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肝炎等克服緊急対策研究事業中間・事後評価委員名簿

(○:委員長)

 
沖田 極 社会保険下関厚生病院長・医学博士
肝臓病学、消化器内科学
Management of hepatocellular carcinoma in Japan. Okita K. J Gastroenterology 2006;41:100-106.
Molecular targeted therapy, in Symposium IV “Systemic Therapy for Hepatocellular Carcinoma”, the 5th Seoul International Liver Symposium, Korea, 2009
「新臨床内科学 第9版:肝胆膵疾患」沖田 極(篇集)、高久史麿・尾形悦郎・黒河 清・矢崎善雄(監修)、医学書院、(2009)
 
樋野 興夫 順天堂大学医学部病理・腫瘍学講座 教授
発がん・病理学
Hino O., Tabata S. and Hotta Y.: Evidence for increased in vitro recombination with insertion of human hepatitis B virus DNA. Proc Natl Acad Sci U S A 88: 9248-9252, 1991
Aoki H., Kajino K., Arakawa Y. and Hino O.: Molecular cloning of a rat chromosome putative recombinogenic sequence homologous to the hepatitis B virus encapsidation signal. Proc Natl Acad Sci U S A 93: 7300-7304, 1996
Yasen M., Kajino K., Kano S., Tobita H., Yamamoto J., Uchiumi T., Kon S., Maeda M., Obulhasim G., Arii S. and Hino O.: The up-regulation of Y box binding proteins (dbpA and YB-1) as prognostic markers of hepatocellular carcinoma. Clinical Cancer Research 11: 7354-7361, 2005
 
幕内 雅敏 日本赤十字社医療センター 院長
肝胆膵外科学、肝移植
Ultrasonically guided subsegmentectomy. Makuuchi M, Hasegawa H, Yamazaki S. Surg Gynecol Obstet. 1985 Oct;161(4):346-50.
Safety of hemihepatic vascular occlusion during resection of the liver. Makuuchi M, Mori T, Gunven P, Yamazaki S, Hasegawa H. Surg Gynecol Obstet. 1987 Feb;164(2):155-8.
Preoperative portal embolization to increase safety of major Hepatectomy for hilar bile duct carcinoma: a preliminary report. Makuuchi M, Thai BL, Takayasu K, Takayama T, Kosuge T, Gunven P, Yamazaki S, Hasegawa H, Ozaki H. Surgery 1990 May;107(5):521-7.
 
三田村 圭二 新宿石川病院 院長、昭和大学医学部 客員教授
消化器病学
Mitamura, K., BH. Hoyer, A. Ponzetto, J. Nelson, R. Purcell, and J. Gerin,
Woodchuck hepatitis virus DNA in woodchuck liver tissues.
Hepatology  2  47S-50S  1982
Kumagai, Y., J. Chiba, T. Sata, S. Ohtaki, and K. Mitamura
A new tumor-associated antigen useful for serodiagnosis of
hepatocellular carcinoma, defined by monoclonal antibody KM-2
Cancer Res  52  4987-4994  ,1992
Ito, T., K. Yasui, J. Mukaigawara, A. Katsume, M. Kohara, and K. Mitamura
Acquisition of susceptibility to hepatitis C virus replication in HepG2 cells by fusion with primary human hepatocytes: establishment of a quantitative assay for hepatitis C virus infectivity in a cell culture system
Hepatology  34  566-572  ,2001
宮村 達男 国立感染症研究所 所長
ウイルス学
Detection of antibody against antigen expressed by molecularly cloned hepatitis C virus cDNA: Application to diagnosis and blood screening for post transfusion hepatitis. Miyamura T, Saito I, Katayama T, Kikuchi S, Tateda A, Houghton M, Choo Q-L, Kuo G. Proc Natl Acad Sci USA. 1990; 87:983-987.
Hepatitis C virus infection is associated with the development of hepatocellular carcinoma. Saito I, Miyamura T, Ohbayashi A, Harada H, Katayama T, Kikuchi S, Watanabe Y, Koi S, Onji M, Ohta Y, Choo Q-L, Houghton M, Kuo G. Proc Natl Acad Sci USA. 1990; 87:6547-6549.
The HBx gene of hepatitis B virus induces liver cancer. Kim C-M, Koike K, Saito I, Miyamura T, Jay G. Nature. 1991; 351:317-320.
 
村上 清史 金沢大学 名誉教授
分子遺伝
The transcriptional transactivation function of HBx protein is important for its augmentation role in hepatitis B virus replication. Tang H, Delgermaa L, Huang F, Oishi N, Liu L, He L, Zhao L, *Murakami S., J. Virol., 2005, 79(9): 5548-5556.
Effect of Hepatitis C Virus (HCV) NS5B-Nucleolin Interaction on HCV Replication with HCV Subgenomic Replicon. Shimakami T, Honda M, Kusakawa T, Murata T, Shimotohno K, Kaneko S *Murakami S. J. Virol., 2006, 80 (7): 3332–334.
Hepatitis B Virus X protein overcomes oncogenic RAS-induced senescence in human immortalized cells. Cancer Science, Oishi N, Khurts S, Nakamoto Y, Honda M, Kaneko S, *Murakami S. Cancer Science, 2007, 98(10): 1540-1548.
 
矢野 右人 長崎県病院企業団 企業長
国立病院機構長崎医療センター 名誉院長
ウイルス肝炎
Impact of aging on the development of hepatocellular carcinoma in patients with 
posttransfusion chronic hepatitis C. 
Hamada H, Yatsuhashi H, Yano K, Daikoku M, Arisawa K, Inoue O, Koga M, Nakata K,
 Eguchi K, Yano M.
Cancer. 2002 Jul 15;95(2):331-9.
The Long-term Pathological Evolution of Chronic Hepatitis C
Michitami Yano, Hiromitsu Kumada, Masayoshi Kage, Kenji Ikeda, Kazuhide Shimamatsu,
Osami Inoue,  Etsuko Hashimoto, Jay H. Lefkowitch, Jurgen Ludwig and Kunio Okuda
HEPATOLOGY 23 (6) : 1334-1340, 1996.6
Quantitative immunoelectrophoresis as a method for determination of hepatitis B antigen
Standardization and comparison with other methods
M. Yano and I. Tripatzis
Z.Immun.-Forsch Bd. 146 : S174-186, 1973.
 
山口 一成 熊本大学発生医学研究所 非常勤研究員
血液学、ウイルス腫瘍学、輸血感染症
Human T-cell leukemia virus type I (HTLV-1) proviral load and disease progression in asymptomatic HTLV-1 carriers: a nationwide prospective study in Japan. Iwanaga M, Watanabe T, Utsunomiya A, Okayama A, Uchimaru K, Koh KR, Ogata M, Kikuchi H, Sagara Y, Uozumi K, Mochizuki M, Tsukasaki K, Saburi Y, Yamamura M, Tanaka J, Moriuchi Y, Hino S, Kamihir S, Yamaguchi K. Blood 116:8,1211-1219, 2010
Differential susceptibity of peripheral blood CD5+ and CD5- B cells to apoptosis in chronic hepatitis C patients. Mizuochi T, Ito M, Takai K, Yamaguchi K. Biochem Biophys Res Commun. 389(3):512-5. 2009
Human T-lymphotropic virus type 1 in Japan. Yamaguchi K. Lancet 343:213-216 ,1994
 
吉澤 浩司 広島大学 名誉教授
ウイルス肝炎の疫学
Hepatitis B virus(HBV) screening strategy to ensure the safety of blood for transfusion through a combination of immunological testing and nucleic acid amplification testing –Japanese experience-
H.Yugi, M.Mizui, J.Tanaka and H.Yoshizawa
J.clin.virol , 2006 36;(1) 56-64
Titeration of hepatitis B virus infectivity in the sera of pre-acute and late acute phase of HBV infection : Transmission experiments to chimeric mice with human liver repopulated hepatocytes.
A.Tabuchi , J.Tanaka , K.Katayama , M.Mizui , H.Matsukura , H.Yugi , T.Shimada , Y.Miyakawa and H.Yoshizawa
J.Med.virol , 2008 80:2064-2068
A novel hepatitis B virus surface antigen immunoassary as sensitive as hepatitis B virus nuleic acid testing in detecting early infection.
N.Matsubara , O.Kusano , Y.Sugiyama , T.Itoh , M.Mizui, J.Tanaka and H.Yoshizawa
Transfusion , 2009 March ; 49:585-595

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