表 17β−エストラジオールの遺伝毒性
Test system | Result | Dose | Reference | |
Without exogenous matabolic system |
With exogenous matabolic system |
(LED or HID) ug/ml or mg/kg |
||
Salmonella typhimurium TA100, TA1535, TA1537, TA1538, TA98, reverse mutation | - | - | 2500 ug/plate | Lang & Redman (1979) |
Salmonella typhimurium TA1535, TA1537, TA1538, reverse mutation | - | - | 500 ug/plate | Ingerowski et al. (1981) |
Salmonella typhimurium TA100, TA1535, TA1537, TA1538, TA98, reverse mutation | - | - | 500 ug/plate | Lang & Reimann (1993) |
Salmonella typhimurium TA100, TA1535, TA1537, TA1538, TA98, reverse mutation | - | - | 5000ug/plate | Richold (1988) |
DNA strand breaks, cross-links or related damage, mouse brain DNA in vitro | (+) | NT | 27.2 | Yamafuji et al. (1971) |
DNA strand breaks, cross-links or related damage, Chinese hamster V79 DNA in vitro | - | - | 816 | Swenberg (1981) |
DNA single-strand breaks, rat hepatocytes in vitro | - | NT | 82 | Sina et al. (1983) |
DNA repair exclusive of unscheduled DNA synthesis, female C57BL mouse mammary epithelial cells in vitro | - | NT | 0.2 | Telang et al. (1992) |
Unscheduled DNA synthesis, Syrian hamster embryo cells in vtro | - | NT | 10 | Tsutsui et al. (1987) |
Gene mutation, Chinese hamster lung V79 cells, hprt locus in vitro | - | - | 27.2 | Drevon et al. (1981) |
Gene mutation, Chinese hamster lung V79 cells, ouabain in vitro | - | - | 27.2 | Drevon et al. (1981) |
Gene mutation, Syrian hamster embryo cells, hprt and Na+/K+ ATPase loci in vitro | - | NT | 10 | Tsutsui et al. (1987) |
Gene mutation, Chinese hamster lung V79 cells, hprt locus in vitro | + | - | 10-10M | Rajah & Pento (1995) |
Gene mutation, Mouse lymphoma L5178Y cells, tk locus in vitro | - | - | 255, 174ug/ml | Richold (1988) |
Gene mutation, human breast cancer MCF-7 cells, MTXr in vitro | + | - | 10-8M | Thibodeau et al. (1998) |
Sister chromatid exchange, mouse cervical fibroblasts and kindney cells in vitro | - | NT | 2.7 | Hillbertz-Nilsson & Rorsberg (1985) |
Sister chromatid exchange, Syrian hamste embryo cells in vitro | - | NT | 10 | Tsutsui et al. (1987) |
Micronucleus formation, Syrian hamster embryo cells in vitro | +** | NT | 2.72 | Schnitzler et al. (1994) |
Micronucleus formation, Chinese hamster lung V79 cells in vitro | +** | NT | 20x10-6M | Eckert and Stopper (1996) |
Micronucleus formation, ovine seminal vesicle cells in vitro | +** | NT | 2.72 | Schnitzler et al. (1994) |
Chromosomal aberration, Syrian hamster embryo cells in vitro | - | NT | 10 | Tsutsui et al. (1987) |
Chromosomal aberration, Syrian hamster embryo cells in vitro | - | NT | 8.17 | Tsutsui et al. (1987) |
Chromosomal aberrations, Chinese hamster lung V79 cells in vitro | + | 3x10-5M | Sato et al (1992) | |
Aneuploidy, male Chinese hamster DON cells in vitro | + | NT | 13.6 | Wheeler et al. (1986) |
Test system | Result | Dose | Reference | |
Without exogenous matabolic system |
With exogenous matabolic system |
(LED or HID) ug/ml or mg/kg |
||
Aneuploidy, Syrian hamster embryo cells in vitro | + | NT | 10 | Tsutsui et al. (1987, 1990) |
Aneuploidy, Syrian hamster embryo cells in vitro | + | NT | 0.82 | Tsutsui et al. (1997) |
Cell transformation, BALB/c3T3 embryo-derived mouse fibroblasts | + | NT | 5.5 | Liehr et al. (1987a) |
Cell transformation, C3H 10T1/2 mouse cells | + | NT | 0.27 | Kennedy & Weichselbaum (1981) |
Cell transformation, Syrian hamster embryo cells | + | NT | 3 | Tsutsui et al. (1987) |
Cell transformation, Syrian hamster embryo cells | NT | + | 3 | Hayashi et al. (1996) |
Cell transformation, Syrian hamster embryo cells | + | NT | 2.72 | Tsutsui et al. (1997) |
Cell transformation, female C57BL mouse mammary epithelial cells | - | NT | 0.2 | Telang et al. (1992) |
Cell transformation, primary baby rat kedney + HPV16 + ras | - | NT | 0.27 | Pater et al. (1990) |
Sister chromatid exchange, human lymphocytes in vitro | - | NT | 13.6 | Hill & Wolff (1983) |
Sister chromatid exchange, human lymphocytes in vitro | - | - | 27.2 | Banduhn & Obe (1985) |
Micronucleus formation, human lymphocytes in vitro | + | NT | 1.3 | Banduhn & Obe (1985) |
Chromosomal aberration, human lymphocytes in vitro | - | NT | 100 | Stenchever et al. (1969) |
Chromosomal aberration, human lymphocytes in vitro | - | - | 27.2 | Banduhn & Obe (1985) |
Aneuploidy, human lymphocytes in vitro | (+) | NT | 13.6 | Banduhn & Obe (1985) |
Aneuploidy, human foreskin JHU-1 fibroblasts in vitro | + | NT | 20 | Tsutsui et al. (1990) |
Microtuble disruption, human breast cancer MCF-7 and MDA-MB-231 cells, MTXr in vitro | + | 50 uM | Aizu-Yokota et al, (1994) | |
DNA strand breaks, cross-links or related damage, male Syrian hamster kidney and liver in vivo | (+) | 22.5 mg impx1, 2wk | Han & Liehr (1994) | |
DNA strand breaks, cross-links or related damage, male Syrian hamster kidney in vivo | + | 250 mg/d impx1, 7d | Han & Liehr (1994) | |
DNA strand breaks, cross-links or related damage, male Syrian hamster liver in vivo | - | 250 mg/d impx1, 7d | Han & Liehr (1994) | |
DNA strand breaks, cross-links or related damage, male Syrian hamster kidney and liver in vivo | - | 150 ipx1 | Han & Liehr (1994) | |
Sister chromatid exchange, female NMRI mouse uterine cervix and uterine horn epithelial cells in vivo | + | 5 ug scx1 | Forsberg (1991) | |
Sister chromatid exchange, female NMRI kidney cells in vivo | - | 5 ug scx1 | Forsberg (1991) | |
Chromosomal aberrations, male Syrian hamster renal cortical cells in vivo | + | 125 ug/d impx1, 5 ml | Banerjee et al. (1994) | |
Chromosomal aberrations, Rat bone marrow and spermatogonia in vivo | - | 100mg/kg | Richold (1988) | |
Test system | Result | Dose* | Reference | |
Without exogenous matabolic system |
With exogenous matabolic system |
(LED or HID) ug/ml or mg/kg |
||
Micronucleus formation, B6C3F1 mouse and F344 rat bone marrow, in vivo | - | 1250 mg/kg | Shelby et al. (1997) | |
Micronucleus formation, CBA mouse bone marrow, in vivo | - | 0.02 mg/kg | Ashby et al. (1997) | |
Micronucleus formation, AP rat bone marrow, in vivo | - | 150 mg/kg | Ashby et al. (1997) | |
Micronucleus formation, BDF1 & CD-1 mouse peripheral blood, in vivo | - | 2000mg/kg | Morita et al. (1997) | |
Micronucleus formation, Swiss albino mouse bone marrow, in vivo | + | 0.1mg/kg | Dhillon & Dhillon (1995) | |
Microsatellite instability, Syrian hamster, estrogen induced kidney tumor cells, in vivo | + | 25 mg, impx2, 6mo | Hodgson et al. (1998) | |
Aneuploidy, female NMRI mouse uterine cervix and uterine horn epithelial cells in vivo | - | 5 ug scx1 | Forsberg (1991) | |
Aneuploidy, female NMRI mouse kidney cells in vivo | - | 5 ug scx1 | Forsberg (1991) | |
Aneuploidy, male Syrian hamster renal tubular cells in vivo | + | 20 mg impx1, 3.5 mo | Li et al. (1993) | |
Increase in nuclear DNA content (aneuploidy), female BALB/c mouse cervicovaginal epithelium in vivo | + | 25 ug scx5 | Hajek et al. (1993) |