放射線被ばくと多発性骨髄腫との因果関係を明らかにするために種々の疫学調査が実施されている。そこで、文献を系統的に検索し、検索された文献をもとにして多発性骨髄腫と放射線被ばくとの因果関係を判断することとした。 文献は、主として「PubMed」を用いて、key wordsとしてradiation、 multiple myeloma 、epidemiologyで検索した。
疫学調査に関する文献
原子力施設等の作業者に関するもの
E.S.Gilbert et al.：Mortality of workers at the Hanford site: 1945-1986. Health Phys, 64, 577-590 (1993)
E.S.Gilbert ea al.: Analyses of combined mortality data on workers at the Hanford Site, Oak Ridge National Laboratory, and Rocky Flats Nuclear Weapons Plant. Radiat Res 120, 19-35 (1989)
S.Wing et al.: A case control study of multiple myeloma at four nuclear facilities. Ann Epidemiol 10 ,144-153 (2000)
C.R.Muirhead et al.: Follow up of mortality and incidence of cancer 1952-98 in men from the UK who participated in the UK’s atomospheric nuclear weapon tests and experimental programmes.Occup Environ Med 60,165-172（2003）
E.Cardis et al.: Effects of low doses and low dose rates of external ionizing radiation: cancer mortality among nuclear industry workers in three countries. Radiat. Res. 142, 117-132 (1995)
放射線診療患者に関するもの
J.L.Hatcher et al,: Diagnostic radiation and the risk of multiple myeloma (United States). Cancer Causes Control 12, 755 ?761 (2001)
P. D.Inskip: Leukemia, lymphoma, and multiple myeloma after pelvic radiotherapy for benign disease. Radiat.Res. 135, 108-124 (1993)
原子力施設等の周辺住民に関するもの
D.Forman et al. : Cancer near nuclear installations. Nature.329,499-505 (1987)
C.R.Muirhead et al. : Follow up of mortality and incidence of cancer 1952-98 in men from the UK who participated in the UK’s atomospheric nuclear weapon tests and experimental programes. (2003)
J.D.Boice Jr. et al. : Cancer mortality in a Texas county with prior uranium mining and milling activities, 1950-2001. J.Radiat. Prot. 23, 247-262 (2003)
M.Dousset : Cancer mortality around La Hague nuclear facilities. Health Phys. 56,875-884 (1989)
今後入手が必要な文献
R.Z.Omar et al. : Cancer mortality and morbidity among plutonium workers at the Sellafield plant of British Nuclear Fuels. Br. J. Cancer 79, 1288-1301 (1999)
A.J.Douglas et al.: Cancer mortality and morbidity among workers at the Sellafield plant of British Nuclear Fuels. Br J Cancer 70, 1232-1243 (1994)
P.G.Smith et al. : Mortality of workers at the Sellafield plant of British Nuclear Fuels. Br. Med. J. 293, 845-854 (1986)
G.M.Kendall et al. : Mortality and occupational exposure to radiation : fierst analysis of the National Registry for Radiation Workers. BMJ 304, 220-225 (1992)
C.R.Muirhead et al. : Occupational radiation exposure and mortality: second analysis of the National Registry for Radiation Workers. J Radiat Prot. 19, 3-26 (1999)
V.Beral et al.: Mortality of employees of the Atomic Weapons Establishment,1951-82. BMJ 297,757-770 (1988)
T.Iwasaki et al.: Second analysis of mortality of nuclear industry workers in Japan, 1986-1997. Radiat.Res. 159, 228-238 (2003)
J.X.Wang et al. : Cancer among medical diagnostic x-ray workers in China. J Natl Cancer Inst. 80, 344-350 (1988)
D.L.Preston et al. : Cancer incidence in atomic bomb survivors. Part III. Leukemia, lymphoma and multiple myeloma, 1950-1987. Radiat, Res. 137 (2 Suppl) : S68-S97 (1994)
Y.Shimizu et al.: Risk of cancer among atomic bomb survivors. J Radiat Res. 32 (Suppl) 54-63 (1991) （Overview paper で具体的な数値等は示されていない）
Y.Shimizu et al.: Mortality among atomic bomb survivors. J.Radiat. Res. 32 (Suppl) 212-230 (1991)
Y.Shimizu et al.: Studies of the mortality of A-bomb survivors. 9. Mortality, 1950-1985 : Part 2. Cancer mortality based on the recently revised doses (DS86). Radiat. Res. 121, 120-141 (1990)
S.C.Darby et al. : A summary of mortality and incidence of cancer in men from the United Kingdom who participated in the United Kingdom’s atmospheric nuclear weapon tests and experimental programmes. BMJ 296, 332-338 (1988)
S.C.Darby et al.: Further follow up of mortality and incidence of cancer in men from the United Kingdom who participated in the United Kingdom’s atmospheric nuclear weapon tests and experimental programmes. BMJ 307, 1530-1535（1993）
C.Dong et al.: Second primary neoplasms among 53 159 haematolymphoproliferative malignancy patients in Sweden, 1958-1996: a search for common mechanisms. Br J Cancer 85,997-1005 (2001)
A.M.Stom et al. : Cancer incidence among Danish Thorotrast exposed patients. J. Natl. Cancer Inst. 84, 1318-1325 (1992)
A.M.Carstensen et al. : Leukemia and other related hematological disorders among Danish patients exposed to Thorotrast. Radiat. Res. 134, 224-245 (1993)
S.C.Darby et al. : Mortality in a cohort of women given X-ray therapy for metropathia haemorrahagica. Int J Cancer 56, 793-801 (1994)
P.Vineis et al. : Italian multicentre case-control study of hematolymphopoietic malignancies. Med. Lav. 81, 506-512 (1990)
L.Tomasek et al. : Radon exposure and cancers other than lung cancer among uranium miners in West Bohemia. Lancet 341, 919-923(1993)
S.S.Strom et al.: Excess leukemia and multiple myeloma in a mining county in northeast Texas. Tex. Med. 90, 7 (1994)
G.Lopez-Abente et al. Leukemia, lymphomas, and myeloma mortality in the vicinity of nuclear power plants and nuclear fuel facilities in Spain. Cancer Epi. Biomaeker Prev. 8, 925-934 (1999)
R.J.Black et al. : Cancer incidence in a population potentially exposed to radium-226 at Dalgety Bay, Scotland. Br. J. Cancer 69, 140-143 (1994)
総論的な文献
D.Hubert et al.: Risks of cancer among workers of nuclear industry. Bull. Cancer 79, 5-23 (1992)
D.A.Riedel et al. : The epidemiology of multiple myeloma. Hematol. Oncol. Clin. North Am. 6, 225-247 (1992)
B.G.Durie: The epidemiology of multiple myeloma. Semin Hematol 38, 1-5 (2001)
G.J.Morgan et al. : Myeloma aetiology and epidemiology. Biomed. Pharmacother. 56, 223-234 (2002)