culture system Hepatology 34 566-572 2001
宮村 達男 国立感染症研究所 名誉所員
ウイルス学
An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis. Kuo,G., Choo,Q-L., Alter,H.J., Gitnick,G.L., Redeker,A.G., Purcell,R.H., Miyamura,T. Dienstag J.L., Alter,M.J., Stevens,C.E., Tegtmeier,G.E., Bonino,F., Colombo,M., Lee,W-S., Kuo,C., Berger,K., Shuster,J.R., Overby,L.R., Bradley,D.W., and Houghton,M. Science 244: 362-364, 1989.
Detection of antibody against antigen expressed by molecularly cloned hepatitis C virus cDNA: Application to diagnosis and blood screening for post transfusion hepatitis. Miyamura,T., Saito,I., Katayama,T., Kikuchi,S., Tateda,A., Houghton,M., Choo,Q-L., and Kuo,G. Proc.Natl.Acad.Sci.USA, 87: 983-987, 1990.
A cDNA fragment of hepatitis C virus isolated from an implicated donor of post-transfusion non-A, non-B hepatitis in Japan. Kubo,Y., Takeuchi,K., Boonmar,S., Katayama,T., Choo,Q-L., Kuo,G., Weiner,A.W., Bradley,D.W., Houghton,M., Saito,I., and Miyamura,T.  Nucl.Acids Res. 17:10367-10372, 1989.
 
村上 清史 金沢大学名誉教授、金沢学院大教授
ほくりく健康創造クラスター研究統括
分子遺伝学
Hepatitis B Virus X protein overcomes oncogenic RAS-induced senescence in human immortalized cells. Oishi N, Khurts S, Nakamoto Y, Honda M, Kaneko S, *Murakami S. Cancer Science, 98(10): 1540-1548, (2007)
Effect of Hepatitis C Virus (HCV) NS5B-Nucleolin Interaction on HCV Replication with HCV Subgenomic Replicon. Shimakami T, Honda M, Kusakawa T, Murata T, Shimotohno K, Kaneko S *Murakami S. J. Virol., 80 (7): 3332–3340, (2006).
The Molecular functions and the biological roles of Hepatitis B Virus X protein (HBx) Tang H, Oishi N, Kaneko S, *Murakami S.  Cancer Sci., 97(10):977-983,  (2006)
 
矢野 右人 国立病院機構長崎医療センター名誉院長
ウイルス性肝炎
Quantitative immunoelectrophoresis as a method for determination of hepatitis B antigen
Standardization and comparison with other methods
M. Yano and I. Tripatzis    Z.Immun.-Forsch Bd. 146 : S174-186, 1973.
Prevention of HBV Mother-Infant Transmission
Michitami Yano, Heiichiro Tajim  Acta Paediatrica Japonica 28 (3) : 300-305, 1986
The Long-term Pathological Evolution of Chronic Hepatitis C
Michitami Yano, Hiromitsu Kumada, Masayoshi Kage, Kenji Ikeda, Kazuhide Shimamatsu, Osami Inoue, Etsuko Hashimoto, Jay H. Lefkowitch, Jurgen Ludwig and Kunio Okuda
HEPATOLOGY 23 (6) : 1334-1340, 1996.6
 
山口 一成 熊本大学発生医学研究所、学術研究員
血液学、ウイルス学、ワクチン、感染症
Polycomb-mediated loss of miR-31 activates NIK-dependent NF-kB pathway in adult T-cell leukemia and other cancers. Yamagishi M, Nakano K, Miyake A, Yamochi T, Kagami Y, Tsutsumi A, Matsuda Y, Sato-Otsubo A, Muto S, Utsunomiya A, Yamaguchi K, Uchimaru K, Ogawa S, Watanabe T. Cancer Cell 21(1): 121-135,2012
Current prevalence of HTLV-1 in Japan as determinined by screening of blood donors. Satake M, Yamaguchi K, Tadokoro K. J Med Virol 84(2):327-35,2012
HCV infection and B-cell lymphomagenesis. Ito M, Kusunoki H, Mochida K, Yamaguchi K, Mizuochi T: Advances in Hematology 2011 July 20 10.1155
 
吉澤 浩司 広島大学 名誉教授
ウイルス肝炎の疫学
Natural histories of hepatitis C virus infection in men and women simulated by the Markov model. Tanaka J. Kumada H. Ikeda K. Mizui M. Hino K. Katayama K. kumagai J. Kamiya Y . Miyakawa Y. Yoshizawa H. J.Med.Virol.2003,70.378-386.
Livir disease in hepatitis C vinus carriers identified at blood donation and their outcomes with or without interferon treatment:Study on 1019 carriers followed for 5-10 years. Mizui M. Yokoyama T. Tsuji K. Arataki K. Yamaguchi S. Miura T. Kitamoto M. Takezaki E. Orimen S. Sakata T. Kamada K. Maruhashi A. Tamura T. Nakamura T. Ishida K. Teramen K. Miyakawa Y. Yoshizawa H. Hepatology Reserch 2007,37.994-1001.
Minimum infectiours dose of hepatitis B virus in chimpanzees and difference in dynamics of viremia between genotype A and genotype C. Komiya Y. Katayama K. Yugi H. Mizui M. Matsukura H. Tomoguri T. Miyakawa Y. Tabuchi A. Tanaka J. Yoshizawa H. Transfusion. 2008,48.286-294.

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