内分泌かく乱化学物質の健康影響に関する検討会中間報告書追補

［検討協力者、参考資料・文献等］

１試験スキーム：別冊１－１

検討協力者（○は班長）
菅野純○（国立医薬品食品衛生研究所安全性生物試験研究センター毒性部）、板井昭子（（株）医薬分子設計研究所所長）、（株）ビアコア、高月峰夫（化学物質評価研究機構安全性評価技術研究所）

参考資料・文献等

・厚生科学研究費補助金（生活安全総合研究事業）「内分泌かく乱化学物質の作用機構に焦点をあてた新しいハイ・スループット・スクリーニング法の開発に関する研究」（主任研究者：菅野純国立医薬品食品衛生研究所安全性生物試験研究センター毒性部第一室長）

・厚生科学研究費補助金（生活安全総合研究事業）「内分泌かく乱化学物質等、生活環境中化学物質による人の健康影響についての試験法に関する調査研究」（主任研究者：今井清（財）食品薬品安全センター秦野研究所副所長）

・「レポーター遺伝子導入ヒト由来培養細胞株を用いた超高速分析法に関する試験研究」（武吉正博・宮田優子・山崎寛治・矢可部芳州・高月峰夫化学物質評価研究機構安全性評価技術研究所）

・ Task Force on Endocrine Disrupters Testing and Assessment (EDTA) of the Test Guideline Programme: OECD Report of the Initial Work towards the Validation of the Rodent Uterotropic Assay: Phase I (ENV/JM/TG/EDTA (2001)1); Progress of Work on the Validation of the Rodent Uterotropic Assay: Phase II Status Report (Including Statistical Evaluation of Results)(ENV/JM/TG/EDTA(2001)2); Progress of Work on the Validation of the Rodent Hershberger Assay: Phase I Status Report (ENV/JM/TG/EDTA(2001)3)

・ J. Kanno, L. Onyon, J. Haseman, P. Fenner-Crisp, J. Ashby and W. Owens, The OECD Program to Validate the Rat Uterotropic Bioassay to Screen Compounds for in Vivo Estrogenic Responses: Phase I, Environmental Health Perspectives, Vol. 109, No. 8, August 2001, 785-794.

２採取・分析法：別冊１－２

検討協力者（○は班長）
中澤裕之○（星薬科大学薬品分析化学教室）、岡尚男・近藤文雄・猪狩誉友、伊藤裕子、後藤智美（愛知県衛生研究所）、堀江正一・石井里枝・吉田栄充（埼玉県衛生研究所）、月岡忠・寺澤潤一（長野県衛生公害研究所）、藤巻照久・平山クニ（神奈川県衛生研究所）、堀伸二郎（大阪府立公衆衛生研究所）、北田善三（奈良県衛生研究所）、吉村吉博・加藤嘉代子・井之上浩一（星薬科大学薬品分析化学教室）、牧野恒久（東海大学医学部産婦人科）

参考資料・文献等

・厚生科学研究費補助金（生活安全総合研究事業）「ポリ塩化ビニル製手袋中のフタル酸ジ２－エチルヘキシルの食品中への移行に関する研究」（主任研究者：中澤裕之星薬科大学教授）

（ビスフェノールＡ分析法）

・今中雅章，佐々木久美子，根本了，植田英一，村上恵美子，宮田大典，外海泰秀：食品衛生学雑誌，42， 71-78 (2001)

・環境庁水質保全局、"外因性内分泌撹乱化学物質調査暫定マニュアル"（平成10年10月）
（ビスフェノールＡ分析法：GC/MSによる分析）

・河村葉子，佐野比呂美，山田隆：食品衛生学雑誌，40，158-165 (1999)
（ビスフェノールＡ分析法：HPLCあるいはLC/MSによる分析）

・瀧野昭彦，津田泰三，小島美穂子，原田浩之，和田稔：食品衛生学雑誌，40, 325-333 (1999)

・堀江正一，吉田栄充，石井里枝，小林進，中澤裕之：分析化学，48，579-587 (1999)

・ T. Yoshida, M. Horie, H. Nakazawa: Food Addit. Contam., 18、 69-75 (2001)

・ Y. Takano, H.C.Lee, Y. Ishibashi, S. Kohra, N. Tominaga, K. Arizono: J. Health.Sci.,45, 39-40 (1999)

（フタル酸エステル類分析法）

・衛生試験法・注解2000、日本薬学会編、金原出版、2000.

・津村ゆかり、石光進、中村優美子、吉井公彦、岡田舞、外海泰秀食品衛生学会誌、41、254-260（2000）

・外因性内分泌かく乱化学物質調査暫定マニュアル（水質、底質、水生生物）平成10年10月、環境庁水質保全局水質管理課

（フタル酸エステル類分析法：GC/MSによる分析）

・ M. Sharman, W.A. Read, L. Casle and J. Gilbert, Food Addit. Contam., 11, 375 -385 (1994)

・ B. D. Page and G. Lacroix, Food Addit. Contam, 12, 129-151 (1995)

・ L. Castle, J. Gilbert and T.Eklund, Food Addit. Contam., 7 , 591-596 (1990)

・ G.Di. Bella, M. Saitta, M. Pellerino. F. Salvo and G. Dugo, J. Agric. Food.Chem., 47, 1009-1012 (1999)

・ A. Penalver, E. Pocurull, F. Borrull and RM. Marce, J. Chromatgr, A , 872, 191-201 (2000)

・ JH. Peterson and T. Breindahl, Food Addit. Contam., 17, 133-141 (2000)

・津村ゆかり、石光進、中村優美子、吉井公彦、開原亜樹子、外海泰秀、食品衛生学会誌 42、128-132（2001）

（フタル酸エステル類分析法：HPLCによる分析）

・ S. Jara, C. Lysebo, T. Greibrokk, and E. Lundance, Anal. Chim. Acta. 407, 165-171 (2000)

・ M.H.W. Morelli Cardoso, E.R.Lachter, D. Tabak, S.Abrantes and O.M.G., de Moraes, J. High Resolut. Chromatog. 22, 70 -72 (1999)
（ノニルフェノール分析法）

・佐々木久美子、高附巧、根本了、今中雅章、衛藤修一、村上恵美子、豊田正武：食衛誌、40, 460-472 (1999)

・根本了、高附巧、佐々木久美子、豊田正武：食衛誌、41, 377-380 (2000)

・ P.L. Ferguson, C.R. Iden and B.J. Brownawell: Anal. Chem., 72, 4322-4330 (2000)

・米久保淳、佐々木俊哉、一木満貴子、金井みき子、佐々木秀輝：分析化学、48, 571-577 (1999)

・ T. Tsuda K. Suga, E. Kaneda and M. Ohsuga: J. Chromatogr. B, 746, 305-309 (2000)

・ K. Inoue, Y. Yoshimura, T. Makino and H.Nakazawa : Analyst, 125, 1959-1961 (2000)

・ T. Tsuda A. Takino, M. Kojima, H. Harada and K. Muraki: J. Chromatogr. B, 723, 273-279 (1999)

・河村葉子、前原玉枝、飯嶋広代、山田隆：食衛誌、41, 212-218 (2000)

３低用量問題：別冊１－３

検討協力者（○は班長）
井上達○・関沢純・五十嵐勝秀・菅野純・渋谷淳・中田琴子・長谷川隆一・江馬眞・（国立医薬品食品衛生研究所）、井藤悦朗（（社）日本化学物質安全・情報センター）、今井清（（財）食品薬品安全センター秦野研究所）、長村義之（東海大学）、白井智之（名古屋市立大学）、鈴木勝士（日本獣医畜産大学）、福島昭治（大阪市立大学）、三森国敏（東京農工大学）

参考資料・文献等

・ Ashby J, Tinwell H & Haseman J (1999) Lack of effects for low dose levels of bisphenol A and diethylstilbestrol on the prostate gland of CF1 mice exposed in utero, Regul. Toxicol. Pharm. 30, 156-166

・ Ema M, Fujii S, Furukawa M, Kiguchi M, Ikka T and Harazono A (2001) Rat two-generation reproductive toxicity study of bisphenol A, Reprod. Toxicol., 15, 505-523

・ Gupta C (2000) Reproductive malformation of the male offspring following maternal exposure to estrogenic chemicals, Exper. Biol. Med. 224(2), 61-68

・ Nagel SC, vom Saal FS, Thayer KA, Dhar M, Boechler M, and Welshons WV (1997) Relative binding affinity-serum modified access (RBA-SMA) assay predicts the ralative in vivo bioactivity of the xenoestrogens bisphenol A and octylphenol, Environ. Health Persp., 105, 70-76

・ NTP/NIEHS (2001) NTP Report of the Endocrine Disruptors Low Dose Peer Review, Chapter 5 Report of the Statistics Subpanel, 5-6, 12, US EPA/NTP-NIEHS

・ National Research Council (1999) Hormonally Active Agents in the Environment. National Academy Press. pp. 430

・ Odum J, Tinwell H, Jones K, Van Miller, Joiner RL & Tobin G (2001) Effect of rodent diets on the sexual development of the rat, Toxicological Science, 61, 115-127

・大竹千代子、関沢純（印刷中）Diethylstilbestrol の低用量試験での陽性反応再現性確立への提案、第４回日本内分泌かく乱化学物質学会研究発表会、つくば

・関沢純、配島由二、土屋利江（2001）ビスフェノールＡ重合樹脂成型血液透析器使用のリスク・ベネフィット分析、日本リスク研究学会第１４回研究発表会、73-74頁

・ Vom Saal FS, Cooke PS, Buchanan DL, Palanza P, Thayer KA, Nagel SC, Parmigiani S and Welshons WV (1998) A physiologically based approach to the study of bisphenol A and estrogenic chemicals on the size of reproductive organs, daily sperm production and behavior, Toxocol. Ind/ Health 14, 239-259

・吉田緑、勝田真一、渡辺元、田谷一善、前川明彦 (2001) 胎仔期および授乳期の低用量-BisphenolA暴露がラット雌性生殖器系に及ぼす影響、第28回日本トキシコロジー学会、年会講演要旨集、122頁。

４暴露疫学等調査：別冊１－４

検討協力者（○は班長、△は副班長）

全体総括：紫芝良昌○（三宿病院院長）

暴露調査等：牧野恒久△（東海大学医学部産婦人科）、中澤裕之（星薬科大学薬学部）、織田肇（大阪公衆衛生研究所）、塩田邦郎（東京大学農学生命科学大学院）、鈴森薫（名古屋市立大学医学部産婦人科）

疫学研究：津金昌一郎△・花岡知之・原めぐみ（国立がんセンター研究所支所臨床疫学研究部）、坪野吉孝（東北大学大学院医学系研究科）、岸玲子・加藤静恵・笠井世津子・倉橋典絵（北海道大学大学院医学研究科）、岩本晃明・野澤資亜利（聖マリアンナ医大泌尿器科）

参考資料・文献等
（暴露調査等）

・厚生科学研究費補助金（生活安全総合研究事業）「内分泌かく乱化学物質に関する生体試料（さい帯血等）分析法の開発とその実試料分析結果に基づくヒト健康影響についての研究」（主任研究者：牧野恒久東海大学医学部産婦人科学教授）

（疫学研究）

・厚生科学研究費補助金（生活安全総合研究事業）「内分泌かく乱化学物質の人の生殖機能等への影響に関する研究」（主任研究者：津金昌一郎国立がんセンター研究所支所臨床疫学研究部長

・厚生科学研究費補助金（生活安全総合研究事業）「内分泌かく乱物質の生殖機能と次世代への影響、特に生殖泌尿器系・先天異常の成因に関する疫学的研究」（主任研究者：岸玲子北海道大学大学院医学研究科教授）

・厚生科学研究費補助金（生活安全総合研究事業）「内分泌かく乱物質等の生活環境中の化学物質による健康影響－日本人正常男性の生殖機能に関する総合的研究」（主任研究者：岩本晃明聖マリアンナ医大泌尿器科教授）

（乳がん）

・ Aronson KJ, Miller AB, Woolcott CG, Sterns EE, McCready DR, Lickley LA, Fish EB, Hiraki GY, Holloway C, Ross T, Hanna WM, SenGupta SK, Weber JP. Breast adipose tissue concentrations of polychlorinated biphenyls and other organochlorines and breast cancer risk. Cancer Epidemiol Biomarkers Prev 2000;9(1):55-63.

・ Aschengrau A, Coogan PF, Quinn M, Cashins LJ. Occupational exposure to estrogenic chemicals and the occurrence of breast cancer: an exploratory analysis. Am J Ind Med 1998;34(1):6-14.

・ Bagga D, Anders KH, Wang HJ, Roberts E, Glaspy JA. Organochlorine pesticide content of breast adipose tissue from women with breast cancer and control subjects. J Natl Cancer Inst 2000;92(9):750-3.

・ Bibbo M, Haenszel WM, Wied GL, Hubby M, Herbst AL. A twenty-five-year follow-up study of women exposed to diethylstilbestrol during pregnancy. N Engl J Med 1978;298(14):763-7.

・ Brian DD, Tilley BC, Labarthe DR, O'Fallon WM, Noller KL, Kurland LT. Breast cancer in DES-exposed mothers: absence of association. Mayo Clin Proc 1980;55(2):89-93.

・ Calle EE, Mervis CA, Thun MJ, Rodriguez C, Wingo PA, Heath CW, Jr. Diethylstilbestrol and risk of fatal breast cancer in a prospective cohort of US women. Am J Epidemiol 1996;144(7):645-52.

・ Colton T, Greenberg ER, Noller K, Resseguie L, Van Bennekom C, Heeren T, Zhang Y. Breast cancer in mothers prescribed diethylstilbestrol in pregnancy. Further follow-up. Jama 1993;269(16):2096-100.

・ Dello Iacovo R, Celentano E, Strollo AM, Iazzetta G, Capasso I, Randazzo G. Organochlorines and breast cancer. A study on Neapolitan women. Adv Exp Med Biol 1999;472:57-66.

・ Demers A, Ayotte P, Brisson J, Dodin S, Robert J, Dewailly E. Risk and aggressiveness of breast cancer in relation to plasma organochlorine concentrations. Cancer Epidemiol Biomarkers Prev 2000;9(2):161-6.

・ Dorgan JF, Brock JW, Rothman N, Needham LL, Miller R, Stephenson HE, Jr., Schussler N, Taylor PR. Serum organochlorine pesticides and PCBs and breast cancer risk: results from a prospective analysis (USA). Cancer Causes Control 1999;10(1):1-11.

・ Falck F, Jr., Ricci A, Jr., Wolff MS, Godbold J, Deckers P. Pesticides and polychlorinated biphenyl residues in human breast lipids and their relation to breast cancer. Arch Environ Health 1992;47(2):143-6.

・ Grimalt JO, Sunyer J, Moreno V, Amaral OC, Sala M, Rosell A, Anto JM, Albaiges J. Risk excess of soft-tissue sarcoma and thyroid cancer in a community exposed to airborne organochlorinated compound mixtures with a high hexachlorobenzene content. Int J Cancer 1994;56(2):200-3.

・ Guttes S, Failing K, Neumann K, Kleinstein J, Georgii S, Brunn H. Chlororganic pesticides and polychlorinated biphenyls in breast tissue of women with benign and malignant breast disease. Arch Environ Contam Toxicol 1998;35(1):140-7.

・ Hardell L, Lindstrom G, Liljegren G, Dahl P, Magnuson A. Increased concentrations of octachlorodibenzo-p-dioxin in cases with breast cancer--results from a case-control study. Eur J Cancer Prev 1996;5(5):351-7.

・ Helzlsouer KJ, Alberg AJ, Huang HY, Hoffman SC, Strickland PT, Brock JW, Burse VW, Needham LL, Bell DA, Lavigne JA, Yager JD, Comstock GW. Serum concentrations of organochlorine compounds and the subsequent development of breast cancer. Cancer Epidemiol Biomarkers Prev 1999;8(6):525-32.

・ Holford TR, Zheng T, Mayne ST, Zahm SH, Tessari JD, Boyle P. Joint effects of nine polychlorinated biphenyl (PCB) congeners on breast cancer risk. Int J Epidemiol 2000;29(6):975-82.

・ Hoyer AP, Grandjean P, Jorgensen T, Brock JW, Hartvig HB. Organochlorine exposure and risk of breast cancer. Lancet 1998;352(9143):1816-20.

・ Hoyer AP, Jorgensen T, Brock JW, Grandjean P. Organochlorine exposure and breast cancer survival. J Clin Epidemiol 2000;53(3):323-30.

・ Hoyer AP, Jorgensen T, Grandjean P, Hartvig HB. Repeated measurements of organochlorine exposure and breast cancer risk (Denmark). Cancer Causes Control 2000;11(2):177-84.

・ Hunter DJ, Hankinson SE, Laden F, Colditz GA, Manson JE, Willett WC, Speizer FE, Wolff MS. Plasma organochlorine levels and the risk of breast cancer. N Engl J Med 1997;337(18):1253-8.

・ Kettles MK, Browning SR, Prince TS, Horstman SW. Triazine herbicide exposure and breast cancer incidence: an ecologic study of Kentucky counties. Environ Health Perspect 1997;105(11):1222-7.

・ Krieger N, Wolff MS, Hiatt RA, Rivera M, Vogelman J, Orentreich N. Breast cancer and serum organochlorines: a prospective study among white, black, and Asian women. J Natl Cancer Inst 1994;86(8):589-99.

・ Laden F, Collman G, Iwamoto K, Alberg AJ, Berkowitz GS, Freudenheim JL, Hankinson SE, Helzlsouer KJ, Holford TR, Huang HY, Moysich KB, Tessari JD, Wolff MS, Zheng T, Hunter DJ. 1,1-Dichloro-2,2-bis(p-chlorophenyl)ethylene and polychlorinated biphenyls and breast cancer: combined analysis of five U.S. studies. J Natl Cancer Inst 2001;93(10):768-76.

・ Laden F, Hankinson SE, Wolff MS, Colditz GA, Willett WC, Speizer FE, Hunter DJ. Plasma organochlorine levels and the risk of breast cancer: an extended follow-up in the Nurses' Health Study. Int J Cancer 2001;91(4):568-74.

・ Liljegren G, Hardell L, Lindstrom G, Dahl P, Magnuson A. Case-control study on breast cancer and adipose tissue concentrations of congener specific polychlorinated biphenyls, DDE and hexachlorobenzene. Eur J Cancer Prev 1998;7(2):135-40.

・ Lopez-Carrillo L, Blair A, Lopez-Cervantes M, Cebrian M, Rueda C, Reyes R, Mohar A, Bravo J. Dichlorodiphenyltrichloroethane serum levels and breast cancer risk: a case-control study from Mexico. Cancer Res 1997;57(17):3728-32.

・ Mendonca GA, Eluf-Neto J, Andrada-Serpa MJ, Carmo PA, Barreto HH, Inomata ON, Kussumi TA. Organochlorines and breast cancer: a case-control study in Brazil. Int J Cancer 1999;83(5):596-600.

・ Millikan R, DeVoto E, Duell EJ, Tse CK, Savitz DA, Beach J, Edmiston S, Jackson S, Newman B. Dichlorodiphenyldichloroethene, polychlorinated biphenyls, and breast cancer among African-American and white women in North Carolina. Cancer Epidemiol Biomarkers Prev 2000;9(11):1233-40.

・ Moysich KB, Ambrosone CB, Vena JE, Shields PG, Mendola P, Kostyniak P, Greizerstein H, Graham S, Marshall JR, Schisterman EF, Freudenheim JL. Environmental organochlorine exposure and postmenopausal breast cancer risk. Cancer Epidemiol Biomarkers Prev 1998;7(3):181-8.

・ Moysich KB, Shields PG, Freudenheim JL, Schisterman EF, Vena JE, Kostyniak P, Greizerstein H, Marshall JR, Graham S, Ambrosone CB. Polychlorinated biphenyls, cytochrome P4501A1 polymorphism, and postmenopausal breast cancer risk. Cancer Epidemiol Biomarkers Prev 1999;8(1):41-4.

・ Mussalo-Rauhamaa H, Hasanen E, Pyysalo H, Antervo K, Kauppila R, Pantzar P. Occurrence of beta-hexachlorocyclohexane in breast cancer patients. Cancer 1990;66(10):2124-8.

・ Olaya-Contreras P, Rodriguez-Villamil J, Posso-Valencia HJ, Cortez JE. Organochlorine exposure and breast cancer risk in Colombian women. Cad Saude Publica 1998;14(Suppl 3):125-32.

・ Romieu I, Hernandez-Avila M, Lazcano-Ponce E, Weber JP, Dewailly E. Breast cancer, lactation history, and serum organochlorines. Am J Epidemiol 2000;152(4):363-70.

・ Saracci R, Kogevinas M, Bertazzi PA, Bueno de Mesquita BH, Coggon D, Green LM, Kauppinen T, L'Abbe KA, Littorin M, Lynge E, et al. Cancer mortality in workers exposed to chlorophenoxy herbicides and chlorophenols. Lancet 1991;338(8774):1027-32.

・ Schecter A, Toniolo P, Dai LC, Thuy LT, Wolff MS. Blood levels of DDT and breast cancer risk among women living in the north of Vietnam. Arch Environ Contam Toxicol 1997;33(4):453-6.

・ Schreinemachers DM. Cancer mortality in four northern wheat-producing states. Environ Health Perspect 2000;108(9):873-81.

・ Stellman SD, Djordjevic MV, Britton JA, Muscat JE, Citron ML, Kemeny M, Busch E, Gong L. Breast cancer risk in relation to adipose concentrations of organochlorine pesticides and polychlorinated biphenyls in Long Island, New York. Cancer Epidemiol Biomarkers Prev 2000;9(11):1241-9.

・ Titus-Ernstoff L, Hatch EE, Hoover RN, Palmer J, Greenberg ER, Ricker W, Kaufman R, Noller K, Herbst AL, Colton T, Hartge P. Long-term cancer risk in women given diethylstilbestrol (DES) during pregnancy. Br J Cancer 2001;84(1):126-33.

・ Unger M, Kiaer H, Blichert-Toft M, Olsen J, Clausen J. Organochlorine compounds in human breast fat from deceased with and without breast cancer and in a biopsy material from newly diagnosed patients undergoing breast surgery. Environ Res 1984;34(1):24-8.

・ van't Veer P, Lobbezoo IE, Martin-Moreno JM, Guallar E, Gomez-Aracena J, Kardinaal AF, Kohlmeier L, Martin BC, Strain JJ, Thamm M, van Zoonen P, Baumann BA, Huttunen JK, Kok FJ. DDT (dicophane) and postmenopausal breast cancer in Europe: case- control study. Bmj 1997;315(7100):81-5.

・ Ward EM, Schulte P, Grajewski B, Andersen A, Patterson DG, Jr., Turner W, Jellum E, Deddens JA, Friedland J, Roeleveld N, Waters M, Butler MA, DiPietro E, Needham LL. Serum organochlorine levels and breast cancer: a nested case-control study of Norwegian women. Cancer Epidemiol Biomarkers Prev 2000;9(12):1357-67.

・ Wolff MS, Berkowitz GS, Brower S, Senie R, Bleiweiss IJ, Tartter P, Pace B, Roy N, Wallenstein S, Weston A. Organochlorine exposures and breast cancer risk in New York City women. Environ Res 2000;84(2):151-61.

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・ Wolff MS, Zeleniuch-Jacquotte A, Dubin N, Toniolo P. Risk of breast cancer and organochlorine exposure. Cancer Epidemiol Biomarkers Prev 2000;9(3):271-7.

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（子宮内膜症）

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５リスクコミュニケーション

検討協力者
内山充（（財）日本薬剤師研修センター理事長）、神沼二眞（前国立医薬品食品衛生研究所化学物質情報部長）

参考資料・文献等

・ RadEFX Ionizing Radiation Health Effect Forum

・ US-EPA EDSTAC Report Chapter 6 "Communication and Outreach"

・放射線疫学研究手法に関する概要情報

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・	厚生科学研究費補助金（生活安全総合研究事業）「内分泌かく乱化学物質の作用機構に焦点をあてた新しいハイ・スループット・スクリーニング法の開発に関する研究」（主任研究者：菅野純国立医薬品食品衛生研究所安全性生物試験研究センター毒性部第一室長）
・	厚生科学研究費補助金（生活安全総合研究事業）「内分泌かく乱化学物質等、生活環境中化学物質による人の健康影響についての試験法に関する調査研究」（主任研究者：今井清（財）食品薬品安全センター秦野研究所副所長）
・	「レポーター遺伝子導入ヒト由来培養細胞株を用いた超高速分析法に関する試験研究」（武吉正博・宮田優子・山崎寛治・矢可部芳州・高月峰夫化学物質評価研究機構安全性評価技術研究所）
・	Task Force on Endocrine Disrupters Testing and Assessment (EDTA) of the Test Guideline Programme: OECD Report of the Initial Work towards the Validation of the Rodent Uterotropic Assay: Phase I (ENV/JM/TG/EDTA (2001)1); Progress of Work on the Validation of the Rodent Uterotropic Assay: Phase II Status Report (Including Statistical Evaluation of Results)(ENV/JM/TG/EDTA(2001)2); Progress of Work on the Validation of the Rodent Hershberger Assay: Phase I Status Report (ENV/JM/TG/EDTA(2001)3)
・	J. Kanno, L. Onyon, J. Haseman, P. Fenner-Crisp, J. Ashby and W. Owens, The OECD Program to Validate the Rat Uterotropic Bioassay to Screen Compounds for in Vivo Estrogenic Responses: Phase I, Environmental Health Perspectives, Vol. 109, No. 8, August 2001, 785-794.

・	今中雅章，佐々木久美子，根本了，植田英一，村上恵美子，宮田大典，外海泰秀：食品衛生学雑誌，42， 71-78 (2001)
・	環境庁水質保全局、"外因性内分泌撹乱化学物質調査暫定マニュアル"（平成10年10月）（ビスフェノールＡ分析法：GC/MSによる分析）
・	河村葉子，佐野比呂美，山田隆：食品衛生学雑誌，40，158-165 (1999) （ビスフェノールＡ分析法：HPLCあるいはLC/MSによる分析）
・	瀧野昭彦，津田泰三，小島美穂子，原田浩之，和田稔：食品衛生学雑誌，40, 325-333 (1999)
・	堀江正一，吉田栄充，石井里枝，小林進，中澤裕之：分析化学，48，579-587 (1999)
・	T. Yoshida, M. Horie, H. Nakazawa: Food Addit. Contam., 18、 69-75 (2001)
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・	衛生試験法・注解2000、日本薬学会編、金原出版、2000.
・	津村ゆかり、石光進、中村優美子、吉井公彦、岡田舞、外海泰秀食品衛生学会誌、41、254-260（2000）
・	外因性内分泌かく乱化学物質調査暫定マニュアル（水質、底質、水生生物）平成10年10月、環境庁水質保全局水質管理課

・	M. Sharman, W.A. Read, L. Casle and J. Gilbert, Food Addit. Contam., 11, 375 -385 (1994)
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・	JH. Peterson and T. Breindahl, Food Addit. Contam., 17, 133-141 (2000)
・	津村ゆかり、石光進、中村優美子、吉井公彦、開原亜樹子、外海泰秀、食品衛生学会誌 42、128-132（2001）

・	S. Jara, C. Lysebo, T. Greibrokk, and E. Lundance, Anal. Chim. Acta. 407, 165-171 (2000)
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・	佐々木久美子、高附巧、根本了、今中雅章、衛藤修一、村上恵美子、豊田正武：食衛誌、40, 460-472 (1999)
・	根本了、高附巧、佐々木久美子、豊田正武：食衛誌、41, 377-380 (2000)
・	P.L. Ferguson, C.R. Iden and B.J. Brownawell: Anal. Chem., 72, 4322-4330 (2000)
・	米久保淳、佐々木俊哉、一木満貴子、金井みき子、佐々木秀輝：分析化学、48, 571-577 (1999)
・	T. Tsuda K. Suga, E. Kaneda and M. Ohsuga: J. Chromatogr. B, 746, 305-309 (2000)
・	K. Inoue, Y. Yoshimura, T. Makino and H.Nakazawa : Analyst, 125, 1959-1961 (2000)
・	T. Tsuda A. Takino, M. Kojima, H. Harada and K. Muraki: J. Chromatogr. B, 723, 273-279 (1999)
・	河村葉子、前原玉枝、飯嶋広代、山田隆：食衛誌、41, 212-218 (2000)

・	Ashby J, Tinwell H & Haseman J (1999) Lack of effects for low dose levels of bisphenol A and diethylstilbestrol on the prostate gland of CF1 mice exposed in utero, Regul. Toxicol. Pharm. 30, 156-166
・	Ema M, Fujii S, Furukawa M, Kiguchi M, Ikka T and Harazono A (2001) Rat two-generation reproductive toxicity study of bisphenol A, Reprod. Toxicol., 15, 505-523
・	Gupta C (2000) Reproductive malformation of the male offspring following maternal exposure to estrogenic chemicals, Exper. Biol. Med. 224(2), 61-68
・	Nagel SC, vom Saal FS, Thayer KA, Dhar M, Boechler M, and Welshons WV (1997) Relative binding affinity-serum modified access (RBA-SMA) assay predicts the ralative in vivo bioactivity of the xenoestrogens bisphenol A and octylphenol, Environ. Health Persp., 105, 70-76
・	NTP/NIEHS (2001) NTP Report of the Endocrine Disruptors Low Dose Peer Review, Chapter 5 Report of the Statistics Subpanel, 5-6, 12, US EPA/NTP-NIEHS
・	National Research Council (1999) Hormonally Active Agents in the Environment. National Academy Press. pp. 430
・	Odum J, Tinwell H, Jones K, Van Miller, Joiner RL & Tobin G (2001) Effect of rodent diets on the sexual development of the rat, Toxicological Science, 61, 115-127
・	大竹千代子、関沢純（印刷中）Diethylstilbestrol の低用量試験での陽性反応再現性確立への提案、第４回日本内分泌かく乱化学物質学会研究発表会、つくば
・	関沢純、配島由二、土屋利江（2001）ビスフェノールＡ重合樹脂成型血液透析器使用のリスク・ベネフィット分析、日本リスク研究学会第１４回研究発表会、73-74頁
・	Vom Saal FS, Cooke PS, Buchanan DL, Palanza P, Thayer KA, Nagel SC, Parmigiani S and Welshons WV (1998) A physiologically based approach to the study of bisphenol A and estrogenic chemicals on the size of reproductive organs, daily sperm production and behavior, Toxocol. Ind/ Health 14, 239-259
・	吉田緑、勝田真一、渡辺元、田谷一善、前川明彦 (2001) 胎仔期および授乳期の低用量-BisphenolA暴露がラット雌性生殖器系に及ぼす影響、第28回日本トキシコロジー学会、年会講演要旨集、122頁。

全体総括：	紫芝良昌○（三宿病院院長）
暴露調査等：	牧野恒久△（東海大学医学部産婦人科）、中澤裕之（星薬科大学薬学部）、織田肇（大阪公衆衛生研究所）、塩田邦郎（東京大学農学生命科学大学院）、鈴森薫（名古屋市立大学医学部産婦人科）
疫学研究：	津金昌一郎△・花岡知之・原めぐみ（国立がんセンター研究所支所臨床疫学研究部）、坪野吉孝（東北大学大学院医学系研究科）、岸玲子・加藤静恵・笠井世津子・倉橋典絵（北海道大学大学院医学研究科）、岩本晃明・野澤資亜利（聖マリアンナ医大泌尿器科）

・	厚生科学研究費補助金（生活安全総合研究事業）「内分泌かく乱化学物質の人の生殖機能等への影響に関する研究」（主任研究者：津金昌一郎国立がんセンター研究所支所臨床疫学研究部長
・	厚生科学研究費補助金（生活安全総合研究事業）「内分泌かく乱物質の生殖機能と次世代への影響、特に生殖泌尿器系・先天異常の成因に関する疫学的研究」（主任研究者：岸玲子北海道大学大学院医学研究科教授）
・	厚生科学研究費補助金（生活安全総合研究事業）「内分泌かく乱物質等の生活環境中の化学物質による健康影響－日本人正常男性の生殖機能に関する総合的研究」（主任研究者：岩本晃明聖マリアンナ医大泌尿器科教授）

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